Development of Neural Network Formation Technique using X-ray Micro Beams

• Project/Area Number: 19360040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied physics, general
• Research Institution: Osaka University
• Principal Investigator: IIDA Toshiyuki Osaka University, 大学院・工学研究科, 教授 (60115988)
• Co-Investigator(Kenkyū-buntansha): KATO Yushi 大阪大学, 大学院・工学研究科, 准教授 (40224547) ; SATO Fuminobu 大阪大学, 大学院・工学研究科, 助教 (40332746)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2007: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
• Keywords: 放射線 / X線マイクロビーム / 細胞照射 / 神経培養細胞 / 放射線照射効果 / マイクロフォーカスX線源 / 単一細胞照射 / マイクロチャンバーアレイ

Research Abstract

近年、放射線の利用分野は拡大し、特に放射線治療などの医学・医療分野への重要性が高まっている。そして、この分野における放射線利用技術の高度化を進めるためには、放射線ビーム利用を対象とする先端工学と医学・医療分野等の複合領域における研究や技術開発が不可欠となっている。本研究では、ミクロな視点から、医学・医療分野における放射線利用技術の高度化を図った。具体的には、単一細胞の放射線影響を調べるために、細胞核の大きさのビーム径を有する卓上型X線マイクロビーム照射装置を開発した。さらに、培養細胞PC12の放射線照射効果を利用して、このX線マイクロビームを用いた培養細胞の分化誘導技術を開発した。

