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Research and development of a therapeutic exercise preconditioning for muscle atrophy and circulatory failure with non-insulin-dependent diabetes mellitus

Research Project

Project/Area Number 19300196
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHimeji Dokkyo University

Principal Investigator

TAKEDA Isao  Himeji Dokkyo University, 医療保健学部, 教授 (00163402)

Co-Investigator(Kenkyū-buntansha) ISHIHARA Akihiko  京都大学, 大学院・人間環境学研究科, 教授 (90184548)
KAJIYA Fumihiko  川崎医療福祉大学, 医療技術学部, 教授 (70029114)
SUGAWARA Motoaki  姫路獨協大学, 医療保健学部, 教授 (60010914)
MURAKAMI Shinichiro  姫路獨協大学, 医療保健学部, 教授 (30454763)
FUJINO Hidemi  神戸大学, 大学院・保健学研究科, 教授 (20278998)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2007: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywordsリハビリテーション / 運動療法 / 糖尿病 / 微小循環 / プレコンディショニング / 筋萎縮 / 運動 / 血管構造
Research Abstract

Exercise training has long been utilized as one of therapy in the non-insulin-dependent diabetes mellitus. The effects of a therapeutic exercise preconditioning on the myocyte and the microcirculation of skeletal muscle in diabetic rats was investigated. The preconditioning consisted of exercise at either low-(aerobic) or Hi-(unaerobic) intensity and included five 60 or 30 min sessions per week for 3 weeks, respectively. Both treated diabetic rats exhibited a decrease in plasma glucose, glycohemoglobin, and reactive oxygen species (ROS) compared with those of the diabetic rats but did not completely normalize levels. The capillary volume in diabetic muscle was significantly less, i.e., capillary regression. In three exercise-trained diabetic muscles, the capillary volumes were increased toward control levels and completely normalize levels. In summary, the results of the present study provide evidence for the effectiveness of exercise training in reducing some of the muscle circulatory complications associated with diabetes mellitus.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (96 results)

All 2010 2009 2008 2007 Other

All Journal Article (42 results) (of which Peer Reviewed: 31 results) Presentation (50 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis2010

    • Author(s)
      Nagatomo F, Gu N, Fujino H, Takeda I, Ishihara A
    • Journal Title

      Clin Exp Med 10

      Pages: 7-13

    • NAID

      120005260236

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article] Comparision of capillary architecture between slow and fast muscles in rats using a cofocal laser scanning microscope2010

    • Author(s)
      Murakami S, Fujino H, Takeda I, Momota R, Kumagishi K, Ohtsuka A
    • Journal Title

      Acta Medica Okayama 64(1)

      Pages: 11-18

    • Related Report
      2009 Final Research Report
  • [Journal Article] Hyperbaric oxygen exposure improves blood glucose level and muscle oxidative capacity in rats with type 2 diabetes2010

    • Author(s)
      Gu N, Nagatomo F, Fujino H, Takeda I, Tsuda K, Ishihara A
    • Journal Title

      Diabetes Technology and Therapeutics 12(2)

      Pages: 125-133

    • Related Report
      2009 Final Research Report
  • [Journal Article] Exercise exerts neuroprotective effects on Parkinson's disease model of rats2010

    • Author(s)
      Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, Wang F, Baba T, Tayra JT, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I
    • Journal Title

      Brain Res 1310C

      Pages: 200-207

    • Related Report
      2009 Final Research Report
  • [Journal Article] Comparision of capillary architecture between slow and fast muscles in rats using a cofocal laser scanning microscope2010

    • Author(s)
      Murakami S, Fujino H, Takeda I, Momota R, Kumagishi K, Ohtsuka A
    • Journal Title

      Acta Medica Okayama 64

      Pages: 11-18

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperbaric oxygen exposure improves blood glucose level and muscle oxidative capacity in rats with type 2 diabetes.2010

    • Author(s)
      Gu N, Nagatomo F, Fujino H, Takeda I, Tsuda K, Ishihara A
    • Journal Title

      Diabetes Technology and Therapeutics 12

      Pages: 125-133

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exercise exerts neuroprotective effects on Parkinson's disease model of rats2010

