Exploring novel innate immune stimulants ; Structure elucidation, chemical synthesis and functions of bacterial surface components

• Project/Area Number: 19310144
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Osaka University
• Principal Investigator: FUJIMOTO Yukari Osaka University, 大学院・理学研究科, 准教授 (00362616)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2007: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 自然免疫 / 複合糖質 / 有機合成化学 / ペプチドグリカン / Nod1 / 気管上皮細胞毒素

Research Abstract

In order to understand the molecular structures and bioactivities of innate immune stimulators in the environment, we isolated and elucidated the structures of natural innate immune receptor (eg. Nod1)'s ligands, and also succeeded the chemical synthesis of bacterial cell wall peptidoglycan fragments (including tracheal cytotoxin (TCT)), and a phsphoglycolipid from an extreme thermophile, for the first time.

Research Products

• [Journal Article] Characterization of natural human nucleotide-binding oligomerization domain protein 1 (NOD1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment. (2010)
  • Author(s): Pradipta, A.R., Fujimoto, Y., Hasegawa, M., Inohara, N., Fukase, K.
  • Journal Title: J.Biol.Chem. 285 Pages: 23607-23613
  • Peer Reviewed
• [Journal Article] Widely applicable deprotection method of 2,2,2-trichloroethoxycarbonyl (Troc) group using tetrabutylammonium fluoride. (2010)
  • Author(s): Huang, C-y., Wang, N., Fujiki, K., Otsuka, Y., Akamatsu, M., Fujimoto, Y., Fukase, K.
  • Journal Title: J.Carbohydr.Chem. 29 Pages: 1-9
  • Peer Reviewed
• [Journal Article] The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation. (2010)
  • Author(s): Azuma, M., Sawahata R., Akao, Y., Ebihara, T., Yamazaki, S., Matsumoto, M., Hashimoto, M., Fukase, K., Fujimoto, Y., Seya, T.
  • Journal Title: PLos One 5
  • NAID: 120002414850
  • Peer Reviewed
• [Journal Article] Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. (2010)
  • Author(s): Asano, J., Tada, H., Onai, N., Sato, T., Horie, Y., Fujimoto, Y., Fukase, K., Suzuki, A., Mak, T.W., Ohteki, T.
  • Journal Title: J.Immunol. 184 Pages: 736-745
  • Peer Reviewed
• [Journal Article] Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells. (2010)
  • Author(s): Gutsmann, T., Howe, J., Zahringer, U., Garidel, P., Schromm, A.B., Koch, M.H., Fujimoto, Y., Fukase, K., Moriyon, I., Martinez-de-Tejada, G., Brandenburg, K.
  • Journal Title: Innate Immun. 16 Pages: 39-47
  • Peer Reviewed
• [Journal Article] Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant. (2010)
  • Author(s): Bongat, A.F.G., Saksena, R., Adamo, R., Fujimoto, Y., Shiokawa, Z., Peterson, D. C., Fukase, K., Vann, W.F., Kova., P.
  • Journal Title: Glycoconj.J. 27 Pages: 69-77
  • Peer Reviewed
• [Journal Article] Characterization of natural human nucleotide-binding oligomerization domain protein 1 (NOD1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment. (2010)
  • Author(s): Pradipta, A.R.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 23607-23613
  • Peer Reviewed
• [Journal Article] Self and non-self recognition with bacterial and animal glycans, surveys by synthetic chemistry. (2010)
  • Author(s): Fujimoto, Y.
  • Journal Title: Methods in Enzymology Volume: 478 Pages: 323-342
  • Peer Reviewed
• [Journal Article] Widely applicable deprotection method of 2,2,2-trichloroethoxycarbonyl (Troc) group using tetrabutylammonium fluoride. (2010)
  • Author(s): Huang, C-y.
  • Journal Title: J.Carbohydr.Chem. Volume: 29 Pages: 1-9
  • Peer Reviewed
• [Journal Article] The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation. (2010)
  • Author(s): Azuma, M.
  • Journal Title: PLos One Volume: 5
  • Peer Reviewed
• [Journal Article] Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. (2010)
  • Author(s): Asano, J.
  • Journal Title: J Immunol. Volume: 184 Pages: 736-45
  • Peer Reviewed
• [Journal Article] Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells. (2010)
  • Author(s): Gutsmann, T.
  • Journal Title: Innate Immun. Volume: 16 Pages: 39-47
  • Peer Reviewed
• [Journal Article] Multimeric bivalent immunogens from recombinant tetanus to xin Hc fragment, synthetic hexasaccharides, and a glycopeptide adjuvant. (2010)
  • Author(s): Bongat, A.F.G.
  • Journal Title: Glycoconj.J Volume: 27 Pages: 69-77
  • Peer Reviewed
• [Journal Article] Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities. (2009)
  • Author(s): Fujimoto, Y., Hashimoto, M., Furuyashiki, M., Katsumoto, M., Seya, T., Suda, Y., Fukase, K.
  • Journal Title: ChemBioChem 10 Pages: 2273-2403
  • Peer Reviewed
• [Journal Article] Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions. (2009)
  • Author(s): Fujimoto, Y., Konishi, Y., Kubo, O., Hasegawa, M., Inohara, N., Fukase. K.
  • Journal Title: Tetrahedron Lett. 50 Pages: 3631-3634
  • Peer Reviewed
• [Journal Article] Characterization of N-terminal Structure of TLR2-activating Lipoprotein in Staphylococcus aureus. (2009)
  • Author(s): Tawaratsumida, K., Furuyashiki, M., Katsumoto, M., Fujimoto, Y., Fukase, K., Suda Y., Hashimoto, M.
