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Search for Natural Products Which Enhance the Effect of Tumor Suppressor Protein

Research Project

Project/Area Number 19310140
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Living organism molecular science
Research InstitutionChiba University (2008-2009)
Kanazawa University (2007)

Principal Investigator

TSUKAMOTO Sachiko  Chiba University, 大学院・生命科学研究部, 教授 (40192190)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywordsユビキチン / プロテアソーム / がん抑制遺伝子産物 / 抗がん剤 / p53 / 天然低分子化合物 / 海洋生物 / 海洋無脊椎動物 / 海洋由来微生物 / がん挿制遺伝子 / 天然資源 / 低分子化合物 / がん治療薬 / Mdm2 / COP1 / Ubc13-Uev1A
Research Abstract

p53 plays an important role on suppression of tumor, and the drugs which enhance the effect of p53 will treat a various cancer. In this study, we search for compounds, which inhibit the interactions of p53-Hdm2 and Ubc13-Uev1A from marine organisms.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (44 results)

All 2010 2009 2008 2007 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (22 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Aaptamine, an Alkaloid from the Sponge Aaptos suberitoides, functions as a Proteasome Inhibitor2010

    • Author(s)
      S. Tsukamoto, H. Yokosawa(10名のうち1番目)
    • Journal Title

      Bioorg. Med. Chem. Lett 20

      Pages: 3341-3343

    • NAID

      120002599084

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the Ubiquitin-proteasome System by Natural Products for Cancer Therapy2010

    • Author(s)
      S. Tsukamoto, H. Yokosawa
    • Journal Title

      Planta Medica (Review)

    • NAID

      120003072384

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the Ubiquitin-proteasome System by Natural Products for Cancer Therapy(Review)2010

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Planta Med. 72(In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aaptamine, an Alkaloid from the Sponge Aaptos suberitoides, functions as a Proteasome Inhibitor2010

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Bioorg.Med.Chem.Lett. 20(In press)

    • NAID

      120002599084

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting Aaptos suberitoides HN N OCH3 H3CO aaptamine N N OCH3 HO isoaaptamine H3C HN N OCH3 HO demethylaaptamine OH O HO O (R)-(-)-Hexylitaconic acid the Proteasome Pathway2009

    • Author(s)
      S. Tsukamoto, H. Yokosawa
    • Journal Title

      Expert Opin. Ther. Targets 13

      Pages: 605-621

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereochemical Studies of Hexylitaconic Acid, an Inhibitor of p53-HDM2 Interaction2009

    • Author(s)
      A. Nakahashi, N. Miura, K. Monde, S. Tsukamoto
    • Journal Title

      Bioorg. Med. Chem. Lett 19

      Pages: 3027-3030

    • NAID

      120001342680

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absolute Configuration of the α,ω-Bifunctionalized Sphingolipid Leucettamol A from Leucetta sp. by Deconvoluted Exciton Coupled CD2009

    • Author(s)
      D.S. Dailisay, S. Tsukamoto, T.F. Molinski
    • Journal Title

      J. Nat. Prod 72

      Pages: 353-359

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting the Proteasome Pathway(Review)2009

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Expert Opin.Ther.Targets 13

      Pages: 605-621

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereochemical Studies of Hexylitaconic Acid, an Inhibitor of p53-HDM2 Interaction2009

    • Author(s)
      Atsushi Nakahashi
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 3027-3030

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absolute Configuration of the α,ω-Bifunctionalized Sphingolipid Leucettamol A from Leucetta sp.by Deconvoluted Exciton Coupled CD2009

    • Author(s)
      Doralyn S.Dailisay
    • Journal Title

      J.Nat.Prod. 72

      Pages: 353-359

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of Antipodal (-)-Versicolamide B and Notoamides L-N from a Marine-derived Aspergillus sp.2009

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Org. Lett. 11

      Pages: 1297-1300

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of Notoamide E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-derived Fungus, Aspergillus sp.2009

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      J. Am. Chem. Soc. 131

      Pages: 3834-3835

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absolute Configuration of the a,co-Bifunctionalized Sphingolipid Leucettamol A from Leucetta sp. by Deconvoluted Exciton Coupled CD2009

    • Author(s)
      D. S. Dailisay
    • Journal Title

      J. Nat. Prod. 72

      Pages: 353-359

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 展開するプロテアソーム阻害剤研究2008

    • Author(s)
      塚本佐知子、横沢英良
    • Journal Title

      実験医学・増刊(田中啓二)(羊土社) 26

      Pages: 122-127

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ユビキチンリガーゼを分子標的とする新規抗がん剤の海洋生物からの探索2008

    • Author(s)
      塚本佐知子
    • Journal Title

      薬学研究の進歩 24

      Pages: 45-51

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leucettamol A: A New Inhibitor of Ubc13-Uev1A Interaction Isolated from a Marine Sponge, Leucetta aff. microrhaphis2008

    • Author(s)
      S. Tsukamoto, T. Takeuchi, H. Yokosawa(10名のうち1番目)
    • Journal Title

      Bioorg. Med. Chem. Lett 18

      Pages: 6319-6320

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leucettamol A: A New Inhibitor of Ubc13-UevlA Interaction Isolated from a Marine Sponge, Leucetta aff. Microrhaphis2008