    • Author(s)
      Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan W, Kadota T, Wang F, Baba T, Tayra J T, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I
    • Journal Title

      Brain Res 1310C

      Pages: 200-207

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperbaric oxygenation restores age-related decline in oxidative enzyme activity of the tibialis anterior muscle in mice.2010

    • Author(s)
      Nishizaka T, Nagatomo F, Fujino H, Nomura T, Sano T, Higuchi K, Takeda I, Ishihara A
    • Journal Title

      Enzyme Research (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hyperbaric oxygenation on blood pressure levels of spontaneously hypertensive rats.2010

    • Author(s)
      Nagatomo F, Gu N, Fujino H, Takeda I, Ishihara A.
    • Journal Title

      Clin Exp Hypertens (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of exercise preconditioning on hindlimb unloading-induced atrophy of rat soleus muscle2009

    • Author(s)
      Fujino H, Ishihara A, Murakami S, Yasuhara T, Kondo H, Mohri S, Takeda I
    • Journal Title

      Roy RR. Acta Physiol (Oxf) 197(1)

      Pages: 65-74

    • Related Report
      2009 Final Research Report
  • [Journal Article] Thermal preconditioning prevents fiber type transformation of the unloading induced-atrophied muscle in rats2009

    • Author(s)
      Takeda I, Fujino H, Murakami S, Kondo H, Nagatomo F, Ishihara A
    • Journal Title

      J Muscle Res Cell Motil 30(3-4)

      Pages: 145-152

    • Related Report
      2009 Final Research Report
  • [Journal Article] Skeletal muscle characteristics of rats with obesity, diabetes, hypertension, and hyperlipidemia2009

    • Author(s)
      Nagatomo F, Gu N, Fujino H, Takeda I, Tsuda M Ishihara A
    • Journal Title

      J Atheroscler Thromb 16

      Pages: 576-585

    • NAID

      10026143425

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article] Thermal preconditioning prevents fiber type transformation of the unloading induced-atrophied muscle in rats2009

    • Author(s)
      Takeda I, Fujino H, Murakami S, Kondo H, Nagatomo F, Ishihara A
    • Journal Title

      J Muscle Res Cell Motil 30

      Pages: 145-152

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of exercise preconditioning on hindlimb unloading-induced atrophy of rat soleus muscle2009

    • Author(s)
      Fujino H, Ishihara A, Murakami S, Yasuhara T, Kondo H, Mohri S, Takeda I, Roy RR
    • Journal Title

      Acta Physiol(Oxf) 197

      Pages: 65-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The alteration of a mechanical property of bone cells during the process of changing from osteoblasts to osteocytes.2009

    • Author(s)
      Sugawara Y, Ando R, Kamioka H, Ishihara Y, Murshid SA, Hashimoto K, Kataoka N, Tsujioka K, Kajiya F, Yamashiro T, Takano-Yamamoto T.
    • Journal Title

      Bone 43

      Pages: 19-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct measurement of nitric oxide concentration in CAPD dialysate.2009

    • Author(s)
      Mochizuki S, Takayama A, Sasaki T, Horike H, Kashihara N, Ogasawara Y, Kajiya F, Kitawaki T, Oka H.
    • Journal Title

      Perit Dial Int 29

      Pages: 111-114

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hindlimb unloading at early postnatal growth on cell body size in spinal motoneurons innervating soleus muscle of rats.2009

    • Author(s)
      Nagatomo F, Ishihara A, Ohira Y.
    • Journal Title

      Int J Dev Neurosci 27

      Pages: 21-26

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines : the 'Power Rehabilitation' program.2009

    • Author(s)
      Murakami S, Otsuki T, Maeda M, Miura Y, Morii S, Kiyokane K, Hayakawa S, Maeda A, Imakawa T, Harada S, Handa T, Nishimura Y, Murakami S, Kumagai N, Hayashi H, Chen Y, Suemori S, Fukushima Y, Nishida S, Fukushima K.
    • Journal Title

      Int J Mol Med 23

      Pages: 81-88

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical usefulness of wave intensity analysis.2009

    • Author(s)
      Sugawara M, Niki K, Ohte N, Okada T, Harada A.
    • Journal Title

