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categorization of movements and neural representation of cognitive operations

Research Project

Project/Area Number 19300139
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionTohoku University

Principal Investigator

MUSHIAKE Hajime  Tohoku University, 大学院・医学系研究科, 教授 (80219849)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords大脳皮質 / 高次機能 / 神経生理学 / 運動野 / 前頭前野 / 両手動作 / 細胞活動 / 動作 / カテゴリー
Research Abstract

There are multiple motor areas and prefrontal areas in the frontal cortex. We trained monkeys to perform bimanual sequential tasks. We found that neuronal activity in the lateral prefrontal cortex (LPFC), pre-SMA and SMA were related to action (pronation or supination) or effector (right hand or left hand) and combination of these parameters. Some of these neurons were related to category of actions rather than particular movements. Although neurons representing each category of movemnts were frequently found in these areas, it is of interest that neuronal activity representing individual actions, abundant in medial premotor areas, was not common in the LPFC. Thus, we propose a trend in hierarchical organization of the frontal cortex with respect to the planning of sequential actions : a category of sequences in the LPFC, a sequence of actions in higher motor areas, and a plan of individual actions in the primary motor and premotor cortex. This functional difference implies the generation of neural representations to enable planning of structured event complexes at a conceptual level.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (47 results)

All 2010 2009 2008 2007 Other

All Journal Article (22 results) (of which Peer Reviewed: 18 results) Presentation (23 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Covert representation of second-next movement in the pre-supplementary motor area of monkeys2009

    • Author(s)
      Nakajima T, Hosaka R, Mushiake H, Tanji J.
    • Journal Title

      Journal of Neurophysiology 101(4)

      Pages: 1883-1889

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interval-time coding by neurons in the presupplementary and supplementary2009

    • Author(s)
      Mita Akihisa, Mushiake Hajime, Shima Keisetsu, Matsuzaka Yoshiya, Tanji Jun
    • Journal Title

      motor areas nature neuroscience (AOP 2009. 3. 2) 12

      Pages: 502-507

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the prefrontal cortex in problem solving International Review of Neurobiology (Elsevier)2009

    • Author(s)
      Mushiake H, Sakamoto K, Saito N, Inui T., Aihara K, Tanji J
    • Journal Title

      International Review of Neurobiology Vol 85 2009-Advances in Pharmacology 85

      Pages: 1-11

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高次運動野による身体性認知行動制御-前補足運動野と補足運動野を中心に-2009

    • Author(s)
      虫明元, 乾敏郎, 丹治順
    • Journal Title

      Clinical Neuroscience 27巻7号

      Pages: 784-788

    • Related Report
      2009 Final Research Report
  • [Journal Article] Which object appeared longer?2009

    • Author(s)
      Tanji J, Mushiake H
    • Journal Title

      Neuron. 63

      Pages: 148-149

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高次運動野による身体性認知行動制御-前補足運動野と補足運動野を中心に-2009

    • Author(s)
      虫明元, 乾敏郎, 丹治順
    • Journal Title

      Clinical Neuroscience 27

      Pages: 784-788

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Covert representation of second-next movement in the pre-supplementary motor area of monkeys.2009

    • Author(s)
      Nakajima T, Hosaka R, Mushiake H, 丹治順
    • Journal Title

      Journal of neurophysiology 101

      Pages: 1883-1889

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interval time coding by neurons in the presupplementary and supplementary motor areas2009

    • Author(s)
      Mita A, 虫明元, Shima K, Matsuzaka Y, 丹治順
    • Journal Title

      Nature neuroscience 12

      Pages: 502-507

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural activity in the human brain signals logical rule identification.2009

    • Author(s)
      Tachibana K, Suzuki K, Mori E, Miura N, Kawashima R, Horie K, Sato S, 丹治順, 虫明元
    • Journal Title

      Journal of neurophysiology 102

      Pages: 1526-1537

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the prefrontal cortex in problem solving.2009

    • Author(s)
      虫明元, Sakamoto K, Saito N, 乾敏郎, Aihara K, 丹治順
    • Journal Title

      International review of neurobiology 85

      Pages: 1-11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Which object appeared longer?2009

    • Author(s)
      丹治順, 虫明元
    • Journal Title

      Neuron 63

      Pages: 148-149

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Covert representation of second-next movement in the pre-suppl ementary motor area of monkeys2009

    • Author(s)
      Nakajima T, Hosaka R, Mushiake H and Tanii J.
    • Journal Title

