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Research oftargetproteinfor endocrine-disruptingchemicals such as bisphenol A during development of the central nervous system

Research Project

Project/Area Number 19310041
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionKwansei Gakuin University

Principal Investigator

IMAOKA Susumu  Kwansei Gakuin University, 理工学部, 教授 (60145795)

Co-Investigator(Kenkyū-buntansha) OKADA Kazushi  関西学院大学, 理工学研究科, 博士研究員 (40423892)
KINOSHITA Tsutomu  立教大学, 理学部, 教授 (30161532)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2007: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords内分泌かく乱化学物質 / プロテインジスルヒドイソメラーゼ(PDI) / アフリカツメガエル腔 / ビスフェノールA / Notch signal / γ-セクレターゼ / プロテインジスルヒドイソメラーゼ / アフリカツメガエル胚 / 水酸化PCB / プロティンジスルヒドイソメラーゼ
Research Abstract

ビスフェノールA(BpA)やノニルフェノールは、プラスチック製品の添加剤などとして使用され、河川の水や食物の容器などで検出されている。最近これらの化合物が中枢神経系の発達に影響を及ぼしている可能性が示唆された。本研究ではこれらの化合物が、アルツハイマー病などの脳の病気や発生過程において中枢神経形成に関わるNotchシグナル系で働いているγ-セクレターゼに直接作用していることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (84 results)

All 2009 2008 2007

All Journal Article (27 results) (of which Peer Reviewed: 23 results) Presentation (52 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis2009

    • Author(s)
      Baba, K., Okada, K., Kinoshita, T., Imaoka, S.
    • Journal Title

      Toxicol. Sci. 108

      Pages: 344-355

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anovel electron transport system for thermostable CYP175Al from Thermus thermophilus HB22009

    • Author(s)
      Mandai, T., Fujiwara, S., Imaoka, S.
    • Journal Title

      FEBS J. 276

      Pages: 2416-2429

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxylated polychlorinated biphenyls (PCBs) interacts with protein disulfide isomerase and inhibits its activity2009

    • Author(s)
      Okada, K., Hashimoto, S., Funae, Y., Imaoka, S.
    • Journal Title

      Chem Res. Toxicol. 22

      Pages: 899-904

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction and engineering of thermostable self-sufficient cytochrome P4502009

    • Author(s)
      Mandai, T., Fujiwara.S., Imaoka, S.
    • Journal Title

      Biochem. Biophys. Res. Commun. 384

      Pages: 61-65

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel electron transport system for thermostable CYP175A1 from Thermus thermophilus HB27.2009

    • Author(s)
      Mandai T.
    • Journal Title

      FEBS J. 276

      Pages: 2416-2429

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis.2009

    • Author(s)
      Baba K.
    • Journal Title

      Toxicol. Sci. 108

      Pages: 344-355

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxylated polychlorinated biphenyls (PCBs) interact with protein disulfide isomerase and inhibits its activity.2009

    • Author(s)
      Okada K.
    • Journal Title

      Chem. Res. Toxicol. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction and engineering of a thermostable self-sufficient cytochrome P450.2009

    • Author(s)
      Mandai T.
    • Journal Title

      Biochem. Biophys. Res. Commun. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of CYP3A aggravates endotoxin-induced liver injury in hypophysectomized female rats2008

    • Author(s)
      Takemura, S., Minamiyama, Y., Toyokuni, S., Imaoka, S., Hai, S., Kubo, S., Hirohashi, K., Funae, Y., Okada, S.
    • Journal Title

      Hepatol Res. 38

      Pages: 70-78

    • NAID

      10020117058

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] VEGF-enhanced proliferation under hypoxia by an autocrine mechanism in human vascular smooth muscle cells2008

    • Author(s)
      Osada-Oka, M., Ikeda, T., Imaoka, S., Akiba, S., Sato, T.
    • Journal Title

      J. Atheroscler. Thromb. 15

      Pages: 26-33

    • NAID

      10022607720

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of psychotropic drugs on the 21-hydroxylation of neurosteroids, progesterone and allopregnanolone, catalyzed by rat CYP2D4 and human CYP2D6 in the brain2008

