Is an increase in GLUT4 mRNA in response to exercise training mediated by MEF2?
Project/Area Number |
19300225
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Sports science
|
Research Institution | National Institute of Health and Nutrition |
Principal Investigator |
EZAKI Osamu National Institute of Health and Nutrition, 基礎栄養プログラム, プログラムリーダー (90191923)
|
Co-Investigator(Kenkyū-buntansha) |
三浦 進司 独立行政法人国立健康・栄養研究所, プロジェクトリーダー (10342932)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
|
Keywords | インスリン抵抗性 / GLUT4 / 運動 / 高脂肪食 / トランスジェニックマウス / 筋肉 / 脂肪組織 / 遺伝子 / 生体分子 / 糖尿病 / 発現制御 / バイオテクノロジー |
Research Abstract |
To examine whether MEF2 was involved in an increase in GLUT4 mRNA by exercise training, MEF2 overexpressed transgenic mice in skeletal muscles were produced. MEF2 overexpressed mice did not increase GLUT4 mRNA in skeletal muscles. Transcription co-activators, PGC-1α-b and PGC-1α-c, are increased by exercise training and activate MEF2. However, PGC-1α-b or PGC-1α-c overexpressed mice did not increase GLUT4 mRNA in skeletal muscles. These data suggested that MEF2 was not involved in an increase in GLUT4 mRNA by exercise training.
|
Report
(4 results)
Research Products
(26 results)
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[Journal Article] The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.2010
Author(s)
Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y
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Journal Title
Biochem J. 427
Pages: 171-178
Related Report
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[Journal Article] The cathepsin L gene is a direct target of FOXO1 in the skeleta 1 muscle.2010
Author(s)
Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y.
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Journal Title
Biochem J. 427
Pages: 171-178
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
河盛隆造・岩本安彦編集江崎治
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Journal Title
糖尿病最新の治療2010-2012(南江堂)
Pages: 99-104
Related Report
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[Journal Article] Ubiquitin C-terminal hydrolase-L3-Knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.2009
Author(s)
Setsuie R, Suzuki M, Kabuta T, Fujita H, Miura S, Ichihara N, Yamada D, Wang YL, Ezaki O, Suzuki Y, Wada K
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Journal Title
FASEB J. 23
Pages: 4148-4157
Related Report
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[Journal Article] Ubiquitin C-terminal hydrolase-L3-knockout mice are resistant to diet-induced obesity and show increased activation of AMP-activated protein kinase in skeletal muscle.2009
Author(s)
Setsuie R, Suzuki M, Kabuta T, Fujita H, Miura S, Ichihara N, Yamada D, Wang YL, Ezaki O, Suzuki Y, Wada K.
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Journal Title
FASEB J. 23
Pages: 4148-4157
Related Report
Peer Reviewed
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