  • Journal Title: J.Biol.Chem. 284 Pages: 9147-9152
  • Peer Reviewed
• [Journal Article] Lipopeptides from Staphylococcus aureus as Tlr2 Ligands : Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities. (2009)
  • Author(s): Fujimoto, Y.
  • Journal Title: ChemBioChem Volume: 10 Pages: 2273-2403
  • Peer Reviewed
• [Journal Article] Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions. (2009)
  • Author(s): Fujimoto, Y.
  • Journal Title: Tetrahedron Lett. Volume: 50 Pages: 3631-3634
  • Peer Reviewed
• [Journal Article] Characterization of N-terminal Structure of TLR2-activating Lipoprotein in Staphylococcus aureus. (2009)
  • Author(s): Tawaratsumida, K.
  • Journal Title: J.Biol.Chem. Volume: 284 Pages: 9147-9152
  • Peer Reviewed
• [Journal Article] Synthesis of diaminopimelic acid-containing peptidoglycan fragments and tracheal cytotoxin (TCT) for investigation of their biological functions. (2008)
  • Author(s): Kawasaki, A., Karasudani, Y., Otsuka, Y., Hasegawa, M., Inohara, N., Fujimoto, Y., Fukase, K.
  • Journal Title: Chem.Eur.J. 14 Pages: 10318-10330
  • Peer Reviewed
• [Journal Article] Autophagic control of listeria through intracellular innate immune recognition in drosophila. (2008)
  • Author(s): Yano, T., Mita, S., Ohmori, H., Oshima, Y., Fujimoto, Y., Ueda, R., Takada, H., Goldman, W.E., Fukase, K., Silverman, N., Yoshimori, T., Kurata, S.
  • Journal Title: Nat.Immunol. 9 Pages: 908-916
  • Peer Reviewed
• [Journal Article] Synthesis of Rubrivivax gelatinosus lipid A and analogues for investigation of the structural basis for immunostimulating and inhibitory activities. (2008)
  • Author(s): Fukase, Y., Fujimoto, Y., Adachi, Y., Suda, Y., Kusumoto, S., Fukase, K.
  • Journal Title: Bull.Chem.Soc.Japan. 81(Award Article) Pages: 796-819
  • NAID: 10021076555
  • Peer Reviewed
• [Journal Article] A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. (2008)
  • Author(s): Hasegawa, M., Fujimoto, Y., Lucas, P.C., Nakano, H., Fukase, K., Nunez, G., Inohara, N.
  • Journal Title: EMBO J. 27 Pages: 373-383
  • Peer Reviewed
• [Journal Article] Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine. (2008)
  • Author(s): Tohno, M., Shimazu, T., Aso, H., Uehara, A., Takada, H., Kawasaki, A., Fujimoto, Y., Fukase, K., Saito, T., Kitazawa, H.
  • Journal Title: Mol.Immunol. 45 Pages: 1807-1817
  • Peer Reviewed
• [Journal Article] Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide : Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling. (2008)
  • Author(s): Rallabhandi, P., Awomoyi, A., Thomas, K.E., Phalipon, A., Fujimoto, Y., Fukase, K., Kusumoto, S., Qureshi, N., Sztein, M.B., Vogel, S.N.
  • Journal Title: J.Immunol. 180 Pages: 1139-1147
  • Peer Reviewed
• [Journal Article] Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functios. (2008)
  • Author(s): Kawasaki, A.
  • Journal Title: Chem., Eur., J. 14 Pages: 10318-10330
  • Peer Reviewed
• [Journal Article] Autophagic control of listeria through intracellular innate immune recognition in drosophila. (2008)
  • Author(s): Yano, T.
  • Journal Title: Nature Immunoloogy 9 Pages: 908-916
  • Peer Reviewed
• [Journal Article] Molecular cloning and functional characterization of porcine nucleotid e-binding oligomerization domain-1 (NOD1)recognizing minimum agonists (2008)
  • Author(s): Tohno, M.
  • Journal Title: Mol. Iminunol. 45 Pages: 1807-1817
  • Peer Reviewed
• [Journal Article] A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kB activation. (2008)
  • Author(s): Hasegawa, M.
  • Journal Title: EMBO J. 27 Pages: 373-383
  • Peer Reviewed
• [Journal Article] Differential activation of human TLR4 by escherichia coli and shigella flexneri 2a lipopolysaccharide : combined effects of lipid A acylation state and TLR4 polymorphisms on signaling. (2008)
  • Author(s): Rallabhandi, P.
  • Journal Title: J. Immunol. 180 Pages: 1139-1147
  • Peer Reviewed
• [Journal Article] Synthesis of Rubrivivax gelatinosus iipid A and analogues for investigation of the structural basis for immunostimulating and inhibitory activities (2008)
  • Author(s): Fukase, Y.
  • Journal Title: Bull. Chem. Soc. Jpn. 81 Pages: 796-819
  • Peer Reviewed
• [Journal Article] Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine (2008)
  • Author(s): M. Tohno
  • Journal Title: Mol. Immunol. 45 Pages: 1807-1817
  • Peer Reviewed
• [Journal Article] A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation (2008)
  • Author(s): M. Hasegawa
  • Journal Title: EMBO J. 27 Pages: 373-383
  • Peer Reviewed
• [Journal Article] Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling (2008)
  • Author(s): P. Rallabhandi
  • Journal Title: J. Immunol. 180 Pages: 1139-1147
  • Peer Reviewed
• [Journal Article] Synthesis of immunoregulatory Helicobacter pylori lipopolysaccharide partial structures. (2007)
  • Author(s): Fujimoto, Y., Iwata, M., Imakita, N., Shimoyama, A., Suda, Y., Kusumoto, S., Fukase, K.