    • Author(s)
      Niwa, T., Okada, K., Hiroi, T., Imaoka, S., Nanmatsu, S., Funae, Y.
    • Journal Title

      Biol. Pharm. Bull. 31

      Pages: 348-351

    • NAID

      110006623054

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MafG controls hypoxic response of cells by accumulating HIF-1alpha in the nuclei2008

    • Author(s)
      Ueda, K., Xu, J., Morimoto, H., Kawabe, A., Imaoka, S.
    • Journal Title

      FEBS Lett 582

      Pages: 2357-2364

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between bisphenol derivatives and protein disulfide isomerase (PDI) and inhibition of PDI functions : Requirement of chemical structure for binding to PDI2008

    • Author(s)
      Hashimoto, S., Okada, K., Imaoka, S.
    • Journal Title

      J. Biochem. 144

      Pages: 335-342

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epoxyeicosa-trienoic acids and/or their metabolites promote hypoxic response of cells2008

    • Author(s)
      Suzuki, S., Oguro, A., Osada-Oka, M., Funae, Y., Imaoka, S.
    • Journal Title

      J. Pharmacol. Sci. 108

      Pages: 79-88

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MafG controls hypoxic response of cells by accumulating HIF-lalpha in the nuclei.2008

    • Author(s)
      Ueda K.
    • Journal Title

      FEBS Lett. 582

      Pages: 2357-2364

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells.2008

    • Author(s)
      Suzuki s.
    • Journal Title

      J. Pharmacol. Sci. 108

      Pages: 79-88

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between bisphenol derivatives and protein disulfide isomerase (PDI) and inhibition of PDI functions.2008

    • Author(s)
      Hashimoto s.
    • Journal Title

      J. Biochem. 144

      Pages: 335-342

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 is responsible for nitric oxide generation from NO-Aspirin and other organic nitrates2007

    • Author(s)
      Minamiyama, Y., Takemura, S., Imaoka, S., Funae,Y., Okada, S.
    • Journal Title

      Drug Metab. Pharmacokinet. 22

      Pages: 15-19

    • NAID

      10018732868

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Over-expression of protein disulfide isomerase reduces the release of growth hormone induced by bisphenol A and/or T(3)2007

    • Author(s)
      Okada, K., Imaoka, S., Hashimoto, S., Hiroi, T., Funae, Y.
    • Journal Title

      Mol. Cell Endocrinol 278

      Pages: 44-51

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects ofligands for Ah receptor on hypoxic response of cells2007

    • Author(s)
      Sawada, T,, Kubo, T., Osada-Oka, M., Imaoka, S.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 1916-1919

    • Related Report
      2008 Final Research Report
  • [Journal Article] Differential response to aryl hydrocarbon receptor ligands in cell types2007

    • Author(s)
      Okada, K,, Sawada, T., Imaoka, S.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 1866-1869

    • Related Report
      2008 Final Research Report
  • [Journal Article] Synthesis of fluorescent and photoaffinity-labeled derivatives ofbisphenol A and their inhibitory activity toward hypoxic expression of erythropoietin2007

    • Author(s)
      Maezawa, N., Tsuchikawa, H., Katsumura, S., Kubo, T., Imaoka, S.
    • Journal Title

      Bioorg. Med. Chem. Lett. 17

      Pages: 5121-1524

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of Xenopus HIF-prolyl 4-hydroxylase and rescue of a small-eye phenotype caused by Siah2 Over-expression2007

    • Author(s)
      Imaoka S.
    • Journal Title

      Biochemical and Biophysical Research Communications 355(2)

      Pages: 419-425

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Over-expression ofprotein disulfide isomerase reduces the release of growth hormone induced by bisphenol A and/or T.2007

    • Author(s)
      Okada K.
    • Journal Title

      Molccular and Cellular Endocrinology 278(1-2)

      Pages: 44-51

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of fluorescent and photoaffinity-labeled derivatives of bisphenol A and their inhibitory activity toward hypoxic expression of erythropoietin2007

    • Author(s)
      Maezawa N.
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters 17(18)

