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Development of highly-sensitive immunosensors for detecting multi-analytes

Research Project

Project/Area Number 19350044
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Analytical chemistry
Research InstitutionUniversity of Hyogo

Principal Investigator

MIZUTANI Fumio  University of Hyogo, 大学院・物質理学研究科, 教授 (80118603)

Co-Investigator(Kenkyū-buntansha) 丹羽 修  産業技術総合研究所, 生物機能工学研究部門, 研究副部門長 (70392644)
栗田 僚二  産業技術総合研究所, 生物機能工学研究部門, 研究員 (50415676)
久本 秀明  大阪府立大学, 大学院・工学研究科, 准教授 (00286642)
Co-Investigator(Renkei-kenkyūsha) NIWA Osamu  独立行政法人産業技術総合研究所, バイオメディカル研究部門, 副研究部門長 (70392644)
KURITA Ryoji  独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究員 (50415676)
HISAMOTO Hideaki  大阪府立大学, 工学研究科, 教授 (00286642)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywords化学センサー / 免疫センサー / 疾病マーカー / マイクロ分析 / バイオセンサー / 化学増幅 / 多項目測定 / 簡易測定 / マイクロチップ / 高感度測定 / 電気化学 / 酵素免疫測定 / ペプチドホルモン
Research Abstract

Highly-sensitive, simple and rapid immunoassay systems have been prepared for the determination of multianalyte involving biomarkers whose concentrations in biological fluids are as low as pM-levels. Chemical amplification techniques have been developed and used for enhancing the sensitivity, and microfluidic devices have been employed for serving simple and rapid assay procedure. A "drop-and-sip" fluid-handling technique and a particle-manipulation technique based on dielectrophoresis have successfully applied for developing pump-free immunosensing devices.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (128 results)

All 2010 2009 2008 2007 Other

All Journal Article (45 results) (of which Peer Reviewed: 40 results) Presentation (78 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Competitive multi-immunosensing of pesticides based on the particle manipulation with negative-dielectrophores2010

    • Author(s)
      Ramon-Azcon Javier、安川智之、Hyun Jung Lee、末永智一、Francisco Sanchez-Baeza、Maria-Pilar Marco、水谷文雄
    • Journal Title

      Biosens. Bioelectron. Vol.25

      Pages: 1928-1933

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid and simple immunosensing system for simultaneous detection of tumor markers based on negative-dielectrophoretic manipulation of microparticles2010

    • Author(s)
      Hyun Jung Lee、Sang Hyun Lee、安川智之、Ramon-Azcon Javier、水谷文雄、伊野浩介、珠玖仁、末永智一
    • Journal Title

      Talanta Vol.81

      Pages: 657-663

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemical monitoring of hydrogen peroxide released from leucocytes on horseradish peroxidise redox polymer coated electrode chip2010

    • Author(s)
      井上久美、伊野浩介、珠玖仁、葛西重信、安川智之、水谷文雄、末永智一
    • Journal Title

      Biosens. Bioelectron. Vol.25

      Pages: 1723-1728

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly sensitive determination of N1, N12-diacetylspermine based on electrochemical charge accumulation2010

    • Author(s)
      安川智之、稲積伸悟、原田理恵、品川真吾、能勢博、水谷文雄
    • Journal Title

      Chem. Lett. Vol.39

      Pages: 88-89

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of immunosensors using a microfluidic device with an interdigitated array electrode modified with antibodies2010

    • Author(s)
      平野悠、安川智之、沢屋敷吉弘、珠玖仁、水谷文雄、末永智一
    • Journal Title

      Electrochemistry Vol.78

      Pages: 175-177

    • NAID

      130002150585

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly sensitive determination of N^1, N^<12>-diacetylspermine based on electrochemical charge accumulation2010

    • Author(s)
      安川智之, 稲積伸悟, 原田理恵, 品川真吾, 能勢博, 水谷文雄
    • Journal Title

      Chemistry Letters Vol.39

      Pages: 88-89

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of immunosensors using a microfluidic device with an interdigitated array electrode modified with antibodies2010

    • Author(s)
      平野悠, 安川智之, 沢屋敷吉弘, 珠玖仁, 水谷文雄, 末永智一
    • Journal Title

      Electrochemistry Vol.78

      Pages: 175-177

    • NAID

      130002150585

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemical monitoring of hydrogen peroxide released from leucocytes on horseradish peroxidise redox polymer coated electrode chip2010

    • Author(s)
      井上久美, 伊野浩介, 珠玖仁, 葛西重信, 安川智之, 水谷文雄, 末永智一
    • Journal Title

      Biosensors and Bioelectronics Vol.25

      Pages: 1723-1728

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid and simple immunosensing system for simultaneous detection of tumor markers based on negative-dielectrophoretic manipulation of microparticles2010