  • Journal Title: Tetrahedron Lett. 48 Pages: 6577-6581
  • Peer Reviewed
• [Journal Article] Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism. (2007)
  • Author(s): Fujimoto, Y., Inamura, S., Kawasaki, A., Shiokawa, Z., Shimoyama, A., Hashimoto, T., Kusumoto, S., Fukase, K.
  • Journal Title: J.Endotoxin Research 13 Pages: 189-196
  • Peer Reviewed
• [Journal Article] Synthesis and functional analysis of the key compounds responsible for signal transduction. (2007)
  • Author(s): Fujimoto, Y.
  • Journal Title: Yuki Gosei Kagaku Kyokaishi 65 Pages: 1170-1178
  • NAID: 10020006877
  • Peer Reviewed
• [Journal Article] Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. (2007)
  • Author(s): Uehara, A., Fujimoto, Y., Fukase, K., Takada, H.
  • Journal Title: Mol.Immunol. 44 Pages: 3100-3111
  • Peer Reviewed
• [Journal Article] Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. (2007)
  • Author(s): Park, J.H., Kim, Y.G., Shaw, M., Kanneganti, T.D., Fujimoto, Y., Fukase, K., Inohara, N., Nunez, G.
  • Journal Title: J.Immunol. 179 Pages: 514-521
  • Peer Reviewed
• [Journal Article] Evidence of immunostimulating lipoprotein existing in the natural lipoteichoic acid fraction. (2007)
  • Author(s): Hashimoto, M., Furuyashiki, M., Kaseya, R., Fukada, Y., Akimaru, M., Aoyama, K., Okuno, T., Tamura, T., Kirikae, T., Kirikae, F., Eiraku, N., Morioka, H., Fujimoto, Y., Fukase, K., Takashige, K., Moriya, Y., Kusumoto, S., Suda, Y.
  • Journal Title: Infect.Immun. 75 Pages: 1926-1932
  • Peer Reviewed
• [Journal Article] Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI). (2007)
  • Author(s): Azuma, M., Matsuo, A., Fujimoto, Y., Fukase, K., Hazeki, K., Hazeki, O., Matsumoto, M., Seya, T.
  • Journal Title: Biochem.Biophys.Res.Commun. 354 Pages: 574-578
  • Peer Reviewed
• [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses. (2007)
  • Author(s): Hasegawa, M., Kawasaki, A., Yang, K., Fujimoto, Y., Masumoto, J., Breukink, E., Nunez, G., Fukase, K., Inohara, N.
  • Journal Title: J.Biol.Chem. 282 Pages: 11757-11764
  • Peer Reviewed
• [Journal Article] Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism (2007)
  • Author(s): Y. Fujimoto
  • Journal Title: Journal of Endotoxin Research 13 Pages: 189-196
  • Peer Reviewed
• [Journal Article] Synthesis of immunoregulatory Helicobacter pylori lipopoly-saccharide partial structures (2007)
  • Author(s): Y. Fujimoto
  • Journal Title: Tetrahedron Letters 48 Pages: 6577-6581
  • Peer Reviewed
• [Journal Article] A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses (2007)
  • Author(s): M. Hasegawa
  • Journal Title: Journal of Biological Chemistry 282 Pages: 11757-11764
  • Peer Reviewed
• [Journal Article] Nod1/RICK and TLR Signaling Regulate Chemokine and Antimicrobial Innate Immune Responses in Mesothelial Cells (2007)
  • Author(s): J.-H. Park
  • Journal Title: J. Immunol. 179 Pages: 514-521
  • Peer Reviewed
• [Journal Article] Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines (2007)
  • Author(s): A. Uehara
  • Journal Title: Mol. Immunol. 44 Pages: 3100-3111
  • Peer Reviewed
• [Journal Article] Evidence of immunostimulating lipoprotein existing in the natural lipoteichoic acid fraction (2007)
  • Author(s): M. Hashimoto
  • Journal Title: Infect. Immun. 75 Pages: 1926-1932
  • Peer Reviewed
• [Journal Article] Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI) (2007)
  • Author(s): M. Azuma
  • Journal Title: Biochem. Biophys. Res. Commun. 354 Pages: 574-578
  • Peer Reviewed
• [Journal Article] 生体内の情報伝達に関わる鍵化合物の合成と機能解析 (2007)
  • Author(s): 藤本ゆかり
  • Journal Title: 有機合成化学協会誌 65 Pages: 1170-1170
  • NAID: 10020006877
  • Peer Reviewed
• [Presentation] Comprehensive Chemical Synthesis of Peptidoglycan Fragments for Exploring Recognition Proteins (2010)
  • Author(s): N.Wang
  • Organizer: International Symposium on Environmentally Benign Synthesis
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2010-10-22
• [Presentation] Molecular Basis of Endotoxic Activities Based on Synthesized Various Lipid A/LPS Partial Structures. (2010)
  • Author(s): Y.Fujimoto
  • Organizer: 2010 Joint Meeting between the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society.
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-10-09
• [Presentation] Innate Immunostimulatory Lipopeptides of Staphylococcus aureus as TLR2 Ligands ; Prediction with mRNA Expression, Chemical Synthesis, and TLR2-mediated NK Activation. (2010)
  • Author(s): Y.Fujimoto
  • Organizer: 2010 Joint Meeting between the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society.
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-10-09
• [Presentation] Peptidoglycan fragments released to the environment ; Analysis, chemical synthesis and Nod1 stimulation. (2010)
  • Author(s): Y.Fujimoto
  • Organizer: 2010 Joint Meeting between the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society.
