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Mechanism of increase inphysical activity using a novel animal model of high wheel running

Research Project

Project/Area Number 19300222
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Sports science
Research InstitutionThe University of Tokushima

Principal Investigator

NAKAYA Yutaka  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (50136222)

Co-Investigator(Renkei-kenkyūsha) HARADA NAGAKATSU  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40359914)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Keywordsスポーツ栄養学 / 運動 / インスリン抵抗性 / 海馬 / 心肥大 / 交感神経 / 脂肪細胞 / カルシウムチャネル / β遮断薬 / SPORTSラット / エピネフリン / 肥満 / 脂肪 / グレリン / ユビキチン / モノアミン / インスリン感受性 / 心拍数 / 培養心筋細胞
Research Abstract

To understand mechanisms of modified physical activities, we studied neuropsychological characteristics in SPORTS rat. In the hippocampus of SPORTS rats, the levels of norepinephrine (NE) in the extracellular fluid were increased, whereas those in the whole homogenate of the tissue were decreased. The protein expression and the activity levels of monoamine oxidase A (MAOA) were decreased in the hippocampus of SPORTS rats, suggesting that the elevation of extracellular NE by decreased MAOA activities in hippocampus determine the neural basis of the psychological regulation of exercise motives in the SPORTS rats.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008 2007 Other

All Journal Article (23 results) (of which Peer Reviewed: 22 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] beta-Adrenergic-AMPK pathway phosphorylates acetyl-CoA carboxylase in a high-epinephrine rat model2010

    • Author(s)
      Hattori A, Mawatari K, Tsuzuki S, Yoshioka E, Toda S, Yoshida M, Yasui 5, Furukawa H, Morishima M, Ono K, Ohnishi T, Nakano M, Harada N, Takahashi A, Nakaya Y
    • Journal Title

      SPORTS. Obesity 18

      Pages: 48-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] beta-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model, SPORTS.2010

    • Author(s)
      Hattori A
    • Journal Title

      Obesity 18

      Pages: 48-54

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes.2010

    • Author(s)
      Chung LT.
    • Journal Title

      Biochem Biophys Res Commun 391

      Pages: 995-999

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myosin IIA participates in docking of Glut4 storage vesicles with the plasma membrane in 3T3-L1 adipocytes.2009

    • Author(s)
      Kim Chung le T, Hosaka T, Harada N, Jambaldorj B, Fukunaga K, Nishiwaki Y, Teshigawara K, Sakai T, Nakaya Y, Funaki M
    • Journal Title

      Biochem Biophys Res Commun 391

      Pages: 995-999

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary phosphorus acutely impairs endothelial function.2009

    • Author(s)
      Shuto E, Taketani Y, Tanaka R, Harada N, Isshiki M, Sato M, Nashiki K, Amo K, Yamamoto H, Higashi Y, Nakaya Y, Takeda E
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 1504-1512

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression.2009

    • Author(s)
      Kim Chung le T, Hosaka T, Yoshida M, Harada N, Sakaue H, Sakai T, Nakaya Y
    • Journal Title

      Biochem Biophys Res Commun 390

      Pages: 613-618

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyphenols prevent clinorotation-induced expression of atrogenes in mouse C2Cl2 skeletal myotubes2009

    • Author(s)
      Hemdan DI
    • Journal Title

      J Med Invest 56

      Pages: 26-32

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary phosphorus acutely impairs endothelial function.2009

    • Author(s)
      Shuto E
    • Journal Title

      J Am Soc Nephrol 20

      Pages: 1504-1512

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice.2009

    • Author(s)
      Yoshida M
    • Journal Title

      Biochim Biophys Acta 1791

      Pages: 39-52

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beta-adrenergic-AMPK pathway phosphorylates acetyl-CoA carboxylase in a high epinephrine rat model, SPORTS2009

