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Involvement of dietary AGEs in the life style-related disease

Research Project

Project/Area Number 19300254
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionHokuriku University

Principal Investigator

TAKEUCHI Masayoshi  Hokuriku University, 薬学部, 教授 (20154982)

Co-Investigator(Kenkyū-buntansha) SATO Takashi  北陸大学, 薬学部, 講師 (30325451)
TAKINO Jun-ichi  北陸大学, 薬学部, 助手 (00440529)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
KeywordsAGEs / Toxic AGEs (TAGE) / 終末糖化産物 / 生活習慣病 / 糖尿病 / メイラード反応 / 清涼飲料水 / 健康食品 / 飲食品 / 飲食料品
Research Abstract

体内や飲食品中では糖質と蛋白質が反応した糖化産物が常に形成されている。本助成研究により、研究代表者が見出した悪玉物質が食後の高血糖によって形成されること、飲食品中には悪玉物質のもとになる単純糖質と糖化産物が多量に含まれること、飲食品中糖化産物が生体内悪玉物質の作用を増強することが明らかになった。
飲食品中の糖化産物や単純糖質の摂取制限と言う概念が、生活習慣病の予防を考える上で、重要な理論の一つになることが示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (98 results)

All 2009 2008 2007 Other

All Journal Article (33 results) (of which Peer Reviewed: 32 results) Presentation (51 results) Book (8 results) Remarks (6 results)

  • [Journal Article] Involvement of toxic AGEs (TAGE) in the pathogenesis of diabetic vascular complications and Alzheimer's disease.2009

    • Author(s)
      Takeuchi M & Yamagishi S
    • Journal Title

      J. Alzheimers Dis. 16

      Pages: 845-858

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of high-AGE beverage on RAGE and VEGF expression in the liver and kidneys.2009

    • Author(s)
      Sato T, Takino J, Takeuchi M et al (3)
    • Journal Title

      Eur. J. Nutr. 48

      Pages: 6-11

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of toxic AGEs (TAGE)in the pathogenesis of diabetic vascular complications and Alzheimer's disease.2009

    • Author(s)
      Masavoshi Takeuchi
    • Journal Title

      J. Alzheimers Dis. 16

      Pages: 1-14

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pigment epithelium-derived factor (PEDF)prevents platelet activation and aggregation in diabetic rats by blocking deleterious effects of advanced glycation end products (AGEs).2009

    • Author(s)
      Sho-ichi Yamagishi
    • Journal Title

      Diabetes Metabolism Res. Rev. 25

      Pages: 266-271

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Independent determinants of soluble form of receptor for advanced glycation end products in elderly hypertensive patients.2009

    • Author(s)
      Kazuo Nakamura
    • Journal Title

      Metabolism 58

      Pages: 421-425

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of high-AGE beverage on RAGE and VEGF expression in the liver and kidneys.2009

    • Author(s)
      Takashi Sato
    • Journal Title

      Eur. J. Nutr. . 48

      Pages: 6-11

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glyceraldehyde-derived advanced glycation end products (AGEs): A novel biomarker of postprandial hyperglycemia in diabetic rats.2008

    • Author(s)
      Kitahara Y, Takeuchi M et al (4)
    • Journal Title

      Clin. Exp. Med. 8

      Pages: 175-177

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of advanced glycation end products (AGEs) in the pathogenesis of Alzheimer's disease.2008

    • Author(s)
      Takeuchi M & Yamagishi S
    • Journal Title

      Curr. Pharm. Des. 14

      Pages: 973-978

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells.2008

    • Author(s)
      Iwamoto K, Kanno K, Takeuchi M et al (4)
    • Journal Title

      J. Gastroenterol. 43

      Pages: 298-304

    • NAID

      10021268317

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating advanced glycation end products (AGEs) and soluble form of receptor for AGEs (sRAGE) are independent determinants of serum monocyte chemoattractant protein-1 (MCP-1) levels in patients with type 2 diabets.2008