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-10-08
• [Presentation] 細菌細胞壁ペプチドグリカンによる免疫活性化機構解明を目指したNod1/Nod2リガンド標識体の合成 (2010)
  • Author(s): 藤木勝将
  • Organizer: 第4回バイオ関連化学シンポジウム
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2010-09-26
• [Presentation] Entamoeba histolytica由来NKT細胞刺激作用を有するイノシトールリン脂質の合成研究 (2010)
  • Author(s): 佐藤昌紀
  • Organizer: 第37回有機反応懇談会
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2010-08-02
• [Presentation] 自然免疫活性化機構解明を目指したポルフィロモナス・ジンジバリス菌リピドAの網羅的合成 (2010)
  • Author(s): 佐伯昭典
  • Organizer: 第37回有機反応懇談会
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2010-08-02
• [Presentation] Synthesis of GPI structure of EhPIa and EhPIb from Entamoeba histolytica, which activate NKT cell (2010)
  • Author(s): M.Sato
  • Organizer: International Symposium on Organelle Network : Interface among Infection-Immunity, Cell Biology and Glycobiology
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
  • Year and Date: 2010-04-12
• [Presentation] Molecular Basis of Endotoxic Activities Based on Synthesized Various Lipid A/LPS Partial Structures. (2010)
  • Author(s): 藤本ゆかり
  • Organizer: 2010 Joint Meeting between the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society.
  • Place of Presentation: (Vancourver, Canada
• [Presentation] Synthesis of Parasitic Bacterial Lipopolysaccharide Partial Structures for Elucidation of the Immunoregulating Function (2010)
  • Author(s): A.Shimoyama
  • Organizer: The 25th International Carbohydrate Symposium (ICS2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Peptidoglycan Fragments Library for Exploring Recognition Proteins (2010)
  • Author(s): N.Wang
  • Organizer: The 25th International Carbohydrate Symposium (ICS2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Natural human Nod1 ligand released from bacterial supernatants (2010)
  • Author(s): A.R.Pradipta
  • Organizer: The 25th International Carbohydrate Symposium (ICS2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Synthesis of fluorescence-labeled Nod1/Nod2 ligands for elucidation of immunostimulating mechanism of bacterial cell wall peptidoglycan (2010)
  • Author(s): K.Fujiki
  • Organizer: The 25th International Carbohydrate Symposium (ICS2010)
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] Synthesis of Parasitic Bacterial Lipopolysaccharide Partial Structures for Elucidation of the Immunoregulating Function (2010)
  • Author(s): A.Shimoyama
  • Organizer: International Symposium on Organelle Network : Interface among Infection-Immunity, Cell Biology and Glycobiology
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
• [Presentation] Synthesis of Peptidoglycan Fragment Library for Investigating Their Biofunctions (2010)
  • Author(s): N.Wang
  • Organizer: The 21st Symposium on Medicinal and Fine Chemistry (FJS-2010)
  • Place of Presentation: 京都ガーデンパレス(京都府)
• [Presentation] 寄生性細菌リポ多糖部分構造の効率的合成および免疫活性化機構解明 (2010)
  • Author(s): 下山敦史
  • Organizer: 第27回有機合成化学セミナー
  • Place of Presentation: 舞子ヴィラ(兵庫県)
• [Presentation] 免疫制御を目指したアジュバント複合体の合成研究 (2010)
  • Author(s): 加治木泰範
  • Organizer: 第43回若手ペプチド夏の勉強会
  • Place of Presentation: ウェルネスパーク五色(兵庫)
• [Presentation] Peptidoglycan Fragments Library for Exploring Recognition Proteins/Domains (2010)
  • Author(s): N.Wang
  • Organizer: 第45回天然物化学談話会
  • Place of Presentation: ホテル明山荘(愛知県)
• [Presentation] ランチオニン含有細菌細胞壁ペプチドグリカン部分構造の合成 (2010)
  • Author(s): 大塚祐治
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
• [Presentation] 細菌細胞壁ペプチドグリカン受容体Nod1の天然型リガンドの同定 (2010)
  • Author(s): PRADIPTA, Ambara Rachmat
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
• [Presentation] 免疫活性化機構解明を目指したペプチドグリカン蛍光標識体の合成研究 (2010)
  • Author(s): 藤木勝将
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
• [Presentation] Helicobacter pyloriリポ多糖部分構造の合成および免疫活性化機構解明と制御 (2010)
  • Author(s): 下山敦史
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
• [Presentation] Synthesis of Parasitic Bacterial Lipopolysaccharide Partial Structures for Elucidation and Regulation of Innate Immune System. (2009)
  • Author(s): Y.Fujimoto
  • Organizer: The 3rd Japanese-German Core-to Core Meeting.
