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Life time control of biodegradable composites for scaffolds in bone tissue engineering

Research Project

Project/Area Number 19360050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionKyoto University

Principal Investigator

HOJO Masaki  Kyoto University, 工学研究科, 教授 (70252492)

Co-Investigator(Kenkyū-buntansha) ADACHI Taiji  京都大学, 工学研究科, 准教授 (40243323)
田中 基嗣  金沢工業大学, 基礎教育部, 講師 (30346085)
西野 孝  神戸大学, 工学部, 教授 (40180624)
Co-Investigator(Renkei-kenkyūsha) TANAKA Mototsugu  金沢工業大学, 工学部, 講師 (30346085)
NISHINO Takashi  神戸大学, 工学部, 教授 (40180624)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords材料設計 / プロセス / 物性 / 評価 / 複合材料 / 生分解性樹脂 / 組織再生工学 / ハイドロキシアパタイト / ポリ乳酸 / スカフォールド / 骨リモデリング / 機械材料・材料力学 / 複合材料・物性 / 構造・機能材料 / HAp / Hap
Research Abstract

Hydroxyapatite (HAp)/poly-L-lactic acid (PLLA) composite material was developed for the development of biodegradable three-dimensional porous scaffolds for bone tissue engineering. Both particle and fiber type HAp was compared Interface control was also tried for HAp particle. These mesoscopic factors had great influence on the deformation and fracture behavior of HAp/PLLA composites. Moreover, hydrolysis of this composite material was strongly affected by the surface treatment of HAp particles.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (45 results)

All 2010 2009 2008 2007 Other

All Journal Article (32 results) (of which Peer Reviewed: 32 results) Presentation (9 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Mode I fatigue delamination of Zanchor-reinforced CF/epoxy laminates.2010

    • Author(s)
      Hojo, M., Nakashima, K., Kusaka, T., Tanaka, M., Adachi, T., Fukuoka T., Ishibashi, M.
    • Journal Title

      International Journal of Fatigue Vol.32

      Pages: 37-45

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of fiber array irregularities on microscopic interfacial normal stress states of transversely loaded UD-CFRP from viewpoint of failure initiation2009

    • Author(s)
      Hojo, M., Mizuno, M., Hobbiebrunken, T., Adachi, T., Tanaka, M., Ha, S.K.
    • Journal Title

      Composites Science and Technology 69(11-12)

      Pages: 1726-1734

    • NAID

      120001433464

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Damage characterization of fibre metal laminates under interlaminar shear load2009

    • Author(s)
      Hinz, S., Omoori, T., Hojo, M., Schulte, K.
    • Journal Title

      Composites: Part A Vol.40

      Pages: 925-931

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluid pressure response in poroelastic materials subjected to cyclic loading2009

    • Author(s)
      Kameo, Y., Adachi, T., Hojo, M.
    • Journal Title

      Journal of the Mechanics and Physics of Solids Vol.57

      Pages: 1815-1827

    • NAID

      120001723785

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strain field in actin filament network in lamellipodia of migrating cells: Implication for network reorganization2009

    • Author(s)
      Adachi, T., Okeyo, K.O., Shitagawa, Y., Hojo, M.
    • Journal Title

      Journal of Biomechanics Vol.42

      Pages: 297-302

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computer simulation of trabecular remodeling in human proximal femur using large-scale voxel FE models: Approach to understanding Wolff's law2009

    • Author(s)
      Tsubota, K., Suzuki, Y., Yamada, T., Hojo, M., Makinouchi, A., Adachi, T.
    • Journal Title

      Journal of Biomechanics Vol.42,Issue8

      Pages: 1088-1094

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coarse-grained Modeling and Simulation of Actin Filament Behavior Based on Brownian Dynamics Method2009

    • Author(s)
      Shimada, Y., Adachi, T., Inoue, Y., Hojo, M.
    • Journal Title

