Development of novel bone remodeling substitutes with nonvolatile static electrical field

• Project/Area Number: 19300169
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: YAMASHITA Yamashita Tokyo Medical and Dental University, 生体材料工学研究所, 教授 (70174670)
• Co-Investigator(Kenkyū-buntansha): 伊藤 聰一郎 国際医療福祉大学, 臨床医学研究センター, 教授 (10242190) ; 永井 亜希子 東京医科歯科大学, 生体材料工学研究所, 特任講師 (40360599) ; 田中 優実 東京医科歯科大学, 生体材料工学研究所, 助教 (00436619) ; 中村 美穂 東京医科歯科大学, 生体材料工学研究所, 助教 (40401385)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 分極 / バイオセラミックス / ハイドロキシアパタイト / リン酸カルシウム / 炭酸含有アパタイト / スキャホールド / バイオインターフェイス / 硬組織代替デバイス

Research Abstract

抄録なし

Research Products

• [Journal Article] Controlled Biomineralization of Calcite under Surface Electric Field on Polarized Substrates (2009)
  • Author(s): Wada N, Tanaka Y, Nakamura M,Kanamura K,, Yamashita K
  • Journal Title: J Am Ceram Soc (in press) Pages: 13-13
• [Journal Article] Ion conduction mechanism in Ca deficient hydroxyapatite whisker (2009)
  • Author(s): Tanaka Y, Nakamura M, Nagai A, ToyamaT and Yamashita K
  • Journal Title: Mater.Sci.Eng.B-Solid (in press) Pages: 5-5
• [Journal Article] Polarized Hydroxyapatite Promotes Spread and Motility of Osteoblastic Cells (2009)
  • Author(s): Nakamura M, Nagai S, Tanaka Y,Sekijima Y, Yamashita K
  • Journal Title: J Biomed Mater Res A (in press) Pages: 9-9
• [Journal Article] Efficacy of polarized hydroxyapatite and silk fibroin composite dressing on epidermal recovery from full-thickness porcine skin wounds (2009)
  • Author(s): Okabayashi R, Nakamura M, OkabayashiT, Tanaka Y, Nagai A, Yamashita K
  • Journal Title: J Biomed Mater Res Applied Biomaterials B (in press) Pages: 11-11
• [Journal Article] Electrostatic surface charge acceleration of bone ingrowth of porous hydroxyapatite/β-tricalcium phosphate ceramics (2009)
  • Author(s): Nakamura S, Kobayashi T, Nakamura M,Itoh S, Yamashita K.
  • Journal Title: J Biomed Mater Res A (in press) Pages: 29-29
• [Journal Article] Formation of Calcite Thin Films by Cooperation of Polyacrylic Acid and Self-generating Electric Field due to Aligned Dipoles of Polarized Substrates (2009)
  • Author(s): Wada N, Nakamura M, Tanaka Y,Kanamura K, Yamashita K
  • Journal Title: J Colloid Interface Sci 330 Pages: 374-379
• [Journal Article] Enhanced in vivo Responses of Osteoblasts in Electrostatically Activated Zone by Hydroxyapatite Electrets (2009)
  • Author(s): Nakamura S, Kobayashi T, Nakamura M, Yamashita K
  • Journal Title: J Mater Sci 20 Pages: 99-103
• [Journal Article] Formation of Calcite Thin Films by Cooperation of Polyacrylic Acid and Self-generating Electric Field due to Aligned Dipoles of Polarized Substrates. (2009)
  • Author(s): Wada N, et al
  • Journal Title: J Colloid Interf Sci 330 Pages: 374-379
  • Peer Reviewed
• [Journal Article] Enhanced in vivo Responses of Osteoblasts in Electrostatically Activated Zone by Hydroxyapatite Electrets. (2009)
  • Author(s): Nakamura S, et al
  • Journal Title: J. Mater. Sci. : Mater. Med. 20 Pages: 99-103
  • Peer Reviewed
• [Journal Article] Na+-fastionic conducting glass-ceramics of silicophosphates (2008)
  • Author(s): Okura T, Monma H, Yamashita K
  • Journal Title: J Electroceram (in press) Pages: 6-6
• [Journal Article] Electrovector effect on bone-like apatite crystal growth on inside pores of polarized porous hydroxyapatite ceramics in simulated body fluid (2008)
  • Author(s): Iwasaki T, Tanaka Y, Nakamura M, Nagai A, Katayama K, Yamashita K
  • Journal Title: J Ceram Soc Jpn 116 Pages: 23-27
  • NAID: 110006614235
• [Journal Article] Hydroxyapatite Electret Accelerates Reendothelialization and Attenuates Intimal Hyperplasia Occurring After Endothelial Removal of the Rabbit Carotid Artery (2008)
  • Author(s): Nagai A, Yamashita K, Imamura M, AzumaH
  • Journal Title: Life Sci 82(23-24) Pages: 1162-1168
• [Journal Article] Conduction properties of non-stoichiometric hydroxyapatite whiskers for biomedical use (2008)
  • Author(s): Tanaka Y, Takata S, Shimoe K,Nakamura M, Nagai A, Toyama T, Yamashita K.
