Pore-Size Control and Fictionalization of Nanoporous Membrane Prepared from Block Copolymer Precursor for Medical Device Materials
| Project/Area Number |
19350107
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Polymer/Textile materials
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
UEHARA Hiroki Gunma University, 大学院・工学研究科, 准教授 (70292620)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
|
|---|
| Keywords | ナノ・ポーラス / ブロック共重合体 / 細孔膜 / 医用材料 / 自己組織化 / インテリジェント・メンブレン |
|---|
| Research Abstract |
Nanoporous membranes with different pore dimensions were prepared from a series of polyethylene (PE)/polystyrene (PS) diblock copolymer films by acid etching under various conditions. Scanning probe microscope (SPM) observation indicated that the pore morphology was emphasized by elongation of etching time with elimination of amorphous PS phase. However, further etching destructs the PE crystalline phase which supports the network geometry of nanoporous membrane. For quantitative analyses of pore morphology, pore size distribution was evaluable by the height profiles extracted from a series of the scanning probe microscope images. The pore size was controllable by acid treatment conditions. Their biological applications were examined by cell proliferation tests using Hep G2 cells. Cell proliferation was confirmed for all membranes prepared in this study. However, membranes exhibiting typical nanoporous morphologies gave the lower numbers of cells after cell removal treatment by trypsin addition and centrifugation, compared to those for un-etched membrane having smooth surface. These results indicate the robust attachment between cell and membrane surface for the former membrane.
|
Report
(4 results)
Research Products
(24 results)
-
-
[Journal Article] Novel Design Solving the Conductivity vs Water-Uptake Trade-Off for Polymer Electrolyte Membrane by Bicontinuous Crystalline/Amorphous Morphology of Block Copolymer2009
Author(s)
Hiroki Uehara, Masaki Kakiage, Miho Sekiya, Tsukasa Yamagishi, Takeshi Yamanobe, Katsuhiko Nakajima, Toshio Watanabe, Kumiko Nomura, Kohei Hase, Masatoshi Matsuda
-
Journal Title
Macromolecules Vol.42, No.20
Pages: 7627-7630
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
