Probabilistic Models of the Marginal Distribution of Gene Expression
Project/Area Number |
19310128
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
基礎ゲノム科学
|
Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
HORTON Paul National Institute of Advanced Industrial Science and Technology, 生命情報工学研究センター, 研究チーム長 (00371071)
|
Co-Investigator(Kenkyū-buntansha) |
HORIMOTO Katsuhisa 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究チーム長 (40238803)
ABURATANI Sachiyo 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 研究員 (10361627)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
|
Keywords | 遺伝子発現 / 次世代シーケンサー / TSS-Seq法 / 転写頻度 / Quality Scores / 配列度数修正 / プロモータ解析 / 組織特異性 / 遺伝子分類 / 転写制御 / 発生の制御 / 細胞学 / 確率モデル / 確立モデル |
Research Abstract |
1) Established a method for automatically constructing probabilistic mixture models of gene expression from microarray data. 2) Performed analysis on the marginal distribution of genes and hypothesized that the noise in microarray experiments hinders proper analysis. 3) Established a method for correcting the influence of misreads to allow next-generation sequencer mRNA sequence data to be used for precise analysis of gene expression.
|
Report
(4 results)
Research Products
(16 results)