      Med Biol Eng Comput 47

      Pages: 197-206

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of exercise preconditioning on hindlimb unloading-induced atrophy of rat soleus muscle.2009

    • Author(s)
      Fujino H, Ishihara A, Murakami S, Yasuhara T, Kondo H, Mohri S, Takeda I, Roy RR
    • Journal Title

      Acta Physiol (Oxf) (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skeletal Muscle Characteristics of Rats with Obesity, Diabetes, Hypertension, and Hyperlipidemia2009

    • Author(s)
      Nagatomo F, Gu N, Fujino H, Takeda I, Tsuda M, Ishihara A
    • Journal Title

      Journal of Atherosclerosis and Thrombosis (in press)

    • NAID

      10026143425

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.2009

    • Author(s)
      Nakamura K, Shimizu J, Kataoka N, Hashimoto K, Ikeda T, Fujio H, Ohta-Ogo K, Ogawa A, Miura A, Mohri S, Nagase S, Morita H, Kusano KF, Date H, Matsubara H, Mochizuki S, Hashimoto K, Kajiya F, Ohe T.
    • Journal Title

      Int J Cardiol (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression levels of heat shock proteins in the soleus and plantaris muscles of rats after hindlimb suspension or spaceflight2008

    • Author(s)
      Ishihara A, Fujino H, Nagatomo F, Takeda I, Ohira Y
    • Journal Title

      J Physiol Sci 58(6

      Pages: 413-417

    • NAID

      10023967062

    • Related Report
      2009 Final Research Report
  • [Journal Article] Glucose regulation of dipeptidyl peptidase IV gene expression is mediated by hepatocyte nuclear factor-lalpha in epithelial intestinal cells.2008

    • Author(s)
      Gu N, Tsuda M, Matsunaga T, Adachi T, Yasuda K, Ishihara A, Tsuda K
    • Journal Title

      Clin Exp Pharmacol Physiol 35

      Pages: 1433-1439

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression levels of heat shock proteins in the soleus and plantaris muscles of rats after hindlimb suspension or spaceflight.2008

    • Author(s)
      Ishihara A, Fujino H, Nagatomo F, Takeda I, Ohira Y.
    • Journal Title

      J Physiol Sci 58

      Pages: 413-417

    • NAID

      10023967062

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coronary microcirculation in the beating heart.2008

    • Author(s)
      Kajiya F, Yada T, Hiramatsu O, Ogasawara Y, Inai Y, Kajiya M.
    • Journal Title

      Med Biol Eng Comput 46

      Pages: 411-419

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 廃用性筋萎縮における毛細血管リモデリングと血管増殖因子の抑制2008

    • Author(s)
      藤野 英己, 上月 久治, 武田 功, 笹井 宣昌, 村上 慎一郎, 村田 伸, 石井 禎基, 松永 秀俊, 石原 昭彦, 梶谷 文彦
    • Journal Title

      理学療法科学 23

      Pages: 203-208

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 身体組成と上・下肢および四肢周径に関する研究2008

    • Author(s)
      甲斐 義浩, 藤野 英己, 村田 伸, 竹井 和人, 村田 潤, 武田 功
    • Journal Title

      理学療法科学 23

      Pages: 241-244

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 地域在住女性高齢者の開眼片足立ち保持時間と身体機能との関係2008

    • Author(s)
      村田 伸, 大山 美智江, 太田 尾浩, 村田 潤, 豊田 謙二, 藤野 英己, 弓岡 光徳, 武田 功
    • Journal Title

      理学療法科学 23

      Pages: 79-83

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualisation of the effects of dilazep on rat afferent and efferent arterioles in vivo2008

    • Author(s)
      Nakamoto H, Ogasawara Y, Kajiya F
    • Journal Title

      Hypertens Res 31

      Pages: 315-324

    • NAID

      10024360034

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Cu,Zn-SOD in the synthesis of endogenous vasodilator hydrogen peroxide during reactive hyperemia in mouse mesenteric microcirculation in vivo2008

    • Author(s)
      Yada T, Shimokawa H, Morikawa K, Takaki A, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F.
    • Journal Title

      Am J Physiol Heart Circ Physiol 294

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 地域在住高齢者の足把持力に関する研究2008

    • Author(s)
      村田 伸, 大山 美智江, 太田 尾浩, 村田 潤, 豊田 謙二, 藤野 英己, 弓岡 光徳, 武田 功
    • Journal Title