    • Author(s)
      Sachiko Tsukamoto
    • Journal Title

      Bioorg. Med. Chem. Lett. 18

      Pages: 6319-6320

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 展開するプロテアソーム阻害剤研究(総説)2008

    • Author(s)
      塚本 佐知子
    • Journal Title

      実験医学増刊 26

      Pages: 242-247

    • Related Report
      2007 Annual Research Report
  • [Presentation] 創薬を指向した天然薬物学研究(日本薬学会学術振興賞受賞講演)2010

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山(全日空ホテル)(招待)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 海綿Xestospongia cf. vansoestiから得られたテトラヒドロイソキノリンアルカロイドの構造と生物活性2010

    • Author(s)
      長澤由美子
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山(桃太郎アリーナ)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 海綿Aaptos suberitoidesより得られたaaptamine類のプロテアソーム阻害作用2010

    • Author(s)
      山之口瑠美
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山(桃太郎アリーナ)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 創薬を指向した天然薬物学研究(日本薬学会学術振興賞受賞講演)(招待講演)2010

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      全日空ホテル(岡山)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 海綿 Aaptos suberitoides より得られた aaptamine 類のプロテアソーム阻害作用2010

    • Author(s)
      山之口瑠美
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      桃太郎アリーナ(岡山)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 海綿 Xestospongia cf.vansoesti から得られたテトラヒドロイソキノリンアルカロイドの構造と生物活性2010

    • Author(s)
      長澤由美子
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      桃太郎アリーナ(岡山)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ユビキチン-プロテアソームシステムを標的とする海洋由来低分子化合物の探索2009

    • Author(s)
      塚本佐知子
    • Organizer
      第51回天然有機化合物討論会
    • Place of Presentation
      名古屋(名古屋市公会堂)
    • Year and Date
      2009-10-07
    • Related Report
      2009 Final Research Report
  • [Presentation] ユビキチン-プロテアソームシステムを標的とする海洋由来低分子化合物の探索2009

    • Author(s)
      塚本佐知子
    • Organizer
      第51回天然有機化合物討論会
    • Place of Presentation
      名古屋市公会堂(名古屋)
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 海洋由来真菌から得られた新規notoamidesの構造と生合成経路に関する考察2009

    • Author(s)
      塚本佐知子
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都(京都薬科大学)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Stereochemical sudies of hexylitaconic acid, an inhibitor of p53-HDM2 interaction2009

    • Author(s)
      Atsufumi Nakahashi
    • Organizer
      Chirality 2009 (ISCD): 21st International Symposium and Exhibit on Chirality
    • Place of Presentation
      Breckenridge (Colorado), USA
    • Year and Date
      2009-07-12
    • Related Report
      2009 Final Research Report
  • [Presentation] p53-Hdm2複合体形成阻害物質ヘキシルイタコン酸の赤外円二色性による立体化学解析2009

    • Author(s)
      中橋徳文
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      船橋(日本大学船橋キャンパス)
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 海綿Aaptos aaptosから得られたプロテアソーム阻害物質2009

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 海綿Aaptos aaptosから得られたプロテアソーム阻害物質2009

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第129回年会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2009-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 海洋田釆糸状菌から得られた新規ノトアミド類の構造と生合成研究2008

    • Author(s)
      塚本佐知子
    • Organizer
      第50回天然有機化合物討論会
    • Place of Presentation
      福岡
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ユビキチン-プロテアソームシステムを阻害するleucettamol Aとその誘導体の活性について2008

    • Author(s)
      塚本佐知子
    • Organizer
      第12回がん分子標的治療研究会総会
    • Place of Presentation
      東京(学術総合センター)
    • Year and Date
      2008-06-26
    • Related Report
      2009 Final Research Report
  • [Presentation] ユビキチンープロテアソームシステムを阻害するleucettamol Aとその誘導体の活性について2008

    • Author(s)
      塚本佐知子
    • Organizer
      第12回がん分子標的治療研究会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] ユビキチンシステムを標的とする天然からの創薬リード化合物の探索2008

    • Author(s)
      塚本 佐知子
    • Organizer
      日本薬学会第128年会(シンポジウム)
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] インドネシア産海綿Leucetta microrhaphisから得られたプロテアソーム阻害物質2008

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] ユビキチンシステムを標的とする天然からの創薬リード化合物の探索2008

    • Author(s)
      塚本佐知子
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] インドネシア産海綿Leucetta microrhaphis から得られたプロテアソーム阻害物質2008

    • Author(s)
      塚本 佐知子
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Search for natural products inhibiting the Uhc13 ubiquitin E2 enzyme-Uev1A complex formation2008

    • Author(s)
      Sachiko Tsukamoto
    • Organizer
      Gordon Research Conference(Marine Natural Products)
    • Place of Presentation
      Ventura(CA,USA)
    • Year and Date
      2008-02-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] ユビキチン依存的分解系を標的とする海洋生物由来の低分子化合物の探索2007

    • Author(s)
      塚本佐知子
    • Organizer
      大阪府立大学有機化学研究会第48回講演会(白鷺セミナー)
    • Place of Presentation
      大阪(大阪府立大学)
    • Year and Date
      2007-10-24
    • Related Report
      2009 Final Research Report
  • [Book] アイピーシー、天然物化学2008

    • Author(s)
      塚本佐知子
    • Publisher
      海洋生物
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/shoyaku/site/TOP.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/shoyaku/site/TOP.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://web.mac.com/stsuka

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2019-04-12  

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