| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using organic matrices is a soft ionization technique that causes very less fragmentation of the analytes. However, matrix ion interface and detector saturation are inevitable in the MALDI-MS analysis of low-mass molecules (<m/z 500), and this makes the characterization of small molecules difficult despite the significance of such characterization. As an approache involving the use of organic-matrix-free LDI-MS for analyzing small molecules in a MALDI instrument, we have investigated a new and facile method for synthesizing two-dimensional (2D) nanoparticles on substrates for the applications of surface-assisted laser desorption/ionization-mass spectrometry (SALDI-MS). New types of nanostructured substrates for organic-matrix-free LDI-MS have been found : (1) Platinum nanoflowers, (2) rod-like zinc oxide nanoparticles,, (3) urea-modified titania nanoparticles, and (4) FePtCu magnetic nanoparticles. The feasibility of using these nanomaterials for SALDI-MS has been demonstrated.
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