    • Author(s)
      Nakamura K, Yamagishi S, Takeuchi M et al (5)
    • Journal Title

      Diabtes Metab. Res. Rev. 24

      Pages: 109-114

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan inhibits advanced glycation end products (AGEs)-elicited endothelial cell injury by suppressing AGE receptor (RAGE) expression via peroxisome proliferators-activated receptor-γ activation.2008

    • Author(s)
      Sho-ichi Yamagishi
    • Journal Title

      Protein Pept. Lett. 15

      Pages: 850-853

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of advanced glycation end products (AGEs)in the pathogenesis of Alzheimer's disease.2008

    • Author(s)
      Masayoshi Takeuchi
    • Journal Title

      Curr. Pharm. Des. 14

      Pages: 973-978

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pigment epithelium-derived factor (PEDF)ameliorates advanced glycation end product (AGE)-induced hepatic insulin resistance in vitro by suppressing Rac-1 activation.2008

    • Author(s)
      Takafumi Yoshida
    • Journal Title

      Horm. Metab. Res. 40

      Pages: 620-625

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glyceraldehyde-derived advanced glycation end products (AGEs) : A novel biomarker of postprandial hyperglycemia in diabetic rats.2008

    • Author(s)
      Yoshiro Kitahara
    • Journal Title

      Clin. Exp. Med. 8

      Pages: 175-177

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes.2008

    • Author(s)
      Kazuo Nakamura
    • Journal Title

      Microvasc. Res. 76

      Pages: 52-56

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells.2008

    • Author(s)
      Keiko Iwamoto
    • Journal Title

      J. Gastroenterol. 43

      Pages: 298-304

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan, an angiotensin II type l receptor blocker, inhibits advanced glycation end-product (AGE)-elicited hepatic insulin resistance via peroxisome proliferator-activated receptor-gamma activation.2008

    • Author(s)
      Takafumi Yoshida
    • Journal Title

      J. Int. Med. Res. 36

      Pages: 237-243

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olmesartan blocks advanced glycation end products (AGEs)-induced angiogenesis in vitro by suppressing receptor for AGEs(RAGE)expression.2008

    • Author(s)
      Sho-ichi Yamagishi
    • Journal Title

      Microvasc. Res. 75

      Pages: 130-134

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating advanced glycation end products (AGEs)and soluble form of receptor for AGEs (sRAGE)are independent determinants of serum monocyte chemoattractant protein-l(MCP-l)levels in patients with type 2 diabets.2008

    • Author(s)
      Kazuo Nakamura
    • Journal Title

      Diabtes Metab. Res. Rev. 24

      Pages: 109-114

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食事性AGEsと未病2008

    • Author(s)
      竹内正義
    • Journal Title

      未病と抗老化 17

      Pages: 32-39

    • NAID

      40016029932

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Diagnostic utility of serum or cerebrospinal fluid levels of toxic advanced glycation end-products (TAGE) in early detection of Alzheimer's disease.2007

    • Author(s)
      Takeuchi M, Sato T, Takino J et al (4)
    • Journal Title

      Med. Hypotheses 69

      Pages: 1358-1366

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are correlated with AGEs in both diabetic and non-diabetic subjects.2007

    • Author(s)
      Nakamura k, Yamagishi S, Takeuchi M et al (3)
    • Journal Title

      Clin. Exp. Med. 7

      Pages: 188-190

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum level of advanced glycation end-products (AGEs) is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population.2007

    • Author(s)
      Yamagishi S, Adachi H, Takeuchi M et al (5)
    • Journal Title

      Horm. Metab. Res. 39

      Pages: 845-848

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells.2007

    • Author(s)
      Yamamoto Y, Yonekura H, Takeuchi M (8)
    • Journal Title

      Diabetes Res. Clin. Pract. 77 Suppl 1

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation.2007

    • Author(s)
      Yokoi M,
    • Journal Title

      Br. J. Ophthalmol. 91

      Pages: 397-398

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes2007

    • Author(s)
      Unoki H
    • Journal Title

      Diabetes Res. Clin, Pract. 76

      Pages: 236-244

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of AST-120(Kremezine)is a promising therapeutic strategy for advanced glycation end product(AGE)-related disorders2007