  • Place of Presentation: Koln, Germany
  • Year and Date: 2009-11-10
• [Presentation] 酸性糖KDOを含むリポ多糖活性部分構造合成と機能解析 (2009)
  • Author(s): 下山敦史
  • Organizer: 第36回有機反応懇談会
  • Place of Presentation: 関西大学(兵庫県)
  • Year and Date: 2009-08-03
• [Presentation] イミデート構造内包型脱離基を用いた立体選択的グリコシル化反応 (2009)
  • Author(s): 森修子
  • Organizer: 第36回有機反応懇談会
  • Place of Presentation: 関西大学(兵庫県)
  • Year and Date: 2009-08-03
• [Presentation] 自然免疫活性化機構解明と制御を目指した寄生性細菌リポ多糖部分構造の合成研究 (2009)
  • Author(s): 下山敦史
  • Organizer: 第10回関西グライコサイエンスフォーラム
  • Place of Presentation: 大阪市立大学(大阪府)
  • Year and Date: 2009-05-16
• [Presentation] 自然免疫を活性化する細菌細胞壁ペプチドグリカン・フラグメントの構造解析,合成と機能 (2009)
  • Author(s): 藤本ゆかり
  • Organizer: 第51回天然有機化合物討論会
  • Place of Presentation: 名古屋市公会堂,愛知県
• [Presentation] Synthesis and Biofunction of Innate Immunostimulating Glycoconjugates from Bacteria (2009)
  • Author(s): 藤本ゆかり
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: Senri Life Science Center, Osaka
• [Presentation] Synthesis and Biofunction of Nod1 Ligands of Peptidoglycan ; Innate Immunostimulating Glycoconjugates from Bacteria (2009)
  • Author(s): 藤本ゆかり
  • Organizer: 15th European Carbohydrate Symposium (Eurocarb2009)
  • Place of Presentation: Viena, Austria
• [Presentation] 細胞内自然免疫受容体Nod1に対するリガンドの合成と免疫増強作用 (2009)
  • Author(s): 藤本ゆかり
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学,千葉
• [Presentation] Synthesis and Biofunction of Innate Immunostimulating Glycoconjugates from Bacteria (2009)
  • Author(s): Y.Fujimoto
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
• [Presentation] Synthesis and Biofunction of Nod1 Ligands of Peptidoglycan ; Innate Immunostimulating Glycoconjugates from Bacteria (2009)
  • Author(s): Y.Fujimoto
  • Organizer: 15th European Carbohydrate Symposium
  • Place of Presentation: Viena, Austria
• [Presentation] Synthesis of Peptidoglycan Fragments with a New Disaccharide Building Block (2009)
  • Author(s): C.Huang
  • Organizer: The 11th International Kyoto conference on New Aspests of Organic Chemistry (IKCOC-11)
  • Place of Presentation: リーガロイヤルホテル京都(京都府)
• [Presentation] Natural Nod1 ligands released from bacteria : Isolation, characterization, and chemical synthesis. (2009)
  • Author(s): Ambara R.Pradipta
  • Organizer: 20th Joint Glycobiology Meeting of the Study Groups for Glycobiology from Netherlands, Belgium, France and Germany
  • Place of Presentation: Koln, Germany
• [Presentation] Innate Immunostimulatory Lipopeptides of Staphylococcus aureus as TLR2 Ligands ; Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities (2009)
  • Author(s): K.Fukase
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
• [Presentation] Synthesis of Parasitic Bacterial Lipopolysaccharide Partial Structures for Elucidation and Regulation of Innate Immune System (2009)
  • Author(s): A.Shimoyama
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
• [Presentation] Synthesis and innate immunostimulating activities of bacterial cell wall peptidoglycan partial structures containing lanthionine (2009)
  • Author(s): Y.Otsuka
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
• [Presentation] Stereoselective Glycosylation by Using Latent Imidate Structures as Leaving Group (2009)
  • Author(s): M.Mori
  • Organizer: Combinatorial Chemistry and Chemical Biology toward A New Paradigm for Drug Discovery (CCCB)
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
• [Presentation] Isolation and Characterization of Natural Nod1 Ligands from Bacterial Culture Supernatant (2009)
  • Author(s): Ambara R.Pradipta
  • Organizer: 2nd Switzerland-Japan Biomolecular Chemistry Symposium
  • Place of Presentation: 東京大学(東京都)
• [Presentation] 自然免疫を活性化する細菌細胞壁ペプチドグリカン・フラグメントの構造解析,合成と機能 (2009)
  • Author(s): 藤本ゆかり
  • Organizer: 第51回天然有機化合物討論会
  • Place of Presentation: 名古屋市公会堂(愛知県)
• [Presentation] イミデート構造内包型脱離基を用いた立体選択的グリコシル化反応 (2009)
  • Author(s): 森修子
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 飛騨・世界生活文化センター(岐阜県)
• [Presentation] 免疫活性化機構解明を目指したペプチドグリカンと蛍光イメージングのための分子プローブの合成研究 (2009)
  • Author(s): 藤木勝将
  • Organizer: 第44回天然物化学談話会
  • Place of Presentation: つくばグランドホテル(茨城県)
• [Presentation] 寄生性細菌リポ多糖部分構造の合成および免疫活性化機構解明と制御 (2009)
  • Author(s): 下山敦史
  • Organizer: ケミカルバイオロジー学会 第4回年会
  • Place of Presentation: 神戸市産業振興センター(兵庫県)
• [Presentation] 細胞内自然免疫受容体Nod1に対するリガンドの合成と免疫増強作用 (2009)
  • Author(s): 藤本ゆかり
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] 紅色光合成細菌リピドAとその類縁体の効率的な合成と機能 (2009)
  • Author(s): 深瀬嘉之
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] 免疫刺激活性をもつPorphyromonas gingivalis リピドAの合成研究 (2009)
  • Author(s): 笠松千郁
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] 高度好熱菌Thermus thermophilus由来リン酸化糖脂質およびその類縁体の合成と免疫刺激活性 (2009)
  • Author(s): 光延邦浩
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] ランチオニン含有細菌細胞壁ペプチドグリカン部分構造の合成 (2009)
  • Author(s): 大塚祐治
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] Latentなイミデート構造を脱離基に用いた立体選択的グリコシル化反応 (2009)
  • Author(s): 森修子
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 舟橋
• [Presentation] Synthesis of peptidoglycan fragments and their labeled derivatives for elucidation of immunostimulating mechanism (2009)
  • Author(s): K. Fujiki
  • Organizer: Clinical and Traslational Research on Cancer : Glycomics Application
  • Place of Presentation: Ise-Shima
• [Presentation] Isolation and structure elucidation of immunostimulatory native Nodi ligand (2009)
  • Author(s): A. R. Pradipta
  • Organizer: Clinical and Traslational Research on Cancer : Glycomics Application
  • Place of Presentation: Ise-Shima
• [Presentation] Synthesis and Biological Activity of Helicobacter pylori Lipopolysaccharide Partial Structures (2008)
  • Author(s): A. Shimoyama
  • Organizer: 8th HGPI meeting
  • Place of Presentation: Fort worth, U. S. A.