    • Author(s)
      H.J.Lee, S.H.Lee, 安川智之, J.Ramon-Azcon, 水谷文雄, 伊野浩介, 珠玖仁, 末永智一
    • Journal Title

      Talanta Vol.81

      Pages: 657-663

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzyme-Release Capillary as a Facile Enzymatic Biosensing Parts for Capillary-Assembled Microchip2009

    • Author(s)
      Terence G. Henares、前川英治、大久保文人、水谷文雄、関澤隆一、八尾俊男、久本秀明
    • Journal Title

      Anal. Sci. Vol.25

      Pages: 1025-1028

    • NAID

      10025214172

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of a surface-modified poly(dimethysiloxane) layer for the preparation of amperometric glucose sensor2009

    • Author(s)
      前川英治、北野奈央、安川智之、水谷文雄
    • Journal Title

      Electrochemistry Vol.77

      Pages: 319-321

    • NAID

      10024973368

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 酸素および過酸化水素のポリジメチルシロキサン膜透渦性を利用するアンペロメトリックグルコースセンサー2009

    • Author(s)
      安川智之, 前川英治, 水谷文雄
    • Journal Title

      分析化学 58巻

      Pages: 639-644

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of surface- modified poly(dimethylsiloxane)layer for the preparation of amperometric glucose sensor2009

    • Author(s)
      前川英治, 北野奈央, 安川智之, 水谷文雄
    • Journal Title

      Electrochemistry Vol.77

      Pages: 319-321

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzyme-release capillary as a facile enzymatic biosensing part for a Capillary-assembled microchip2009

    • Author(s)
      T.G.Henares, 前川英治, 大久保文人, 水谷文雄, 八尾俊男, 関澤隆一, 久本秀明
    • Journal Title

      Analytical Sciences Vol.25

      Pages: 1025-1028

    • NAID

      10025214172

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immobilization of glucose oxidase on poly(dimethylsiloxane)layer by using poly(L-lysine)as a polymer backbone2009

    • Author(s)
      安川智之, 前川英治, 水谷文雄
    • Journal Title

      Analytical Sciences Vol.25

      Pages: 1159-1162

    • NAID

      10025622951

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cisplatin-based DNA sensing with enhanced current response2009

    • Author(s)
      吉本有希, 安川智之, 水谷文雄
    • Journal Title

      Analyst Vol.134

      Pages: 2113-2117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzyme immunoassay of insulin at picomolar levels based on the coulometric determination of hydrogen peroxide2008

    • Author(s)
      水谷文雄、太田栄次、三重安弘、丹羽修、安川智之
    • Journal Title

      Sensors Actuators B Vol.135

      Pages: 304-308

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Highly-sensitive biosensors with chemically-amplified responses2008

    • Author(s)
      水谷文雄、加藤大、栗田僚二、三重安弘、佐藤縁、丹羽修
    • Journal Title

      Electrochemistry Vol.78

      Pages: 515-521

    • NAID

      10021027597

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single drop analysis of various proteases in a cancer cell lysate using capillary-assembled Mmcrochip2008

    • Author(s)
      Terence G. Henares、水谷文雄、関澤隆一、久本秀明
    • Journal Title

      Anal. Bioanal. Chem. Vol.391

      Pages: 2507-2512

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparisons of enzymatic recycling electrodes to measure aminophenol for developing highly sensitive assay system of atrial natriuretic peptides2008

    • Author(s)
      三重安弘、小綿恵子、平野悠、丹羽修、水谷文雄
    • Journal Title

      Anal. Sci. Vol.24

      Pages: 577-582

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface modification of thin polyion complex film for surface plasmon resonance immunosensor2008

    • Author(s)
      栗田僚二、平田芳樹、矢吹聡一、横田淑美、加藤大、佐藤縁、水谷文雄、丹羽修
    • Journal Title

      Sensors Actuators B Vol.130

      Pages: 320-325

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biosensors utilizing monolayers on electrode surfaces2008

    • Author(s)
      水谷文雄
    • Journal Title

      Sensors Actuators B Vol.130

      Pages: 14-20

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Drop-and-Sip" fluid handling technique for the reagent-release capillary (RRC)-based capillary-assembled microchip (CAs-CHIP): Sample delivery optimization and reagent release behavior in RRC2008

    • Author(s)
      Terence G. Henares、水谷文雄、関澤隆一、久本秀明
    • Journal Title

      Anal. Sci. Vol.24

      Pages: 127-132

    • NAID

      10020143686

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current development in microfluidic immunosensing chip2008