    • Author(s)
      Yamagishi S
    • Journal Title

      Med. Hypotheses 69

      Pages: 666-668

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated levels of serum advanced glycation end-products in patients with nonalcoholic steatohepatitis2007

    • Author(s)
      Hyogo H
    • Journal Title

      J. Gastroenterol. Hepatol. 22

      Pages: 1112-1119

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells2007

    • Author(s)
      Yamamoto Y
    • Journal Title

      Diabetes Res Clin Pract 77Suppl1

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical demonstration of advanced glycation end products and the effects of advanced glycation end products in ossified ligament tissues in vitro.2007

    • Author(s)
      Yokosuka K
    • Journal Title

      Spine 32:E337-E339. 32

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum level of advanced glycation end-products(AGEs)is an independent determinant of plasminogen activator inhibitor-1(PAI-1)in nondiabetic general population.2007

    • Author(s)
      Yamagishi S
    • Journal Title

      Horm. Metab. Res.39:845-848(2007) 39

      Pages: 845-848

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating advanced glycation end products(AGEs)and soluble form of receptor for AGEs(sRAGE)are independent determinants of serum monocyte chemoattractant protein-1(MCP-1)levels in patients with type2 diabets2007

    • Author(s)
      Nakamura K
    • Journal Title

      Diabtes Metab. Res. Rev. 24

      Pages: 109-114

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of soluble form of receptor for advanced glycation end products(sRAGE)are correlated with AGEs in both diabetic and non-diabetic subjects2007

    • Author(s)
      Nakamura k
    • Journal Title

      Clin. Exp. Med. 7

      Pages: 188-190

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生体内毒性AGEs(TAGE)形成と食事性AGEs のクロストークから食事指導を考える2009

    • Author(s)
      竹内正義
    • Organizer
      第54 回日本透析医学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Toxic AGEs(TAGE)の細胞障害性は食後高血糖と食事性AGEs によってコントロールされる2009

    • Author(s)
      竹内正義
    • Organizer
      第52 回日本糖尿病学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 内因性及び外因性AGEs からみた生活習慣病発症・進展予防の新たな考え方2009

    • Author(s)
      竹内正義
    • Organizer
      日本薬学会第129 年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 飲料中AGEs 及び糖含有量から生活習慣病の発症・進展予防を考える2009

    • Author(s)
      白井ひかり
    • Organizer
      日本薬学会第129 年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 生活習慣病の発症・進展に及ぼす食品中AGEs 含有量の比較検討2009

    • Author(s)
      河上美穂子
    • Organizer
      日本薬学会第129 年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞内グリセルアルデヒド由来AGEs の肝細胞毒性2009

    • Author(s)
      瀧野純一
    • Organizer
      日本薬学会第129 年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 内因性及び外因性AGEsからみた生活習慣病発症・進展予防の新たな考え方2009

    • Author(s)
      竹内正義
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病における終末糖化産物(AGEs)の関与とその阻止2009

    • Author(s)
      白井ひかり
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病の発症・進展に及ぼす食品中AGEs含有量の比較検討2009

    • Author(s)
      河上美穂子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞内グリセルアルデヒド由来AGEsの肝細胞毒性2009

    • Author(s)
      瀧野純一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Accumulation of advanced glycation end-products (AGEs) are associated with poor putcomes in follicular and embryonic development and achievement of pregnancy by IVF/ICSI : Possible novel therapy for poor responders by decreasing AGEs2008

    • Author(s)
      Masao Jinno
    • Organizer
      The American Society for Reproductive Medicine 64th Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of endogeneous aldehyde-derived advanced glycation end products on the development of Alzheimer's disease.2008

    • Author(s)
      Michiru Muramatsu
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 培養肝細胞におけるグリセルアルデヒド由来AGEsの細胞内形成と細胞毒性2008