      理学療法科学 23

      Pages: 79-83

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis2007

    • Author(s)
      Yasuhara T, Hara K, Maki M, Matsukawa N, Fujino H, Date I, Borlongan CV
    • Journal Title

      Neuroscience 149

      Pages: 182-191

    • Related Report
      2009 Final Research Report
  • [Journal Article] Lack of exercise,via hindlimb suspension,impedes endogenous neurogenests2007

    • Author(s)
      Yasuhara T, Hara K, Maki M, Matsukawa N, Fujino H, Date I, Borlongan CV.
    • Journal Title

      Neuroscience 149

      Pages: 182-191

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibre type distribution and gene expression levels of both succinate dehydrogenase and peroxisome proliferator-activated receptor gamma coactivator-lalpha of fibres in the soleus muscle of Zucker diabetic fatty rats2007

    • Author(s)
      Adachi T, Kikuchi N, Yasuda K, Anahara R, Gu N, Matsunaga T, Yamamura T, Mori C, Tsujimoto G, Tsuda K, Ishihara A.
    • Journal Title

      Exp Physiol 92

      Pages: 449-455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HNF-1alpha participates in glucose regulation of sucrase-isomaltase gene expression in epithelial intestinal cells2007

    • Author(s)
      Gu N, Adachi T, Matsunaga T, Tsujimoto G, Ishihara A, Yasuda K, Tsuda K
    • Journal Title

      Biochem Biophys Res Commun 353

      Pages: 617-622

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell size and oxidative enzyme activity of rat biceps brachii and tricepsbrachii muscles2007

    • Author(s)
      Matsumoto A, Nagatomo F, Mori A, Ohira Y, Ishihara A.
    • Journal Title

      J Physiol Sci 57

      Pages: 311-316

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperbaric exposure with high oxygen concentration improves altered fiber types in the plantaris muscle of diabetic Goto-Kakizaki rats2007

    • Author(s)
      Matsumoto A, Nagatomo F, Yasuda K, Tsuda K, Ishihara A
    • Journal Title

      J Physiol Sci 57

      Pages: 133-136

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hyperbaric exposure with high oxygen concentration on the physical activity of developing rats2007

    • Author(s)
      Matsumoto A, Okiura T, Morimatsu F, Ohira Y, Ishihara A.
    • Journal Title

      Dev Neurosci 29

      Pages: 452-459

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hyperbaric exposure with high oxygen concentration on glucoseand insulin levels and skeletal muscle-fiber properties in diabetic rats2007

    • Author(s)
      Yasuda K, Adachi T, Gu N, Matsumoto A, Matsunaga T, Tsujimoto G, Tsuda K, Ishihara A.
    • Journal Title

      Muscle Nerve 35

      Pages: 337-343

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperbaric oxygenation restores age-related decline in oxidative enzyme activity of the tibialis anterior muscle in mice

    • Author(s)
      Nishizaka T, Nagatomo F, Fujino H, Nomura T, Sano T, Higuchi K, Takeda I, Ishihara A
    • Journal Title

      Enzyme Research (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of hyperbaric oxygenation on blood pressure levels of spontaneously hypertensive rats

    • Author(s)
      Nagatomo F, Gu N, Fujino H, Takeda I, Ishihara A
    • Journal Title

      Clin Exp Hypertens (in press)

    • Related Report
      2009 Final Research Report
  • [Presentation] Capillary hemodynamics and expression of angiogenic regulators in metabolically different rat muscles2010

    • Author(s)
      Fujino H, Kondo H, Murakami S, Nagatomo F, Takeda I, Ishihara A, Roy RR
    • Organizer
      57th American college of sports medicine
    • Place of Presentation
      Baltimore
    • Related Report
      2009 Final Research Report
  • [Presentation] Exercise Preconditioning Attenuates Oxidative Stress and Hyperglycemia in Spontaneously Diabetic Torii rat2010

