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Energetics in arterioles during nitric oxide dependent and independent vasodilation

Research Project

Project/Area Number 19300154
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionShibaura Institute of Technology (2008-2009)
The University of Tokyo (2007)

Principal Investigator

SHIBATA Masahiro  Shibaura Institute of Technology, システム理工学部, 教授 (60158954)

Co-Investigator(Kenkyū-buntansha) 市岡 滋  埼玉医科大学, 医学部, 教授 (60306272)
Co-Investigator(Renkei-kenkyūsha) ICHIOKA Shigeru  埼玉医科大学, 医学部, 教授 (60306272)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords生体システム / フィジオーム / 生物・生体工学 / 細胞・組織 / 循環器・高血圧 / 生理学 / 微小循環 / 酸素輸送 / 毛細血管 / 生体顕微鏡
Research Abstract

The objective of this study was to evaluate whether the nitric oxide (NO) would decrease vessel wall oxygen consumption by decreasing the mechanical work of vascular smooth muscle. The oxygen consumption rate (QO_2) of arteriolar walls in rat cremaster muscle was determined in vivo during NO dependent and -independent vasodilation based on the intra- and perivascular oxygen tension (PO_2) measured by phosphorescence quenching technique. NO dependent vasodilation was induced by increased NO production due to increased blood flow, while NO independent vasodilation was induced by topical administration of papaverine. The energy efficiency was evaluated by the variable ratio of wall tension to QO_2 between normal and vasodilated conditions. NO dependent and -independent dilation increased arteriolar diameters by 13% and 17%, respectively. Vascular wall QO_2 decreased significantly during both dilations. There was no significant difference between the energy efficiency during NO dependent and -independent vasodilation, suggesting the decrease in vascular wall QO_2 produced by NO to be related to a decrease in the mechanical work of vascular smooth muscle.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (29 results)

All 2010 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 8 results) Presentation (11 results) Book (2 results)

  • [Journal Article] Oxygen consumption by arteriolar wall during enhancement and inhibition of nitric oxide synthesis.2009

    • Author(s)
      Shibata M, Ohura N, Ichioka S
    • Journal Title

      IFMBE Proceedings 25

      Pages: 125-128

    • Related Report
      2009 Final Research Report
  • [Journal Article] Oxygen dynamics around arterioles in skeletal muscle.2009

    • Author(s)
      Shibata M, Ohura N, Ichioka S
    • Journal Title

      Clinical Hemorheology and Microcirculation. 42

      Pages: 226-226

    • Related Report
      2009 Final Research Report
  • [Journal Article] Oxygen consumption by arteriolar wall during enhancement and inhibition of nitric oxide synthesis2009

    • Author(s)
      Shibata M, Ohura N, Ichioka S
    • Journal Title

      IFMBE Proceedings 25

      Pages: 125-128

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxygen dynamics around arterioles in skeletal muscle2009

    • Author(s)
      Shibata M, Ohura N, Ichioka S
    • Journal Title

      Clinical Hemorheology and Microcirculation 42

      Pages: 226-226

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological role of nitric oxide in oxygen consumption by arteriolar wall.2008

    • Author(s)
      Shibata M, Yamakoshi T, Yamakoshi K
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc

      Pages: 1389-1392

    • Related Report
      2009 Final Research Report
  • [Journal Article] Oxygen consumption of keloids and hypertrophic scars.2008

    • Author(s)
      Ichioka S, Ando T, Shibata M, Sekiya N, Nakatsuka T
    • Journal Title

      Ann Plast Surg 60

      Pages: 194-197

    • Related Report
      2009 Final Research Report
  • [Journal Article] A technique to visualize wound bed microcirculation and the acute effect of negative pressure.2008

    • Author(s)
      Ichioka S, Watanabe H, Sekiya N, Shibata M, Nakatsuka T
    • Journal Title

      Wound Repair Regen 16

      Pages: 460-465

    • NAID

      10031181484

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effect of vibration on skin blood flow in an in vivo microcirculatory model.2008

    • Author(s)
      Nakagami G, Sanada H, Matsui N, Kitagawa A, Yokogawa H, Sekiya N, Ichioka S, Sugama J, Shibata M
    • Journal Title

      BioScience Trends 1

      Pages: 161-166

    • Related Report
      2009 Final Research Report
  • [Journal Article] Oxygen consumption of keloids and hypertrophic scars2008

    • Author(s)
      Ichioka, Shibata, (他3名)
    • Journal Title

      Ann Plast Surg 60

      Pages: 194-197

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A technique to visualize wound bed microcirculation and the acute effect of negative pressure2008

    • Author(s)
      Ichioka, Shibata, (他3名)
    • Journal Title

      Wound Repair Regen 16

      Pages: 460-465

    • NAID

      10031181484

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of vibration on skin blood flow in an in vivo microcirculatory model2008

    • Author(s)
      Nakagami, Shibata, (他7名)
    • Journal Title

      BioScience Trends 1

      Pages: 161-166

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxygen consumption of keloids and hypertrophic scars2008

    • Author(s)
      S.Ichioka, T.Ando, M.Shibata, N.Sekiya, T.Nakatsuka
    • Journal Title