  • Journal Title: J Ceram Soc Jpn 116 Pages: 815-821
  • NAID: 110006792183
• [Journal Article] Effect of Substitution of Si with V and Mo on Ionic Conductivity of Na5YSi3O12-type Glass-Ceramics (2008)
  • Author(s): Okura T, Takahashi T, Monma H, Yamashita K
  • Journal Title: Solid State Ionics 179 Pages: 1291-1295
• [Journal Article] Yamashita K. Rate of bonelike apatite formation accelerated on polarized porous hydroxyapatite (2008)
  • Author(s): Iwasaki T, Tanaka Y, Nakamura M, Nagai A, Hashimoto K, Toda Y, Katayama K
  • Journal Title: J Am Ceram Soc 12 Pages: 3943-3949
• [Journal Article] Involvement of altered arginase activity, arginase I expression and NO production in accelerated intimal hyperplasia following cigarette smoke extract (2008)
  • Author(s): Nagai A, Imamura M, Watanabe T, Azuma H
  • Journal Title: Life Sci 83 Pages: 453-459
• [Journal Article] Comparison of hydroxyapatite with carbonate apatite in osteoclastic cell resorptive activity (2008)
  • Author(s): Ohashi N, Nakamura M, Nagai A, Tanaka Y, Sekijima Y, Yamashita K
  • Journal Title: Key Eng Mater 361-363 Pages: 1039-1042
• [Journal Article] Regulation of osteoblast-like cell behaviors on hydroxyapatite by electrical polarization (2008)
  • Author(s): Nakamura M, Ohashi N, Nagai A, Sekijima Y, Tanaka Y, Yamashita K
  • Journal Title: Key Eng Mater 361-363 Pages: 1055-1058
• [Journal Article] 生体骨の電気エネルギー蓄積特性 (2008)
  • Author(s): 山下仁大、中村美穂、岡林留美、王巍、田中優実、永井亜希子
  • Journal Title: JJBEPSRS 22 Pages: 15-1
  • NAID: 40016415678
• [Journal Article] Simulation of Bone Ingrowth on Polarized Porous Hydroxyapatite Ceramics. (2008)
  • Author(s): Iwasaki T, et al
  • Journal Title: J Am Ceram Soc. 116 Pages: 23-27
  • Peer Reviewed
• [Journal Article] Hydroxyapatite Electret Accelerates Reendothelialization and Attenuates Intimal Hyperplasia Occurring After Endothelial Removal of the Rabbit Carotid Artery. (2008)
  • Author(s): Nagai A, et al
  • Journal Title: Life Sci. 82 Pages: 1162-1168
  • Peer Reviewed
• [Journal Article] Electrovector effect on bone-like apatite crystal growth on inside pores of polarized porous hydroxyapatite ceramics in simulated body fluid. (2008)
  • Author(s): Iwasaki T, et al
  • Journal Title: J Ceram Soc Jpn 116 Pages: 23-27
  • Peer Reviewed
• [Journal Article] Conduction properties of non-stoichiometric hydroxyapatite whiskers for biomedical use. (2008)
  • Author(s): Tanaka Y, et al
  • Journal Title: J Ceram Soc Jpn 116 Pages: 815-821
  • NAID: 110006792183
  • Peer Reviewed
• [Journal Article] Effect of Substitution of Si with V and Mo on Ionic Conductivity of Na_5YSi_3O_<12>-type Glass-Ceramics (2008)
  • Author(s): Okura T, et al
  • Journal Title: Solid State Ionics 179 Pages: 1291-1295
  • Peer Reviewed
• [Journal Article] Involvement of altered arginase activity, arginase I expression and NO production in accelerated intimal hyperplasia following cigarette smoke extract. (2008)
  • Author(s): Nagai A, et al
  • Journal Title: Life Sci 83 Pages: 453-459
  • Peer Reviewed
• [Journal Article] 生体骨の電気エネルギー蓄積特性. (2008)
  • Author(s): 山下仁大, ら
  • Journal Title: 日本生体電気・物理刺激研究会誌 22 Pages: 15-19
  • NAID: 40016415678
• [Journal Article] 分極ハイドロキシアパタイトの生体材料科学 (2008)
  • Author(s): 田中優実, ら
  • Journal Title: Phosphorus letter 63[1] Pages: 5-13
  • NAID: 40016311882
  • Peer Reviewed
• [Journal Article] Development of polarized hydroxyapatite ceramics and coatings for novel applications. (2008)
  • Author(s): Yamashita K, et al
  • Journal Title: Global roadmap for ceramics & ICC2 proceedings Pages: 1-6
• [Journal Article] Comparison of hydroxyapatite with carbonate apatite in osteoclastic cell resorptive activity. (2008)
  • Author(s): Ohashi N, et al
  • Journal Title: Key Eng Mater 361-363 Pages: 1039-1042
• [Journal Article] Regulation of osteoblast-like cell behaviors on hydroxyapatite by electrical polarization. (2008)
  • Author(s): Nakamura M, et al
  • Journal Title: Key Eng Mater 361-363 Pages: 1055-1058
• [Journal Article] Enhanced bonebonding of hydroxyapatite-coated titaniu mimplants by electrical polarization (2007)
  • Author(s): Kobayashi T, Itoh S, Nakamura S, Nakamura M, Shinomiya K, Yamashita K
  • Journal Title: J Biomed Mater Res 82 Pages: 145-151
• [Journal Article] Interaction of ablood coagulation factor on electrically polarized hydroxyapatite surfaces (2007)
  • Author(s): Nakamura M, Niwa K, Nakamura S, Sekijima Y, Yamashita K
  • Journal Title: J Biomed Mater Res 82 Pages: 29-36
• [Journal Article] Alterations of NOS, arginase, and DDAH protein expression in rabbit cavernous tissue after administration of cigarette smoke extract (2007)
  • Author(s): Imamura M, Waseda Y, Marinova G V, Ishibashi T, Obayashi S, Sasaki A, Nagai A, Azuma H.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 293
• [Journal Article] Moduration of osteoblast-like cell behavior cultured on hydroxyapatite by thrombin (2007)
  • Author(s): Nakamura M, Ohashi N, Nagai A, Sekijima Y, Tanaka Y, Nakamura S., Yamashita K.