      Pages: 5121-5124

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential response to arylhydrocarbon receptor ligands in cell types2007

    • Author(s)
      Okada K.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 1866-1869

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Effects of ligands for AHreceptor on hypoxic response of cells2007

    • Author(s)
      Sawada T.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 1916-1919

    • Related Report
      2007 Annual Research Report
  • [Presentation] 眼の発生過程における低酸素応答系因子の生理機能の解明2008

    • Author(s)
      佐藤夢子, 村口太一, 馬場一信, 木下勉, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞の酸素濃度応答におけるMafGを介したNrf2とHIF-1alphaの役割について2008

    • Author(s)
      森本陽香, 上田耕次, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] protein disulfide isomeraseの発生過程における生理機能解析2008

    • Author(s)
      津田貴子, 山崎絢子, 木下勉, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] アフリカツメガエルの中胚葉形成におけるNotchシグナルの役割に関する研究2008

    • Author(s)
      春田有紀, 坂本千春, 今岡進, 木下勉
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Notchシグナル阻害による発生異常の解析2008

    • Author(s)
      馬場一信, 木下勉, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 酸化ストレス応答因子Nrf2パートナーMafGによる低酸素応答制御2008

    • Author(s)
      上田耕次, 森本陽香, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 眼の発生過程における低酸素応答系因子の生理機能の解明2008

    • Author(s)
      佐藤夢子
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞の酸素濃度応答におけるMafGを介しかNrf2とHIF-lalphaの役割について2008

    • Author(s)
      森本陽香
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] protein disulfide isomeraseの発生過程における生理機能解析2008

    • Author(s)
      澤田貴子
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] アフリカツメガェルの中胚葉形成におけるNotchシグナルの役割に関する研究2008

    • Author(s)
      春田有紀
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Notchシグナル阻害による発生異常の解析2008

    • Author(s)
      馬場一信
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酸化ストレス応答因子Nrf2パートナーMafGによる低酸素応答制御2008

    • Author(s)
      上田耕次
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低酸素応答におけるSmall Mafの機能解析2008

    • Author(s)
      川辺淳美, 上田耕次, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 低酸素応答に影響を及ぼす外来因子とそのメカニズムの解明2008

    • Author(s)
      園淵了慈, 上田耕次, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] AhR及びHIF-1alphaとNF-kappaBの相互作用とその生理的意義2008

    • Author(s)
      小紫亮, 原理恵, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] EETとその代謝酵素sEHの低酸素応答における生理機能について2008

    • Author(s)
      大黒亜美, 鈴木佐知子, 坂元弘一, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] AhR及びHIF-lalphaとNF-kappaBの相互作用とその生理的意義2008

    • Author(s)
      小紫亮
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低酸素応答に影響を及ぼす外来因子とそのメカニズムの解明2008

    • Author(s)
      園淵了慈
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低酸素応答におけるSmall Mafの機能解析2008

    • Author(s)
      川辺淳美
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Thermus thermophilus HB27由来CYP175A1の新規電子伝達系因子の同定とその酵素学的解析2008

    • Author(s)
      萬代敬生, 藤原伸介, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Final Research Report
  • [Presentation] protein disulfide isomerase (PDI)のビスフェノールA及びT3結合ドメインの同定と生理機能解析2008

    • Author(s)
      橋本翔子, 岡田和嗣, 今岡進
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Final Research Report
  • [Presentation] EETとその代謝酵素sEHの低酸素応答における生理機能について2008

    • Author(s)
      大黒亜美
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Thermus thermophilus HB27由来CYP175A1の新規電子伝達系因子の同定とその酵素学的解析2008

    • Author(s)
      萬代敬生
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Protein disulfide isomerase (PDT)のビスフェノールA及びT3結合ドメインの同定と生理機能解析2008

    • Author(s)
      橋本翔子
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] プロテインジスルフイドイソメラーゼ (PDI)ヘビスフェノールA類縁体結合能と酵素活性について2008

    • Author(s)
      橋本翔子, 岡田和嗣, 今岡進
    • Organizer
      第35回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 低酸素ストレス応答に影響を及ぼす外来因子とそのメカニズムの解明2008