    • Author(s)
      Hattori A, et al
    • Journal Title

      Obesity (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nakaya 7, High-dose dietary supplementation of vitamin A induces brain-derived neurotrophic factor and nerve growth factor production in mice with simultaneous deficiency of vitamin A and zinc.2008

    • Author(s)
      D Kheirvari S, Uezu K, Yamamoto S
    • Journal Title

      Nutr Neurosci 11

      Pages: 228-234

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alternative splicing produces a constitutively active form of human SREBP-1.2008

    • Author(s)
      Harada N, Yonemoto H, Yoshida M, Yamamoto H, Yin Y, Miyamoto A, Hattori A, Wu Q, Nakagawa T, Nakano M Teshigawara K, Mawatari K, Hosaka T, Takahashi A, Nakaya Y
    • Journal Title

      368

      Pages: 820-826

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reactive oxygen species induced by diamide inhibit insulin-induced ATP-sensitive potassium channel activation in cultured vascular smooth muscle cells.2008

    • Author(s)
      Mawatari K, Yasui S, Morizumi R, Hamamoto A, Furukawa H, Koyama K, Hattori A, Yoshioka E, Yoshida M, Nakano M, Teshigawara K, Harada N, Hosaka T, Takahashi A, Nakaya Y
    • Journal Title

      Asia Pac J Clin Nutr 17Suppl1

      Pages: 162-166

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 運動習慣形成と脳内神経伝達物質2008

    • Author(s)
      中屋豊
    • Journal Title

      臨床スポーツ医学 25巻10号

      Pages: 1181-1186

    • NAID

      10026156186

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Alternative splicing produces a constitutively active form of human SREBP-12008

    • Author(s)
      Harada N, et al.
    • Journal Title

      Biochem Biophys Res Commun 368巻2号

      Pages: 127-134

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription factors Csx/Nkx2. 5 and GATA4 distinctly regulate expression of Ca(2+) channels in neonatal rat heart.2007

    • Author(s)
      Wang Y, Morishima M, Zheng M, Uchino T, Mannen K, Takahashi A, Nakaya Y, Komuro 1, One K
    • Journal Title

      J Mol Cell Cardiol 42

      Pages: 1045-1053

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physical exercise-associated gene expression signatures in peripheral blood.2007

    • Author(s)
      Kawai T, Morita K, Masuda K, Nishida K, Sekiyama A, Teshima-KondoS, Nakaya Y, Ohta M, Saito T, Rokutan K
    • Journal Title

      Clin J Sport Med 17

      Pages: 0-0

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] APS-mediated Ubiquitination of the Insulin Receptor Enhances its Internalization, but does not Induce its Degradation.2007

    • Author(s)
      Kishi K, Mawatari K, Sakai-Wakamatsu K, Yuasa T, Wang M, Ogura-Sawa M, Nakaya Y, Hatakeyama S, Dina Y
    • Journal Title

      Endocr J 54

      Pages: 77-88

    • NAID

      10019479382

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning of a murine glycerol-3-phosphate acyltransferase-like protein 1 (xGPAT1).2007

    • Author(s)
      Harada N, Hara S, Yoshida M, Zenitani T, Mawatari K, Nakano M, Takahashi A, Hosaka T, Yoshimoto K, Nakaya Y
    • Journal Title

      Mol Cell Biochem 297

      Pages: 41-51

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Haemolysin produced by Vibrio mimicus activates two C1(2) secretory pathways in cultured intestinal-like Caco-2 cells.2007

    • Author(s)
      Takahashi A, Miyoshi S, Takata N, Nakano M, Hamamoto A, Mawatari K, Harada N, Shinoda S, Nakaya Y
    • Journal Title

      Cell Microbiot 9

      Pages: 583-595

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physical exercise-associated gene expression signatures in peripheral blood.2007

    • Author(s)
      Kawai T
    • Journal Title

      Clin J Sport Med 17

      Pages: 375-383

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+channels in neonatal rat heart2007