      Journal of Neurophysiology 101

      Pages: 1883-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discharge Synchrony during the Transition of Behavioral Goal Representations Encoded by Discharge Rates of Prefrontal2008

    • Author(s)
      Sakamoto K, Mushiake H, Saito N, Aihara K, Yano M, Tanji J
    • Journal Title

      Neurons Cerebral Cortex 18

      Pages: 2036-2045

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 運動学習-大脳皮質・基底核の観点から-2008

    • Author(s)
      虫明元, 橘香織, 乾敏郎, 丹治順
    • Journal Title

      総合リハビリテーション 36巻10号

      Pages: 973-979

    • Related Report
      2009 Final Research Report
  • [Journal Article] 運動学習-大脳皮質・基底核の観点から-2008

    • Author(s)
      虫明元, 橘香織, 乾敏郎, 丹治順
    • Journal Title

      総合リハビリテーション 36

      Pages: 973-979

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Decoding higher-order motor information from primate non-primary motor cortices2007

    • Author(s)
      Nakajima T, Mushiake H, Inui, Tanji J
    • Journal Title

      Technology and Health Care 15

      Pages: 103-110

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Categorization of behavioral sequences in the prefrontal cortex2007

    • Author(s)
      Shima K, Isoda M, Mushiake H, Tanji J
    • Journal Title

      Nature 445

      Pages: 315-318

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concept based behavioural planning and lateral prefrontal cortex2007

    • Author(s)
      Jun Tanji, Keisetsu Shima, Hajime Mushiake
    • Journal Title

      Trends in Cognitive Sciences 12

      Pages: 528-534

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 目的志向性行動計画の神経機構2007

    • Author(s)
      虫明元, 斉藤尚弘, 坂本寛一, 奥山澄人, 乾敏郎, 丹治順
    • Journal Title

      脳21 第10巻4号

      Pages: 27-32

    • Related Report
      2009 Final Research Report
  • [Journal Article] Decoding higher-order motor information from primate non-primary motor cortices2007

    • Author(s)
      Nakajima T, Mushiake H, Inui and Tanji
    • Journal Title

      Technology and Health Care 15

      Pages: 103-110

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Categorization of behavioral sequences in the prefrontal cortex2007

    • Author(s)
      Shima K, Isoda M, Mushiake H and Tanji J
    • Journal Title

      Nature 445

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concept based behavioural planning and lateral prefrontal cortex2007

    • Author(s)
      Jun Tanji, Keisetsu Shima, And Hajime Mushiake
    • Journal Title

      Trends in Cognitive Sciences 12

      Pages: 528-534

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規運動準備器に見られる内側運動野LFPのβ振動の減少2010

    • Author(s)
      保坂亮介, 中島敏, 虫明元, 合原一幸, 山口陽子
    • Organizer
      日本物理学会春期大会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 身体性認知神経科学の視点からみた認知行動の神経機構2009

    • Author(s)
      虫明元
    • Organizer
      第24回生体・生理工学シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-24
    • Related Report
      2009 Final Research Report
  • [Presentation]2009

    • Author(s)
      NAKAJIMA T, HOSAKA R, TANJI J, MUSHIAKE H
    • Organizer
      Activity of putative pyramidal neurons and interneurons in medial motor areas during performance of a memory-guided sequential motor task
    • Place of Presentation
      Chicago USA
    • Year and Date
      2009-10-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Activity of putative pyramidal neurons and interneurons in medial motor areas during performance of a memory-guided sequential motor task Oct 20, 2009 Chicago USA2009

    • Author(s)
      NAKAJIMA T, HOSAKA R, TANJI J, MUSHIAKE H
    • Organizer
      SFN39
    • Place of Presentation
      Chicago USA
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Platform for multi-function brain electrode system2009

    • Author(s)
      Mushiake H
    • Organizer
      第32回神経科学会名古屋
    • Place of Presentation
      Nagoya JAPAN
    • Year and Date
      2009-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 身体を操作する脳と環境を操作する脳 サテライトシンポジウム脳・身体・機械の新たな結びつき2009

    • Author(s)
      Mushiake H
    • Organizer
      第32回神経科学会名古屋
    • Place of Presentation
      Nagoya JAPAN
    • Year and Date
      2009-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] The influence of interrupting a memory-guided sequential motor task on prefrontal neuronal activity2009

    • Author(s)
      Nakajima T, Miyazaki A, Mushiake H, Tanji J
    • Organizer
      第32回神経科学会名古屋
    • Place of Presentation
      Nagoya JAPAN
    • Year and Date
      2009-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] The interrupting effect of a visually-guided motor task on retrieval of a memorized motor sequence2009

