| Project/Area Number |
19310137
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Chiba University |
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Principal Investigator |
TAKAYAMA Hiromitsu Chiba University, 大学院・薬学研究院, 教授 (90171561)
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| Co-Investigator(Kenkyū-buntansha) |
HORIE Shunji 城西国際大学, 薬学部, 教授 (50209285)
KITAJIMA Mariko 千葉大学, 大学院・薬学研究院, 准教授 (60195261)
KOGURE Noriyuki 千葉大学, 大学院・薬学研究院, 助教 (80396689)
五十嵐 一衛 千葉大学, 名誉教授 (60089597)
星野 忠治 千葉大学, 大学院・薬学研究院, 准教授 (90257220)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 鎮痛薬 / 脳機能改善薬 / アルカロイド / 成分探索 / 不斉全合成 / 構造活性相関 / 全合成 / リコポジウム / オピオイド / 脳機能 / 認知症 / インドール / NMDA受容体 |
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| Research Abstract |
In order to find new biologically active compounds that act on the brain nervous systems, we have investigated plant alkaloids. As a result, several new alkaloids having opioid agonistic activity or acetylcholine-esterase inhibitory activity were found. Their asymmetric total syntheses were also achieved. Further, based on those natural products, we have developed potent channel blocker on NMDA receptors, which would be a seed molecule for dementia medicine, as well as novel and quite potent opioid agonist, which would be a lead compound for new analgesic.
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