Computational analysis of human proteins addressing the relationship between intrinsic disorder and alternative splicing
| Project/Area Number |
19310133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied genomics
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| Research Institution | Maebashi Institute of Technology |
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Principal Investigator |
NISHIKAWA Ken Maebashi Institute of Technology, 工学部・生命情報学科, 教授 (10093288)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUCHI Satoshi 国立遺伝学研究所, 助教 (70360336)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 情報解析 / 天然変性タンパク質 / スプライシング / 真核生物 / ゲノム / 構造ドメイン / 不規則領域 / 構造未知ドメイン / 細胞内局在 / 天然タンパク質 / 転写因子 / 膜タンパク質 |
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| Research Abstract |
For all human proteins encoded on the genome, we have succeeded to classify protein molecules into structured or intrinsically disordered (ID) regions using the method we developed in this project. As a result, we revealed the total fractions of ordered/disordered regions of human proteins at a first time. Analyzing locations of alternative splicing (AS) data along the protein sequence, we have also revealed that AS events occur in proportion to the fraction of ID regions of proteins.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] The GTOP database in 2009: updated content and novel features to expand and deepen insights into protein structures and functions.2009
Author(s)
Fukuchi, S., Homma, K., Sakamoto, S., Sugawara, H., Tateno, Y., Gojobori, T., Nishikawa, K.
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Journal Title
Related Report
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