Development of Chiral Bronsted Acid Catalysts
Project/Area Number |
19350026
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Organic chemistry
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Research Institution | Gakushuin University |
Principal Investigator |
AKIYAMA Takahiko Gakushuin University, 理学部, 教授 (60202553)
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Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
|
Keywords | 不斉合成 / 有機合成化学 / 触媒 / エナンチオ選択性 / リン酸 / キラルブレンステッド酸 / 有機触媒 / インドール / Friedel-Craftsアルキル化反応 / 速度論的光学分割 / アルドール反応 / 非対称化 / イミン / 含窒素化合物 / 量子化学計算 |
Research Abstract |
Asymmetric reactions by means of chiral phosphoric acid derived from (R)-BINOL as chiral Bronsted acid were investigated. Transfer hydrogenation reaction was achieved by use of a novel hydrogen donor. In order to expand the scope of the chiral phosphoric acid catalyzed reactions, intramolecular aldol reaction was studied and the corresponding cyclohexenone were obtained with excellent enantioselectivities.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Chiral Phosphoric Acid Catalyzed Desymmetrization of meso-1, 3-Diones : Asymmetric Synthesis of Chiral Cyclohexenones2010
Author(s)
Mori, K., Katoh, T., Suzuki, T., Noji, T., Yamanaka, M., Akiyama, T.
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Journal Title
Angew.Chem.Int.Ed. 48
Pages: 9652-9654
Related Report
Peer Reviewed
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