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Fabrication of chiral recognition by stimuli-responsive coacervate

Research Project

Project/Area Number 19300173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionNational Institute for Materials Science (2009)
Kagoshima University (2007-2008)

Principal Investigator

AOYAGI Takao  Kagoshima University, 生体材料センター, 領域コーディネーター (40277132)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Kazuya  鹿児島大学, 大学院・理工学研究科, 助教 (40347084)
AOKI Takashi  京都工芸繊維大学, 大学院・工芸科学研究科, 准教授 (80231760)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywordsバイオマテルアル / ハイドロゲル / 刺激応答性 / 温度応答性 / コアセルベート / 相分離挙動 / 相転移挙動 / 分子認識 / 水和現象 / 脱水和現象
Research Abstract

We newly designed isopropylacrylamide(IPAAm)-based copolymers randomly containing carboxyl or hydroxyl groups. Their temperature-responsive behavior on comonomer composition, salt concentration and pH of the solution was precisely investigated. Furthermore, we studied coacervate droplet formation and corresponding micrometer-sized hydrogel by effective cross-linking reaction. Using the two kinds of IPAAm-based copolymer with different functional moieties, the obtained coacervate was completely fusion-type and the hydrogel showed semi-interpenetrating polymer network structure. Furthermore, the obtained hydrogel showed very sensitive temperature-and pH-responsive properties.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (28 results)

All 2010 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (16 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Coil-Globule Transition and/or Coacervation of Temperature and pH Dual-Responsive Carboxylated Poly(N-isopropylacrylamide)2009

    • Author(s)
      T. Maeda, M. Takenouchi, K. Yamamoto, T. Aoyagi
    • Journal Title

      Polymer Journal 41

      Pages: 181-188

    • NAID

      10025090892

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stimuli-Responsive Coacervate Induced in Binary Functionalized Poly(N-isopropylacrylamide) Aqueous System and Novel Method for Preparing Semi-IPN Microgel Using the Coacervate2009

    • Author(s)
      T. Maeda, Y. Akasaki, K. Yamamoto, T. Aoyagi
    • Journal Title

      Langmuir 25

      Pages: 9510-9517

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assembly behavior of double thermo-responsive block copolymers with controlled response temperature in aqueous solution2009

    • Author(s)
      Y.Kotsuchibashi
    • Journal Title

      Journal of Colloid and Interface Science 336

      Pages: 67-72

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] timuli-Responsive Coacervate Induced in Binary Functionalized Poly(N-isopropylacrylamide) Aqueous System and Novel Method for Preparing Semi-IPN Microgel Using the Coacervate2009

    • Author(s)
      T.Maeda
    • Journal Title

      Langmuir 25

      Pages: 9510-9517

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Characterization of Double Thermo-Responsive Block Copolymer Consisting N-isopropylacrylamide by Atom Transfer Radical Polymerization2008

    • Author(s)
      Y. Kotsuchibashi
    • Journal Title

      Journal of Polymer Science, Part A : Polymer Chemistry 46

      Pages: 6142-6150

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective surface modification by stimuli-responsive polymers onto the magnetite nanoparticles by layer-by-layer method2008

    • Author(s)
      K. Yamamoto
    • Journal Title

      Applied Surface Science 255

      Pages: 384-387

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparations and Characterizations of Nano-Sized Complexes Consisting of Stimuli-Responsive Block Copolymers and PAMAM Dendrimers2008

    • Author(s)
      Y. Kuboshima
    • Journal Title

      Transaction of the Materials Research Society of Japan 33

      Pages: 149-152

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coil-Globule Transition and/or Coacervation of Temperature and pH Dual-Responsive Carboxylated Poly (N-isopropylacrylamide)

    • Author(s)
      T. Maeda
    • Journal Title

      Polyer Journal (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] コアセルベーションを引き起こす高分子二成分系から作製したsemi-IPNマイクロゲルの刺激応答性評価2010

    • Author(s)
      児玉祐季, 前田智広, 赤崎祐介, 山元和哉, 青柳隆夫
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京都, 東京大学山上会館
    • Year and Date
      2010-01-14
    • Related Report
      2009 Final Research Report
  • [Presentation] コアセルベーションを引き起こす高分子二成分系から作製したSemi-IPNマイクロゲルの刺激応答性評価2010

    • Author(s)
      児玉祐季
    • Organizer
      第21回高分子ゲル研究討論会
    • Place of Presentation
      東京大学山上会館(東京)
    • Year and Date
      2010-01-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクリルアミド型温度応答性高分子のコアセルベート形成における分子量効果2009