  • Journal Title: J Ceram Soc Jpn 115 Pages: 205-209
• [Journal Article] Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. (2007)
  • Author(s): Wang W, Itoh S, Matsuda A, Ichinose S, Shinomiya K, Hata Y, Tanaka J
  • Journal Title: J Biomed Mater Res Part A 84A Pages: 557-566
• [Journal Article] Enhancement of peripheral nerve regeneration by using bioabsorbable polymer tubes packed with fibrin gel (2007)
  • Author(s): Nakayama K, Takakuda K, Koyama Y, Itoh S, Wang W, Mukai T, Shirahama N
  • Journal Title: Artif Organs 31 Pages: 500-508
• [Journal Article] Possible involvement of enhanced arginase activity due to up-regulated arginases and decreased hydroxyarginine in accelerating intimal hyperplasia with hyperglycemia (2007)
  • Author(s): Ishizaka M, Nagai A, Iwanaga M, Imamura M, Azuma H
  • Journal Title: Vasclul Pharmacol 47 Pages: 272-280
• [Journal Article] Hydrothermal Crystallization of Carbonate-Containing Hydroxyapatite Coatings Prepared by Radiofrequency-Magnetron Sputtering Method (2007)
  • Author(s): Nakamura S, Hamagami J, Yamashita K.
  • Journal Title: J Biomed Mater Res 80 Pages: 102-106
• [Journal Article] Effects of Electrical Polarization on Phenomena Inside Pores of Hydroxyapatite in Stimulated Body Fluid (2007)
  • Author(s): Iwasaki T, Tanaka Y, Katayama K, Yamashita K
  • Journal Title: Arch BioCeram Res 7 Pages: 35-38
• [Journal Article] ハイドロキシアパタイト・コーティングしたチタン・インプラントのポーリング処理による骨接合促進効果 (2007)
  • Author(s): 伊藤聰一郎、小林孝之、中村聡、中村美穂、四宮謙一、山下仁大
  • Journal Title: Orthopaedic Ceram Implants 26 Pages: 9-11
• [Journal Article] 連通性ハイドロキシアパタイト多孔体のポーリング処理による骨成長促進 (2007)
  • Author(s): 山下仁大、伊藤聰一郎、王巍
  • Journal Title: Orthopaedic Ceram. Implants 26 Pages: 13-17
• [Journal Article] 連通性ハイドロキシアパタイト多孔体のポーリング処理による骨形成促進 (2007)
  • Author(s): 伊藤聰一郎、四宮謙一、中村聡、中村美穂、山下仁大
  • Journal Title: 日本生体電気・物理刺激研究会誌 21 Pages: 11-15
• [Journal Article] Enhanced Bone Bonding of Hydroxyapatite-coated Titanium Implants by Electrical Polarization (2007)
  • Author(s): T. Kobayashi, et. al.
  • Journal Title: J. Biomed. Mater. Res. 82A Pages: 145-151
  • Peer Reviewed
• [Journal Article] Interaction of A Blood Coagulation Factor on Electrically Polarized Hydroxyapatite Surfaces (2007)
  • Author(s): M. Nakamura, et. al.
  • Journal Title: J. Biomed. Mater. Res. Applied Biomaterials B 82 Pages: 29-36
  • Peer Reviewed
• [Journal Article] Possible involvement of enhanced arginase activity due to up-regulated arginases and decreased hydroxyarginine in accelerating intimal hyperplasia with hyperglycemia (2007)
  • Author(s): M. Ishizaka, et. al.
  • Journal Title: Vasclul. Pharmacol. 47 Pages: 272-280
  • Peer Reviewed
• [Journal Article] LeGeros RZ. Fabrication and in vivo Historogical Evaluation of a Novel Zn-containing β-Tricalcium Phosphate Cemen
  • Author(s): Li X, Sogo Y, Ito A, Mutsuzaki H, Ochiai N, Kobayashi T, Nakamura S, Yamashita K
  • Journal Title: Mater Sci Eng C (in press)
• [Journal Article] Electrostatic Surface Charge Boosting Bone Ingrowth of Porous Ceramics
  • Author(s): Nakamura S, Kobayashi T, Itoh S, Yamashita K
  • Journal Title: J Biomed Mater Res A (in press)
• [Presentation] Low temperature degradation and biomedical properties of Y-TZPceramics (2008)
  • Author(s): Tanaka Y, Ukai N, Nishio K and Yamashita K
  • Organizer: Ceramic Engineering and Science Proceedings(CESP)(239-248)
  • Year and Date: 2008-07-29
• [Presentation] Development of polarized hydroxyapatite ceramics and coatings for novel applications (2008)
  • Author(s): Yamashita K, Tanaka Y, Robotti P, Bianchi, G
  • Organizer: Global roadmap for ceramics & ICC2 proceedings(6 pages)
• [Presentation] Electrical and biological properties of polarized hydroxyapatite electrets (2008)
  • Author(s): Tanaka Y, Nakamura M, Wang W, Nagai A and Yamashita K
  • Organizer: Proceedings of 13th International Symposium on electrets(12)
• [Presentation] Development pf ceramic hydroxyapatite electret as vector materials (2008)
  • Author(s): Yamashita K
  • Organizer: The 9^<th> International Symposium on Ceramic Materials and Components for Energy and Environmental Applications & The 4^<th> Laser Ceramics Symposium : International Symposium on Transparent C ramics for Laser
  • Place of Presentation: Shanghai, China
• [Presentation] Past, Present and Future of Ceramic Electrets for Biomedical Applications (2008)
  • Author(s): Yamashita K.
