Multimodal imaging system for biological function measurements by using diffusion light

• Project/Area Number: 19360035
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied optics/Quantum optical engineering
• Research Institution: Keio University
• Principal Investigator: OKADA Eiji Keio University, 理工学部, 教授 (40221840)
• Co-Investigator(Kenkyū-buntansha): KANNARI Fumihiko 慶應義塾大学, 理工学部, 教授 (40204804) ; NAKANO Nobuhiko 慶應義塾大学, 理工学部, 准教授 (40286638)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2007: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
• Keywords: 応用光学・量子光工学 / 光・画像計測工学 / 生物・生体工学 / シミュレーション工学 / 生体医用光工学

Research Abstract

A multimodal system for the brain-function measurement using near-infrared light is investigated to improve the spatial resolution and accuracy of brain-function images. The novel algorithm for image reconstruction using a virtual head phantom is proposed. The 3D-structure of the virtual head phantom is based upon MRI scan of an adult head. The proposed system is evaluated by simulations using the virtual head phantom and experiments. The brain-function images measured by the system using double-density probe arrangement are effectively improved by the image reconstruction algorithm using the virtual phantom.

Research Products

• [Journal Article] Validation of practical diffusion approximation for virtual near infrared spectroscopy using a digital head phantom (2009)
  • Author(s): Yosuke Oki、Hiroshi Kawaguchi、Eiji Okada
  • Journal Title: Optical Review 16巻 Pages: 153-159
  • NAID: 10025304220
  • Peer Reviewed
• [Journal Article] Theoretical and experimental investigation of the influence of frontal sinus on the sensitivity of the NIRS signal in the adult head (2009)
  • Author(s): 岡田英史
  • Journal Title: Advances in Experimental Medicine and Biology 662 Pages: 231-236
  • Peer Reviewed
• [Journal Article] Validation of practical diffusion approximation for virtual near infrared spectroscopy using a digital head phantom (2009)
  • Author(s): 岡田英史
  • Journal Title: Optical Review 16 Pages: 153-159
  • NAID: 10025304220
  • Peer Reviewed
• [Journal Article] Influence of a skull cranial window on the measurement of hemoglobin concentration in cortical tissue by multi-spectral imaging analysis (2009)
  • Author(s): 岡田英史
  • Journal Title: Optical Review 16 Pages: 74-80
  • Peer Reviewed
• [Journal Article] 生体光伝播シミュレーションの近赤外線分光法への応用 (2009)
  • Author(s): 岡田英史
  • Journal Title: 脈管学 49 Pages: 113-119
  • NAID: 10025219802
  • Peer Reviewed
• [Journal Article] 光脳機能イメージングの原理 (2009)
  • Author(s): 岡田英史
  • Journal Title: 映像情報メディカル 41 Pages: 886-891
• [Journal Article] (2009)
  • Author(s): 岡田英史
  • Journal Title: 精神疾患とNIRS 光トポグラフィー検査による脳機能イメージング(NIRSデータのシミュレーション)(中山書店)
• [Journal Article] 近赤外分光法による脳機能計測 (2009)
  • Author(s): 岡田英史
  • Journal Title: 光技術コンタクト 47 Pages: 14-19
• [Journal Article] Theoretical analysis of crosstalk between oxygenated and deoxygenated haemoglobin in focal brain-activation measurements by near-infrared topography (2008)
  • Author(s): Hiroshi Kawaguchi、Nobuhiko Okui、Koichiro Sakaguchi、Eiji Okada
  • Journal Title: Opto-electronics Review 16巻 Pages: 404-412