    • Author(s)
      Terence G. Henares、水谷文雄、久本秀明
    • Journal Title

      Anal. Chim. Acta Vol.611

      Pages: 17-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] バイオセンサの高感度化と化学増幅2008

    • Author(s)
      水谷文雄
    • Journal Title

      マテリアルインテグレーション Vol.21、No.5

      Pages: 174-180

    • Related Report
      2009 Final Research Report
  • [Journal Article] バイオセンシング技術の最新動向2008

    • Author(s)
      水谷文雄
    • Journal Title

      化学工学 Vol.72、No.9

      Pages: 456-459

    • NAID

      10021982171

    • Related Report
      2009 Final Research Report
  • [Journal Article] バイオチップの走査型電気顕微鏡解析2008

    • Author(s)
      安川智之、珠玖仁、水谷文雄、末永智一
    • Journal Title

      表面技術 Vol.59、No.12

      Pages: 818-824

    • Related Report
      2009 Final Research Report
  • [Journal Article] Comparison of Enzymatic Recycling Electrodes for Measuring Aminophenol : Development of a Highly Sensitive Natriuretic Peptide Assay System2008

    • Author(s)
      三重安弘, 他
    • Journal Title

      Analytical Sciences 24

      Pages: 577-582

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly-sensitive Biosensors with Chemically-amplified Responses2008

    • Author(s)
      水谷文雄, 他
    • Journal Title

      Electrochemistry 76

      Pages: 515-521

    • NAID

      130002150719

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-drop Analysis of Various Proteases in a Cancer Cell Lysate Using a Capillary-assembled Microchip2008

    • Author(s)
      Terence G. Henares, 他
    • Journal Title

      Analytical and Bioanalytical Chemistry 391

      Pages: 2507-2512

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current Development in Microfluidic Immunosensing Chip2008

    • Author(s)
      Terence G. Henares, 他
    • Journal Title

      Analytica Chemica Acta 611

      Pages: 17-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオセンシング技術の最新動向2008

    • Author(s)
      水谷文雄
    • Journal Title

      化学工学 72

      Pages: 456-459

    • NAID

      10021982171

    • Related Report
      2008 Annual Research Report
  • [Journal Article] バイオチップの走査型電気化学顕微鏡解析2008

    • Author(s)
      安川智之, 他
    • Journal Title

      表面技術 59

      Pages: 818-824

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Enzyme Immunoassay of Insulin at Picomolar Levels Based on the Coulometric Determination of Hydrogen Peroxide2008

    • Author(s)
      水谷文雄, 他
    • Journal Title

      Sensors and Actuators B 135

      Pages: 304-308

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Drop-and-Sip" Fluid Handling Technique for the Reagent-Release Capillary(RRC)-based Capillary-Assembled Microchip(CAs-CHIP):Sample Delivery Optimization and Reagent Release Behavior in RRC2008

    • Author(s)
      Terence G. Henares, 他
    • Journal Title

      Analytical Sciences 24

      Pages: 127-132

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosensors Utilizing Monolayers on Electrode Surfaces2008

    • Author(s)
      水谷 文雄
    • Journal Title

      Sensors and Actuators, B 130

      Pages: 14-20

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface Modification of Thin Polyion Complex Film for Surface Plasmon Immunosensor2008

    • Author(s)
      栗田 僚二, 他
    • Journal Title

      Sensors and Actuators, B 130

      Pages: 320-325

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Capillary-assembled microchip for the electrochemical determination of glucose2007

    • Author(s)
      稲積伸悟、久本秀明、水谷文雄
    • Journal Title

      Chem. Lett. Vol.36

      Pages: 1242-1243

    • NAID

      10019961693

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of hydrogen peroxide based on the charge accumulation and electrochemical reduction at an osmium complex/peroxidase-coated electrode2007

    • Author(s)
      水谷文雄、太田栄次、三重安弘、丹羽修
    • Journal Title

      Chem. Lett. Vol.36

      Pages: 1148-1149

    • NAID

      10019845872

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of capillary immunosensor for the capillary-assembled microchip (CAs-CHIP) integration2007

    • Author(s)
      Terence G. Henares、水谷文雄、関澤隆一、久本秀明
    • Journal Title

      Sens. Mat. Vol.19

      Pages: 249-259

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple enzyme linked immunosorbent assay system on a capillary-assembled microchip integrating valving and immuno-reaction functions2007

    • Author(s)
      Terence G. Henares、舩野俊一、寺部茂、水谷文雄、関澤隆一、久本秀明
    • Journal Title

      Anal. Chim. Acta Vol.589

      Pages: 173-179

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integration of multi-analyte sensing functions on a capillary-assembled microtip: simultaneous determination of ion concentration and enzymatic activities by "drop-and sip" technique2007