    • Author(s)
      Kondo H, Fujino H, Murakami S, Nagatomo F, Takeda I, Ishihara A
    • Organizer
      57th American college of sports medicine
    • Place of Presentation
      Baltimore
    • Related Report
      2009 Final Research Report
  • [Presentation] II型糖尿病に対するプレコンディショニング運動が酸化ストレスに及ぼす予防効果2010

    • Author(s)
      藤野英己, 村上慎一郎, 近藤浩代, 武田功
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜
    • Related Report
      2009 Final Research Report
  • [Presentation] 非インスリン依存型糖尿病モデルラットのヒラメ筋ミオシン重鎖アイソフォームのタイプ移行と酸化的リン酸化活性の変化2010

    • Author(s)
      村上慎一郎, 藤野英己, 近藤浩代, 小幡太志, 弓影秀樹, 高見博文, 松永秀俊, 武田功
    • Organizer
      第45回日本理学療法学術大会
    • Place of Presentation
      岐阜
    • Related Report
      2009 Final Research Report
  • [Presentation] 高脂肪食および自発走運動がメタボリックシンドロームラットの骨格筋における遺伝子発現と筋線維の代謝特性に与える影響2010

    • Author(s)
      永友文子, 顧寧, 藤野英己, 武田功, 津田謹輔, 石原昭彦
    • Organizer
      第53回糖尿病学会
    • Place of Presentation
      岡山
    • Related Report
      2009 Final Research Report
  • [Presentation] Fiber capillary regression and endothelial apoptosis against disuse atrophy in rat soleus muscle: role of angiogenic regulators2010

    • Author(s)
      Fujino H, Kondo H, Murakami S, Nagatomo F, Takeda I, Ishihara A, Roy RR
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim
    • Related Report
      2009 Final Research Report
  • [Presentation] Abnormality of capillarity and oxidative enzyme activity in slow muscle of type 2 diabetic rats2010

    • Author(s)
      Murakami S, Fujino H, Kondo H, Takeda I, Momota R, Kumagishi K, Ohtsuka A
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim
    • Related Report
      2009 Final Research Report
  • [Presentation] Interaction of the effects between estrogen receptor-alpha polymorphism and physical activity or nutrient on bone mass in Japanese young women2010

    • Author(s)
      Kondo H, Fujino H, Murakami S, Takeda I, Ishihara A
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim
    • Related Report
      2009 Final Research Report
  • [Presentation] 非インスリン依存型糖尿病モデルラットのヒラメ筋の毛細血管構築、ミオシン重鎖アイソフォーム、及び酸化的リン酸化活性の変化2010

    • Author(s)
      村上慎一郎, 藤野英己, 近藤浩代, 武田功, 百田龍輔, 熊岸加苗, 大塚愛二
    • Organizer
      第115回解剖学会総会
    • Place of Presentation
      岩手
    • Related Report
      2009 Final Research Report
  • [Presentation] Skeletal muscle characteristics of rats with type 2 diabetes2010

    • Author(s)
      Nagatomo F, Gu N, Fujino H, Tsuda K, Ishihara A
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Final Research Report
  • [Presentation] Responses of pro- and anti-angiogenic factors to capillary in rat soleus muscle after hindlimb unloading2009

    • Author(s)
      Fujino H, Kondo H, Murakami S, Nagatomo F, Takeda I, Ishihara A
    • Organizer
      49th The American Society for Cell Biology
    • Place of Presentation
      San Diego convention center, San Diego, USA
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Statins differentiate adult rat bone marrow stromal cells into neurons2009

    • Author(s)
      Kondo H, Fujino H.
    • Organizer
      49th The American Society for Cell Biology
    • Place of Presentation
      San Diego convention center, San Diego, USA
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 廃用性筋萎縮による遅筋型ミオシン重鎖の減少に対するプレコンディショニング温熱負荷の予防効果2009

    • Author(s)
      藤野英己, 村上慎一郎, 近藤浩代, 永友文子, 武田功, 石原昭彦
    • Organizer
      第17回日本物理療法学会
    • Place of Presentation
      神戸医療大学(兵庫)
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] c-fos expression in spinal neurons in response to different hindlimb loading during treadmill locomotion in adult rats2009

    • Author(s)
      Zhong H, Fujino H, Tillakaratne N.JK, Lavrov I, Edgerton VR, Roy RR
    • Organizer
      Society of Neuroscience meeting 2009
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 共焦点レーザー顕微鏡を用いたラットの遅筋と速筋の毛細血管構築の比較2009

