| Project/Area Number |
19330164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
WATANABE Masataka Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 特任研究員 (50092383)
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| Co-Investigator(Kenkyū-buntansha) |
KODAMA Tohru 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 (20195746)
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| Co-Investigator(Renkei-kenkyūsha) |
HONNDA Yoshiko 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (50142154)
KOJIMA Takashi 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (30225429)
KUWAHATA Taku 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (70415537)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | がまん / サル / 前頭連合野 / ニューロン / 神経伝達物質 / セルフコントロール / リタリン / ADHD / ゴーノーゴー課題 |
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| Research Abstract |
Recently, both young and old people do not have enough patience. There are two kinds of patience ; one is to give up immediate small reward for later and much larger reward, and the other is to inhibit predominant response tendency to follow the social or moral rule. The prefrontal cortex plays important roles in the control of patience behavior. Primate prefrontal neurons show activity changes in relation to patience behavior. Methylphenidate (Ritalin) is known to control patience behavior in ADHD patients. Application of this drug to the monkey induced improvement in self-control behavior as well as inducing increase in dopamine release in the prefrontal cortex and striatum.
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