    • Author(s)
      園淵了慈, 上田耕次, 今岡進
    • Organizer
      第35回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Final Research Report
  • [Presentation] PDIとカルレティキュリンの相互作用に及ぼすビスフェノールAの影響2008

    • Author(s)
      岡田和嗣, 幸田秀紀, 今岡進
    • Organizer
      第35回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] フェノール性環境化学物質による発生異常のメカニズム解析2008

    • Author(s)
      馬場一信, 岡田和嗣, 今岡進
    • Organizer
      第35回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] プロテインジスルフィドイソメラーゼ(PDI)へのビスフェノールA類縁体結合能と酵素活性について2008

    • Author(s)
      橋本翔子
    • Organizer
      第35回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Modulation of hypoxic response of HUAEC by EETs and DHETs2008

    • Author(s)
      Sachiko S, Oguro A, Imaoka S
    • Organizer
      5th International EDHF Symposium Endothelium, Vasoactive Factors and Inflammation
    • Place of Presentation
      Tampere, Finland
    • Year and Date
      2008-06-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Characterization of EET-metabolic enzyme, soluble epoxide hydrolase2008

    • Author(s)
      Oguro A, Suzuki S, Imaoka S
    • Organizer
      5th International EDHF Symposium Endothelium, Vasoactive Factors and Inflammation
    • Place of Presentation
      Tampere, Finland
    • Year and Date
      2008-06-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Biological roles of small Maf protein in oxidative stress and hypoxia response of the cells2008

    • Author(s)
      Morimoto H, Ueda K, Imaoka S
    • Organizer
      5th International EDHF Symposium Endothelium, Vasoactive Factors and Inflammation
    • Place of Presentation
      Tampere, Finland
    • Year and Date
      2008-06-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Modulation of hypoxic response of HUAEC by EETs and DHETs2008

    • Author(s)
      Sachiko S.
    • Organizer
      5th International EDHF Symposium
    • Place of Presentation
      Tampere (Finland)
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characterization of EET-metabolic enzyme, soluble epoxide hydrolase2008

    • Author(s)
      Oguro A.
    • Organizer
      5th International EDHF Symposium
    • Place of Presentation
      Tampere (Finland)
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Biological roles of small Maf protein in oxidative stressand hypoxia response of the cells2008

    • Author(s)
      Morimoto H.
    • Organizer
      5th International EDHF Symposium
    • Place of Presentation
      Tampere (Finland)
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Biological function of HIF-1 and prolyl 4-hydroxylase during embryonic development of Xenopus laevis2008

    • Author(s)
      Muraguchi T, Sonofuchi R, Kinoshita T, Imaoka S
    • Organizer
      Keystone symposia - Molecular, cellular, physiologial, and pathogenic response to hypoxia
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-01-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Biogical roles of Nrf2 in hypoxia response of Hep3B cells2008

    • Author(s)
      Morimoto H, Ueda K, Imaoka S
    • Organizer
      Keystone symposia - Molecular, cellular, physiologial, and pathogenic response to hypoxia
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-01-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Cytochrome P450 and solube epoxide hydrolase modulate VEGF expression under hypoxia2008

    • Author(s)
      Oguro A, Suzuki S, Imaoka S
    • Organizer
      Keystone symposia - Molecular, cellular, physiologial, and pathogenic response to hypoxia
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-01-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Biological function of HIF-1 and prolyl 4-hydroxylase during embryonic development of Xenopus laevis2008

    • Author(s)
      Muraguchi T.
    • Organizer
      Keystone symposia-Molecular, cellular, physiological, and pathogenic response to hypoxia
    • Place of Presentation
      Vancouver Canada
    • Year and Date
      2008-01-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] BisphenolA結合タンパク質とその相互作用因子CRTの機能解析2007

    • Author(s)
      幸田秀紀, 岡田和嗣, 今岡進
    • Organizer
      第30回日本分子生物学会年会第80回日本生化学大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Differential response to aryl-hydrocarbon receptor ligands in cell types2007