    • Author(s)
      Miyazaki A, Nakajima T, Shima K, Mushiake H
    • Organizer
      IUPS 2009 The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto JAPAN
    • Year and Date
      2009-07-30
    • Related Report
      2009 Final Research Report
  • [Presentation] (2009)The interrupting effect of a visually-guided motor task on retrieval of a memorized motor sequence2009

    • Author(s)
      Miyazaki A, Nakajima T, Shima K, Mushiake H
    • Organizer
      IUPS 2009 The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto JAPAN
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation]2008

    • Author(s)
      S. OKUYAMA, H. MUSHIAKE, T. INUI, J. TANJI
    • Organizer
      Flexible behavior in numerosity based operation by monkeys
    • Place of Presentation
      Washington DC USA
    • Year and Date
      2008-11-18
    • Related Report
      2009 Final Research Report
  • [Presentation]2008

    • Author(s)
      T. NAKAJIMA, R. HOSAKA, H. MUSHIAKE, J. TANJ
    • Organizer
      Reference frame of action-related neuronal activity in the pre-supplementary motor area
    • Place of Presentation
      Washington DC USA
    • Year and Date
      2008-11-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Reference frame of action-related neuronal activity in the pre-supplem entary motor area2008

    • Author(s)
      NAKAJIMA, R. HOSAKA, H. MUSHIAKE, J. TANJ
    • Organizer
      SFN38
    • Place of Presentation
      Washington DC USA
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 問題解決の枠組みからの前頭前野機能2008

    • Author(s)
      虫明元
    • Organizer
      ニューロコンピューティング研究会 (NC)
    • Place of Presentation
      仙台
    • Year and Date
      2008-10-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 問題解決の視点からの前頭前野機能2008

    • Author(s)
      虫明元
    • Organizer
      第41回 山口県 Neuroscience 研究会
    • Year and Date
      2008-10-02
    • Related Report
      2009 Final Research Report
  • [Presentation] 運動学習の神経基盤日本リハビリテーション医学会2008

    • Author(s)
      虫明元
    • Organizer
      近畿地方会第25回学術集会
    • Place of Presentation
      特定医療法人大道会森之宮病院 大阪
    • Year and Date
      2008-09-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Relationship between Neural Activities and Local Field Potential in Medial Motor Areas of Awake Monkeys2008

    • Author(s)
      Hosaka R, Nakajima T, Mushiake H, Aihara K
    • Organizer
      第31回神経科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Flexible behavior in numerosity-based operation task by monkeys2008

    • Author(s)
      Okuyama S. Tanji J, Inui T. Mushiake H
    • Organizer
      第31回神経科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Second-next-movement-selective neuronal activity in the pre-supplementary and supplementary motor areas during a bimanual sequential motor task2008

    • Author(s)
      Nakajima T, Hosaka R, Tanji J, Mushiake H
    • Organizer
      第31回神経科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Involvement of the prefrontal cortex in dynamical representations in problem solving situations. XI WORKSHOP ON APOPTOSIS IN BIOLOGY AND MEDICINE2008

    • Author(s)
      Hajime Mushiake
    • Organizer
      第11回神経細胞死・変性による疾患ならびにその治療薬に関するワークショップ
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] Representation of the motor coordinates in neuronal activity of medial frontal motor cortices2007

    • Author(s)
      Nakajima T, Mushiake H, Hosaka R, Tanji J
    • Organizer
      第30回神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-11
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Behavioral analysis of Japanese monkeys during a numerosity-based operation task2007

    • Author(s)
      Okuyama S. Mushiake H, Inui T. Tanji J
    • Organizer
      第30回神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Difference in transition of goal representation between putative pyramidal neurons and interneurons in the primate prefrontal cortex2007

    • Author(s)
      Sakamoto K, Yoshida S, Mushiake H, Aihara K, Tanji J
    • Organizer
      第30回神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Action Planning and Motor Control サテライトシンポジウム「脳と心のメカニズム」2007

    • Author(s)
      Mushiake H.
    • Organizer
      Action Planning and Motor Control
    • Place of Presentation
      北海道札幌
    • Year and Date
      2007-08-24
    • Related Report
      2009 Final Research Report
  • [Book] 学習と脳 -器用さを護得する脳-2007

    • Author(s)
      久保田競, 虫明 元, 宮井一郎
    • Total Pages
      197
    • Publisher
      サイエンス社
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.tohoku.ac.jp/org/medical/10/index.html

    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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