      Molecular and Cellular Biomechanics 6(3)

      Pages: 161-174

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wall boundary model for primitive chain network simulations2009

    • Author(s)
      Okuda, S., Inoue, Y., Masubuchi, Y., Uneyama, T., Hojo, M.
    • Journal Title

      The Journal of Chemical Physics Vol.130

    • NAID

      120002086117

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of fiber array irregularities on microscopic interfacial normal stress states of transversely loaded UD-CFRP from viewpoint of failure initiation2009

    • Author(s)
      M.Hojo, M.Mizuno, T.Hobbiebrunken, T.Adachi, M.Tanaka, S.K.Ha
    • Journal Title

      Composites Science and Technology 69

      Pages: 1726-1734

    • NAID

      120001433464

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change in fatigue property and its relation to critical current for YBCO coated conductor with additional Culayer2009

    • Author(s)
      Y.Yoshida, M.Hojo, M.Sugano, T.Adachi, Y.Inoue, K.Shikimachi, N.Hirano, S.Nagaya
    • Journal Title

      Physica C 469

      Pages: 1476-1479

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluid Pressure Response in Poroelastic Materials Subjected to Cyclic Loading2009

    • Author(s)
      Y.Kameo, T.Adachi, M.Hojo
    • Journal Title

      Journal of the Mechanics and Physics of Solids 57

      Pages: 1815-1827

    • NAID

      120001723785

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In-situ observation of interfacial crack propagation in GF/epoxy model composite using bifiber specimens in mode I and mode II loading2008

    • Author(s)
      Hojo, M., Matsushita, Y., Tanaka, M., Adachi, T.
    • Journal Title

      Composites Science and Technology Vol.68

      Pages: 2678-2689

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of non-uniform fiber arrangement on microscopic stress and failure initiation in thermally and transversely loaded CF/epoxy laminated composites2008

    • Author(s)
      Hobbiebrunken, T., Hojo, M., Jin, K.K., Ha, S.K.
    • Journal Title

      Composites Science and Technology Vol.68

      Pages: 3107-3113

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In-situ observation of interfacial debonding process induced by matrix crack propagation in two-dimensional unidirectional model composites2008

    • Author(s)
      Tanaka, M., Kawaguchi, T., Hojo, M., Ochiai, S., Nakanishi, Y.
    • Journal Title

      Composite Interfaces 15(1)

      Pages: 75-94

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zanchor強化CFRP積層材のモードI層間き裂進展挙動の実験的評価2008

    • Author(s)
      日下貴之, 渡辺圭子, 北條正樹, 福岡俊康, 石橋正康
    • Journal Title

      日本複合材料学会誌 34(3)

      Pages: 102-108

    • NAID

      10023982978

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zanchor強化CFRP積層材のモードII層間き裂進展挙動の実験的評価2008

    • Author(s)
      渡辺圭子, 日下貴之, 北條正樹, 福岡俊康, 石橋正康
    • Journal Title

      日本複合材料学会誌 34(6)

      Pages: 226-232

    • NAID

      10023983238

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transient response of fluid pressure in a poroelasitic material under uniaxial cyclic loading2008

    • Author(s)
      Kameo, Y., Adachi, T., Hojo, M.
    • Journal Title

      Journal of the Mechanics and Physics of Solids 56(5)

      Pages: 1794-1805

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous Observation of Calcium Signaling Response and Membrane Deformation due to Localized Mechanical Stimulus in Single Osteoblast-like Cells2008

    • Author(s)
      Adachi, T., Sato, K., Higashi, N., Tomita, Y., Hojo, M.
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials 1(1)

      Pages: 43-50

    • NAID

      120001741839

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3次元編み構造からなる生分解性複合材料スカフォールドの力学的特性と生分解性特性の評価2008

    • Author(s)
      日和千秋, 横田久美子, 中井善一, 田中信生, 井上俊之, 安達泰治, 北條正樹, 馬場俊介
    • Journal Title