  • Organizer: The 25^<th> Korea-Japan International Seminar on Ceramics
  • Place of Presentation: Kangnung, Korea
• [Presentation] Hydoroxyapatite Electret (2008)
  • Author(s): Nagai A, Yamashita K
  • Organizer: Seminar Series at Radboud University Nijmegen Medical Center
  • Place of Presentation: The Netherlands
• [Presentation] Effects of Polarization in vivo and in vitro. Seminar series at Department of Biomaterials (2008)
  • Author(s): Nakamura M, Nagai A, Yamashita K
  • Organizer: University Nijmegen
  • Place of Presentation: Netherlands
• [Presentation] Effects of Novel Bioceramics on a Blood Coagulation Factor (2008)
  • Author(s): Nakamura M, Niwa K, Sekijima Y, Nagai A, Yamashita K.
  • Organizer: 52^<nd> German Thrombosis and Hematosis(GTH)Congress
  • Place of Presentation: Germany
• [Presentation] Low-temperature-degradation and biomedical properties of Y-TZP ceramics (2008)
  • Author(s): Tanaka Y, Ukai N, Nishio K, Yamashita K
  • Organizer: 32nd International Conference & Exposition on Advanced Ceramics and Composites
  • Place of Presentation: Florida
• [Presentation] Morphology and Motility of Osteoblastic Cells Cultured on Polarized Hydroxyapatite (2008)
  • Author(s): Nakamura M, Nagai A, Tanaka Y, Wang W, Sekijima Y, Yamashita K
  • Organizer: The IUMRS International Conference 2008
  • Place of Presentation: Nagoya,Japan
• [Presentation] Electret bioceramics for bone regeneration (2008)
  • Author(s): Wang W, Itoh S, Nakamura M, Tanaka Y,Nagai A, Yamashita K
  • Organizer: 2008CMCEE & LCS conference
  • Place of Presentation: Shanghai, China
• [Presentation] Electrical and biological properties of polarized hydroxyapatite electrets (2008)
  • Author(s): Tanaka Y, Nakamura M, Wang W, NagaiA, Yamashita K
  • Organizer: 13th International Symposium on electrets(ISE13)
  • Place of Presentation: Tokyo
• [Presentation] CO2 Laser Irradiation Enhances Interaction of 45S5 Bioglass with Dentin (2008)
  • Author(s): Bakry A, Matin K, Tanaka, Y, Takahash H, Otsuki M, Yamashita K, Tagami J
  • Organizer: IADR 86th General Session &apm; Exhibition
  • Place of Presentation: Toronto
• [Presentation] Ion conduction mechanism in Ca deficient hydroxyapatite whisker (2008)
  • Author(s): Tanaka Y, Nakamura M, Nagai A, ToyamaT, Yamashita K
  • Organizer: Joint Conferences of The 2nd International Conference on the Science and Technology for Advanced Ceramics(STAC)and The 1st International Conference on Science and Technology of Solid Surfa e and Interface(STSI)
  • Place of Presentation: Chiba
• [Presentation] Hydroxyapatite electret suppresses intimal hyperplasia in a rabbit model of vascular injury (2008)
  • Author(s): Nagai A, Azuma H, Ichikawa H, Imamura M, Nakamura M, Kobayashi M, Yamashita K
  • Organizer: 8^<th> World Biomaterial Congress
  • Place of Presentation: The Netherlands
• [Presentation] Enhanced Bone Ingrowth into Hydroxyapatite with Interconnected Pores by Electrical Polarization (2008)
  • Author(s): Wang W, Itoh S, Nakamura M, Tanaka Y, Nagai A, Yamashita K
  • Organizer: 8th World Biomaterials Congress 2008
  • Place of Presentation: Amsterdam, Netherland
• [Presentation] Migration and Morphogenesis of Endothelial Cells Cultured on Polarized Hydroxyapatite (2008)
  • Author(s): Nakamura M, Kaneda M, Morita I, Nagai A, Sekijima Y, Tanaka Y, Yamashita K
  • Organizer: 8th World Biomaterials Congress
  • Place of Presentation: Amsterdam, Netherland
• [Presentation] Promotive effects of a silk fibroin and polarized hydroxyapatite on epidermal recovery from full-thickness skin wounds (2008)
  • Author(s): Okabayashi R, Nakamura M, Okabayashi T, Tanaka Y, Nagai A, Yamashita K.