    • Author(s)
      村上慎一郎, 藤野英己, 武田功, 百田龍輔, 熊岸加苗, 近藤浩代, 大塚愛二
    • Organizer
      日本解剖学会64回中国・四国支部学術集会
    • Place of Presentation
      高知大学医学部(高知)
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] II型糖尿病ラット(GOTO-KAKIZAKIラット)のヒラメ筋の筋線維タイプの変化2009

    • Author(s)
      熊岸加苗, 村上慎一郎, 藤野英己, 武田功, 百田龍輔, 近藤浩代, 大塚愛二
    • Organizer
      日本解剖学会64回中国・四国支部学術集会
    • Place of Presentation
      高知大学医学部(高知)
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 萎縮筋での毛細血管網退行と血管新生抑制因子の発現2009

    • Author(s)
      藤野英己, 永友文子, 近藤浩代, 村上慎一郎, 武田功, 石原昭彦
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 閉経後女性の身体特性とエストロゲンレセプターα遺伝子多型の踵骨と大腿骨骨指標の比較2009

    • Author(s)
      近藤浩代, 藤野英己, 山下剛範, 武田功, 石原昭彦
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高気圧・高濃度酸素への曝露による関節炎ラットの酸化ストレス抑制効果2009

    • Author(s)
      永友文子, 藤野英己, 森彩子, 松本亜希子, 武田功, 石原昭彦
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Activation of spinal neurons during treadmill stepping : incline effect.2009

    • Author(s)
      Fujino H, Zhong H, Tillakaratne N.JK, Ishihara A, Edgerton VR, Roy RR
    • Organizer
      XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto International Conference Center(ICC Kyoto), Kyoto, Japan
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Remodeling of capillary and responses of pro- and anti- angiogenic factors in atrophied muscle2009

    • Author(s)
      Fujino H, Kondo H, Murakami S, Takeda I, Ishihara A
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京慈恵会医科大学(東京)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genetic variations in estrogen receptor alpha determine bone mass and body characteristics in postmenopausal women2009

    • Author(s)
      Kondo H, Fujino H, Takeda I, Ishihara A
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京慈恵会医科大学(東京)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Implications of angiogenic factors and thrombospondin-1 underlying capillary regression in chronically unloaded rat soleus muscle.2009

    • Author(s)
      Fujino H, Ishihara A, Murakami S, Kondo H, Zhong H, Roy RR, Edgerton VR
    • Organizer
      American college of sports medicine
    • Place of Presentation
      Wasington state convention & trade center, Seattle, USA
    • Year and Date
      2009-05-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Estrogen receptor-alpha genotype affects exercise and nutrient intake-related change of bone mass2009

    • Author(s)
      Kondo H, Fujino H, Funahashi T, Suzuki K
    • Organizer
      American college of sports medicine
    • Place of Presentation
      Wasington state convention & trade center, Seattle, USA
    • Year and Date
      2009-05-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病モデルラットにおける骨格筋の組織化学的特性と遺伝子発現2009

    • Author(s)
      永友文子, 顧寧, 藤野英己, 武田功, 津田謹輔, 石原昭彦
    • Organizer
      第52回日本糖尿病学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Responses of pro- and anti-angiogenic factors to capillary in rat soleus muscle after hindlimb unloading2009

    • Author(s)
      Fujino H, Kondo H, Murakami S, Nagatomo F, Takeda I, Ishihara A
    • Organizer
      49th The American Society for Cell Biology
    • Place of Presentation
      San Diego
    • Related Report
      2009 Final Research Report
  • [Presentation] Statins differentiate adult rat bone marrow stromal cells into neurons2009

    • Author(s)
      Kondo H, Fujino H
    • Organizer
      49th The American Society for Cell Biology
    • Place of Presentation
      San Diego
    • Related Report
      2009 Final Research Report
  • [Presentation] c-fos expression in spinal neurons in response to different hindlimb loading during treadmill locomotion in adult rats2009

