| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
|---|
| Research Abstract |
We have generated mortalin specific antibodies that showed cell-internalizing features. These antibodies were validated as nano-carriers. Antibodies were conjugated with quantum dots, FITC and expression plasmids that were delivered to cancer cells successfully. Cancer cells were labeled with various kinds of quantum dots to generate multicolor cells for long term imaging. We have demonstrated that (1) the antibody can be used for optic tagging of cells with quantum dots, (2) the optically tagged cells can be used for long term imaging of cells and (3) the tagged cells undergo normal differentiation in vitro and in vivo.
|