  • Organizer: 8th World Biomaterials Congress
  • Place of Presentation: Amsterdam, Netherland
• [Presentation] Enhanced Osteoconductivity of Hydroxyapatite by Electrical Polarization Processing (2008)
  • Author(s): Wang W, Itoh S, Yamashita K
  • Organizer: The 9th Japan-Korea Congress of Plastic and Reconstructive Surgery
  • Place of Presentation: Okinawa, Japan
• [Presentation] 水酸アパタイト/フィブリンコンポジットフィルムの創製と細胞応答性評価 (2008)
  • Author(s): 征矢朋子, 中村美穂, 橋本和明, 戸田喜朝, 山下仁大
  • Organizer: 第12回生体関連セラミックス討論会
  • Place of Presentation: 横浜
• [Presentation] 分極アパタイトによる平滑筋肉腫細胞の機能制御 (2008)
  • Author(s): 宮崎遥, 永井亜希子, 片山恵一, 山下仁大
  • Organizer: 第12回生体関連セラミックス討論会
  • Place of Presentation: 横浜
• [Presentation] 炭酸アパタイトセラミックスの酸素ガス応答 (2008)
  • Author(s): 笹木眞澄, 田中優実, 大倉利典, 門間秀毅,山下仁大
  • Organizer: 第12回生体関連セラミックス討論会
  • Place of Presentation: 横浜
• [Presentation] 分極セラミックスの局所場による表面機能制御 (2008)
  • Author(s): 中村美穂, 永井亜希子, 田中優実, 山下仁大
  • Organizer: 粉体粉末冶金協会第102回講演大会
  • Place of Presentation: 福岡
• [Presentation] 分極ハイドロキシアパタイトが骨芽細胞様細胞遊走性に与える効果 (2008)
  • Author(s): 中村美穂, 永井亜希子, 関島安隆, 田中優実,山下仁大
  • Organizer: 日本バイオマテリアル学会シンポジウム2008
  • Place of Presentation: 東京
• [Presentation] Electret Bioceramics for bone Tissue Regeneration (2008)
  • Author(s): Wang W, Itoh S, Nagai A, Yamashita K
  • Organizer: 日本バイオマテリアル学会シンポジウム
  • Place of Presentation: 東京
• [Presentation] 血管平滑筋細胞のフェノタイプ変換における分極アパタイトの作用 (2008)
  • Author(s): 永井亜希子, 中村美穂, 山下仁大
  • Organizer: 日本バイオマテリアル学会シンポジウム
  • Place of Presentation: 東京
• [Presentation] 分極水酸アパタイトの骨芽細胞様細胞接着能と遊走性 (2008)
  • Author(s): 中村美穂, 永井亜希子, 山下仁大
  • Organizer: 第18回無機リン化学討論会
  • Place of Presentation: 奈良
• [Presentation] 分極セラミックスの材料合成への応用 (2008)
  • Author(s): 中村美穂, 山下仁大
  • Organizer: 2008年度セラミックス総合研究会
  • Place of Presentation: 宮島
• [Presentation] 分極ハイドロキシアパタイト上における骨芽細胞挙動評価 (2008)
  • Author(s): 中村美穂, 永井亜希子, 関島安隆, 田中優実, 山下仁大
  • Organizer: 第21回日本セラミックス協会秋季シンポジウム
  • Place of Presentation: 北九州
• [Presentation] 根管充填材として応用可能なリン酸八カルシウムセメントの開発 (2008)
  • Author(s): 今村由紀, 田中優実, 山下仁大
  • Organizer: 第20年度春季第51回日本歯科理工学会学術講演会
  • Place of Presentation: 神奈川
• [Presentation] 電気的表面改質を利用した高耐湿性ジルコニアセラミックスの創製 (2008)
  • Author(s): 田中優実, 山下仁大
  • Organizer: 第20年度春季第51回日本歯科理工学会学術講演会
  • Place of Presentation: 神奈川
• [Presentation] 分極ハイドロキシアパタイト界面における細胞挙動評価 (2008)
  • Author(s): 中村美穂、永井亜希子、大橋菜多里、関島安隆、田中優実、山下仁大
  • Organizer: 第7回日本再生医療学会総会
  • Place of Presentation: 大阪
• [Presentation] バイオセラミックスの電気分極処理及び生体に及ぼす影響 (2008)
  • Author(s): 王巍、伊藤総一郎、中村美穂、田中優実、山下仁大
  • Organizer: 第7回日本再生医療学会
  • Place of Presentation: 大阪
• [Presentation] 非化学量論ハイドロキシアパタイトの分極機構 (2008)
  • Author(s): 田中優実, 岩崎健, 中村美穂, 永井亜希子, 片山恵一, 山下仁大
  • Organizer: 日本セラミックス協会
  • Place of Presentation: 2008年年会, 新潟
• [Presentation] Development pf ceramic hydroxyapatite electret as vector materials. (2008)
  • Author(s): Yamashita K
  • Organizer: The 9^<th> International Symposium on Ceramic Materials and Components for Energy and Environmental Applications & The 4^<th> Laser Ceramics Symposium : International Symposium on Transparent Ceramics for Laser
  • Place of Presentation: Shanghai, China
• [Presentation] Hydoroxyapatite Electret (2008)
  • Author(s): Nagai A, et al
  • Organizer: Series at Radboud University Nijmegen Medical Center
  • Place of Presentation: The Netherlands
• [Presentation] Effects of Polarization in vivo and in vitro. (2008)
  • Author(s): Nakamura M, et al
  • Organizer: Series at Radboud University Nijmegen Medical Center
  • Place of Presentation: The Netherlands
• [Presentation] Ion conduction mechanism in Ca deficient hydroxyapatite whisker. (2008)
  • Author(s): Tanaka Y, et al