    • Author(s)
      Terence G. Henares, 、高石雅之、吉田直矢、寺部茂、水谷文雄、関澤隆一、久本秀明
    • Journal Title

      Anal. Chem. Vol.79

      Pages: 908-915

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Determination of Hydrogen Peroxide Based on the Charge Accumulation and Electrochemical Reduction at an Osmium Complex/Peroxidase-coated Electrode2007

    • Author(s)
      水谷 文雄, 他
    • Journal Title

      Chemistry Letters 36

      Pages: 1148-1149

    • NAID

      10019845872

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Capillary-assembled Microchip for the Electrochemical Determination of Glucose2007

    • Author(s)
      稲積 伸悟, 他
    • Journal Title

      Chemistry Letters 36

      Pages: 1242-1243

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of the apparent Michaelis constant of glucose oxidase immobilized on a microelectrode with respect to oxygen

    • Author(s)
      安川智之、後藤圭佑、水谷文雄
    • Journal Title

      Electroanalysis (印刷中)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Negative-dielectrophoresis to develop an immunodevice for analysis of pesticides residues in food2010

    • Author(s)
      Ramon-Azcon Javier, 他
    • Organizer
      第49回化学センサ研究発表会
    • Place of Presentation
      富山
    • Related Report
      2009 Final Research Report
  • [Presentation] 変換ストリッピングを利用した高感度免疫測定法の開発2010

    • Author(s)
      安川智之, 他
    • Organizer
      電気化学会第77回大会
    • Place of Presentation
      富山
    • Related Report
      2009 Final Research Report
  • [Presentation] 変換ストリッピング法を応用した免疫測定の高感度化2010

    • Author(s)
      吉本芳美, 他
    • Organizer
      表面技術協会第121講演大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 微粒子マニピュレーションによる迅速なイムノセンシング2010

    • Author(s)
      安川智之, 他
    • Organizer
      日本機械学会第22回バイオエンジニアリング講演会
    • Place of Presentation
      岡山
    • Related Report
      2009 Final Research Report
  • [Presentation] 変換ストリッピング法を応用した免疫測定の高感度化2010

    • Author(s)
      吉本芳美, 井口美帆, 安川智之, 水谷文雄
    • Organizer
      表面技術協会第121講演大会
    • Place of Presentation
      成蹊大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 変換ストリッピングを利用した高感度免疫測定法の開発2010

    • Author(s)
      安川智之, 吉本芳美, 水谷文雄
    • Organizer
      電気化学会第77回大会
    • Place of Presentation
      富山大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 電化蓄積法を利用した高感度ジアチルスペルミン計測2009

    • Author(s)
      安川智之, 他
    • Organizer
      電気化学会第76回大会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Enzyme Immunoassay of Insulin at Picomolar Levels Based on the Coulometeric Hydrogen Peroxide Determination2009

    • Author(s)
      水谷文雄, 他
    • Organizer
      8th Asian Conference on Chemical Sensors
    • Place of Presentation
      Daegu(韓国)
    • Related Report
      2009 Final Research Report
  • [Presentation] 微粒子表面に固定化されたグルコースオキシダーゼの高感度電気化学計測2009

    • Author(s)
      吉田悠亮, 他
    • Organizer
      第20回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      金沢
    • Related Report
      2009 Final Research Report
  • [Presentation] 微粒子配列技術による迅速な免疫反応と電気化学計測2009

    • Author(s)
      吉田悠亮, 他
    • Organizer
      分析化学会第58年会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] 尿中腫瘍マーカーの高感度計測とクレアチニンセンサによる補正2009

    • Author(s)
      原田理恵, 他
    • Organizer
      分析化学会第58年会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] 微粒子配列化による迅速性と電荷蓄積による高感度化を融合した免疫センサ2009

    • Author(s)
      安川智之, 他
    • Organizer
      第48化学センサ研究発表会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 尿中ジアセチルスペルミンとクレアチニンの同時測定2009

    • Author(s)
      水谷文雄, 他
    • Organizer
      2009年電気化学秋季大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 微粒子操作技術による迅速な免疫測定2009

    • Author(s)
      安川智之, 他
    • Organizer
      東京コンファレンス2009
    • Place of Presentation
      千葉
    • Related Report
      2009 Final Research Report
  • [Presentation] 誘電泳動による免疫反応を介した微粒子の捕捉とその電気化学検出2009

    • Author(s)
      吉田悠亮, 他
    • Organizer
      第19回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] 誘電泳動による微粒子集積化技術の免疫測定への応用2009

    • Author(s)
      安川智之, 他
    • Organizer
      第19回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] 誘電泳動による微粒子の迅速配列法を用いた免疫測定2009