  • Peer Reviewed
• [Journal Article] Theoretical analysis of crosstalk between oxygenated and deoxy genated haemoglobin in focal brain-activation measurements by near-infrared topography (2008)
  • Author(s): Hiroshi Kawaguchi
  • Journal Title: Opto-electronics Review 16 Pages: 404-412
  • Peer Reviewed
• [Journal Article] 近赤外光を用いた脳機能イメージング (2008)
  • Author(s): 川口拓之
  • Journal Title: O Plus E 30 Pages: 595-598
• [Journal Article] 頭部組織の光伝播シミュレーションと脳機能計測 (2007)
  • Author(s): 川口拓之、岡田英史
  • Journal Title: 36巻 Pages: 686-692
  • NAID: 10020286514
  • Peer Reviewed
• [Journal Article] 光脳機能イメージングの理論的背景にもとづく留意点 (2007)
  • Author(s): 岡田 英史
  • Journal Title: 認知神経科学 9 Pages: 202-206
  • Peer Reviewed
• [Journal Article] 頭部組織の光伝播シミュレーションと脳機能計測 (2007)
  • Author(s): 川口 拓之
  • Journal Title: 光学 36 Pages: 686-692
  • Peer Reviewed
• [Journal Article] 光脳機能トポグラフィーの画像再構築法 (2007)
  • Author(s): 川口 拓之
  • Journal Title: 画像ラボ 18 Pages: 59-62
  • Peer Reviewed
• [Presentation] 光脳機能イメージングと頭部光伝播解析 (2010)
  • Author(s): 岡田英史
  • Organizer: レーザー学会学術講演会第30回年次大会
  • Place of Presentation: 千里ライフサイエンスセンター, 大阪
  • Year and Date: 2010-02-04
• [Presentation] 最先端光脳機能イメージング技術 (2009)
  • Author(s): 岡田英史
  • Organizer: 第30回日本レーザー医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-03
• [Presentation] 最先端光脳機能イメージング技術 (2009)
  • Author(s): 岡田英史
  • Organizer: 第30回日本レーザー医学会総会
  • Place of Presentation: ホテルグランドヒル市ヶ谷, 東京
  • Year and Date: 2009-12-03
• [Presentation] 光脳機能計測における耐クロストークノイズキャンセラによる表層信号の除去に関する検討 (2009)
  • Author(s): 岡田英史
  • Organizer: 日本光学会年次学術講演会 Optics & Photonics Japan 2009
  • Place of Presentation: 朱鷺メッセ, 新潟
  • Year and Date: 2009-11-24
• [Presentation] Evaluation of spatial resolution of near-infrared topography by a digital head phantom (2009)
  • Author(s): Eiji Okada
  • Organizer: European Conference on Biomedical Optics
  • Place of Presentation: Munich (Germany)
  • Year and Date: 2009-06-17
• [Presentation] Evaluation of spatial resolution of near-infrared topography by a digital head phantom (2009)
  • Author(s): 岡田英史
  • Organizer: European Conference on Biomedical Optics
  • Place of Presentation: International Congress Centre Munich, Germany
  • Year and Date: 2009-06-17
• [Presentation] Analysis of light propagation in head models for probabilistic registration of NIRS data (2009)
  • Author(s): 岡田英史
  • Organizer: European Conference on Biomedical Optics
  • Place of Presentation: International Congress Centre Munich, Germany
  • Year and Date: 2009-06-15
• [Presentation] Extraction of brain-activation component form NIRS signal by using independent component analysis (2009)
  • Author(s): 岡田英史
  • Organizer: European Conference on Biomedical Optics
  • Place of Presentation: International Congress Centre Munich, Germany
  • Year and Date: 2009-06-15
• [Presentation] Phantom experiments for validation of spatial resolution improvement of optical topography for double-density measurement (2009)
  • Author(s): 岡田英史
  • Organizer: European Conference on Biomedical Optics
  • Place of Presentation: International Congress Centre Munich, Germany
  • Year and Date: 2009-06-15
