| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Research Abstract |
We were planning to find small molecules useful for the study of the controlling mechanism of stem cell differentiation to vascular systems. We have studied application of marine natural anti-angiogenic compounds, azumamides, to the in vitro vascular re-organizing model using mouse iPS cells, in which we confirmed their potent effects. Therefore, this model, as well as that using mouse ES cells, was shown to be useful for the study of stem cell differentiation systems. Next, we have evaluated anti-angiogenic effects of analogues of geladine, in which we could identified unknown targets for ageladines besides the known MMP.
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