Research and development of a therapeutic exercise preconditioning for muscle atrophy and circulatory failure with non-insulin-dependent diabetes mellitus
| Project/Area Number |
19300196
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
TAKEDA Isao Himeji Dokkyo University, 医療保健学部, 教授 (00163402)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Akihiko 京都大学, 大学院・人間環境学研究科, 教授 (90184548)
KAJIYA Fumihiko 川崎医療福祉大学, 医療技術学部, 教授 (70029114)
SUGAWARA Motoaki 姫路獨協大学, 医療保健学部, 教授 (60010914)
MURAKAMI Shinichiro 姫路獨協大学, 医療保健学部, 教授 (30454763)
FUJINO Hidemi 神戸大学, 大学院・保健学研究科, 教授 (20278998)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2007: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | リハビリテーション / 運動療法 / 糖尿病 / 微小循環 / プレコンディショニング / 筋萎縮 / 運動 / 血管構造 |
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| Research Abstract |
Exercise training has long been utilized as one of therapy in the non-insulin-dependent diabetes mellitus. The effects of a therapeutic exercise preconditioning on the myocyte and the microcirculation of skeletal muscle in diabetic rats was investigated. The preconditioning consisted of exercise at either low-(aerobic) or Hi-(unaerobic) intensity and included five 60 or 30 min sessions per week for 3 weeks, respectively. Both treated diabetic rats exhibited a decrease in plasma glucose, glycohemoglobin, and reactive oxygen species (ROS) compared with those of the diabetic rats but did not completely normalize levels. The capillary volume in diabetic muscle was significantly less, i.e., capillary regression. In three exercise-trained diabetic muscles, the capillary volumes were increased toward control levels and completely normalize levels. In summary, the results of the present study provide evidence for the effectiveness of exercise training in reducing some of the muscle circulatory complications associated with diabetes mellitus.
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Report
(4 results)
Research Products
(96 results)
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[Journal Article] Exercise exerts neuroprotective effects on Parkinson's disease model of rats2010
Author(s)
Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, Wang F, Baba T, Tayra JT, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I
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Journal Title
Brain Res 1310C
Pages: 200-207
Related Report
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[Journal Article] Exercise exerts neuroprotective effects on Parkinson's disease model of rats2010
Author(s)
Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, Wang F, Baba T, Tayra J T, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I
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Journal Title
Brain Res 1310C
Pages: 200-207
Related Report
Peer Reviewed
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[Journal Article] The alteration of a mechanical property of bone cells during the process of changing from osteoblasts to osteocytes.2009
Author(s)
Sugawara Y, Ando R, Kamioka H, Ishihara Y, Murshid SA, Hashimoto K, Kataoka N, Tsujioka K, Kajiya F, Yamashiro T, Takano-Yamamoto T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines : the 'Power Rehabilitation' program.2009
Author(s)
Murakami S, Otsuki T, Maeda M, Miura Y, Morii S, Kiyokane K, Hayakawa S, Maeda A, Imakawa T, Harada S, Handa T, Nishimura Y, Murakami S, Kumagai N, Hayashi H, Chen Y, Suemori S, Fukushima Y, Nishida S, Fukushima K.
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Journal Title
Int J Mol Med 23
Pages: 81-88
Related Report
Peer Reviewed
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[Journal Article] Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.2009
Author(s)
Nakamura K, Shimizu J, Kataoka N, Hashimoto K, Ikeda T, Fujio H, Ohta-Ogo K, Ogawa A, Miura A, Mohri S, Nagase S, Morita H, Kusano KF, Date H, Matsubara H, Mochizuki S, Hashimoto K, Kajiya F, Ohe T.
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Related Report
Peer Reviewed
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[Journal Article] Fibre type distribution and gene expression levels of both succinate dehydrogenase and peroxisome proliferator-activated receptor gamma coactivator-lalpha of fibres in the soleus muscle of Zucker diabetic fatty rats2007
Author(s)
Adachi T, Kikuchi N, Yasuda K, Anahara R, Gu N, Matsunaga T, Yamamura T, Mori C, Tsujimoto G, Tsuda K, Ishihara A.
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Journal Title
Exp Physiol 92
Pages: 449-455
Related Report
Peer Reviewed
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