    • Author(s)
      瀧野純一
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病における外因性AGEs の関与と吸着除去剤の有用性2008

    • Author(s)
      竹内正義
    • Organizer
      第20 回日本糖尿病性腎症研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 生活習慣病における外因性AGEsの関与と吸着除去剤の有用性2008

    • Author(s)
      竹内正義
    • Organizer
      第20回日本糖尿病性腎症研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 内因性グリセルアルデヒド由来AGEsのアルツハイマー病への関与2008

    • Author(s)
      村松充
    • Organizer
      日本薬学会北陸支部第119回例会
    • Place of Presentation
      金沢
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病におけるAGEsの関与と各種飲料中AGEs含有量の比較検討2008

    • Author(s)
      白井ひかり
    • Organizer
      日本薬学会北陸支部第119回例会
    • Place of Presentation
      金沢
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病における終末糖化産物(AGEs)の関与とその阻止2008

    • Author(s)
      竹内正義
    • Organizer
      第34回関東Lipid Artery研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] ART反復不成功例に対する低量metformin併用排卵誘発 : Insulin抵抗性症候群としての解釈と新治療法に繋がる終末糖化産物(AGEs)の重要性2008

    • Author(s)
      神野正雄
    • Organizer
      第53回日本生殖医学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病の発症・進展における飲食品中AGEs の関与とクレメジンによるAGEs 除去効果2008

    • Author(s)
      竹内正義
    • Organizer
      第23 回日本糖尿病合併症学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 生活習慣病の発症・進展における飲食晶中AGEsの関与とクレメジンによるAGEs除去効果2008

    • Author(s)
      竹内正義
    • Organizer
      第23回日本糖尿病合併症学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] TAGE (toxic AGEs)病因説における飲食品中AGEsの関与とクレメジンによるAGEs除去効果の検討2008

    • Author(s)
      竹内正義
    • Organizer
      第27回腎と骨代謝研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Involvement of endogenous advanced glycation end-products in the development of Alzheimer's disease.2008

    • Author(s)
      Michiru Muramatsu
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Glyceraldehyde-derived advanced glycation end products (AGEs) : A novel biomarker of postprandial hyperglvcemia in diabetic rats.2008

    • Author(s)
      Yuko Jinnouchi
    • Organizer
      44th Annual Meeting of the European Association for the Study of Diabetes
    • Place of Presentation
      Roma
    • Year and Date
      2008-09-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] AApoAIIとAAアミロイドタンパク質の糖化最終産物AGEsによる修飾2008

    • Author(s)
      長谷川寛
    • Organizer
      第23回老化促進モデルマウス(SAM)研究協議会
    • Place of Presentation
      京都
    • Year and Date
      2008-07-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高AGEs 含有飲食品は透析患者の病態に影響を及ぼすか?2008

    • Author(s)
      竹内正義
    • Organizer
      第53 回日本透析医学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-06-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 高AGEs含有飲食品は透析患者の病態に影響を及ぼすか?2008

    • Author(s)
      竹内正義
    • Organizer
      第53回日本透析医学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-06-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高AGEs 含有飲食品は腎不全患者の病態に影響を及ぼすか?2008

    • Author(s)
      竹内正義
    • Organizer
      第51 回日本腎臓学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-31
    • Related Report
      2008 Final Research Report
  • [Presentation] 高AGEs含有飲食品は腎不全患者の病態に影響を及ぼすか?2008

    • Author(s)
      竹内正義
    • Organizer
      第51回日本腎臓学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 飲食料品中に含まれているAGEs は生活習慣病の発症・進展に関連している2008

    • Author(s)
      竹内正義
    • Organizer
      第51 回日本糖尿病学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Final Research Report
  • [Presentation] 飲食料品中に含まれているAGEsは生活習慣病の発症・進展に関連している2008

    • Author(s)
      竹内正義
    • Organizer
      第51回日本糖尿病学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 可溶型AGEs受容体(sRAGE)は、血中TNF-aレベルと相関する2008

