|Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
In order to aim at controlling cellular response via stimuli-responsive polyrotaxanes, the preparation of a variety of polyrotaxanes, the characterization of their properties, and the protein and cellular responses to these polyrotaxanes were performed. Macromolecular inclusion of loose-fit polyrotaxane, temperature-responsive polyrotaxane formation, enhanced binding of mannose-conjugated polyrotaxane with specific protein, and the production of anti-inflammatory cytokine from macrophages were clarified in this study.