    • Author(s)
      安川智之, 他
    • Organizer
      第70回分析化学討論会
    • Place of Presentation
      和歌山
    • Related Report
      2009 Final Research Report
  • [Presentation] 過酸化水素の高感度クーロメトリックセンサを利用したpMレベルのインスリンの免疫測定2009

    • Author(s)
      水谷文雄, 他
    • Organizer
      第70回分析化学討論会
    • Place of Presentation
      和歌山
    • Related Report
      2009 Final Research Report
  • [Presentation] 電荷蓄積法を利用した高感度N1, N12-ジアセチルスペルミン計測2009

    • Author(s)
      安川智之, 他
    • Organizer
      電気化学会第76回大会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 過酸化水素の高感度クーロメトリックセンサを利用したpMレベルのインスリンの免疫測定2009

    • Author(s)
      水谷文雄, 太田栄次, 稲積伸悟, 安川智之
    • Organizer
      第70回分析化学討論会
    • Place of Presentation
      和歌山大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 誘電泳動による微粒子の迅速配列法を用いた免疫測定2009

    • Author(s)
      安川智之, 吉田悠亮, Lee Hyun Jung, 末永智一, 水谷文雄
    • Organizer
      第70回分析化学討論会
    • Place of Presentation
      和歌山大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 誘電泳動による微粒子集積化技術の免疫測定への応用2009

    • Author(s)
      安川智之, Hyun Jung Lee, 珠玖仁, 末永智一, 水谷文雄
    • Organizer
      第19回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      広島大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 誘電泳動による免疫反応を介した微粒子の捕捉とその電気化学検出2009

    • Author(s)
      吉田悠亮, 安川智之, 水谷文雄
    • Organizer
      第19回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      広島大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 微粒子操作技術による迅速な免疫測定2009

    • Author(s)
      安川智之, 吉田悠亮, Javier Ramon-Azcon, 水谷文雄
    • Organizer
      東京コンファレンス2009
    • Place of Presentation
      幕張メッセ
    • Related Report
      2009 Annual Research Report
  • [Presentation] 尿中ジアセチルスペルミンとクレアチニンの同時測定2009

    • Author(s)
      水谷文雄, 原田理恵, 稲積伸悟, 品川真吾, 能勢博, 安川智之
    • Organizer
      2009年電気化学秋季大会
    • Place of Presentation
      東京農工大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 微粒子配列化による迅速性と電荷蓄積による高感度化を融合した免疫センサ2009

    • Author(s)
      安川智之, 吉田悠亮, Javier Ramon-Azcon, 末永智一, 水谷文雄
    • Organizer
      第48化学センサ研究発表会
    • Place of Presentation
      東京農工大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 尿中腫瘍マーカーの高感度計測とクレアチニンセンサによる補正2009

    • Author(s)
      原田理恵, 稲積伸悟, 品川真吾, 能勢博, 安川智之, 水谷文雄
    • Organizer
      分析化学会第58年会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 微粒子配列技術による迅速な免疫反応と電気化学計測2009

    • Author(s)
      吉田悠亮, Ramon-Azcon Javier, 安川智之, 水谷文雄
    • Organizer
      分析化学会第58年会
    • Place of Presentation
      北海道大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 微粒子表面に固定化されたグルコースオキシダーゼの高感度電気化学計測2009

    • Author(s)
      吉田悠亮, Ramon-Azcon Javier, 安川智之, 水谷文雄
    • Organizer
      第20回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      金沢大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Enzyme Immunoassay of Insulin at Picomolar Levels Based on the Coulometeric Hydrogen Peroxide Determination2009

    • Author(s)
      水谷文雄, 太田栄次, 稲積伸悟, 安川智之
    • Organizer
      8th Asian Conference on Chemical Sensors
    • Place of Presentation
      韓国 Daegu 市コンベンションセンター
    • Related Report
      2009 Annual Research Report
  • [Presentation] バイオセンサの新展開2009

    • Author(s)
      水谷文雄
    • Organizer
      フォトニクス技術フォーラム合同研究会 第3回光情報技術研究会, 第3回次世代光学素子研究会
    • Place of Presentation
      大阪科学技術センター
    • Related Report
      2009 Annual Research Report
  • [Presentation] Enzyme Immunoassay for Insulin Using Highly-sensitive Hydrogen Peroxide Sensors Based on Charge Accumulation Systems2008

    • Author(s)
      安川智之, 他
    • Organizer
      Joint International Meeting : 214^<th> Meeting of ECS and 2008 Fall Meeting of ECSJ (PRiME 2008)
    • Place of Presentation
      ホノルル
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Measurement of Enzyme Activity Based on Charge Accumulation Systems for Sensitive Immunoassay2008