    • Author(s)
      Zhong H, Fujino H, Tillakaratne N. JK, Lavrov I, Edgerton VR, Roy RR
    • Organizer
      Society of Neuroscience meeting
    • Place of Presentation
      Chicago
    • Related Report
      2009 Final Research Report
  • [Presentation] 共焦点レーザー顕微鏡を用いたラットの遅筋と速筋の毛細血管構築の比較2009

    • Author(s)
      村上慎一郎, 藤野英己, 武田功, 百田龍輔, 熊岸加苗, 近藤浩代, 大塚愛二
    • Organizer
      日本解剖学会64回中国・四国支部学術集会
    • Place of Presentation
      高知
    • Related Report
      2009 Final Research Report
  • [Presentation] II型糖尿病ラット(GOTO-KAKIZAKIラット)のヒラメ筋の筋線維タイプの変化2009

    • Author(s)
      熊岸加苗, 村上慎一郎, 藤野英己, 武田功, 百田龍輔, 近藤浩代, 大塚愛二
    • Organizer
      日本解剖学会64回中国・四国支部学術集会
    • Place of Presentation
      高知
    • Related Report
      2009 Final Research Report
  • [Presentation] 廃用性筋萎縮による遅筋型ミオシン重鎖の減少に対するプレコンディショニング温熱負荷の予防効果2009

    • Author(s)
      藤野英己, 村上慎一郎, 近藤浩代, 永友文子, 武田功, 石原昭彦
    • Organizer
      第17回日本物理療法学会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 萎縮筋での毛細血管網退行と血管新生抑制因子の発現2009

    • Author(s)
      藤野英己, 永友文子, 近藤浩代, 村上慎一郎, 武田功, 石原昭彦
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Final Research Report
  • [Presentation] 閉経後女性の身体特性とエストロゲンレセプターα遺伝子多型の踵骨と大腿骨骨指標の比較2009

    • Author(s)
      近藤浩代, 藤野英己, 山下剛範, 武田功, 石原昭彦
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Final Research Report
  • [Presentation] 高気圧・高濃度酸素への曝露による関節炎ラットの酸化ストレス抑制効果2009

    • Author(s)
      永友文子, 藤野英己, 森彩子, 松本亜希子, 武田功, 石原昭彦
    • Organizer
      第64回日本体力医学会
    • Place of Presentation
      新潟
    • Related Report
      2009 Final Research Report
  • [Presentation] Activation of spinal neurons during treadmill stepping: incline effect2009

    • Author(s)
      Fujino H, Zhong H, Tillakaratne N. JK, Ishihara A, Edgerton VR, Roy RR
    • Organizer
      XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Final Research Report
  • [Presentation] 糖尿病モデルラットにおける骨格筋の組織化学的特性と遺伝子発現2009

    • Author(s)
      永友文子, 顧寧, 藤野英己, 武田功, 津田謹輔, 石原昭彦
    • Organizer
      第52回日本糖尿病学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Implications of angiogenic factors and thrombospondin-1 underlying capillary regression in chronically unloaded rat soleus muscle2009

    • Author(s)
      Fujino H, Ishihara A, Murakami S, Kondo H, Zhong H, Roy RR, Edgerton VR
    • Organizer
      American college of sports medicine
    • Place of Presentation
      Seattle
    • Related Report
      2009 Final Research Report
  • [Presentation] Estrogen receptor-alpha genotype affects exercise and nutrient intake-related change of bone mass2009

    • Author(s)
      Kondo H, Fujino H, Funahashi T, Suzuki K
    • Organizer
      American college of sports medicine
    • Place of Presentation
      Seattle
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of Exercise Preconditioning on the Microvasculature of Atrophied Muscle2008

    • Author(s)
      Fujino H, Takeda I, Matsumoto A, Ishihara A
    • Organizer
      55th American College of Sports Medicine Annual meeteing
    • Place of Presentation
      Indianapolis
    • Related Report
      2009 Final Research Report
  • [Presentation] Microvascular remodeling and decreased angiogenic factors in the atrophied rat soleus muscle2008

    • Author(s)
      Fujino H, Ishihara A, Murakami S, Kondo H, Takeda I, Tillakatatne NJ, Zhong H, Roy RR, Edgerton VR
    • Organizer
      The Integrative Biology of Exercise V
    • Place of Presentation
      Hilton Head
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of voluntary running exercise under low-or high- oxygen conditions on the soleus muscle in rats2008