• [Presentation] Effect of the optical properties of tissue on simulaiton of light propagation in a head model (2009)
  • Author(s): 岡田英史
  • Organizer: 4th Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: The Shilla Jeju, Korea
  • Year and Date: 2009-05-28
• [Presentation] Evaluation of crosstalk resistance noise canceller for extraction of brain signal in near-infrared spectroscopy (2009)
  • Author(s): 岡田英史
  • Organizer: 4th Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: The Shilla Jeju, Korea
  • Year and Date: 2009-05-28
• [Presentation] Experimental evaluation of spatial resolution of near infrared topogrphy by using head phantom (2009)
  • Author(s): 岡田英史
  • Organizer: 4th Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: The Shilla Jeju, Korea
  • Year and Date: 2009-05-27
• [Presentation] 頭部組織の光学特性値が光伝播シミュレーションに及ぼす影響 (2009)
  • Author(s): 岡田英史
  • Organizer: 第56回応用物理学関係連合講演会
  • Place of Presentation: 筑波大学, つくば
  • Year and Date: 2009-04-01
• [Presentation] 頭部ファントムによる光脳機能トポグラフィの空間分解能の評価 (2009)
  • Author(s): 岡田英史
  • Organizer: 第56回応用物理学関係連合講演会
  • Place of Presentation: 筑波大学, つくば
  • Year and Date: 2009-04-01
• [Presentation] NIRSにおける多重散乱とシミュレーション (2008)
  • Author(s): 岡田英史
  • Organizer: 第10回光脳機能イメージング研究会
  • Place of Presentation: 大阪国際交流センター, 大阪
  • Year and Date: 2008-12-13
• [Presentation] 光脳機能トポグラフィーの空間分解能と感度むらに関する理論的検討 (2008)
  • Author(s): 桐生直哉
  • Organizer: 日本光学会年次学術講演会Optics and Photonics Japan 2008
  • Place of Presentation: つくば国際会議場, つくば
  • Year and Date: 2008-11-05
• [Presentation] 光脳機能計測における生体雑音除去の信号処理アルゴリズムに関する検討 (2008)
  • Author(s): 松井渉
  • Organizer: 日本光学会年次学術講演会Optics and Photonics Japan 2008
  • Place of Presentation: つくば国際会議場, つくば
  • Year and Date: 2008-11-05
• [Presentation] 標準頭部モデルの光伝播解析によるfNIR脳機能計測における測定領域の確率的マッピング (2008)
  • Author(s): 大木陽介
  • Organizer: 日本光学会年次学術講演会Optics and Photonics Japan 2008
  • Place of Presentation: つくば国際会議場, つくば
  • Year and Date: 2008-11-04
• [Presentation] 近赤外光による脳機能計測の感度とプローブ間隔に関する検討 (2008)
  • Author(s): 仁木雄崇
  • Organizer: 日本光学会年次学術講演会Optics and Photonics Japan 2008
  • Place of Presentation: つくば国際会議場, つくば
  • Year and Date: 2008-11-04
• [Presentation] 光脳機能イメージングにおける光散乱のシミュレーション (2008)
  • Author(s): 岡田英史
  • Organizer: 第9回光脳機能イメージング研究会
  • Place of Presentation: 星陵会館, 東京
  • Year and Date: 2008-07-19
• [Presentation] fNIRSの測定原理 (2008)
  • Author(s): 岡田英史
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] fNIRSの計測原理 (2008)
  • Author(s): 岡田英史
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム, 東京
  • Year and Date: 2008-07-09
• [Presentation] Validation of diffusion approximation for the calculation of light propagation in the realistic head modes (2008)
  • Author(s): Yosuke Oki
  • Organizer: 6th International Conference on Optics-photonics Design & Fabrication
  • Place of Presentation: 台北, 台湾
  • Year and Date: 2008-06-10
• [Presentation] Evaluation of the adaptive filter for the extraction of functional brain response from the near-infrared spectroscopy signal (2008)
  • Author(s): Wataru Matsui
  • Organizer: 6th International Conference on Optics-phot onics Design & Fabrication
  • Place of Presentation: 台北, 台湾
  • Year and Date: 2008-06-10
