| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2007: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Research Abstract |
I have developed completely new, monolithic affinity resins for researches of target proteins of certain bioactive substances, which have been very important for novel drag discovery. Based on careful studies, I have realized great suppression of non-specific adsorption of proteins based on "soft" surface of affinity resins and really improved capture of the target proteins, which have been never realized using commercially available affinity resins. In addition, using surface modification, environment of the immobilized ligand has been controlled to capture various target proteins in certain environment. These results will contribute implementation of chemical biology.
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