• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

DEVELOPMENT OF A VASCULAR REHABILITATION METHOD BASED ON REAL-TIME MEASUREMENT OF PLASMA NITRIC OXIDE CONCENTRATION

Research Project

Project/Area Number 19300197
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKawasaki University of Medical Welfare

Principal Investigator

MOCHIZUKI Seiichi (2009)  Kawasaki University of Medical Welfare, 医療技術学部, 教授 (60259596)

後藤 真己 (2007-2008)  Kawasaki University of Medical Welfare, 医療技術学部, 教授 (50148699)

Co-Investigator(Kenkyū-buntansha) KAYANO Isao  川崎医療福祉大学, 医療技術学部, 講師 (70390242)
望月 精一  川崎医療福祉大学, 医療技術学部, 教授 (60259596)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords循環器・高血圧 / 血管生理学 / 血管リハビリテーション / メタボリック症候群 / 一酸化窒素(NO) / 血管機能 / 酸化ストレス / 抗酸化力 / 腹膜透析(CAPD) / 生理学 / リハビリテーション
Research Abstract

The patients with ischemic heart diseases and cerebrovascular dysfunctions (major causes of death of the Japanese) suffer from vascular dysfunctions due to atherosclerotic development, and thus it is important to develop vascular rehabilitation methods as well as preventative methods for such vascular diseases. Nitric oxide (NO) is synthesized from endothelial cells in response to changes in blood flow and exerts various physiological functions such as vascular dilatation (controlling blood pressure and blood flow) and anti-atherosclerosis. In this study, we aimed at i) elaborating simultaneous measurement of in vivo NO concentration in the blood stream together with blood pressure and blood flow velocity on a real-time basis and ii) developing a quantitative analytical method for vascular rehabilitation. We were successful not only in developing a measurement technique but also in confirming the applicability of this technique to a quantitative analysis of i) vascular functions of the subjects with metabolic syndrome and ii) other biological functions.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report

Research Products

(17 results)

All 2010 2009 2008

All Journal Article Presentation

  • [Journal Article] Clear correlation of tetrahydrobiopterin with nitric oxide bioavailability in CAPD2010

    • Author(s)
      Mochizuki S, Takayama A, Sasaki T, Yada T, Endo K, Horike H, Kashihara N, Ogasawara Y, Kajiya F
    • Journal Title

      Blood Purif (印刷中)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clear Correlation of Tetrahydrobiopterin with Nitric Oxide Bioavailability in CAPD2010

    • Author(s)
      Mochizuki S, et al.
    • Journal Title

      Blood Purification (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中間周波磁界曝露によるラット小動脈血管径への影響評価2009

    • Author(s)
      茅野功, 望月精一, 小笠原康夫
    • Journal Title

      生体医工学 47(6)

      Pages: 508-513

    • NAID

      10031199713

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct measurement of nitric oxide concentration in CAPD dialysate2009

    • Author(s)
      Mochizuki S, Takayama A, Sasaki T, Horike H, Kashihara N, Ogasawara Y, Kajiya F, Kitawaki T, Oka H
    • Journal Title

      Perit. Dial. Int. 29(1)

      Pages: 111-114

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of coronary endothelial function by catheter-type NO sensor in high-fat-diet-induced obese dogs2009

    • Author(s)
      Kume T, Kawamoto T, Okura H, Neishi Y, Hashimoto K, Hayashida A, Watanabe N, Kanda Y, Mochizuki S, Goto M, Yoshida K
    • Journal Title

      Circ J 73(3)

      Pages: 562-567

    • NAID

      110007126718

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Coronary Endothelial Function by Catheter -Type NO Sensor in High -Fat-Diet-Induced Obese Dogs2009

    • Author(s)
      Teruyoshi Kume, et al.
    • Journal Title

      Circulation Journal 73

      Pages: 562-567

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma detection of NO by a catheter2008

    • Author(s)
      Goto M, Mochizuki S
    • Journal Title

      Med Biol Eng Comput 46(5)

      Pages: 509-516

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma detection of NO by a catheter2008

    • Author(s)
      Masami Goto
    • Journal Title

      Med Biol Eng Comput 46

      Pages: 509-516

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小動脈血管に対する中間周波磁界曝露の影響評価2009

    • Author(s)
      茅野功
    • Organizer
      日本生体医工学会・専門別研究会バイオメカニクス研究会・第133回研究会
    • Place of Presentation
      倉敷市
    • Year and Date
      2009-12-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 腹膜透析と血液透析における生体組織由来一酸化窒素の動態解析2009

    • Author(s)
      望月精一, 高山綾, 矢田豊隆, 小笠原康夫, 梶谷文彦, 佐々木環
    • Organizer
      第41回化学工学会秋季大会, 「在宅医療の化学工学」シンポジウム
    • Place of Presentation
      東広島市
    • Year and Date
      2009-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 腹膜透析と血液透析の併用療法におけるNOと酸化ストレスの関与2009

    • Author(s)
      望月精一, 小野淳一, 佐々木環, 高山綾, 矢田豊隆, 小笠原康夫, 梶谷文彦
    • Organizer
      第32回日本バイオレオロジー学会年会
    • Place of Presentation
      桐生市
    • Year and Date
      2009-06-04
    • Related Report
      2009 Final Research Report
  • [Presentation] 腹膜透析と血液透析の併用療法におけるNOと酸化ストレスの関与2009

    • Author(s)
      望月精一
    • Organizer
      第32回日本バイオレオロジー学会年会
    • Place of Presentation
      群馬県桐生市
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] NOセンサによる生体内NOの計測2008

    • Author(s)
      望月精一, 後藤真己, 高山綾, 矢田豊隆, 小笠原康夫, 梶谷文彦, 今西敏雄, 赤阪隆史, 佐々木環, 岡久雄
    • Organizer
      第47回日本生体医工学会大会オーガナイズドセッション「血流と血管に関するトピックス2008」
    • Place of Presentation
      神戸市
    • Year and Date
      2008-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Physiological regulation of NO release in the cardiovascular system in vivo2008

    • Author(s)
      Goto M, Mochizuki S, Ogasawara Y, Kajiya F
    • Organizer
      International Symposium on Resistance Arteries
    • Place of Presentation
      オーストラリア・ハミルトン島
    • Year and Date
      2008-02-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Physiological regulation of NO release in the cardiovascular system in vivo2008

    • Author(s)
      後藤 真己
    • Organizer
      International Symposium on Resistance Arteries
    • Place of Presentation
      オーストラリアハミルトン島
    • Year and Date
      2008-02-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Evaluation of nitric oxide bioavailability in coronary vessels of the beating heart2008

    • Author(s)
      Goto M, Mochizuki S, Ogasawara Y, Neishi Y, Kume T, Kawamoto T, Yoshida K
    • Organizer
      International Symposium on Biological and Physiological Engineering/The 22nd SICE Symposium on Biological and Physiological Engineering
    • Place of Presentation
      中華人民共和国・ハルピン市
    • Year and Date
      2008-01-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Physiological regulation of NO release in the cardiovascular system in vivo2008

    • Author(s)
      後藤 真己
    • Organizer
      Evaluation of nitric oxide bioavailability in coronary vessels of the beating heart
    • Place of Presentation
      中国ハルビン
    • Year and Date
      2008-01-13
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi