Synthesis, photo-regulation of DNA polycaenanes and the development of their functions

• Project/Area Number: 19350062
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: Kansai University
• Principal Investigator: OHYA Yuichi Kansai University, 化学生命工学部, 教授 (10213886)
• Co-Investigator(Kenkyū-buntansha): OUCHI Tatsuro 関西大学, 化学生命工学部, 教授 (60067650)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2007: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 超分子化学 / 自己組織化 / ポリカテナン / DNA / 核酸 / 光反応 / 分子マシン / 分子スイッチ / 電気泳動 / 超分子科学

Research Abstract

DNA can recognize their complementary counter strand by hydrogen bonding. Ligation and scission of DNA are possible by enzymes. These characteristics of DNA are useful for construction molecular organizations in nanometer scale. In this study, we carried out to synthesize oligo-catenanes with interlocked supramolecular structures. As results, we succeeded to synthesize oligo-catenanes by enzymatic and photochemical ligation.

Research Products

• [Journal Article] DNAナノアレイと開閉可能なDNAナノボックス-DNAはナノマテリアルとして実用可能か? (2009)
  • Author(s): 大矢裕一
  • Journal Title: 化学 64(8) Pages: 72-73
• [Journal Article] Synthesis of Oligo-DNA Containing Hydrophilic Porphyrin in the Main Chain, and Its Energy Transfer Behavior in Duplex State (2009)
  • Author(s): Y. Ohya, N. Hashimoto, S. Jo, T. Nohori, T. Yoshikuni, T. Ouchi, H. Tamiaki
  • Journal Title: Supramol. Chem 21(3-4) Pages: 301-309
  • Peer Reviewed
• [Journal Article] Polyassembly Formation of Complementary Half-sliding Oligo-DNAs and the Atomic Force Microscopic Observation (2009)
  • Author(s): Y. Ohya, T. Nohori, T. Nishi, S. Jo, T. Ouchi
  • Journal Title: J. Nanosci. Nanotechnol 9(1) Pages: 313-317
  • Peer Reviewed
• [Journal Article] Synthesis of Oligo-DNA Containing Hydrophilic Porphyrin in the Main Chain, and Its Energy Transfer Behavior in Duplex State (2009)
  • Author(s): 大矢裕一
  • Journal Title: Supramol.Chem. 21 Pages: 301-309
  • Peer Reviewed
• [Journal Article] DNAナノアレイと開閉可能なDNAナノボックス-DNAはナノマテリアルとして実用可能か? (2009)
  • Author(s): 大矢裕一
  • Journal Title: 化学 64 Pages: 72-73
• [Journal Article] Synthesis of Oligo-DNA Containing Hydrophilic Porphyrin in the Main Chain (2009)
  • Author(s): Y. Ohya N. Hashimoto, S. Jo, T. Nohori, T. Yoshikuni, T. Ouchi, H. Tamiaki
  • Journal Title: Supramol. Chem. (印刷中)
  • Peer Reviewed
• [Journal Article] Dye Molecular Arrangement Based on Hybridization of DNA, Proceedings of SPIE, Nanobiosystems: Processing (2008)
  • Author(s): Y. Ohya
  • Journal Title: Characterization, and Applications 70400
• [Journal Article] Polyassembly Formation of Complementary Half-sliding Oligo-DNAs and the Atomic Force Microscopic Observation (2008)
  • Author(s): Y. Ohya, T. Nohori, T. Nishi, S. Jo, T. Ouchi
  • Journal Title: J. Nanosci. Nanotechnol. 9 Pages: 313-317
  • Peer Reviewed
• [Journal Article] Dye Molecular Arrangement Based on Hybridization of DNA (2008)
  • Author(s): Y. Ohya
  • Journal Title: Proceedings of SPIE, Nanobiosystems : Processing, Characterization, and Applications 70400
• [Journal Article] Polyassembly Formation of Complementary Half-sliding Oligo-DNAs andthe Atomic Force Microscopic Observation (2008)
  • Author(s): Y.Ohya
  • Journal Title: J.Nanosci.Nanotechnol
  • Peer Reviewed
• [Journal Article] Construction of Supramolecular Assemblies and Self-organized Structures using Oligo-DNAs (2007)
  • Author(s): Y. Ohya, T. Nishi, T. Nohori, S. Jo, K. Ohta, K. Jozuka, T. Ouchi
  • Journal Title: Nucleic Acids Symp. Ser 51 Pages: 37-38
• [Journal Article] Construction of Supramolecular Assemblies and Self-organized Structures Usinu Olio-DNAs (2007)
  • Author(s): Y.Ohya
  • Journal Title: Nucleic Acids Symp.Ser. 51 Pages: 37-38
• [Presentation] Synthesis and Characterization of DNA Catenane as Nanomachine (2009)
  • Author(s): T. Uehara
  • Organizer: JST-CREST International Symposium 2009
  • Place of Presentation: The University of Tokyo
  • Year and Date: 2009-11-10
• [Presentation] Synthesis and Characterization of DNA Catenane as Nanomachine (2009)
  • Author(s): 上原岳暁
  • Organizer: JST-CREST International Symposium 2009
  • Place of Presentation: The University of Tokyo(Tokyo)
  • Year and Date: 2009-11-10
• [Presentation] 光連結反応によるDNAオリゴカテナン合成手法の検討 (2009)
  • Author(s): 上原岳暁
  • Organizer: 第24回生体機能関連化学シンポジウム
  • Place of Presentation: 九州大学
  • Year and Date: 2009-09-14
• [Presentation] 光連結反応によるDNAオリゴカテナン合成手法の検討 (2009)
  • Author(s): 上原岳暁
  • Organizer: 第24回生体機能関連化学シンポジウム
  • Place of Presentation: 九州大学(福岡県)
  • Year and Date: 2009-09-14
• [Presentation] DNAカテナンの合成と分子マシンとしての機能評価 (2009)
  • Author(s): 上原岳暁
  • Organizer: 第19回バイオ・高分子シンポジウム
  • Place of Presentation: 東京大学
  • Year and Date: 2009-07-30
• [Presentation] DNAカテナンの合成と分子マシンとしての機能評価 (2009)
  • Author(s): 上原岳暁
  • Organizer: 第19回バイオ・高分子シンポジウム
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2009-07-30
• [Presentation] DNA鎖中に組み込み可能なポルフィリン誘導体によるポルフィリン・アレイの構築と蛍光共鳴エネルギー移動評価 (2008)
  • Author(s): 吉國拓郎
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2008-09-25
• [Presentation] 光連結反応を利用した環状DNAオリゴカナテン合成手法の検討 (2008)
  • Author(s): 上原岳暁
  • Organizer: 日本化学会第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-09-19
• [Presentation] 蛍光色素導入DNAカテナンの合成 (2008)
  • Author(s): 定司健太
  • Organizer: 日本化学会第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-09-19
• [Presentation] Synthesis of DNA Oligo-Catenane by Template Assisted Catenation (2008)
  • Author(s): K. Jozuka
  • Organizer: Thai-Japan Joint Symposium onAdvances in Materials Science and Environmental Technology
  • Place of Presentation: Chulalongkorn University, Bangkok
  • Year and Date: 2008-08-19
• [Presentation] Synthesis of DNA Oligo-Catenane by Template Assisted Catenation (2008)
  • Author(s): K. Jozuka, K. Ohta, T. Nishi, T. Ouchi
  • Organizer: Thai-Japan Joint Symposium on Advances in Materials Science and Environmental Technology
  • Place of Presentation: Bangkok
  • Year and Date: 2008-08-19
• [Presentation] Dye Molecular Arrangement based on hybridization of DNA (2008)
  • Author(s): Y. Ohya
  • Organizer: Proceedings of SPIE
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 2008-08-12
• [Presentation] Synhesis of DNA Oligo-Catenane by Template Assisted Catenation (2008)
  • Author(s): Y. Ohya
  • Organizer: ISMSC 2008
  • Place of Presentation: Hotel Rivera, Los Vegas
  • Year and Date: 2008-07-13
• [Presentation] Dye Molecular Arrangement Based on Hybridization of DNA (2008)
  • Author(s): Y. Ohya
  • Organizer: SPIE Optics+Photonics 2008
  • Place of Presentation: San Diego
  • Year and Date: 2008-07-13
• [Presentation] Synhesis of DNA Oligo-Catenane by Template Assisted Catenation (2008)
  • Author(s): Y. Ohya, T. Nishi, K. Ohta, K. Jozuka, T. Uehara, T. Ouchi
  • Organizer: ISMSC 2008
  • Place of Presentation: Las Vegas
  • Year and Date: 2008-06-15
• [Presentation] Construction of Supramolecular Assemblies and Self-Oganized Structures Using Oligo-DNAs (2007)
  • Author(s): Y. Ohya
  • Organizer: Fifth International Symposium on Nucleic Acid Chemistry
  • Place of Presentation: The University of Tokyo
  • Year and Date: 2007-11-20
• [Presentation] Construction of Supramolecular Assemblies and Self-Oganized Structures Using Oligo-DNAs (2007)
  • Author(s): Y.Ohya
  • Organizer: Fifth International Symposium on Nucleic Acid Chemistry
  • Place of Presentation: 東京大学
  • Year and Date: 2007-11-20
• [Presentation] Template Assisted Polycatenation(TAPC)法によるDNAオリゴカテナンの選択的合成 (2007)
  • Author(s): 定司健太
  • Organizer: 第22回生体機能関連化学シンポジウム
  • Place of Presentation: 東北大学
  • Year and Date: 2007-09-28
• [Presentation] DNA鎖中にポルフィリンを導入したポルフィリン・アレイの構築とエネルギー移動評価 (2007)
  • Author(s): 吉國拓郎
  • Organizer: 第22回生体機能関連化学シンポジウム
  • Place of Presentation: 東北大学
  • Year and Date: 2007-09-28
• [Presentation] Template Assisted Polycatenation(TAPC)法を応用したDNAオリゴカテナンの合成 (2007)
  • Author(s): 定司健太
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2007-09-19
• [Presentation] 多重会合能を有するオリゴDNAコンジュゲートの設計と多重会合体のモルホロジー (2007)
  • Author(s): 大矢裕一
  • Organizer: 第17回バイオ・高分子シンポジウム
  • Place of Presentation: 上智大学
  • Year and Date: 2007-07-31
• [Book] Bottom-up Nanofablication (2009)
  • Author(s): Y. Ohya
  • Publisher: American Scientific Publishers
• [Book] Bottom-up Nanofablication Volume 4 (2009)
  • Author(s): Y. Ohya
  • Total Pages: 454
  • Publisher: American Scientific Publishers
• [Book] Bottom-up Nanofablication
  • Author(s): Y.Ohya
  • Publisher: American Scientific Publishers