    • Author(s)
      Wang Y
    • Journal Title

      J Mol Cell Cardiol 42

      Pages: 1045-1053

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insuhn resistance in mice2007

    • Author(s)
      Hirasaka K
    • Journal Title

      Diabetes 56

      Pages: 2511-2522

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脂質合成律速酵素グリセロール-3-リン酸アシルトランスフェラーゼ2の膜トポロジー解析2010

    • Author(s)
      中川忠彦
    • Organizer
      第240回徳島医学会学術集会
    • Place of Presentation
      徳島大学長井記念ホール,徳島
    • Year and Date
      2010-02-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳卒中モデルラットを用いた非メタボリックシンドローム型脳卒中発症予防法の検討2010

    • Author(s)
      阪上浩
    • Organizer
      第13回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館,京都
    • Year and Date
      2010-01-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Extracellular Matrix with the Rigidity of Adipose Tissues Helps 3T3-L1 Adipocytes Maintain Insulin Responsiveness.2009

    • Author(s)
      QINKAI LI
    • Organizer
      The American Diabetes Association 69th Scientific Sessions
    • Place of Presentation
      the Morial Convention Center in New Orleans, LA
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] MyosinlIA enhances membrane fusion of GLUT4-containing vesicles, but not recycling endosomes, with the plasma membrane2009

    • Author(s)
      Kim Chung le T, Hosaka T, Jambaldorj B, Fukunaga K, Nishiwaki Y, Nakaya Y, Funaki M
    • Organizer
      第5回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Extracellular matrix with the rigidity of adipose tissues helps 3T3-L1 adipocytes maintain insulin responsiveness2009

    • Author(s)
      Li Q, Hosaka T, Jambaldorj B, Nakaya Y, Funaki M
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Myosin IIA enhances membrane fusion of GLUT4-containing vesicles, but not recvcline endosomes, with the plasma membrane.2009

    • Author(s)
      Chung Thi Kim Le
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル大阪,大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高運動性モデルラット(SPORTS)の海馬ノルエピネフリン神経伝達亢進が体循環に及ぼす影響2008

    • Author(s)
      森島真幸, 中屋豊, 小野克重
    • Organizer
      日本病態生理学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-20
    • Related Report
      2009 Final Research Report
  • [Presentation] SPORTSラットの自発運動においてL型カルシウムチャネルは重要な調節因子である2008

    • Author(s)
      森島真幸, 王岩, 秋吉裕子, 中屋豊, 小野克重
    • Organizer
      目本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 高い運動習性を持つラット系(SPORTS)の確立と運動習性形成メカニズム2007

    • Author(s)
      中屋豊
    • Organizer
      第4回運動器科学研究会
    • Place of Presentation
      鳴門市
    • Year and Date
      2007-08-29
    • Related Report
      2009 Final Research Report
  • [Presentation] High-intensity voluntary exercise attenuates cardiac sympathetic activity in SPORTS(Spontaneously- Running-Tokushima-Shikoku)rats2007

    • Author(s)
      Morishima M, Nakaya Y, Ono K
    • Organizer
      Internal society for Heart Research
    • Place of Presentation
      Italy
    • Year and Date
      2007-06-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 高運動性モデルラット(SPORTS)の海馬ノルエピネフリン神経伝達亢進が体循環に及ぼす影響2007

    • Author(s)
      森島真幸, 中屋豊, 小野克重
    • Organizer
      第17回日本病態生理学会
    • Place of Presentation
      那覇市
    • Year and Date
      2007-01-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 高い運動習性を持つラット系(SPORTS)の確立と運動習性形成メカニズム2007

    • Author(s)
      中屋 豊
    • Organizer
      運動器科学研究会
    • Place of Presentation
      鳴門市
    • Related Report
      2007 Annual Research Report
  • [Remarks] Dr.Nakaya's Lab

    • URL

      http://square.umin.ac.jp/stress/english/nakaya.html

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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