  • Year and Date: 2008-11-13
• [Presentation] 免疫刺激活性を持つペプチドグリカン部分構造の合成 (2008)
  • Author(s): 大塚祐治
  • Organizer: 第35回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-01
• [Presentation] 3-Nitro-2-pyridyl基を脱離基として用いたグリコシル化反応の研究 (2008)
  • Author(s): 森修子
  • Organizer: 第35回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2008-08-01
• [Presentation] 架橋構造を持つLys型細菌細胞壁ペプチドグリカン部分構造の合成と生物活性 (2008)
  • Author(s): 小西康子
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-27
• [Presentation] ランチオニン含有細菌細胞壁ペプチドグリカン部分構造の合成と生物活性 (2008)
  • Author(s): 烏谷幸枝
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-27
• [Presentation] ヘリコバクターピロリ細胞表層成分リポ多糖部分構造の合成 (2008)
  • Author(s): 下山敦史
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-26
• [Presentation] 免疫刺激活性を持つグラム陽性菌由来リポペプチドの合成研究 (2008)
  • Author(s): 勝本麻美
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-26
• [Presentation] Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures (2008)
  • Author(s): A. Shimoyama
  • Organizer: The 1st International Global COE Symposium on Bio-Environmental Chemistry
  • Place of Presentation: Osaka
  • Year and Date: 2008-01-28
• [Presentation] Synthesis of meso-DAP containing peptidoglycan fragments for investigation of molecular basis for the innate immunostimulation (2008)
  • Author(s): A. Kawasaki
  • Organizer: The 1st International Global COE Symposium on Bio-Environmental Chemistry
  • Place of Presentation: Osaka
  • Year and Date: 2008-01-27
• [Presentation] 自然免疫を活性化するバクテリア由来複合糖質の合成と機能 (2008)
  • Author(s): 藤本ゆかり
  • Organizer: 第6回糖質科学コンソーシアム(JCGG)シンポジウム
  • Place of Presentation: 東京コンファレンスセンター,東京
• [Presentation] Synthetic study of bacterial glycoconjugates for understanding the molecular basis of innate immune system. (2008)
  • Author(s): 藤本ゆかり
  • Organizer: The 22nd Naito Conference on Chemical Biology.
  • Place of Presentation: The Chateraise Gateaux Kingdom SAPPORO, Sapporo
• [Presentation] Synthesis of diaminopimelic acidcontaining peptidoglycan fragmentsand tracheal cytotoxin (TCT) forinvestigation of their biologicalfunctions (2008)
  • Author(s): 藤本ゆかり
  • Organizer: 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS2008)
  • Place of Presentation: Edinburgh, UK
• [Presentation] Synthesis of immunostimulatorypeptidoglycan fragments recognized bythe intracellular receptors (2008)
  • Author(s): 藤本ゆかり
  • Organizer: The International Conference on Biodiversity and Natural Products ((IUPAC) ICOB-6 and ISCNP-26)
  • Place of Presentation: Charlottetown, Canada
• [Presentation] Synthetic study of bacterial glycoconjugates for understanding the molecular basis of innate immune system (2008)
  • Author(s): 藤本ゆかり
  • Organizer: The 10th International Symposium on Biotechnology, Metal Complexes and Catalysis (BMC-X)
  • Place of Presentation: Zhengzhou, China
• [Presentation] 自然免疫を活性化するバクテリア由来複合糖質の合成と機能 (2008)
  • Author(s): 藤本ゆかり
  • Organizer: 第6回糖質科学コンソーシアム (JCGG) シンポジウム
  • Place of Presentation: 東京
• [Presentation] Synthesis of Peptidoglycan Fragments on Solid-Phase Supports (2008)
  • Author(s): C. -Y. Huang
  • Organizer: The 9th International Symposium on Organic Reactions
  • Place of Presentation: Chiayi, Taiwan
• [Presentation] Synthesis and Biological Activity of Helicobacter pylori Lipopolysaccharide Partial Structures (2008)
  • Author(s): A. Shimoyama
  • Organizer: Glycobiology2008
  • Place of Presentation: Fort Worth, U. S. A.
