| Project/Area Number |
19310084
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NISHINO Yoshinori The Institute of Physical and Chemical Research, 石川X線干渉光学研究室, 専任研究員 (40392063)
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| Co-Investigator(Kenkyū-buntansha) |
MAESHIMA Kazuhiro 国立遺伝学研究所, 構造遺伝学研究センター, 教授 (00392118)
高橋 幸生 大阪大学, 大学院・工学研究科付属フロンティア研究センター, 特任講師 (00415217)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Yukio 大阪大学, 大学院・工学研究科・付属フロンティア研究センター, 特任講師 (00415217)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Keywords | コヒーレントX線 / 染色体 / X線回折顕微法 / ナノ構造解析 / 位相コントラストイメージング / オルガネラ / 高次構造 / 位相回復 / コヒーレントX線回折顕微法 / 細胞内構造 / 低温生物試料 |
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| Research Abstract |
We performed research in bioimaging with x-ray diffraction microscopy on various aspects concerning microscope hardware development, sample preparation, data acquisition, data analysis, etc. We achieved results including first three-dimensional observation of a cellular organelle using hard x-rays leading research in the field. Our study also provided structural information of biological interest. For example, in the chromosome image which we successfully visualized, axial structure was observed first without staining or other methods to artificially enhance image contrast.
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