      材料 57(9)

      Pages: 868-874

    • NAID

      130002085620

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 編物複合材料の再生医療用スカフォールドへの適用(I)-生分解性樹脂による編物複合材料の開発-2008

    • Author(s)
      田中信生, 日和千秋, 井元俊之, 安達泰治, 北條正樹, 馬場俊輔
    • Journal Title

      材料システム 26巻

      Pages: 79-88

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 編物複合材料の再生医療用スカフォールドへの適用(II)-マウス骨芽細胞様細胞による骨組織形成過程-2008

    • Author(s)
      日和千秋, 沖添晃政, 中井善一, 田中信生, 安達泰治, 北條正樹, 馬場俊輔
    • Journal Title

      材料システム 26巻

      Pages: 89-95

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In-situ observation of interfacial crack propagation in GF/epoxy modelcomposite using bifiber specimens in mode I and mode II loading2008

    • Author(s)
      Hojo, M., Matsushita, Y., Tanaka, M., Adachi, T.
    • Journal Title

      Composites Science and Technology 68

      Pages: 2678-2689

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two different mechanisms of fatigue damage due to cyclic stress loading at 77 K for MOCVD-YBCO-coated conductors2008

    • Author(s)
      Sugano, M., Yoshida, Y., Hojo, M., Shikimachi, K., Hirano, N., Nagaya, S.
    • Journal Title

      Superconductor Science and Technology 21

      Pages: 54006-54006

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of non-uniform fiber arrangement on microscopic stress and failureinitiation in thermally and transversely loaded CF/epoxy laminated composites2008

    • Author(s)
      Hobbiebrunken, T., Hojo, M., Jin, K. K., Ha, S. K.
    • Journal Title

      Composites Science and Technology 68

      Pages: 3107-3113

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental determination of the true epoxy resin strength using micro-scaled specimens2007

    • Author(s)
      Hobbiebrunken, T., Fiedler, B., Hojo, M., Tanaka, M.
    • Journal Title

      Composites Part A Vol.38

      Pages: 814-818

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of interfacial crack for foam core sandwich panel with crack arrester2007

    • Author(s)
      Hirose, Y., Hojo, M., Fujiyoshi, A., Matsubara, G.
    • Journal Title

      Advanced Composite Materials 16(1)

      Pages: 11-30

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of local strain on cell membrane at initiation point of calcium signaling response to applied mechanical stimulus in osteoblastic cell2007

    • Author(s)
      Sato, K., Adachi, T., Ueda, D., Hojo, M., Tomita, Y.
    • Journal Title

      Journal of Biomechanics Vol.40.Issue6

      Pages: 1246-55

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト大腿骨近位部海綿骨の骨梁リモデリングシミュレーション2007

    • Author(s)
      安達泰治, 鈴木優介, 坪田健一, 北條正樹
    • Journal Title

      日本骨形態計測学会雑誌 17巻

      Pages: 15-20

    • NAID

      10024126884

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of spatial distribution of defects on bending deformation and critical current in Bi2223/Ag superconducting composite tapes2007

    • Author(s)
      Hojo, M., Nakamura, M., Tanaka, M., Adachi, T., Sugano, M., Ochiai, S. and Osamura, K.
    • Journal Title

      Materials Science Forum 539-543

      Pages: 739-744

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct measurement of mechanical properties of Bi2223 filament using Ag alloy removed tape2007

    • Author(s)
      Hojo, M., Hashimoto, M., Tanaka, M., Adachi, T., Sugano, M., Ochiai, S. and Osamura, K.
    • Journal Title

      Physica C 463-465

      Pages: 863-866

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental determination of the true epoxy resin strength using micro-scaled specimens2007

    • Author(s)
      Hobbiebrunken, T., Fiedler, B., Hojo, M. and Tanaka, M.
    • Journal Title

