| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Research Abstract |
We examined the mechanism of human cellular response against ionizing irradiation. For this purpose, we analyzed the structure and dynamics of the radiation-induced nuclear foci and reorganization of damaged chromatin. We found that DNA damage-induced release of histone H2AX, a variant of histone H2A, from damaged chromatin is required for the DNA damage-induced focus formation of RAD51. The release of H2AX from damaged chromatin is regulated by acetylation and ubiquitination of H2AX by TIP60 and UBC13, respectively, We also found that histone H2AZ, another H2A variant, is released from chromatin after induction of DNA damage.
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