  • Organizer: Joint Conferences of The 2nd International Conference on the Science and Technology for Advanced Ceramics (STAC) and The 1st International Conference on Science and Technology of Solid Surface and Interface (STSI)
  • Place of Presentation: Chiba, Japan
• [Presentation] nhanced Bone Ingrowth into Hydroxyapatite with Interconnected Pores by Electrical Polarization (2008)
  • Author(s): Wang W, et al
  • Organizer: 8^<th> World Biomaterial Congress
  • Place of Presentation: The Netherlands
• [Presentation] Migration and Morphogenesis of Endothelial Cells Cultured on Polarized Hydroxyapatite. (2008)
  • Author(s): Nakamura M, et al
  • Organizer: 8^<th> World Biomaterial Congress
  • Place of Presentation: The Netherlands
• [Presentation] Promotive effects of a silk fibroin and polarized hydroxyapatite on epidermal recovery from full-thickness skin wounds. (2008)
  • Author(s): Okabayashi R, et al
  • Organizer: 8^<th> World Biomaterial Congress
  • Place of Presentation: The Netherlands
• [Presentation] CO2 Laser Irradiation Enhances Interaction of 45S5 Bioglass with Dentin. (2008)
  • Author(s): Bakry A, et al
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: Toronto, July
• [Presentation] Electrical and biological properties of polarized hydroxyapatite electrets. (2008)
  • Author(s): Tanaka Y, et al
  • Organizer: 13th International Symposium on electrets (ISE13)
  • Place of Presentation: Tokyo, Japan
• [Presentation] Electret bioceramics for bone regeneration. (2008)
  • Author(s): Wang W, et al
  • Organizer: 2008CMCEE&LCS conference
  • Place of Presentation: Shanghai, China
• [Presentation] Morphology and Motility of Osteoblastic Cells Cultured on Polarized Hydroxyapatite. (2008)
  • Author(s): Nakamura M, et al
  • Organizer: The IUMRS International Conference 2008
  • Place of Presentation: Nagoya, Japan
• [Presentation] 電気的表面改質を利用した高耐湿性ジルコニアセラミックスの創製. (2008)
  • Author(s): 田中優実, ら
  • Organizer: 第20年度春季第51回日本歯科理工学会学術講演会
  • Place of Presentation: 神奈川
• [Presentation] 根管充填材として応用可能なリン酸八カルシウムセメントの開発. (2008)
  • Author(s): 今村由紀, ら
  • Organizer: 第20年度春季第51回日本歯科理工学会学術講演会
  • Place of Presentation: 神奈川
• [Presentation] 分極セラミックスの材料合成への応用. (2008)
  • Author(s): 中村美穂, ら
  • Organizer: 2008年度セラミックス総合研究会
  • Place of Presentation: 宮島、広島
• [Presentation] 分極水酸アパタイトの骨芽細胞様細胞接着能と遊走性. (2008)
  • Author(s): 中村美穂, ら
  • Organizer: 第18回無機リン化学討論会
  • Place of Presentation: 奈良
• [Presentation] 血管平滑筋細胞のフェノタイプ変換における分極アパタイトの作用. (2008)
  • Author(s): 永井亜希子, ら
  • Organizer: 日本バイオマテリアル学会シンポジウム
  • Place of Presentation: 東京
• [Presentation] 分極ハイドロキシアパタイトが骨芽細胞様細胞遊走性に与える効果. (2008)
  • Author(s): 中村美穂, ら
  • Organizer: 日本バイオマテリアル学会シンポジウム
  • Place of Presentation: 東京
• [Presentation] 分極セラミックスの局所場による表面機能制御. (2008)
  • Author(s): 中村美穂, ら
  • Organizer: 粉体粉末冶金協会第102回講演大会
  • Place of Presentation: 福岡
• [Presentation] 分極アパタイトによる平滑筋肉腫細胞の機能制御. (2008)
  • Author(s): 宮崎遥, ら
  • Organizer: 第12回生体関連セラミックス討論会
  • Place of Presentation: 横浜
• [Presentation] 水酸アパタイト/フィブリンコンポジットフィルムの創製と細胞応答性評価. (2008)
  • Author(s): 征矢朋子, ら
  • Organizer: 第12回生体関連セラミックス討論会
  • Place of Presentation: 横浜
• [Presentation] β-TCPを固定した神経再生用キトサンファイバーチューブの作製. (2008)
  • Author(s): 山本直樹, ら
  • Organizer: 第12回生体関連セラミックス討論会
  • Place of Presentation: 横浜
• [Presentation] Electrovector Effects of Polarized Ceramic Hydroxyapatite and Composites (2007)
  • Author(s): K. Yamashita
  • Organizer: Composites at Lake Louise 2007
  • Place of Presentation: Lake Louise, Canada
  • Year and Date: 2007-11-01
• [Presentation] Hydroxyapatite electret modulates phenotypic conversion of vascular smooth muscle cells (2007)
  • Author(s): Nagai A, Azuma H, Ichikawa H, ImamuraM, Nakamura M, Kobayashi M, Yamashita K.
