Distribution, behavior, and biological effects of pharmaceuticals and antibiotics in coastal marine environments

• Project/Area Number: 19310039
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: TAKADA Hideshige Tokyo University of Agriculture and Technology, 大学院・農学研究院, 教授 (70187970)
• Co-Investigator(Kenkyū-buntansha): 新井 崇臣 東京大学, 海洋研究所, 准教授 (70323631) ; 大地 まどか 東京農工大学, 大学院・共生科学技術研究院, 准教授 (40447511)
• Co-Investigator(Renkei-kenkyūsha): OHJI Madoka 東京農工大学, 大学院・農学研究院, 准教授 (40447511)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000); Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: 河口域 / 雨天時越流下水 / トリクロサン / メチルトリクロサン / トリクロカルバン / 堆積物 / 歴史変遷 / サルファメトキサゾール / 殺菌剤 / 雨天時越流 / 柱状堆積物 / 微量化学物質汚染評価 / 沿岸域 / 抗生物質 / 医薬品 / サルファ剤 / マクロライド / 保存的挙動 / 熱帯アジア水域 / メコンデルタ / マレーシア

Research Abstract

Behaviors of pharmaceuticals and antibiotics were studied in Tokyo Bay. Sulfonamides and macrolides showed conservative behaviors in an estuary. They were transported toward mouth of Tokyo Bay for a long distance with half distance of ～40km and some of them reached to the open ocean. Pharmaceuticals were supplied to coastal environments via combined sewer overflow. Hydrophobic pharmaceuticals such as triclosan and triclocarban were accumulated in bottom sediments of Tokyo Bay. Similar degree of contamination by the pharmaceuticals and antibiotics were demonstrated also in tropical Asian waters.

Research Products

• [Journal Article] Source analysis of perfluorocarboxylates in Tokyo Bay during dry weather and wet weather using sewage markers. (2011)
  • Author(s): Michio Murakami, Chiaki Morita, Takuya Morimoto, Hideshige Takada
  • Journal Title: Environmental Chemistry Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Evaluation of pharmaceuticals and personal care products (PPCPs) as water-soluble molecular markers of sewage. (2008)
  • Author(s): N.Nakada, H.Takada, 他5名
  • Journal Title: Environmental Science & Technology 42 Pages: 6347-6353
• [Journal Article] Evaluation of pharmaceuticals and personal care products (PPCPs) as water-soluble molecular markers of sewage (2008)
  • Author(s): N. Nakada, H. Takada (7番目), 他5名
  • Journal Title: Environmental Science & Technology 42 Pages: 6347-6353
• [Journal Article] Evaluation of Pharmaceuticals and personal care products (PPCPs)aswater-soluble molecular markers of sewage. (2008)
  • Author(s): Nakada, Norihide, Kiri, Kentaro, Shinohara, Hiroyuki, Harada, Arata, Kuroda, Keisuke, Takizawa, Satoshi, Takada, Hideshige
  • Journal Title: Environmental Science & Technology 42
  • Peer Reviewed
• [Journal Article] Distribution of macrolides, sulfonamides and trimethoprim in tropical waters : ubiquitous occurrence of veterinary antibiotics in the Mekong Delta. (2007)
  • Author(s): S.Managaki, H.Takada, 他3人
  • Journal Title: Environmental Science & Technology 41 Pages: 8004-8010
• [Journal Article] Distribution of macrolides, sulfonamides and trimethoprim in tropical waters : ubiquitous occurrence of veterinary antibiotics in the Mekong Delta (2007)
  • Author(s): S. Managaki, H. Takada (3番目), 他3人
  • Journal Title: Environmental Science & Technology 41 Pages: 8004-8010
• [Journal Article] Distribution of macrolides, sulfonamides and trimethoprim in tropical waters: ubiquitous occurrence of veterinary antibiotics in the Mekong Delta (2007)
  • Author(s): Satoshi Managaki
  • Journal Title: Environmental Science & Technology 41 Pages: 8004-8010
  • Peer Reviewed
• [Journal Article] Source analysis of perfluorocarboxylates in Tokyo Bay during dry weather and wet weather using sewage markers.
  • Author(s): M.Murakami, C.Morita, T.Morimoto, H.Takada
  • Journal Title: Environmental Chemistry in press.
• [Journal Article] 高田秀重流入下水および下水処理水中の水溶性微量有機汚染物質および人為起源マーカーの濃度
  • Author(s): 森本拓也、村松佑紀、竹下綾子、清水亜希子、村上道夫
  • Journal Title: 用水と廃水 印刷中
• [Presentation] 雨天時越流下水に由来するPPCPsの沿岸堆積物への蓄積 (2010)
  • Author(s): 森本拓也, 村松佑紀, 福本由美, 高田秀重
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 中部大学
  • Year and Date: 2010-06-21
• [Presentation] 沿岸域への抗生物質の汚染の広がり (2009)
  • Author(s): 竹下綾子・高田秀重
  • Organizer: 第18回環境化学討論会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2009-06-10
• [Presentation] 熱帯アジア水域における医薬品の汚染実態と毒性評価 (2009)
  • Author(s): 村松佑紀・高田秀重
  • Organizer: 第18回環境化学討論会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2009-06-10
• [Presentation] 雨天時越流に由来する医薬品の東京湾への負荷 (2008)
  • Author(s): 福本由美, 竹下綾子, 真名垣聡, 高田秀重
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-06-11
• [Presentation] 雨天時越流に由来する抗生物質の東京湾への負荷 (2008)
  • Author(s): 竹下綾子, 福本由美, 高田秀重, 真名垣聡
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-06-11
• [Presentation] 熱帯アジア諸国における抗生物質の汚染実態 (2008)
  • Author(s): 中田典秀、村松佑紀、村田綾子、高田秀重
  • Organizer: 第42回日本水環境学会年会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2008-03-20
• [Remarks] ホームページ等