      Ann Plast Surg 60

      Pages: 194-197

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compact capillaroscopy for human skin using CCD video-probe.2007

    • Author(s)
      Shibata M, Ohura N, Sekiya N, Ichioka S, Yamakoshi T, Yamakoshi K, Kamiya A
    • Journal Title

      Microvascular Reviews and Communications 1

      Pages: 4-7

    • NAID

      130004467803

    • Related Report
      2009 Final Research Report
  • [Journal Article] Alpha V beta 3 (αvβ3) integrin inhibition reduces leukocyte-endothelium interaction in a pressure-induced reperfusion model.2007

    • Author(s)
      Ichioka S, Sekiya N, Shibata M, Nakatsuka T
    • Journal Title

      Wound Rep Reg 15

      Pages: 572-576

    • NAID

      10031181381

    • Related Report
      2009 Final Research Report
  • [Journal Article] Compact capillaroscopy for human skin using CCD video-probe2007

    • Author(s)
      M.Shibata, N.Ohura, N, Sekiya, S.Ichioka, T.Yamakoshi, K.Yamakoshi, A Kamiva
    • Journal Title

      Microvascular Reviews and Communications 1

      Pages: 5-8

    • NAID

      130004467803

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alpha V beta3(αvβ3)integrin inhibition reduces leukocyte-endothelium interaction in apressure-induced reperfusion model2007

    • Author(s)
      S.Ichioka, N.Sekiya, M.Shibata, T.Nakatsuka
    • Journal Title

      Wound Repair Regen 15

      Pages: 572-576

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] In vivo vascular wall shear stress in arterioles under normal and dilated conditions2010

    • Author(s)
      柴田政廣, 他
    • Organizer
      日本微小循環学会
    • Place of Presentation
      さいたま市
    • Year and Date
      2010-02-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxygen consumption by arteriolar wall during enhancement and inhibition of nitric oxide synthesis.2009

    • Author(s)
      Shibata M, Ohura N, Ichioka S
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering.
    • Place of Presentation
      Munich
    • Related Report
      2009 Final Research Report
  • [Presentation] Oxygen dynamics around arterioles in skeletal muscle.2009

    • Author(s)
      Shibata M, Ohura N, Ichioka S
    • Organizer
      5th International Conference on Clinical Hemorheology.
    • Place of Presentation
      St.Moritz
    • Related Report
      2009 Final Research Report
  • [Presentation] Oxygen consumption by vascular wall in skeletal muscle arterioles under physiological conditions.2008

    • Author(s)
      Shibata M, Yamakoshi T, Yamakoshi K
    • Organizer
      8^<th> IEEE international Conference on BIBE
    • Place of Presentation
      Athens
    • Related Report
      2009 Final Research Report
  • [Presentation] Energetics in arterioles during nitric oxide dependent and independent vasodilation.2008

    • Author(s)
      Shibata M, Yamakoshi T, Yamakoshi K
    • Organizer
      30^<th> IEEE international Conference on EBM
    • Place of Presentation
      Vancouver
    • Related Report
      2009 Final Research Report
  • [Presentation] Oxygen dynamics around arterioles2008

    • Author(s)
      Shibata M
    • Organizer
      36th Annual ISOTT conference
    • Place of Presentation
      Sapporo
    • Related Report
      2009 Final Research Report
  • [Presentation] Application of phosphorescence quenching technique to in vivo microvascular oxygen measurements.2008

    • Author(s)
      Shibata M, Kawarada A
    • Organizer
      22^<nd> SICE Symposium on Biomedical and Physiological Engineering
    • Place of Presentation
      Harbin
    • Related Report
      2009 Final Research Report
  • [Presentation] Physiological role of nitric oxide in oxygen consumption by arteriolar wall2008

    • Author(s)
      Shibata, (他2名)
    • Organizer
      30^<th> IEEE international Conference on EBM
    • Place of Presentation
      Vancouver
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nitric oxide contribution to vascular wall oxygen consumption in arterioles2007

    • Author(s)
      M.Shibata, N.Ohura, N.Sekiya
    • Organizer
      9th World Conference for Microcirculation
    • Place of Presentation
      Milwaukee
    • Year and Date
      2007-08-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Energetics in arterioles during nitric oxide dependent and independent vasodilation.2007

    • Author(s)
      Shibata M, Yamakoshi T, Yamakoshi K
    • Organizer
      29^<th> IEEE international Conference on EBM
    • Place of Presentation
      Lyon
    • Related Report
      2009 Final Research Report
  • [Presentation] Nitric oxide contribution to vascular wall oxygen consumption in arterioles.2007

    • Author(s)
      Shibata M, Ohura N, Sekiya N, Ichioka S, Kamiya A
    • Organizer
      9th World Conference for Microcirculation
    • Place of Presentation
      Milwaukee
    • Related Report
      2009 Final Research Report
  • [Book] からだと酸素の事典2009

    • Author(s)
      柴田他(共著)
    • Publisher
      朝倉書店
    • Related Report
      2009 Final Research Report
  • [Book] からだと酸素の事典2009

    • Author(s)
      柴田, 他(共著)
    • Total Pages
      596
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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