• [Presentation] Synthesis and Immunostimulatory Activities of Lipopeptides from Gram-positive Bacteria (2008)
  • Author(s): M. Katsumoto
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
• [Presentation] 高度好熱菌Thermus thermophilus由来糖脂質の合成と免疫刺激活性 (2008)
  • Author(s): 光延邦浩
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 横浜
• [Presentation] Synthesis of Biofunctional Molecules Using Microfluidic Systems (2008)
  • Author(s): Y. Mori
  • Organizer: International Symposium on Micro Chemical Process and Synthesis
  • Place of Presentation: Kyoto
• [Presentation] Synthetic study of bacterial glycoconjugates for understanding the molecular basis of innate immune system (2008)
  • Author(s): Y. Fujimoto
  • Organizer: The 22nd Naito Conference on “Chemical Biology
  • Place of Presentation: Sapporo
• [Presentation] ヘリコバクター・ピロリ細胞表層成分リポ多糖部分構造の合成 (2008)
  • Author(s): 下山敦史
  • Organizer: FCCAセミナー/FCCAグライコサイェンス若手フォーラム
  • Place of Presentation: 筑波
• [Presentation] 自然免疫活性化機構の解明を目指したヘリコバクター・ピロリ細胞表層成分リポ多糖部分構造の合成 (2008)
  • Author(s): 下山敦史
  • Organizer: 第28回日本糖質学会年会
  • Place of Presentation: つくば
• [Presentation] 免疫刺激活性を持つグラム陽性菌由来リポペプチドの合成研究 (2008)
  • Author(s): 勝本麻美
  • Organizer: 41回 若手ペプチド夏の勉強会
  • Place of Presentation: 京都
• [Presentation] Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) for investigation of their biological functions (2008)
  • Author(s): Y. Fujimoto
  • Organizer: 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS2008)
  • Place of Presentation: Edinburgh, UK
• [Presentation] Synthesis of Helicohacter pylori Lipopolysaccharide Partial Structures for Investigation of Their Biological Function (2008)
  • Author(s): A. Shimoyama
  • Organizer: 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society (IEIIS2008)
  • Place of Presentation: Edinburgh, UK
• [Presentation] Synthesis of immunostimulatory peptidoglycan fragments recognized by the intracellular receptors (2008)
  • Author(s): Y. Fujimoto
  • Organizer: The International Conference on Biodiversity and Natural Products ((IUPAC) ICOB-6 and ISCN P-26)
  • Place of Presentation: Charlottetown, Canada
• [Presentation] 免疫刺激活性を持つペプチドグリカン部分構造の合成 (2008)
  • Author(s): 大塚祐治
  • Organizer: 第43回 天然物化学談話会
  • Place of Presentation: 大阪
• [Presentation] Isolation and Structure Elucidation of Immunostimulatory Native Nodl Ligands (2008)
  • Author(s): A. R. Pradipta
  • Organizer: Strasbourg Delegates for Joint Symposium in Osaka, 2008
  • Place of Presentation: Osaka
• [Presentation] Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures for Investigation of Their Biological Function (2008)
  • Author(s): A. Shimoyama
  • Organizer: Strasbourg Delegates for Joint Symposium in Osaka, 2008
  • Place of Presentation: Osaka
• [Presentation] グラム陽性菌由来Toll様受容体2 (TLR2) のリガンド同定を目指したリポペプチドの合成研究 (2008)
  • Author(s): 勝本麻美
  • Organizer: 日本ケミカルバイオロジー研究会 第3回年会
  • Place of Presentation: 東京
• [Presentation] meso-ジアミノピメリン酸の新規合成法の開発とグラム陰性菌ペプチドグリカン部分構造の合成 (2007)
  • Author(s): 川崎彰子
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 2007-11-07
• [Presentation] Synthesis of Phosphoglycolipid from Thermus thermophilus HB8 with-Selective Glycosylation (2007)
  • Author(s): Y. Fujimoto
  • Organizer: The Fourth International Symposium on Integrated Synthesis
  • Place of Presentation: Hikone, Japan
  • Year and Date: 2007-09-23
• [Presentation] 高度好熱菌Thermus thermophilus糖脂質の全合成と免疫刺激活性 (2007)
  • Author(s): 藤本ゆかり
  • Organizer: 第49回天然有機化合物討論会
  • Place of Presentation: 札幌
  • Year and Date: 2007-09-19
• [Presentation] 生体内の情報伝達に関わる鍵化合物の合成と機能解析 (2007)
  • Author(s): 藤本ゆかり
  • Organizer: 第24回 有機合成セミナー
  • Place of Presentation: 淡路
  • Year and Date: 2007-09-12
• [Presentation] Synthesis of Helicobacter pylori lipopolysaccharide (LPS) partial structures, which regulate the host's innate immune activation (2007)
  • Author(s): A. Shimoyama
  • Organizer: 5th HGPI meeting/2nd Japanese/German Joint Meeting
  • Place of Presentation: Lubeck, Germany
  • Year and Date: 2007-09-03
• [Presentation] Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structure for the Elucidation of the Innate Immune Activation (2007)
  • Author(s): A. Shimoyama
  • Organizer: 14th European Carbohydrate Symposium
  • Place of Presentation: Lubeck, Germany
  • Year and Date: 2007-09-02
• [Presentation] Synthesis of immunostimulating peptidoglycan fragments recognized by intracellular receptor. (2007)
  • Author(s): Yukari Fujimoto
  • Organizer: American Chemical Society 234th National Meeting & Exposition
  • Place of Presentation: Boston,USA
  • Year and Date: 2007-08-23
• [Presentation] 免疫活性化機構解明を目指した細菌細胞壁ペプチドグリカン部分構造の合成 (2007)
  • Author(s): 小西康子
  • Organizer: 第40回若手ペプチド夏の勉強会
  • Place of Presentation: 小樽
  • Year and Date: 2007-08-05
• [Presentation] 免疫活性化機構解明を目指した細菌細胞壁ペプチドグリカン部分構造の合成 (2007)
  • Author(s): 川崎彰子
  • Organizer: 第27回日本糖質学会年会
  • Place of Presentation: 博多
  • Year and Date: 2007-08-01
• [Presentation] 自然免疫活性化機構解明を目指したリポ多糖部分構造と標識体の合成 (2007)
  • Author(s): 下山敦史
  • Organizer: 第34回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-27
• [Presentation] 高度好熱菌Thermus thermophilus糖脂質の合成と免疫刺激活性 (2007)
  • Author(s): 光延邦浩
  • Organizer: 第34回有機反応懇談会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-27
• [Presentation] Synthesis and Immunoregulatory Activity of LipopolysaccharidePartial Structures for the Elucidation of the Receptor Recognition (2007)
  • Author(s): A. Shimoyama
  • Organizer: The 27th Sapporo Cancer Seminar International Symposium
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2007-07-11
• [Presentation] 高度好熱菌Thermus thermophilus糖脂質の合成と免疫刺激活性 (2007)
  • Author(s): 光延邦浩
  • Organizer: 第42回天然化学談話会
  • Place of Presentation: 仙台
  • Year and Date: 2007-07-11
• [Presentation] 自然免疫を活性化する分子-細菌由来複合糖質の合成と機能解析 (2007)
  • Author(s): 藤本ゆかり
  • Organizer: セミナー"化学千一夜"「あすの化学への夢を語ろう」
  • Place of Presentation: 生駒
  • Year and Date: 2007-06-08
• [Presentation] ペプチドグリカン受容体Nod1の機能解明を目指したリガンドの活性増強と蛍光標識体の合成 (2007)
  • Author(s): 川崎彰子
  • Organizer: 日本ケミカルバイオロジー研究会 第2回年会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-09
• [Presentation] 自然免疫活性化機構解明を目指したリポ多糖部分構造及びその標識体の合成 (2007)
  • Author(s): 下山敦史
  • Organizer: 日本ケミカルバイオロジー研究会 第2回年会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-09
• [Presentation] 高度好熱菌Thermus thermophilus糖脂質の全合成と免疫刺激活性 (2007)
  • Author(s): 藤本ゆかり
  • Organizer: 第49回天然有機化合物討論会
  • Place of Presentation: 札幌コンベンションセンター,北海道
• [Presentation] 生体内の情報伝達に関わる鍵化合物の合成と機能解析 (2007)
  • Author(s): 藤本ゆかり
  • Organizer: 第24回有機合成化学セミナー
  • Place of Presentation: 淡路夢舞台国際会議場,兵庫
• [Presentation] Synthesis of immunostimulating peptidoglycan fragments recognized by intracellular receptor (2007)
  • Author(s): 藤本ゆかり
  • Organizer: The 216th American Chemical Society (ACS) National Meeting
  • Place of Presentation: Boston, USA
• [Book] Methods in Enzymology ; Self and non-self recognition with bacterial and animal glycans, surveys by synthetic chemistry.(Minoru Fukuda Ed.) (2010)
  • Author(s): Fujimoto, Y., Tanaka, K., Shimoyama, A., Fukase, K.
