| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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| Research Abstract |
This project was aimed at developing protein-based biomaterials that serve to improve the survival and engraftment of neural stem/progenitor cells transplanted into central nervous tissues for therapeutic purposes. It was shown that hydrogels made of naturally-occurring polymers such as collagen and hyaluronic acid could be suitably used as base materials. In addition, protein engineering strategies were employed to incorporate growth factors, neurotrophic factors, and/or integrin binding polypeptide domains into the base materials. We demonstrated that such approaches were quite effective for improving survival of cells embedded in the hydrogels.
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