    • Author(s)
      Okada K, Sawada T, Imaoka S
    • Organizer
      27th International Symposium on Halogenated Persistent Organic Pollutants - DIOXIN 2007
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of ligands for AH receptor on hypoxic response of cells2007

    • Author(s)
      Sawada T, Kubo T, Osada-Oka M, Imaoka S
    • Organizer
      27th International Symposium on Halogenated Persistent Organic Pollutants - DIOXIN 2007
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Differential response to arylhydrocarbon receptor ligands in cell types2007

    • Author(s)
      Okada K.
    • Organizer
      27th International Symposium on Halogenated Persistent Organic Pollutants-DIOXIN 2007
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of ligands for AH receptor on hypoxic response of cells2007

    • Author(s)
      Sawada T.
    • Organizer
      27th International Symposium on Halogenated Persistent Organic Pollutants-DIOXIN 2007
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Over-expression of protein disulfide isomerase reducescthe release of growth hormone induced by bisphenolA and/or T32007

    • Author(s)
      Okada K, Imaoka S, Hiroi T, Funae Y
    • Organizer
      International Congress of Toxicology
    • Place of Presentation
      Montreal Canada
    • Year and Date
      2007-07-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of bisphenolA on a hypoxic response pathway during embryonic developmet2007

    • Author(s)
      Imaoka S, Sonofuchi R, Mori T, Kubo T, Kinoshita T
    • Organizer
      International Congress of Toxicology
    • Place of Presentation
      Montreal Canada
    • Year and Date
      2007-07-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Characterization of prorein disulfide isomerase, bisphenolA binding protein on development of Xenopus embryo2007

    • Author(s)
      Hashimoto S, Yamazaki A, Okada K, Kinoshita T, Imaoka S
    • Organizer
      International Congress of Toxicology
    • Place of Presentation
      Montreal Canada
    • Year and Date
      2007-07-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Characterization of protein disulfide isomerase,bisphenol A binding protein,on development of Xenopus embryo2007

    • Author(s)
      Hashimoto S.
    • Organizer
      International Congress of Toxicology
    • Place of Presentation
      Montreal Canada
    • Year and Date
      2007-07-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Over-expression of protein disulfide isomerase reduces the release of growth hormone induced by bisphenolA and/or T32007

    • Author(s)
      Okada K.
    • Organizer
      International Congress of Toxicology
    • Place of Presentation
      Montreal Canada
    • Year and Date
      2007-07-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of bisphenol A on a hypoxic response pathway during embryonic developmet2007

    • Author(s)
      Imaoka S.
    • Organizer
      International Congress of Toxicology
    • Place of Presentation
      Montreal Canada
    • Year and Date
      2007-07-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 水酸化ポリ塩化ビフェニルによる甲状腺ホルモン結合タンパク質PDIの機能阻害2007

    • Author(s)
      岡田和嗣, 今岡進, 船江良彦
    • Organizer
      第34回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-28
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 甲状腺ホルモン結合タンパク質PDIのビスフェノールAによるイソメラーゼ活性阻害メカニズムの解明2007

    • Author(s)
      橋本邦子, 岡田和嗣, 今岡進
    • Organizer
      第34回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-27
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Book] 地球環境と人類の未来を考える生命科学2009

    • Author(s)
      今岡進編
    • Publisher
      丸善
    • Related Report
      2008 Final Research Report
  • [Book] ベーシック生化学2009

    • Author(s)
      畑山巧編
    • Publisher
      化学同人
    • Related Report
      2008 Final Research Report
  • [Book] ベーシック生化学2009

    • Author(s)
      畑山巧編集
    • Publisher
      化学同人
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 融合モノオキシゲナ-ゼ及びそれを用いた酸化物の生産方法2009

    • Inventor(s)
      今岡進
    • Industrial Property Rights Holder
      学校法人関西学院
    • Industrial Property Number
      2009-037089
    • Filing Date
      2009-02-19
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 融合モノオキシゲナーゼ及びそれを用いた酸化物の生産方法2009

    • Inventor(s)
      今岡進
    • Industrial Property Rights Holder
      学校法人関西学院
    • Industrial Property Number
      2009-037089
    • Filing Date
      2009-02-19
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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