  • Publisher: Elsevier
• [Book] Chemical synthesis of bacterial lipid A. In Microbial Glycobiology : Structures, Relevance and Applications, Anthon Moran, Otto Holst, Patrick J Brennan,(Mark von Itzstein Eds.)London (2009)
  • Author(s): Kusumoto, S., Fukase, K., Fujimoto, Y.
  • Publisher: Elsevier
• [Book] Synthesis and biofunctional studies of bacterial immunostimulating glycoconjugates. In Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides.(Nikolay E. Nifantiev Ed.) (2009)
  • Author(s): Fukase, K., Fujimoto, Y.
  • Publisher: Research Signpost and Transworld Research Network
• [Book] Chemical synthesis of bacterial lipid A. In Microbial Glycobiology : Structures, Relevance and Applications (2009)
  • Author(s): Kusumoto, S.
  • Total Pages: 13
  • Publisher: Elsevier
• [Book] Synthesis and biofunctional studies of bacterial immunostimulating glycoconjugates. In Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides. (2009)
  • Author(s): Fukase, K.
  • Total Pages: 30
  • Publisher: Research Signpost and Transworld Research Network
• [Book] Glycoscience 2008 (2009)
  • Author(s): Tanaka, K, Fujimoto., Y. Tanaka, S., Mori, T., Fukase, K.
  • Publisher: Springer-Veriag(in press)
• [Book] Chemical Synthesis of Sugar Chains In Experimental Glycoscience, "Glycochemistry"(Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. Eds.)London (2008)
  • Author(s): Fukase, K., Fujimoto, Y., Tanaka, K.
  • Publisher: Springer-Verlag
• [Book] Combinatorial methods on oligosaccharide synthesis. In Glycoscience, 2nd ed. Chemistry and Chemical Biology(Fraser-Reid, B.O., Tatsuta, K., Thiem, J., Cote, G.L., Flitsch, S., Ito, Y., Kondo, H., Nishimura, S.-i., Yu, B., Eds.)Berlin (2008)
  • Author(s): Tanaka, K., Fujimoto, Y., Tanaka, S., Mori, Y., Fukase, K.
  • Publisher: Springer-Verlag
• [Book] Experimental Glycoscience (2008)
  • Author(s): Fukase, K., Fujimoto, Y., Tanaka, K.
  • Total Pages: 6
  • Publisher: Springer-Verlag
• [Book] Synthesis of Lipopolysaccharide, Peptidoglycan and Lipoteichoic Acid Fragments. In Comprehensive Glycoscience: From Chemistry to Systems Biology(Kamerling, J. P., Boons, G-J., Lee, Y. C., Suzuki, A., Taniguchi, N., Eds.)London (2007)
  • Author(s): Kusumoto, S., Fukase, K., Fujimoto, Y.
  • Publisher: Elsevier
• [Book] Meso-diaminopimelic acid and meso-lanthionine, amino acids peculiar to bacterial cell wall peptidoglycans, activate human epithelial cells in culture via NOD1. In Interface Oral Health Science 2007(Watanabe, M., Okuno, O., Eds.)Tokyo (2007)
  • Author(s): Uehara, A., Fujimoto, Y., Kawasaki, A., Fukase, K., Takada, H.
  • Publisher: Springer
• [Book] Expression of various Toll-like receptors, NOD1, and NOD2, in human oral epithelial cells, and their function. In Interface Oral Health Science 2007(Watanabe, M., Okuno, O., Eds.)Tokyo (2007)
  • Author(s): Sugawara, Y., Uehara, A., Fujimoto, Y., Kawasaki, A., Fukase, K., Sasano, T., Takada, H.
  • Publisher: Springer
• [Book] Comprehensive Glycoscience; "Synthesis of Lipopolysaccharide, Peptidoglycan and Lipoteichoic Acid Fragments" (2007)
  • Author(s): Shoichi Kusumoto
  • Total Pages: 26
  • Publisher: Elsevier(London)
• [Book] Glycoscience 2007 "Combinatorial methods on oligosaccharide synthesis" (2007)
  • Author(s): Katsuori Tanaka
  • Publisher: Springer-Verlag(Berlin)(In press)