  • Organizer: 1st Asian Biomaterials Congress
  • Place of Presentation: Tsukuba, Japan
• [Presentation] Morphological Regulation of Osteoblast-like Cell Behaviors on Hydroxyapatite by Electrical Polarization (2007)
  • Author(s): Nakamura M, Nagai A, Tanaka Y, Sekijima Y, Yamashita K
  • Organizer: 1st Asian Biomaterials Congress
  • Place of Presentation: Tsukuba, Japan
• [Presentation] Bio-activation by small amount addition of hydroxyapatite to Al2O3-mixed Y2O3-stabilized tetragonal zirconia ceramics (2007)
  • Author(s): Tanaka Y, Sasaki T, Kobayashi M, Yamashita K
  • Organizer: 7th Pacific Rim Conference on Ceramic and Glass Technology
  • Place of Presentation: Shanghai, China
• [Presentation] Proliferative effect of thrombin on osteoblast-like cells cultured on hydroxyapatite (2007)
  • Author(s): Nakamura M, Nagai A, Ohashi N, Sekijima Y, Tanaka Y, Hiyama T, Yamashita K
  • Organizer: 7th Pacific Rim Conference on Ceramic and Glass Technology
  • Place of Presentation: Shanghai, China
• [Presentation] Regulation of Osteoblast-like Cell Behaviors on Hydroxyapatite by Electrical Polarization (2007)
  • Author(s): Nakamura M, Nagai A, Ohashi N, Tanaka Y, Sekijima Y, Nakamura S, Yamashita K
  • Organizer: 20th International Symposium on Ceramics in Medicine
  • Place of Presentation: Nantes, France
• [Presentation] Comparison of Hydroxyapatite with Carbonate Apatite in Osteoclastic Cell Resorptive Activity (2007)
  • Author(s): Ohashi N, Nakamura M, Nagai A, Tanaka Y, Sekijima Y, Yamashita K.
  • Organizer: 20th International Symposium on Ceramics in Medicine
  • Place of Presentation: Nantes, France
• [Presentation] Chemical and Physical Properties of Novel Biomedical Glasses in the System of CaO-P2O5-SiO2-Al2O3 (2007)
  • Author(s): Tanaka Y, Sasaki T, Kobayashi M, Yamashita K
  • Organizer: 7th Asian Bioceramics Symposium
  • Place of Presentation: Osaka, Japan
• [Presentation] Effects of electrical polarization on phenomena inside pores of hydroxyapatite in simulated body fluid (2007)
  • Author(s): Iwasaki T, Tanaka Y, Katayama K, Yamashita K
  • Organizer: 7th Asian Bioceramics Symposium
  • Place of Presentation: Osaka, Japan
• [Presentation] Regulation of Endothelial Adhesion and Migration by Electrical Charges Induced on Polarized Hydroxyapatite (2007)
  • Author(s): Nakamura M, Nagai A, Ohashi N, Sekijima Y, Tanaka Y, Nakamura S, Itoh S, Yamashita K
  • Organizer: 21st European Conference on Biomaterials. Brighton,E ast Sussex
  • Place of Presentation: UK
• [Presentation] Enhancement of Osteoclastic Cell Activity on Carbonate Apatite Bioceramics (2007)
  • Author(s): Ohashi N, Nakamura M, Nagai A, Tanaka Y, Sekijima Y, Nakamura S, Ito S, Yamashita K
  • Organizer: 21st European Conference on Biomaterials
  • Place of Presentation: Brighton, East Sussex, UK
• [Presentation] Interaction between Cells and Polarized Hydroxyapatite Implanted to Intraperitoneal Cavity (2007)
  • Author(s): Arai H, Kobayashi T, Nakamura M, Sekijima Y, Nakamura S, Salonen JI, Yamashita K
  • Organizer: 85th International Association for Dental Research
  • Place of Presentation: New Orleans, USA
• [Presentation] 骨芽細胞の石灰化におよぼす分極HAの効果 (2007)
  • Author(s): 関根輝, 中村美穂, 大橋菜多里, 永井亜希子, 田中優実, 橋本和明, 戸田善朝, 山下仁大
  • Organizer: 第11回生体関連セラミックス討論会
  • Place of Presentation: 大阪
• [Presentation] ACPのHAウィスカー転化における諸因子の物質移動に及ばす影響 (2007)
  • Author(s): 下江和樹, 田中優実, 遠山岳史, 山下仁大
