Chemical Biology of Stem cell differentiation
| Project/Area Number |
19310138
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Waseda University |
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Principal Investigator |
NAKAO Yoichi Waseda University, 理工学術院, 准教授 (60282696)
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| Co-Investigator(Kenkyū-buntansha) |
宮本 和明 独・国立病院機構, 中国がんセンター臨床研究部 (30332373)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 生理活性物質 / ケミカルバイオロジー / 天然物有機化学 / 生体機能関連物質 / 細胞分化 / エピゲノム / 多能性幹細胞 |
|---|
| Research Abstract |
We were planning to find small molecules useful for the study of the controlling mechanism of stem cell differentiation to vascular systems. We have studied application of marine natural anti-angiogenic compounds, azumamides, to the in vitro vascular re-organizing model using mouse iPS cells, in which we confirmed their potent effects. Therefore, this model, as well as that using mouse ES cells, was shown to be useful for the study of stem cell differentiation systems. Next, we have evaluated anti-angiogenic effects of analogues of geladine, in which we could identified unknown targets for ageladines besides the known MMP.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Gracilioethers A-C, Anti-malarial Metabolites from the Marine Sponge Agelas gracilis2009
Author(s)
Ueoka, R. ; Nakao, Y. ; Kawatsu, S. ; Yaegashi, J. ; Matsumoto, Y. ; Matsunaga, S. ; Furihata, K. ; van Soest, R.W.M. ; Fusetani, N.
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Journal Title
J. Org. Chem. 74
Pages: 4204-4207
Related Report
Peer Reviewed
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[Journal Article] Aplysinoplides A-C, Cytotoxic Manoalide Derivatives from the Marine Sponge Aplysinopsis digitata2008
Author(s)
Ueoka, R., Nakao, Y., Fuiii, S., van Soest, R. W. M., Matsunaga, S.
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Journal Title
J. Nat. Prod. 71
Pages: 1089-1091
Related Report
Peer Reviewed
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[Journal Article] Absolute Structure of Prunustatin A, a Novel GRP78 Molecular Chaperone Down-Regulator2007
Author(s)
Umeda, Y. ; Furihata, K. ; Sakuda, S. ; Nagasawa, H. ; Ishigami, K. ; Watanabe, H. ; Izumikawa, M. ; Takagi, M. ; Doi, D. ; Nakao, Y. ; Shin-ya, K.
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Journal Title
Org. Lett. 9
Pages: 4239-4242
Related Report
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