Effect of FOS on production of isoflavone metabolite
Project/Area Number |
19300237
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | National Institute of Health and Nutrition |
Principal Investigator |
ISHIMI Yoshiko National Institute of Health and Nutrition, 食品保健機能プログラム, プログラムリーダー (50154159)
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Co-Investigator(Kenkyū-buntansha) |
UEHARA Mariko 東京農業大学, 応用生物学部・栄養科学科, 教授 (20211071)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 生活習慣病 / 骨粗鬆症 / 大豆イソフラボン / 腸内細菌 / 難消化性糖質 / エクオール |
Research Abstract |
In the previous study, we conducted a randomized controlled trial of soybean isoflavones in postmenopausal Japanese women resulting that % change in bone loss in equol producer was significantly lower than that in non-producers in isoflavone treatment group. These results suggest that the enhancement of equol production may efficiently prevent bone loss in estrogen deficient status. In this study, it was appeared that dietary fiber and non-digestible soybean oligosaccharides stimulated equol production and this efficiently led to prevent bone loss in ovariectomized mice. In the intervention study of isoflavones and fructo-oligosaccharide in postmenopausal Japanese women for 2 weeks did not stimulate equol production despite ability to produce equol.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article]2009
Author(s)
Ishimi Y
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Journal Title
Food Factors for Health Promotion, Soybean Isoflavones in Bone Health. Forum Nutr 61(KARGER, Switzerland)
Pages: 104-116
Related Report
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[Journal Article] Comparative activities of daidzein metabolites, equol and O-desmethylangolensin, on bone mineral density and lipid metabolism in ovariectomized mice and in osteoclast cell cultures.2008
Author(s)
Ohtomo T, Uehara M, Penalvo JL, Adlercreutz H, Katsumata S, Suzuki K, Takeda K, Masuyama R, Ishimi Y
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Journal Title
Eur J Nutr. 47
Pages: 273-279
Related Report
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[Journal Article] Effects of soybean isoflavones on bone health and its safety in postmenopausal Japanese women.2008
Author(s)
Ishimi Y, Oka J, Tabata I, Ohtomo T, Ezaki J, Ueno T, Uchiyama S, Toda T, Uehara M, HIguchi M, Yamada K, Wu J
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Journal Title
J Clin Biochem Nutr. 43(suppl)
Pages: 48-52
Related Report
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[Journal Article] Comparative activities of daidzein metabolites, equol and O-desmethylangolensin, on bone mineral density and lipid metabolism in ovariectomized mice and in osteoclast cell cultures2008
Author(s)
Ohtomo T, Uehara M, Penalvo JL, Adlercreutz H, Katsumata S, Suzuki K, Takeda K, Masuyama R, Ishimi Y.
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Journal Title
Eur J Nutr. 47
Pages: 273-279
Related Report
Peer Reviewed
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[Journal Article] Effects of soybean isoflavones on bone health and its safety in postmenopausal Japanese women2008
Author(s)
Ishimi Y, Oka J, Tabata I, Ohtomo T, Ezaki J, Ueno T, Uchiyama S, Toda T, Uehara M, HIguchi M, Yamada K, Wu J
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Journal Title
J Clin Biochem Nutr 43(suppl 1):
Pages: 48-52
Related Report
Peer Reviewed
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