Research Products

• [Journal Article] Radio photo luminescent observation of X-ray microbeam transport in silver activated phosphate glass (2009)
  • Author(s): Y. Aoi, T. Kuchimaru, D. Maki, F. Sato, T.Ikeda, Y.Kato and T.Iida
  • Journal Title: Japan Journal of Applied Physics 48(in press)
  • Peer Reviewed
• [Journal Article] Radiophotoluminescent observation of X-ray microbeam transport in silver-activated phosphate glass (2009)
  • Author(s): Y. Aoi, T. Kuchimaru, D. Maki, F. Sato, T. Ikeda, Y. Kato, T. Iida
  • Journal Title: Japan Journal of Applied Physics (In press)
  • Peer Reviewed
• [Journal Article] Microchamber arrays for the identification of individual cells exposed to an X-ray microbeam (2008)
  • Author(s): T.Kuchimaru, F.Sato, Y.Aoi, T.Fujita, T.Ikeda, K.Shimizu, Y.Kato and T.Iida
  • Journal Title: Radiation and Environmental Biophysics 47 Pages: 535-540
  • Peer Reviewed
• [Journal Article] 単一細胞照射実験のための小型マイクロX線ビーム装置 (2008)
  • Author(s): 青位祐輔、口丸高弘、佐藤文信、加藤裕史、飯田敏行
  • Journal Title: 日本放射線安全管理学会誌 7 Pages: 163-167
  • NAID: 130004175563
  • Peer Reviewed
• [Journal Article] X-ray microbeam measurement with radiophotoluminescent glass plate for single cell irradiation (2008)
  • Author(s): F.Sato, T.Kuchimaru, T.Ikeda, K.Shimizu, Y.Kato, T.Yamamoto T.Iida
  • Journal Title: Radiation Measurements 43 Pages: 912-916
  • Peer Reviewed
• [Journal Article] Three-dimensional track imaging during etching and sequential reconstruction of track structures (2008)
  • Author(s): T.Kuchimaru, F.Sato, K.Honda, Y.Kato and T.Iida
  • Journal Title: Radiation Measurements 43 Pages: 125-127
  • Peer Reviewed
• [Journal Article] Microchamber arrays for the identification of individual cells exposed to an X-ray microbeam (2008)
  • Author(s): T. Kuchimaru, F. Sato, Y. Aoi, T. Fujita, T. Ikeda, K. Shimizu, Y. Kato, T. Iida
  • Journal Title: Radiation and Environmental Biophysics 47 Pages: 535-540
  • Peer Reviewed
• [Journal Article] 単一細胞照射実験のための小型マイクロX線ビーム装置 (2008)
  • Author(s): 青位祐輔, 口丸高弘, 佐藤文信, 加藤裕史, 飯田敏行
  • Journal Title: 日本放射線安全管理学会誌 7 Pages: 163-167
  • NAID: 130004175563
  • Peer Reviewed
• [Journal Article] X-ray microbeam measurement with radiophotoluminescent glass plate for single cell irradiation (2008)
  • Author(s): F. Sato, T. Kuchimaru, T. Ikeda, K. Shimizu, Y. Kato, T. Yamamoto T. Iida
  • Journal Title: Radiation Measurements 43 Pages: 912-916
  • Peer Reviewed
• [Journal Article] Response of CR-39 track detector to low-energy heavy ion beams (2008)
  • Author(s): I. Ishikawa, A. Kishi, W. Kada, F. Sato, Y. Kato, T. Iida
  • Journal Title: Radiation Measurements 43 Pages: 79-81
  • Peer Reviewed
• [Journal Article] A compact system for measurement of radiophotoluminescence of phosphate glass dosimeter (2008)
  • Author(s): Y. Ihara, A. Kishi, W. Kada, F. Sato, Y. Kato, T. Yamamoto, T. Iida
  • Journal Title: Radiation Measurements 43 Pages: 542-545
  • Peer Reviewed
• [Journal Article] Three-dimensional track imaging during etching and sequential reconstruction of track structures (2008)
  • Author(s): T. Kuchimaru, F. Sato, K. Honda, Y. Kato, T. Iida
  • Journal Title: Eadiation Measurements 43 Pages: 125-127
  • Peer Reviewed
• [Journal Article] X-ray Microbeam Measurement with Radiophotoluminescent Glass Plate for Single Irradiation (2008)
  • Author(s): F. Sato, T. Kuchimaru, T. Ikeda, K. Shimizu, Y. Kato, T. Yamamoto and T. Iida
  • Journal Title: Radiation Measurement (in press)
  • Peer Reviewed
• [Journal Article] Digital image analysis on etch pit formation in CR-39 track detector (2008)
  • Author(s): Fuminobu SATO, Takahiro KUCHIMARU, Yushi KATO, and Toshiyuki IIDA
  • Journal Title: Japanese Journal of Applied Physics 47 Pages: 269-272
  • NAID: 40015871604
  • Peer Reviewed
• [Presentation] X-ray microbeam system for irradiation of living cells (2008)
  • Author(s): T.Kuchimaru, F.Sato, Y.Aoi, Y.Kato and T.Iida
  • Organizer: International Conference on Nuclear Micro-probe Technology and Applications
  • Place of Presentation: Debrecen, Hungary
• [Presentation] Development and testing of Micro patterned cell culture platform for biological analysis of single cell irradiation (2008)
  • Author(s): T.Kuchimaru, F.Sato, Y.Aoi, C.Inagawa, T.Ikeda, Y.Kato and T.Iida
  • Organizer: International Conference on Nuclear Micro-probe Technology and Applications
  • Place of Presentation: Debrecen, Hungary
• [Presentation] Development and testing of micropatterned cell culture platform for biological analysis of single cell irradiation (2008)
  • Author(s): T. Kuchimaru, F. Sato, Y. Aoi, C. Inagawa, T. Ikeda, Y. Kato, T. Iida
  • Organizer: International Conference on Nuclear Micro-probe Technology and Applications
  • Place of Presentation: Debrecen, Hungary
• [Presentation] Radiation effects of X-ray micro beam irradiation on the function of neuronal network (2007)
  • Author(s): T.Kuchimaru, F.Sato, T.Fujita, T.Ikeda, K.Shimizu, Y.Kato and T.Iida
  • Organizer: International Congress of Radiation Research
  • Place of Presentation: San Francisco, USA
• [Presentation] Radiation effects of X-ray micro beam irradiation on the function of neuronal network (2007)
  • Author(s): T. Kuchimaru, F. Sato, T. Fujita, T. Ikeda, K. Shimizu, Y. Kato and T. Iida
  • Organizer: International Congress of Radiation Research
  • Place of Presentation: Marriott hotel, San Francisco, USA
• [Book] エックス線取扱の基礎 (2008)
  • Author(s): 小田啓二、佐藤文信、飯田敏行、児玉靖司、高淵雅廣
  • Total Pages: 169
  • Publisher: 財団法人電子科学研究所編集委員会
• [Book] エックス線取扱の基礎・演習 (2007)
  • Author(s): 小田啓二、佐藤文信、飯田敏行、児玉靖司、高淵雅廣
  • Total Pages: 209
  • Publisher: 財団法人電子科学研究所編集委員会