| Project/Area Number |
19300185
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Teikyo University |
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Principal Investigator |
MARUYAMA Kazuo Teikyo University, 薬学部, 教授 (30130040)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
鈴木 亮 帝京大学, 薬学部, 助手 (90384784)
滝澤 知子 帝京大学, 薬学部, 助手 (90260934)
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Ryo 帝京大学, 薬学部, 助教 (90384784)
TAKIZAWA Tomoko 帝京大学, 薬学部, 助手 (90260934)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 低侵襲治療システム / がん遺伝子治療 / リポソーム / 超音波 / ソノポレーション / 組織牡異的遺伝子導入 / 低侵襲 / ナノバブル / 組織特異的遺伝子導入 / リボソーム |
|---|
| Research Abstract |
The preparation method (GMP, controlled size) of bauble liposome was established. The effectiveness of siRNA in vitro and in vivo was observed. However, its effect was not enough for treatment. The condition of ultrasound and bubble liposome amount, etc, should be considered. Mouse bladder cancer therapy by the siRNA for PLK-1 is undergoing.
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