| Project/Area Number |
19310042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
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Principal Investigator |
HARAGUCHI Koichi Daiichi University, College of Pharmaceutical Sciences, 薬学部, 教授 (00258500)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Yoshihisa 徳島文理大学, 香川薬学部, 准教授 (90161132)
MATSUBARA Futoshi 第一薬科大学, 薬学部, 准教授 (60368975)
OGUMA Takatoshi 徳島文理大学, 香川薬学部, 教授 (20446074)
NISHIMURA Eri 第一薬科大学, 薬学部, 助手 (80412550)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 海綿 / 臭素化合物 / 抗菌活性 / リード化合物 / 創薬 / カテコール / LC / MS / 海綿動物 / ハロゲン化合物 / 母乳 / ヒドロキシ臭素化ジフェニルエーテル / 高速液体クロマトグラフ |
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| Research Abstract |
We developed the APCI-LC/MS/MS and ECNI-GC/MS methods for screening of antibacterial brominated products in marine sponges (e.g. Lamellodysidea sp.) from Palau, Micronesia. Broad antibacterial spectra of phenolic products such as tetrabromocatechol, 2,2'-dihydroxy-BB80 and 2'-hydroxy-6-methoxy-BDE68 were observed and these products showed growth inhibitory effects against E. Faecalis, E. Faecius, S. aureus, MRSA and S. pyogenes. These components are expected for lead compounds of antibacterial agents.
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