  • Organizer: 第11回生体関連セラミックス討論会
  • Place of Presentation: 大阪
• [Presentation] 分極アパタイトによる動脈硬化初期病変の修飾 (2007)
  • Author(s): 永井亜希子、東洋、今村公俊、山下仁大
  • Organizer: 第29回日本バイオマテリアル学会
  • Place of Presentation: 大阪
• [Presentation] 分極ハイドロキシアパタイト界面における細胞挙動のin vitro評価 (2007)
  • Author(s): 中村美穂, 永井亜希子, 大橋菜多里, 関島安隆, 田中優実, 山下仁大
  • Organizer: 第29回日本バイオマテリアル学会
  • Place of Presentation: 大阪
• [Presentation] 炭酸含有アパタイトおよびハイドロキシアパタイト上での破骨細胞吸収活性の検討 (2007)
  • Author(s): 大橋菜多里, 中村美穂, Niroshani Soysa, 青木和弘, 大谷啓一, 関島安隆, 田中優実, 永井亜希子, 山下仁大
  • Organizer: 第29回日本バイオマテリアル学会
  • Place of Presentation: 大阪
• [Presentation] 電気分極したHA多孔体による骨再生の促進 (2007)
  • Author(s): 王巍、伊藤総一郎、山下仁大
  • Organizer: 第10回日本組織工学会
  • Place of Presentation: 東京
• [Presentation] バルン傷害後の血管リモデリングへの分極アパタイトによる修飾 (2007)
  • Author(s): 永井亜希子、東洋、今村公俊、山下仁大
  • Organizer: 第51回日本学術会議材料工学連合講演会
  • Place of Presentation: 京都
• [Presentation] ハイドロキシアパタイトの分極特性における水酸化物イオン欠陥の役割 (2007)
  • Author(s): 田中優実, 山下仁大
  • Organizer: セラミックス総合研究会
  • Place of Presentation: 京都
• [Presentation] 水熱法により作成したハイドロキシアパタイトウィスカーのイオン伝導特性 (2007)
  • Author(s): 田中優実、高田成子、遠山岳史、中村聡、小嶋芳行、山下仁大
  • Organizer: 無機マテリアル学会第114回学術講演会
  • Place of Presentation: 東京
• [Presentation] ポーリングアパタイトの腹腔内炎症性細胞に対する作用 (2007)
  • Author(s): 新井宏、中村聡、山下仁大
  • Organizer: 第49回日本歯科理工学会
  • Place of Presentation: 札幌
• [Presentation] 骨伝導性ジルコニアセラミックスの創製 (2007)
  • Author(s): 田中優実、鵜飼奈美、西尾圭史、山下仁大
  • Organizer: 日本セラミックス協会2007年年会
  • Place of Presentation: 東京
• [Presentation] 培養細胞の初期挙動に対するエレクトロベクトルマテリアル効果 (2007)
  • Author(s): 中村美穂、大橋菜多里、永井亜希子、関島安隆、田中優実、中村聡、山下仁大
  • Organizer: 日本セラミックス協会2007年年会
  • Place of Presentation: 東京
• [Presentation] ハイドロキシアパタイトの分極特性における水酸化物イオン欠陥の役割 (2007)
  • Author(s): 岩崎健, 田中優実, 中村美穂, 永井亜希子, 片山恵一, 山下仁大
  • Organizer: 第45回セラミックス基礎科学討論会
  • Place of Presentation: 仙台
• [Book] Fabrication processes for bioceramics, Part1 Chapter 2 Bioceramics and their clinical applications (2008)
  • Author(s): Tanaka Y, Yamashita K
  • Publisher: Woodhead publishing limited
• [Book] Process of Bioceramics (分担 : Chapter 2 (pp.28-52), Part I), Bioceramics and Their Clinical Applications (2008)
  • Author(s): Tanaka Y, et al
  • Publisher: Woodhead Publishing Limited, Cambridge
• [Book] 無機材料必須300 (2008)
  • Author(s): 山下仁大
  • Publisher: 三共出版(株)
• [Book] 生体材料各論1.1.2 分極アパタイト (2008)
  • Author(s): 永井亜希子, ら
  • Total Pages: 7
  • Publisher: 日本セラミックス協会編、日本工業新聞社
• [Book] 機械工学便覧デザイン編β8生体工学、第5章「バイオメディカルエンジニアリング」 (2007)
  • Author(s): 山下仁大
  • Publisher: (日本機械学会編)無機材料
• [Book] バイオミネラリゼーションとそれに倣う新機能材料の創製II第2章「リン酸カルシウム系2バイオミネラリゼーションにおける分極ハイドロキシアパタイトのエレクトロベクトル効果 (2007)
  • Author(s): 山下仁大, 中村美穂
  • Publisher: 加藤隆史監修、シーエムシー出版
• [Book] エネルギーデバイスに見るバイオマテリアル (2007)
  • Author(s): 田中優実
  • Total Pages: 2
  • Publisher: バイオマテリアル
• [Remarks] Tanaka Y, Wang W and Yamashita K. 分極ハイドロキシアパタイトの生体材料科学. Phosphorus letter 2008 ; 63-1 : 5-13
• [Remarks] Wang W, Itoh S, Tanaka Y, Yamashita K. Electrical Polarized hydroxyapatite Ceramics Induced Super Osteoconductivity. Annual Reports of the Institute of Biomaterial and Bioengineering 2007 ; 41 : 2-25
• [Remarks] 田中優実. エネルギーデバイスに見るバイオマテリアル, バイオマテリアル, 2007 : 25[1] : 70-71.
• [Remarks] 田中優実, 山下仁大. 日本歯科理工学会第51回学術講演会発表優秀賞, 9月, 2008年
• [Remarks] 中村美穂, 永井亜希子, 山下仁大. 無機リン化学討論会第5回若手優秀発表賞, 10月, 2008年
• [Remarks]
  • URL: http://www.tmd.ac.jp/i-mde/www/inorg/inorg-j.html
• [Remarks]
  • URL: http://www.tmd.ac.jp/i-mde/www/inorg/inorg-j.html