• [Presentation] Analysis of the relationship between probe spacing and the amplitude of brain signal detected by near-infrared spectroscopy (2008)
  • Author(s): Yutaka Niki
  • Organizer: 6th International Conference on Optics-phot onics Design & Fabrication
  • Place of Presentation: 台北, 台湾
  • Year and Date: 2008-06-10
• [Presentation] Theoretical evaluation of non-uniform sensitivity profile on spatial resolution of near-infrared topography (2008)
  • Author(s): Naoya Kiryu
  • Organizer: 6th International Conference on Optics-photonics Design & Fabrication
  • Place of Presentation: 台北, 台湾
  • Year and Date: 2008-06-10
• [Presentation] Normalized Adult Head Model for the Image Reconstruction Algorithmof NIR Tbpography (2008)
  • Author(s): Hiroshi Kawaguchi
  • Organizer: Optical Society of America, Topical Meeting on Biomedical Optics
  • Place of Presentation: St.Petersburg,Florida,USA
  • Year and Date: 2008-03-16
• [Presentation] 頭部組織の光伝播における前頭洞の影響の解析 (2007)
  • Author(s): 山本 大介
  • Organizer: OPJ2007 日本光学会年次学術講演会
  • Place of Presentation: 大阪大学コンベンションセンター,大阪
  • Year and Date: 2007-11-27
• [Presentation] 生体光伝播シミュレーションの近赤外線分光法への応用 (2007)
  • Author(s): 岡田 英史
  • Organizer: 近赤外線分光法研究会
  • Place of Presentation: まつもと市民芸術館・小ホール,松本
  • Year and Date: 2007-10-27
• [Presentation] Image Reconstruction Algorithm Using the Spatial Sensitivity Profile for Near-Infrared Tbpography: Evaluation by the Virtual Head Phantom (2007)
  • Author(s): Hiroshi Kawaguchi
  • Organizer: 3rd Asian and Pacific Rim Symposiun on Biophotonics
  • Place of Presentation: Cairins,Australia
  • Year and Date: 2007-07-09
• [Presentation] Influence of the Optical Properties of Superficial Tissues on the Path Length Estimation in NIR Imaging of Brain Activity (2007)
  • Author(s): Daisuke Yamamoto
  • Organizer: 3rd Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: Cairins,Australia
  • Year and Date: 2007-07-09
• [Presentation] Effect of the Thickness Variation of Superficial Tissues on the Position Accuracy of Near-Infrared Topography (2007)
  • Author(s): Yosuke Oki
  • Organizer: 3rd Asian and Pacific Rim Symposium on Biophotonics
  • Place of Presentation: Cairins,Australia
  • Year and Date: 2007-07-09
• [Presentation] Modeling of Influence of Frontal Sinus on NIRS Signal of Brain Activation (2007)
  • Author(s): Daisuke Yamamoto
  • Organizer: European Coference on Biomedical Optics
  • Place of Presentation: Munich,Germany
  • Year and Date: 2007-06-21
• [Presentation] Evaluation of the image reconstruction algorithm for near infrared topography by virtual head phantom (2007)
  • Author(s): Eiji Okada
  • Organizer: European Conference on Biomedical Optics
  • Place of Presentation: Munich (Germany)
  • Year and Date: 2007-06-20
• [Presentation] Evaluation of the Image Reconstruction Algorithm for Near Infrared Topography by Virtual Head Phantom (2007)
  • Author(s): Hiroshi Kawaguchi
  • Organizer: European Conference on Biomedical Optics
  • Place of Presentation: Munich,Germany
  • Year and Date: 2007-06-20
• [Book] 精神疾患とNIRS光トポグラフィー検査による脳機能イメージング(NIRSデータのシミュレーション) (2009)
  • Author(s): 川口拓之、岡田英史
  • Publisher: 中山書店