    • Author(s)
      中村和生
    • Organizer
      第51回日本糖尿病学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] PEDF(色素上皮由来因子)はAGEs由来の酸化ストレスの産生を抑制し、初期糖尿病網膜症の発症を阻止する2008

    • Author(s)
      松井孝憲
    • Organizer
      第51回日本糖尿病学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 飲食品中に含まれるAGEsは生活習慣病の発症・進展に関連している2008

    • Author(s)
      竹内正義
    • Organizer
      第62回日本栄養・食糧学会大会
    • Place of Presentation
      埼玉
    • Year and Date
      2008-05-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病予防における外因性AGEs 吸着素材の探索2008

    • Author(s)
      古野理美
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 飲食料品中AGEs は生活習慣病の発症・進展にどの程度関連しているか?2008

    • Author(s)
      竹内正義
    • Organizer
      日本薬学会第128 年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)におけるTAGE(toxic AGEs)の寄与2008

    • Author(s)
      小林由佳
    • Organizer
      日本薬学会第128年会、横浜(2008.3)
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生活習慣病予防における外因性AGEs吸着素材の探索2008

    • Author(s)
      古野理美
    • Organizer
      日本薬学会第128年会、横浜(2008.3)
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 飲食料品中AGEsは生活習慣病の発症・進展にどの程度関連しているか?2008

    • Author(s)
      竹内正義
    • Organizer
      日本薬学会第128年会、横浜(2008.3)
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 食品由来advanced glycation end-products (AGEs):生活習慣病における新たな治療戦略2007

    • Author(s)
      竹内正義
    • Organizer
      第17 回日本メイラード学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2007-11-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 生体において消化・吸収された食品系AGEsの定量法の検討2007

    • Author(s)
      山口敬子
    • Organizer
      第17回日本メイラード学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 食品由来advanced glycation end-products(AGEs):生活習慣病における新たな治療戦略2007

    • Author(s)
      竹内正義
    • Organizer
      第17回日本メイラード学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生活習慣病における終末糖化産物(AGEs)の関与とその阻止2007

    • Author(s)
      竹内正義
    • Organizer
      生体機能と創薬シンポジウム2007 金沢
    • Place of Presentation
      金沢
    • Year and Date
      2007-09-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 生活習慣病における終末糖化産物(AGEs)の関与とその阻止2007

    • Author(s)
      竹内正義
    • Organizer
      生体機能と創薬シンポジウム2007金沢
    • Place of Presentation
      金沢
    • Year and Date
      2007-09-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] AGEs高含有飲料摂取による生活習慣病関連遺伝子発現への影響2007

    • Author(s)
      佐藤隆
    • Organizer
      日本薬学会北陸支部第116回例会、金沢
    • Place of Presentation
      金沢
    • Year and Date
      2007-07-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] TAGE(toxic AGEs)病因説における外因性AGEsの寄与とクレメジン投与による外因性AGEsの除去効果2007

    • Author(s)
      竹内正義
    • Organizer
      第52回日本透析医学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神経細胞内TAGE(toxic AGEs)形成と細胞毒性メカニズム2007

    • Author(s)
      佐藤隆
    • Organizer
      日本生化学会北陸支部第25回大会
    • Place of Presentation
      金沢
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 悪性腫瘍の転移・浸潤におけるTAGE(toxic AGEs)-RAGE(receptor for AGEs)シグナルの寄与2007

    • Author(s)
      瀧野純一
    • Organizer
      日本生化学会北陸支部第25回大会
    • Place of Presentation
      金沢
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 食品の加工・調理により生成されたアマドリ転位生成物の定量2007

    • Author(s)
      山口敬子
    • Organizer
      第61回日本栄養・食糧学会大会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生活習慣病におけるTAGE(toxic AGEs)病因説と外因性AGEsの寄与2007

