DEVELOPMENT OF A VASCULAR REHABILITATION METHOD BASED ON REAL-TIME MEASUREMENT OF PLASMA NITRIC OXIDE CONCENTRATION
| Project/Area Number |
19300197
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
MOCHIZUKI Seiichi (2009) Kawasaki University of Medical Welfare, 医療技術学部, 教授 (60259596)
後藤 真己 (2007-2008) Kawasaki University of Medical Welfare, 医療技術学部, 教授 (50148699)
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| Co-Investigator(Kenkyū-buntansha) |
KAYANO Isao 川崎医療福祉大学, 医療技術学部, 講師 (70390242)
望月 精一 川崎医療福祉大学, 医療技術学部, 教授 (60259596)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 循環器・高血圧 / 血管生理学 / 血管リハビリテーション / メタボリック症候群 / 一酸化窒素(NO) / 血管機能 / 酸化ストレス / 抗酸化力 / 腹膜透析(CAPD) / 生理学 / リハビリテーション |
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| Research Abstract |
The patients with ischemic heart diseases and cerebrovascular dysfunctions (major causes of death of the Japanese) suffer from vascular dysfunctions due to atherosclerotic development, and thus it is important to develop vascular rehabilitation methods as well as preventative methods for such vascular diseases. Nitric oxide (NO) is synthesized from endothelial cells in response to changes in blood flow and exerts various physiological functions such as vascular dilatation (controlling blood pressure and blood flow) and anti-atherosclerosis. In this study, we aimed at i) elaborating simultaneous measurement of in vivo NO concentration in the blood stream together with blood pressure and blood flow velocity on a real-time basis and ii) developing a quantitative analytical method for vascular rehabilitation. We were successful not only in developing a measurement technique but also in confirming the applicability of this technique to a quantitative analysis of i) vascular functions of the subjects with metabolic syndrome and ii) other biological functions.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Evaluation of coronary endothelial function by catheter-type NO sensor in high-fat-diet-induced obese dogs2009
Author(s)
Kume T, Kawamoto T, Okura H, Neishi Y, Hashimoto K, Hayashida A, Watanabe N, Kanda Y, Mochizuki S, Goto M, Yoshida K
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Journal Title
Circ J 73(3)
Pages: 562-567
NAID
Related Report
Peer Reviewed
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[Presentation] NOセンサによる生体内NOの計測2008
Author(s)
望月精一, 後藤真己, 高山綾, 矢田豊隆, 小笠原康夫, 梶谷文彦, 今西敏雄, 赤阪隆史, 佐々木環, 岡久雄
Organizer
第47回日本生体医工学会大会オーガナイズドセッション「血流と血管に関するトピックス2008」
Place of Presentation
神戸市
Year and Date
2008-05-09
Related Report
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