    • Author(s)
      稲積伸悟, 他
    • Organizer
      Joint International Meeting : 214^<th> Meeting of ECS and 2008 Fall Meeting of ECSJ (PRiME 2008)
    • Place of Presentation
      ホノルル
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Electrochemical Enzyme Immunosensing System for a Cardiac Marker Based on Enzymatic Amplification by Glucose Oxidase2008

    • Author(s)
      前川英治, 他
    • Organizer
      Joint International Meeting : 214^<th> Meeting of ECS and 2008 Fall Meeting of ECSJ (PRiME 2008)
    • Place of Presentation
      ホノルル
    • Year and Date
      2008-10-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Multiple Sample Delivery and Caspase-activity Sensing on Capillary-assembled Microchip2008

    • Author(s)
      Terence G. Henares, 他
    • Organizer
      Tokyo Conference 2008, Asian Young Analytical Chemist Session
    • Place of Presentation
      千葉
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 電化蓄積型過酸化水素センサをプラットフォームとする尿中腫瘍マーカーの高感度検出2008

    • Author(s)
      安川智之, 他
    • Organizer
      第46回化学センサ研究発表会
    • Place of Presentation
      沖縄
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Capillary-assembled Microchip (CAs-CHIP) for the Electrochemical Sensing of Glucose2008

    • Author(s)
      水谷文雄, 他
    • Organizer
      12^<th> International Meeting on Chemical Sensors
    • Place of Presentation
      コロンバス
    • Year and Date
      2008-07-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Enzyme Immnunoassay of Insulin at Picomolar Levels Based on the Coulometric Determination of Hydrogen Peroxide2008

    • Author(s)
      水谷文雄, 他
    • Organizer
      12^<th> International Meeting on Chemical Sensors
    • Place of Presentation
      コロンバス
    • Year and Date
      2008-07-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Electrochemical Immunochromatographic Assay of Testosterone Using Nitrocellulose Membrane2008

    • Author(s)
      安川智之, 他
    • Organizer
      12^<th> International Meeting on Chemical Sensors
    • Place of Presentation
      コロンバス
    • Year and Date
      2008-07-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 電化蓄積型過酸化水素計測によるインスリンの高感度免疫計測2008

    • Author(s)
      安川智之, 他
    • Organizer
      第6 9回分析化学討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Higly-sensitive Biosensors with Chemically-amplified Electrochemical Responses2008

    • Author(s)
      水谷文雄, 他
    • Organizer
      6^<th> Asian Conference on Electrochemistry
    • Place of Presentation
      台北
    • Year and Date
      2008-05-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 過酸化水素の高感度クーロメトリック測定と免疫センシングへの応用2008

    • Author(s)
      水谷 文雄, 他
    • Organizer
      第45回化学センサ研究発表会
    • Place of Presentation
      甲府
    • Year and Date
      2008-03-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] マイクロ流路を用いたHRPの局所固定およびその電気化学活性評価2008

    • Author(s)
      稲積 伸悟, 他
    • Organizer
      電気化学会第75会大会
    • Place of Presentation
      甲府
    • Year and Date
      2008-03-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Multiple Protease Activity Sensing in a Single Drop of HeLa Cell Lysate using Capillary Assembled Microchip2008

    • Author(s)
      T. G. Henares, 他
    • Organizer
      22th Intenational Symposium on MicroScale Bioseparations(MSB)
    • Place of Presentation
      ベルリン
    • Year and Date
      2008-03-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Rapid Immunosensing based on microparticle manipuration by negative dielectrophoresis2008

    • Author(s)
      安川智之, 他
    • Organizer
      The IUMRS International Conference in Asia 2008
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] Measurement of Enzyme Activity Based on Charge Accumulation Systems for Sensitive Immunoassay2008

    • Author(s)
      稲積伸悟, 他
    • Organizer
      Joint international meeting: 214th Meeting of ECS - The Electrochemical Society 2008 Fall Meeting of The Electrochemical Society of Japan (PRiME 2008)
    • Place of Presentation
      Honolulu(米国)
    • Related Report
      2009 Final Research Report
  • [Presentation] Enzyme Immunoassay for Insulin Using Highly-Sensitive Hydrogen Peroxide Sensors Based on Charge Accumulation Systems2008

    • Author(s)
      安川智之, 他
    • Organizer
      Joint international meeting: 214th Meeting of ECS - The Electrochemical Society 2008 Fall Meeting of The Electrochemical Society of Japan (PRiME 2008)
    • Place of Presentation
      Honolulu(米国)
    • Related Report
      2009 Final Research Report
  • [Presentation] 銀の電解析出による電荷蓄積法の高感度免疫測定への応用2008

