| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
In the previous study, we conducted a randomized controlled trial of soybean isoflavones in postmenopausal Japanese women resulting that % change in bone loss in equol producer was significantly lower than that in non-producers in isoflavone treatment group. These results suggest that the enhancement of equol production may efficiently prevent bone loss in estrogen deficient status. In this study, it was appeared that dietary fiber and non-digestible soybean oligosaccharides stimulated equol production and this efficiently led to prevent bone loss in ovariectomized mice. In the intervention study of isoflavones and fructo-oligosaccharide in postmenopausal Japanese women for 2 weeks did not stimulate equol production despite ability to produce equol.
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