    • Author(s)
      長峯隆介
    • Organizer
      ゲルワークショップ イン 熊本
    • Place of Presentation
      ホテル法華クラブ熊本(熊本市)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 液-液相分離型温度応答性高分子のコアセルベート形成に及ぼす分子量効果2009

    • Author(s)
      長峯隆介
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学(熊本市)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクリルアミド型温度応答性高分子のコアセルベート型相分離による分子量フラクション効果2009

    • Author(s)
      長峯隆介
    • Organizer
      第46回化学関連支部合同九州大会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] コアセルベーションを引き起こす刺激応答性高分子二成分系の相分離挙動及びSemi-IPNマイクロゲルの作製2008

    • Author(s)
      前田智広, 赤崎祐介, 山元和哉, 青柳隆夫
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪市, 大阪市立大学
    • Year and Date
      2008-09-26
    • Related Report
      2009 Final Research Report
  • [Presentation] コアセルベーションを引き起こす刺激応答性高分子二成分系の相分離挙動及びSemi-IPNマイクロゲルの作製2008

    • Author(s)
      前田智広
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪市(大阪府)
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] アクリルアミド型温度応答性高分子のコアセルベートから作成したSemi-IPNマイクロゲルの刺激応答挙動2008

    • Author(s)
      赤崎祐介
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪市(大阪府)
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 刺激応答性コアセルベートからのSemi-IPNハイドロゲル微粒子の作製2008

    • Author(s)
      前田智広
    • Organizer
      第57回高分子学会年次大会
    • Place of Presentation
      横浜市(神奈川県)
    • Year and Date
      2008-05-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] アクリルアミド型機能性高分子のコアセルベートから調製したハイドロゲル微粒子の刺激応答評価2008

    • Author(s)
      赤崎祐介
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      立教大学
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] アクリルアミド型機能性高分子のコアセルベートから調製したハイドロゲル微粒子の刺激応答評価2008

    • Author(s)
      赤崎祐介, 前田智広, 山元和哉, 青柳隆夫
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京都, 立教大学
    • Year and Date
      2008-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 二種の機能性アクリルアミド型高分子混合系から形成される刺激応答型コアセルベート及びそのゲル化2007

    • Author(s)
      前田智広, 赤崎祐介, 山元和哉, 青柳隆夫
    • Organizer
      第56回高分子討論会
    • Place of Presentation
      名古屋市, 名古屋工業大学
    • Year and Date
      2007-09-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 異なる温度応答性セグメントを有するAB型ブロック共重合体の溶液挙動評価2007

    • Author(s)
      小土橋陽平
    • Organizer
      第56回高分子討論会
    • Place of Presentation
      名古屋工業大学
    • Year and Date
      2007-09-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 二種の機能性アクリルアミド型高分子混合系から形成される刺激応答型コアセルベート及びそのゲル化2007

    • Author(s)
      前田智広
    • Organizer
      第56回高分子討論会
    • Place of Presentation
      名古屋工業大学
    • Year and Date
      2007-09-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Characterization and Application of the Stimuli-Responsive Coacervate Induced in the Poly(N-isopropylacrylamide)-Based Functional Polymers2007

    • Author(s)
      T. Maeda, M. Takenouchi, Y. Akasaki, K. Yamamoto, T. Aoyagi
    • Organizer
      Gel Sympo 2007
    • Place of Presentation
      Tokyo, 東京大学
    • Year and Date
      2007-08-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Characterization and Application of the Stimuli-Responsive Coacervate Induced in the Poly (N-isopropylacrylamide) -Based Functional Polymers2007

    • Author(s)
      T. Maeda
    • Organizer
      GelSympo2007
    • Place of Presentation
      東京大学
    • Year and Date
      2007-08-06
    • Related Report
      2007 Annual Research Report
  • [Book] “バイオマテリアルとしての刺激応答性ポリマー・ゲル"(高分子学会編)"ポリマーフロンティア21シリーズ31「ゲル・イノベーション-分子設計による新機能創出とその応用」2008

    • Author(s)
      青柳隆夫
    • Total Pages
      246
    • Publisher
      エヌティーエス
    • Related Report
      2009 Final Research Report
  • [Book] 医療用ゲルの最新技術と開発2008

    • Author(s)
      青柳隆夫(分筆)
    • Total Pages
      286
    • Publisher
      シーエムシー出版
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.nims.go.jp/bmc/group/smartbiomaterials/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.nims.go.jp.bmc/group/smartbiomaterials/

    • Related Report
      2009 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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