    • Author(s)
      井口美帆, 他
    • Organizer
      日本分析化学会第57年会
    • Place of Presentation
      福岡
    • Related Report
      2009 Final Research Report
  • [Presentation] 電荷蓄積型過酸化水素センサをプラットフォームとする尿中腫瘍マーカーの高感度検出2008

    • Author(s)
      安川智之, 他
    • Organizer
      第46回化学センサ研究発表会
    • Place of Presentation
      沖縄
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of a facile capillary metabolite sensor for capillary-assembled microchip integration2008

    • Author(s)
      Terence G. Henares, 他
    • Organizer
      Tokyo Conference 2008, Asia Young Analytical Chemist Session 2008
    • Place of Presentation
      千葉
    • Related Report
      2009 Final Research Report
  • [Presentation] Electrochemical immunochromatographic assay of testosterone using nitrocellulose membrane2008

    • Author(s)
      安川智之, 他
    • Organizer
      12th International Meeting on Chemical Sensors
    • Place of Presentation
      Columbus(米国)
    • Related Report
      2009 Final Research Report
  • [Presentation] Enzyme immunoassay of insulin at picomolar levels based on the coulometric determination of hydrogen peroxide2008

    • Author(s)
      水谷文雄, 他
    • Organizer
      12th International Meeting on Chemical Sensors
    • Place of Presentation
      Columbus(米国)
    • Related Report
      2009 Final Research Report
  • [Presentation] Capillary-assembled microchip (CAs-CHIP) for the electrochemical sensing of glucose2008

    • Author(s)
      水谷文雄, 他
    • Organizer
      12th International Meeting on Chemical Sensors
    • Place of Presentation
      Columbus(米国)
    • Related Report
      2009 Final Research Report
  • [Presentation] 電荷蓄積型過酸化水素検出によるインスリンの高感度免疫計測2008

    • Author(s)
      安川智之, 他
    • Organizer
      第69回分析化学討論会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] 電気化学的酵素シグナル増幅を用いた心疾患マーカーの酵素免疫測定2008

    • Author(s)
      前川英治
    • Organizer
      第69回分析化学討論会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Highly-sensitive biosensors with chemically-amplified electrochemical responses2008

    • Author(s)
      水谷文雄, 他
    • Organizer
      6th Asian Conference on Electrochemistry
    • Place of Presentation
      台北(台湾)
    • Related Report
      2009 Final Research Report
  • [Presentation] マイクロ流路を用いたHRPの局所固定およびその電気化学活性評価2008

    • Author(s)
      稲積伸悟, 他
    • Organizer
      電気化学会第75回大会
    • Place of Presentation
      山梨
    • Related Report
      2009 Final Research Report
  • [Presentation] 過酸化水素の高感度クーロメトリック測定と免疫センシングへの応用2008

    • Author(s)
      水谷文雄, 他
    • Organizer
      第45回化学センサ研究発表会
    • Place of Presentation
      山梨
    • Related Report
      2009 Final Research Report
  • [Presentation] Single drop analysis of multiple protease activities in HeLa cell lysate by capillary-assembled microchip2008

    • Author(s)
      Terence G Henares, 他
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Multiple protease activity sensing in a single drop of HeLa cell lysate using capillary-assembled microchip2008

    • Author(s)
      Terence G Henares, 他
    • Organizer
      22th International Symposium on MicroScale Bioseparations
    • Place of Presentation
      Berlin(ドイツ)
    • Related Report
      2009 Final Research Report
  • [Presentation] Highly-sensitive determination of hydrogen peroxide based on enzyme/electrochemical reaction sequence2007

    • Author(s)
      水谷 文雄, 他
    • Organizer
      7th East Asian Conference on Chemical Sensors
    • Place of Presentation
      シンガポール
    • Year and Date
      2007-12-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Simultaneous On-chip Determination of a Cancer Marker and Creatinine by Surface Plasmon Resonance in a Microfluidic Channel2007

    • Author(s)
      中元 浩平, 他
    • Organizer
      第16回化学とマイクロ・ナノシステム研究会&ISMM2007
    • Place of Presentation
      つくば
    • Year and Date
      2007-10-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] キャピラリーアッセンブルド・電気化学チップの作製とグルコース測定への応用2007

    • Author(s)
      稲積 伸悟, 他
    • Organizer
      第16回化学とマイクロ・ナノシステム研究会&ISMM2007
    • Place of Presentation
      つくば
    • Year and Date
      2007-10-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] キャピラリー-アセンブルド・マイクロチップ(36)酵素放出キャピラリーの試作とグルコースセンシングへの応用2007

    • Author(s)
      前川 英治, 他
    • Organizer
      日本分析化学会第56年会
    • Place of Presentation
      徳島
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 電気化学並びにSPRによる尿中腫瘍マーカー/クレアチニンの同時測定2007

