Development of chemicals that control the glutathione metabolism and oxidative stress and their use for chemical biology
| Project/Area Number |
19310143
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kyoto University |
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Principal Investigator |
HIRATAKE Jun Kyoto University, 化学研究所, 教授 (80199075)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Bunta 京都大学, 化学研究所, 助教 (10544637)
MIZUTANI Masaharu 神戸大学, 大学院・農学研究科, 准教授 (60303898)
清水 文一 京都大学, 化学研究所, 助教 (50324695)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Bunichi 東洋大学, 生命科学部, 准教授 (50324695)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | グルタチオン / γ-グルタミルシステイン合成酵素 / γ-グルテミルシランスペプチダーゼ / 遷移状態アナログ阻害剤 / 酸化ストレス制御 / 病原性連鎖球菌 / アンチェイジング化粧品 / 急性腎障害軽減 / γ-グルタミルトランスペプチダーゼ / 反応機構依存型阻害剤 / ヒト線維芽細胞 / 細胞レドックスポテンシャル / 急性腎障害 / 酸化ストレス / γ-グルタミルシスティン合成酵素 / 反応機構依存的阻害剤 / ホスホン酸ジエステル / 活性中心マッピング / ヒトGGT / 基質認識残基 / 部位特異的変異 / グルタミンアンタゴニスト / acivicin / X線結晶構造解析 |
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| Research Abstract |
Thisstudy concerns the development and applications of chemical tools that regulate the redox status of cells by designing and synthesizing specific inhibitors of γ-glutamylcysteine synthetase (GCS), therate-determiningenzymeinglutathione synthesis, and γ-glutamyl transpeptidase (GGT), the initial andprimarily important enzyme in the glutathione metabolism.The inhibitors are to serve as chemical probes to investigate the relationships between cell redox potential and various diseases and as leads to agrochemicals and pharmaceuticals, as well as to antiaging cosmetics.
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Report
(4 results)
Research Products
(29 results)
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[Presentation] 腎虚血再灌流傷害に対する新規GGT阻害剤の改善効果について2010
Author(s)
山本真也, 渡辺文太, 平竹潤, 大喜多守, 松村靖夫
Organizer
第83回 日本薬理学会年会 The 83rd Annual Meeting of the Japanese Pharmacological Society
Place of Presentation
大阪国際会議場
Year and Date
2010-03-16
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[Presentation] Rational Design of Specific Inhibitors of γ-Glutamyl Transpeptidase (GGT) and γ-Glutamylcysteine Synthetase (GCS) for Modulating Cellular Glutathione and Redox Status2008
Author(s)
Hiratake, J., Nakajima, M., Han, L., Kawamura, N., Hibi, T., Nakajima, Y.
Organizer
Ehrlich II-2^<nd> World Conference on Magic Bullets
Place of Presentation
Nurnberg, Germany
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