      Composites Part A 38

      Pages: 814-818

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト大腿骨近位部海綿骨の骨梁リモデリングシミュレーション2007

    • Author(s)
      安達泰治, 鈴木優介, 坪田健一, 北條正樹
    • Journal Title

      日本骨形態計測学会雑誌 17

      Pages: 15-20

    • NAID

      10024126884

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mechanical Properties of Bone-Porous Scaffold Structure in Bone Regeneration Predicted by 3D Computational Simulation2009

    • Author(s)
      Hojo, M., Adachi, T., Osako, Y., Tanaka, M.
    • Organizer
      The 11th Japan International SAMPE Symposium and Exhibition
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-11-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Mechanical properties of bone-porous scaffold structure in bone regeneration predicted by 3D computational simulation2009

    • Author(s)
      Hojo, M., Adachi, T.
    • Organizer
      Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Education Ministry (Zhejiang Sci-Tech University) and JCOM Joint Workshop on Composite Materials
    • Place of Presentation
      Zhejian, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Change in Deformation/Fracture Behavior of Interface- Controlled HAp/PLLA Composites by ydrolysis2009

    • Author(s)
      Tanaka, M., Tanaka, H., Hojo, M., Adachi, T., Sugihara, M., Kotera, M., Nishino, T.
    • Organizer
      Proceedings of 17th International Conference on Composite Materials
    • Place of Presentation
      Edinburg
    • Related Report
      2009 Final Research Report
  • [Presentation] Damage Initiation under Transverse Loading of UD-CFRP with Random Fiber Arrangement2009

    • Author(s)
      Hojo, M., Mizuno, M., Hobbiebrunken, T., Adachi, T., , Jin, K.K.
    • Organizer
      Fourth China-Europe Symposium on Processing and Properties of Reinforced Polymers p. 17
    • Place of Presentation
      Guilin, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Transient and Steady-State Behaviors of Fluid Pressure in Poroelastic Materials under Cyclic Axial and Bending Loading2009

    • Author(s)
      Kameo, Y., Adachi, T., Hojo, M.
    • Organizer
      The Fourth Biot Conference on Poromechanics
    • Place of Presentation
      New York
    • Related Report
      2009 Final Research Report
  • [Presentation] Damage Initiation under Transverse Loading of UD-CFRP with Random Fiber Arrangement2009

    • Author(s)
      Masaki Hojo
    • Organizer
      The Fourth China-Europe Symposium on Processing and Properties of Reinforced Polymers
    • Place of Presentation
      Guilin, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨再生のための複合材料スカフォールドの開発2008

    • Author(s)
      北條正樹
    • Organizer
      第47回日本生体医工学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mode I Fatigue Delamination of Zanchor Reinforced CF/Epoxy Laminates2007

    • Author(s)
      Hojo M, Nakashima K, Tanaka M, Adachi T, Kusaka T, Fukuoka T,
    • Organizer
      Fourth International Conference on Fatigue of Composites (ICFC4)
    • Place of Presentation
      Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of fiber array irregularities on microscopic interfacial normal stress state of transversly loaded UD-CFRP from viewpoint of fracture initiation2007

    • Author(s)
      Hojo, M., Mizuno, M., Hobbiebrunken, T., Tanaka, M. and Adachi, T.
    • Organizer
      8th Seminar on Experimental Techniques and Design in Composite Materials
    • Place of Presentation
      Italy
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://ams.me.kyoto-u.ac.jp/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://ams.me.kyoto-u.ac.ip/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://ams.me.kyoto-u.ac.jp/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 三次元製織装置および三次元製織方法2007

    • Inventor(s)
      北條, 安達, 日和, 馬場, 井上, 井元, 田中
    • Industrial Property Rights Holder
      JST, 京大学, 神大, NIRO, アルブラスト, 井元製作所
    • Filing Date
      2007-08-07
    • Related Report
      2007 Annual Research Report
    • Overseas

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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