Clinicopathological study of risk factors for degenerative dementia : the Hisayama Study

• Project/Area Number: 19300125
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kyushu University
• Principal Investigator: IWAKI Toru Kyushu University, 大学院・医学研究院, 教授 (40221098)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Satoshi 九州大学, 大学院・医学研究院, 准教授 (90294917) ; SASAKI Kensuke 九州大学, 大学院・医学研究院, 助教 (80380616) ; KIYOHARA Yutaka 九州大学, 大学院・医学研究院, 教授 (80161602) ; TANIZAKI Yumihiro 九州大学, 大学院・医学研究院, 学術研究員 (30437785)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 認知症 / アルツハイマー病 / 老人斑 / 神経原線維変化 / 糖尿病 / インスリン / 耐糖能異常 / 生活習慣病 / 疫学研究 / 生活習慣

Research Abstract

We examined the association between diabetes-related factors and pathology of Alzheimer's disease in the Hisayama study. The results suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate neuritic plaque formation in combination with the effects of APOE ε4. There were no relationships between diabetes-related factors and neurofibrillary tangles.

Research Products

• [Journal Article] Insulin resistance is associated with the pathology of Alzheimer's disease : the Hisayama Study. (2010)
  • Author(s): Matsuzaki T, et al.
  • Journal Title: Neurology (in press)
  • Peer Reviewed
• [Journal Article] Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama Study. (2009)
  • Author(s): Matsui Y, Tanizaki Y, Arima H, Yonemoto K, Doi Y, Ninomiya T, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y
  • Journal Title: J Neurol Neurosurg Psychiatry. 80(4) Pages: 366-370
  • Peer Reviewed
• [Journal Article] Development of oligomeric prion-protein aggregates in a mouse model of prion disease. (2009)
  • Author(s): Sasaki K, Minaki H, Iwaki T
  • Journal Title: J. Pathol. 219(1) Pages: 123-130
  • Peer Reviewed
• [Journal Article] Prion protein oligomers in Creutzfeldt-Jakob disease detected by gel-filtration centrifuge columns. (2009)
  • Author(s): Minaki H, Sasaki K, Honda H, Iwaki T
  • Journal Title: Neuropathology 29(5) Pages: 536-542
  • NAID: 10028192186
  • Peer Reviewed
• [Journal Article] Incidence and survival of dementia in a general population of Japanese elderly : the Hisayama Study. (2009)
  • Author(s): Matsui Y, et al.
  • Journal Title: J Neurol Neurosurg Psychiatry 80 Pages: 366-370
  • Peer Reviewed
• [Journal Article] Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: The Hisayama study. (2008)
  • Author(s): Fujimi K, Sasaki K, Noda K, Wakisaka Y, Tanizaki Y, Matsui Y, Sekita A, Iida M, Kiyohara Y, Kanba S, Iwaki T
  • Journal Title: Brain Pathol. 18(3) Pages: 317-325
  • Peer Reviewed
• [Journal Article] Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: The Hisayama study. (2008)
  • Author(s): Fujimi K., et al.
  • Journal Title: Brain Pathol. 18 Pages: 317-325
  • Peer Reviewed
• [Journal Article] Incidence and survival of dementia in a general population of Japanese elderly : the Hisayama Study. (2008)
  • Author(s): Matsui Y, et al.
  • Journal Title: J Neurol Neurosurg Psychiatry. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama study (2007)
  • Author(s): Fujimi K, Noda K, Sasaki K, Wakisaka Y, Tanizaki Y, Iida M, Kiyohara Y, Kanba S, Iwaki T