    • Author(s)
      竹内正義
    • Organizer
      第50回日本糖尿病学会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生活習慣病予防におけるTAGE(toxic AGEs)病因説と飲食品由来AGEsの寄与2007

    • Author(s)
      竹内主義
    • Organizer
      第61回日本栄養・食糧学会大会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Book] 食事性AGEs と未病.未病と抗老化2008

    • Author(s)
      竹内正義ほか(4)
    • Related Report
      2008 Final Research Report
  • [Book] 食事性AGEsと未病2008

    • Author(s)
      竹内正義
    • Total Pages
      6
    • Publisher
      (財)博慈会 老人病研究所
    • Related Report
      2007 Annual Research Report
  • [Book] AGEs(終末糖化産物)にはどんなものがあるか -毒性終末糖化産物仮説. 生体の科学2007

    • Author(s)
      竹内正義、瀧野純一、佐藤隆ほか (3)
    • Related Report
      2008 Final Research Report
  • [Book] 生活習慣病における終末糖化産物(AGEs)の関与とその阻止. YAKUGAKU ZASSHI 127 Suppl.2007

    • Author(s)
      竹内正義、佐藤隆、山岸昌一
    • Related Report
      2008 Final Research Report
  • [Book] 生体の科学:特集「グリケーション(糖化)」:AGEs(終末糖化産物)にはどんなものがあるか-毒性終末糖化産物仮説2007

    • Author(s)
      竹内正義
    • Total Pages
      11
    • Publisher
      (財)金原一郎記念医学医療振興財団/医学書院
    • Related Report
      2007 Annual Research Report
  • [Book] 生体の科学:特集「グリケーション(糖化)」:血栓形成とAGEs2007

    • Author(s)
      山岸昌一
    • Total Pages
      4
    • Publisher
      (財)金原一郎記念医学医療振興財団/医学書院
    • Related Report
      2007 Annual Research Report
  • [Book] YAKUGAKU ZASSHI:生活習慣病における終末糖化産物(AGEs)の関与とその阻止2007

    • Author(s)
      竹内正義
    • Total Pages
      4
    • Publisher
      (社)日本薬学会
    • Related Report
      2007 Annual Research Report
  • [Book] 血管医学:糖尿病血管合併症における終末糖化産物(AGEs)の関与とその阻止-AGEsを標的としたクレメジンの新規血管障害保護作用-2007

    • Author(s)
      山岸昌一
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2007 Annual Research Report
  • [Remarks] 2009 年1月22日、北国新聞及び富山新聞朝刊北国健康生きがい支援事業「長寿県いしかわを目指して」~21世紀の健康と医療~第3回フォーラムに関する特集記事

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008年12月21日、北国新聞朝刊北国健康生きがい支援事業「長寿県いしかわを目指して」~21世紀の健康と医療~パネルディスカッション(金沢市文化ホール)に関する記事

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008年11月26日、北国新聞及び富山新聞朝刊北国健康生きがい支援事業「長寿県いしかわを目指して」~21世紀の健康と医療~"食の常識に潜むワナ~知らないと怖い!身近にある飲食物~"第1回フォーラムに関する特集記事

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008年11月13日、東北大学GCOE 特別セミナー(ニュートリノセンター)"生活習慣病における終末糖化産物(AGEs)の関与とその予防"

    • URL

      http://www.scienceweb.tohoku.ac.jp/html/003/004/004_081104.html

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008年11月2日、北國新聞朝刊市民講演会(金沢市文化ホール):北国健康生きがい支援事業「長寿県いしかわを目指して」~21世紀の健康と医療~"食の常識に潜むワナ~知らないと怖い!身近にある飲食物~"に関する記事

    • URL

      http://www.kenko-ikigai.com/college09/hokudai20081101.html

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008年6月13日、北国新聞及び富山新聞朝刊(特集もの忘れクリニック~丈夫がいいね):「食後の高血糖にご注意」に関する特集記事

    • URL

      http://www.scienceweb.tohoku.ac.jp/html/003/004/004_081104/004_081104.pdf

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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