Fabrication of chiral recognition by stimuli-responsive coacervate
| Project/Area Number |
19300173
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute for Materials Science (2009)
Kagoshima University (2007-2008) |
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Principal Investigator |
AOYAGI Takao Kagoshima University, 生体材料センター, 領域コーディネーター (40277132)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Kazuya 鹿児島大学, 大学院・理工学研究科, 助教 (40347084)
AOKI Takashi 京都工芸繊維大学, 大学院・工芸科学研究科, 准教授 (80231760)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | バイオマテルアル / ハイドロゲル / 刺激応答性 / 温度応答性 / コアセルベート / 相分離挙動 / 相転移挙動 / 分子認識 / 水和現象 / 脱水和現象 |
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| Research Abstract |
We newly designed isopropylacrylamide(IPAAm)-based copolymers randomly containing carboxyl or hydroxyl groups. Their temperature-responsive behavior on comonomer composition, salt concentration and pH of the solution was precisely investigated. Furthermore, we studied coacervate droplet formation and corresponding micrometer-sized hydrogel by effective cross-linking reaction. Using the two kinds of IPAAm-based copolymer with different functional moieties, the obtained coacervate was completely fusion-type and the hydrogel showed semi-interpenetrating polymer network structure. Furthermore, the obtained hydrogel showed very sensitive temperature-and pH-responsive properties.
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Report
(4 results)
Research Products
(28 results)
