| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Research Abstract |
Polyketide synthases (PKSs) are important enzymes involved in the construction of basic carbon skeletons of polyketides. In this study, structure and reaction control mechanisms by iterative type I PKSs were investigated. On the 6-methylsalicylic acid synthase, a new catalytic domain named "Thioester Hydrolase" domain was identified which is involved in the product release. In addition, new aspects on the reaction control mechanisms of non-reducing type I PKSs, reducing type I PKSs, and PKS-NRPS (non-ribosomal peptide synthase) were identified.
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