    • Author(s)
      中元 浩平, 他
    • Organizer
      日本分析化学会第56年会
    • Place of Presentation
      徳島
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] キャピラリーアセンブルドマイクロチップへの電気化学測定モジュールの導入と過酸化水素、グルコースの測定2007

    • Author(s)
      稲積 伸悟, 他
    • Organizer
      第1回化学センサー・バイオセンサーおよび計測技術合同ワークショップ
    • Place of Presentation
      横浜
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] キャピラリー-アセンブルド・マイクロチップを用いた細胞破砕液中多種プロテアーゼ活性の同時アッセイ2007

    • Author(s)
      久本 秀明, 他
    • Organizer
      第1回化学センサー・バイオセンサーおよび計測技術合同ワークショップ
    • Place of Presentation
      横浜
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心疾患マーカ検出用マイクロセンシングチップの開発2007

    • Author(s)
      栗田 僚二
    • Organizer
      第30回分析化学若手交流会
    • Place of Presentation
      つくば
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] バイオアッセイにおけるセンサー技術の動向2007

    • Author(s)
      水谷 文雄
    • Organizer
      生物化学的測定研究会第12回学術集会
    • Place of Presentation
      広島
    • Year and Date
      2007-06-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Capillary-assembled microchip(CAs-CHIP)(34):Simple serum Electmlytes analysis by multi-ion chip2007

    • Author(s)
      T. G. Henares, 他
    • Organizer
      第68回分析化学討論会
    • Place of Presentation
      宇都宮
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Highly-sensitive determination of hydrogen peroxide based on enzyme/electrochemical reaction sequence2007

    • Author(s)
      水谷文雄, 他
    • Organizer
      7th East Asian Conference on Chemical Sensors
    • Place of Presentation
      Singapore
    • Related Report
      2009 Final Research Report
  • [Presentation] キャピラリーアセンブルド・電気化学マイクロチップの作製と応用2007

    • Author(s)
      稲積伸悟, 他
    • Organizer
      第53回ポーラログラフィーおよび電気分析化学討論会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of Enzyme-Release Capillary as a Novel Metabolite Sensor for Capillary-Assembled Microchip2007

    • Author(s)
      Terence G Henares, 他
    • Organizer
      ISMM2007
    • Place of Presentation
      つくば
    • Related Report
      2009 Final Research Report
  • [Presentation] "Drop and Sip" Fluid Handring Technique for Reagent-Release Capillary-based Capillary-Assembled Microchip (CAs-CHIP): Multiple Cell Lysate Sample Derivary and Caspase-Activity Sensing2007

    • Author(s)
      Terence G Henares, 他
    • Organizer
      The Eleventh International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Paris(フランス)
    • Related Report
      2009 Final Research Report
  • [Presentation] 酵素反応によるOs錯体酸化体の蓄積/電解還元過程を利用した酸化酵素活性の高感度測定2007

    • Author(s)
      太田栄次, 他
    • Organizer
      第44回化学センサ研究発表会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 化学増幅と高感度免疫センサー2007

    • Author(s)
      水谷文雄, 他
    • Organizer
      第1回化学センサー・バイオセンサーおよび計測技術合同ワークショップ
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] バイオアッセイにおけるセンサー技術の動向2007

    • Author(s)
      水谷文雄
    • Organizer
      生物化学的測定研究会第12回(2007年)学術集会
    • Place of Presentation
      広島
    • Related Report
      2009 Final Research Report
  • [Presentation] Capillary-Assembled Microchip (CAs-CHIP)(35): Towards Chemotheraphy-Induced Cell Death Analysis on a Chip2007

    • Author(s)
      Henares G Terence, 他
    • Organizer
      第15回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Book] バイオセンサーの世界、物質科学の世界、第14章、兵庫県立大学大学院物質理学研究科編2010

    • Author(s)
      水谷文雄
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Book] 物質科学の世界2010

    • Author(s)
      小原孝夫, 高木芳弘, 住山昭彦, 小林寿夫, 馬越健次, 高橋慶紀, 篭島靖, 鳥海幸四郎, 川村春樹, 木村啓作, 中辻慎一, 本間健二, 杉村高志, 水谷文雄
    • Total Pages
      198
    • Publisher
      共立出版
    • Related Report
      2009 Annual Research Report
  • [Book] 電気化学測定と解析テクニック事例集2008

    • Author(s)
      青木幸一, 他
    • Total Pages
      627
    • Publisher
      情報機構
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.sci.u-hyogo.ac.jp/material/analytical_chem/index-j.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.sci.u-hyogo.ac.jp/material/analytical_chem/index-j.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2021-09-21  

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