Studies on degradation of amyloid beta-protein by angiotensin-converting enzyme (ACE)
Project/Area Number |
19300138
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | National Institute for Longevity Sciences,NCGG |
Principal Investigator |
MICHIKAWA Makoto National Institute for Longevity Sciences,NCGG, アルツハイマー病研究部, 部長 (40270912)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2007: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
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Keywords | 精神・神経疾患の病態と治療 / アルツハイマー病 / 蛋白分解酵素 / 治療 / アンギオテンシン変換酵素 / アミロイドベータ蛋白 |
Research Abstract |
アルツハイマー病の病因分子であるamyloid β蛋白(Aβ)の分解酵素であるACEの脳内Aβ沈着に及ぼす影響を解析し、ACEが脳内でAβの分解やAβ42をAβ40に変換する働きをしていることを明らかにした。また、ACEにある2つの主要ドメイン機能は、それぞれ異なる基質(アンギオテンシンIならびにAβ)に対して別の作用を持つことを明らかにした。
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Report
(3 results)
Research Products
(41 results)
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[Journal Article] Angiotensin-converting enzyme converts amyloid β-protein1-42 (Aβ(1-42)) to Aβ(1-40), and its inhibition enhances brain Aβ deposition2007
Author(s)
Zou K, Yamaguchi H, Akatsu H, Sakamoto T, Ko M, Mizoguchi K, Gong JS, Yu W, Yamamoto T, Kosaka K, Yanagisawa K, Michikawa M
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Journal Title
J Neurosci. 27(32)
Pages: 8628-8635
Related Report
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[Journal Article] Angiotensin-converting enzyme converts amyloid β-protein1-42(Aβ(1-42))to Aβ(1-40), and its inhibition enhances brain Aβ deposition2007
Author(s)
Zou K, Yamaguchi H, Akatsu H, Sakamoto T, Ko M, Mizoguchi K, Gong JS, Yu W, Yamamoto T, Kosaka K, Yanagisawa K, Michikawa M.
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Journal Title
J Neurosci 27(32)
Pages: 8628-8635
Related Report
Peer Reviewed
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[Presentation] Angiotensin-concerting enzyme converts Abetal-42 to Abetal-40 and its inhibition enhances brain Abeta deposition2007
Author(s)
Zou K, Yamaguchi H, Akatsu H, Sakamoto T, Ko M, Mizoguchi K, Gong JS, Yu W, Yamamoto T, Koska K, Komano H, Yanagisawa K, Michikawa M
Organizer
第30回日本分子生物学会年会および 第80回日本生化学会大会、シンポジウム
Place of Presentation
横浜
Year and Date
2007-12-14
Related Report
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[Presentation] Angiotensin-converting enzyme converts Aβ1-42 to Aβ1-40 and its inhibition enhances brain Aβ deposition.2007
Author(s)
K. Zou, H. Yamagucih, H. Akatsu T. Sakamoto, M. Ko, K. Mizoguchi, J.-S. Gong, W. Yu, T. Yamamoto, K. Kosaka, K. Yanagisawa, Michikawa M
Organizer
北米神経科学会
Place of Presentation
サンジエゴ、米国
Year and Date
2007-11-06
Related Report
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