  • Journal Title: Dement Geriatr Cogn Disord. 23 Pages: 423-431
  • Peer Reviewed
• [Journal Article] Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama study. (2007)
  • Author(s): Fujimi K., et. al.
  • Journal Title: Dement.Geriatr.Cogn.Disord. 23 Pages: 423-431
  • Peer Reviewed
• [Journal Article] Intraneuronal amyloid beta 42 enhanced by heating but counteracted by formic acid (2007)
  • Author(s): Ohyagi Y., et. al.
  • Journal Title: J.Neurosci.Methods 159 Pages: 134-138
  • Peer Reviewed
• [Journal Article] Insulin resistance is associated with the pathology of Alzheimer' s disease: the Hisayama Study.
  • Author(s): Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matui Y, Sekita A, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T
  • Journal Title: Neurology (in press)
  • Peer Reviewed
• [Presentation] 耐糖能異常とアルツハイマー病の病理学的関連 (2009)
  • Author(s): 松崎尊信
  • Organizer: 第50回日本神経病理学会
  • Place of Presentation: 高松
  • Year and Date: 2009-06-06
• [Presentation] プリオン持続感染細胞株におけるプリオン蛋白重合度の解析 (2009)
  • Author(s): 柴野智子
  • Organizer: 第50回日本神経病理学会
  • Place of Presentation: 高松
  • Year and Date: 2009-06-06
• [Presentation] ペントサンポリ硫酸治療症例におけるプリオン蛋白重合度変化の解析 (2009)
  • Author(s): 本田裕之
  • Organizer: 第50回日本神経病理学会
  • Place of Presentation: 高松
  • Year and Date: 2009-06-06
• [Presentation] 臨床所見で中枢性低換気を合併した家族性パーキンソン症状を示し、病理学的にTDP-43陰性のタウオパチーを認めた46歳女性剖検例 (2009)
  • Author(s): 尾本雅俊
  • Organizer: 第50回日本神経病理学会
  • Place of Presentation: 高松
  • Year and Date: 2009-06-06
• [Presentation] 多彩なプリオン蛋白沈着パターンを示したMM1+2孤発性クロイツフェルト・ヤコブ病の一剖検例 (2009)
  • Author(s): 佐々木健介
  • Organizer: 第50回日本神経病理学会
  • Place of Presentation: 高松
  • Year and Date: 2009-06-06
• [Presentation] (6)本田裕之、プリオン病の病理形態学的および蛋白生化学的定量解析の試み (2008)
  • Author(s): 本田裕之
  • Organizer: 第49回日本神経病理学会
  • Place of Presentation: 東京
• [Presentation] プリオン蛋白オリゴマーの簡便な検出法 (2008)
  • Author(s): 皆木晴彦
  • Organizer: 第49回日本神経病理学会
  • Place of Presentation: 東京
• [Presentation] プリオン病モデルマウスおける重合プリオン蛋白形成の経時的解析 (2008)
  • Author(s): 佐々木健介
  • Organizer: 第49回日本神経病理学会
  • Place of Presentation: 東京
• [Presentation] 耐糖能異常とアルツハイマー病の病理学的関連 (2008)
  • Author(s): 松崎尊信
  • Organizer: 第49回日本神経病理学会
  • Place of Presentation: 東京
• [Presentation] 耐糖能異常とアルツハイマー病の病理学的関連. (2008)
  • Author(s): 松崎尊信
  • Organizer: 第49回日本神経病理学会
  • Place of Presentation: 東京
• [Presentation] Clinicopathological study of dementia: the Hisayama study (2007)
  • Author(s): Iwaki T
  • Organizer: The 4th International Symposium. Kyushu University COE Program. Frontier Research and Education on Lifestyle-Related Diseases based on the Large-scale Cohort Study
  • Place of Presentation: 福岡
• [Presentation] Time course of the development of PrP aggregates in a mouse model of prion disease (2007)
  • Author(s): Sasaki K
  • Organizer: Prion 2007
  • Place of Presentation: 英国エジンバラ
• [Presentation] 高齢者における耐糖能異常と高血圧が認知症発症に及ぼす影響 (2007)
  • Author(s): 谷崎弓裕
  • Organizer: 第49回日本老年医学会
  • Place of Presentation: 札幌
• [Presentation] 一般住民におけるレビー小体型認知症の新しい診断基準に基づく臨床病理学的検討 (2007)
  • Author(s): 藤見恒平
  • Organizer: 第48回日本神経病理学会
  • Place of Presentation: 東京
• [Presentation] 一般住民における、レビー小体型認知症の新しい診断基準に基づく臨床病理学的検討 (2007)
  • Author(s): 藤見 恒平
  • Organizer: 第48回日本神経病理学会
  • Place of Presentation: 東京