    • Author(s)
      Matsumoto A, Mori A, Nagatomo F, Fujino H, Ishihara A
    • Organizer
      XXX International Federation of Sports Medicine
    • Place of Presentation
      Barcelona
    • Related Report
      2009 Final Research Report
  • [Presentation] The effects of loading on spinal neuron c-fos expression in intact adult rats2008

    • Author(s)
      Zhong H, Fujino H, Roy RR, Tillakatatne NJ, Lavrov I Edgerton VR
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington DC
    • Related Report
      2009 Final Research Report
  • [Presentation] 運動プレコンディショニングによる廃用性筋萎縮予防効果;廃用性萎縮筋の毛細血管ネットワークリモデリングと赤血球速度の解析2007

    • Author(s)
      藤野 英己, 上月 久治, 武田 功, 石原 昭彦, 菅原 基晃, 梶谷 文彦
    • Organizer
      第12回酸素ダイナミクス研究会
    • Place of Presentation
      広島
    • Year and Date
      2007-09-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Exercise preconditioning attenuates capillary regression in atrophied soleus muscle2007

    • Author(s)
      Fujino H, Kohzuki H, Takeda I, Kajiya F
    • Organizer
      World Physical Therapy 2007
    • Place of Presentation
      Vancouver
    • Related Report
      2009 Final Research Report
  • [Presentation] プレコンディショニング運動による廃用性萎縮筋の毛細血管・吻合毛細血管ネットワークのリモデリング2007

    • Author(s)
      藤野 英己, 上月 久治, 武田 功, 近藤 浩代, 村田 伸, 石井 禎基, 松永 秀俊, 梶谷 文彦
    • Organizer
      第42回日本理学療法学術大会
    • Place of Presentation
      新潟
    • Related Report
      2007 Annual Research Report
  • [Presentation] Exercise preconditioning attenuates capillary regression in atrophied soleus muscle2007

    • Author(s)
      Fujino H, Kohzuki H, Takeda I, Kajiya F
    • Organizer
      World Physical Therapy 2007
    • Place of Presentation
      カナダ・バンクーバー
    • Related Report
      2007 Annual Research Report
  • [Presentation] プレコンディショニング温熱曝露が廃用佐萎縮筋の毛細血管退行及び血管増殖因子に及ぼす影響2007

    • Author(s)
      藤野 英己, 上月 久治, 武田 功, 長原 真也, 松本 明子, 石原 昭彦
    • Organizer
      第62回日本体力医学会大会
    • Place of Presentation
      秋田
    • Related Report
      2007 Annual Research Report
  • [Presentation] 後肢懸垂前運動が筋疲労および速筋型ミオシン重鎖アイソフォームの発現に及ぼす影響2007

    • Author(s)
      長原 真也, 藤野 英己, 武田 功
    • Organizer
      第62回日本体力医学会大会
    • Place of Presentation
      秋田
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低濃度または高濃度酸素への曝露がラットの酸化ストレス度と抗酸化力に及ぼす影響2007

    • Author(s)
      松本 亜希子, 藤野 英己, 上月 久治, 石原 昭彦
    • Organizer
      第62回日本体力医学会大会
    • Place of Presentation
      秋田
    • Related Report
      2007 Annual Research Report
  • [Presentation] Microvascular remodeling and increased red blood cell velocity in soleus muscle in a rat model of obesity2007

    • Author(s)
      Ishii Y, Itoh H, Otani H, Sasai N, Fujino H, Tsuchiya T
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Book] からだと酸素の辞典(田村守編)2009

    • Author(s)
      藤野英己, 他116名
    • Publisher
      朝倉書店
    • Related Report
      2009 Final Research Report
  • [Book] からだと酸素の辞典2009

    • Author(s)
      藤野英己, 他116名
    • Total Pages
      596
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report
  • [Book] がらだと酸素の辞典(3.15 02conformer-regulator, .25廃用性萎縮筋と酸素)2008

    • Author(s)
      藤野 英己, 他
    • Publisher
      朝倉書店(印刷中)
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www2.kobe-u.ac.jp/~fujitan/index

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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