Modeling of Transport Phenomena and Physical Stimulus Response in Engineered Cartilage Tissue Development

• Project/Area Number: 19360087
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: Hokkaido University
• Principal Investigator: WATANABE Masao Hokkaido University, 大学院・工学研究科, 准教授 (30274484)
• Co-Investigator(Kenkyū-buntansha): SAWAE Yoshinori 九州大学, 大学院・工学研究院, 准教授 (10284530) ; SAKAI Noburo 九州大学, 大学院・工学研究院, 助教 (60346814) ; SANADA Toshiyuki 静岡大学, 工学部, 助教 (50403978)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2007: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
• Keywords: 再生医療 / 軟骨細胞 / 輸送現象 / 拡散 / 移流 / 可視化 / モデリング

Research Abstract

We visualized transport phenomena in developing engineered cartilage tissues. The promotion of mass transfer due to the existence of cells inside test pieces are observed. The cell metabolism increased the diffusion transport. Generated polymers that consist extra-cellular matrices, such as negatively charged keratan sulfate, restrict diffusion transport. We also clarified the effects of advection transport due to the compression on diffusion transport.

Research Products

• [Presentation] 再生軟骨担体ゲル内での物質輸送現象 (2009)
  • Author(s): 野林真, 渡部将平, 野田博敬, 澤江義則, 渡部正夫
  • Organizer: 日本機械学会第21回バイオエンジニアリング講演会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-01-23
• [Presentation] 再生軟骨担体ゲル内での物質輸送現象 (2009)
  • Author(s): 野林真, 渡部将平, 野田博敬, 澤江義則, 渡部正夫
  • Organizer: 日本機械学会第21回バイオエンジニアリング講演会
  • Place of Presentation: 札幌コンベンションセンター, 札幌市白石区
  • Year and Date: 2009-01-23
• [Presentation] 再生軟骨内での移流・拡散輸送現象 (2008)
  • Author(s): 野林真, 北島洋佑, 渡部将平, 澤江義則, 渡部正夫
  • Organizer: 日本機械学会2008年度年次大会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-08-04
• [Presentation] 再生軟骨内での移流・拡散輸送現象 (2008)
  • Author(s): 野林真, 北島洋佑, 渡部将平, 澤江義則, 渡部正夫
  • Organizer: 日本機械学会2008年度年次大会
  • Place of Presentation: 横浜国立大学, 神奈川県横浜市保土ヶ谷区
  • Year and Date: 2008-08-04
• [Presentation] 再生軟骨内における拡散輸送現象 (2008)
  • Author(s): 渡部将平, 北島洋佑, 野林真, 澤江義則, 村上輝夫, 渡部正夫
  • Organizer: 日本機械学会第20回バイオエンジニアリング講演会
  • Place of Presentation: 東京都江東区
  • Year and Date: 2008-01-08
• [Presentation] 再生軟骨内における拡散輸送現象 (2008)
  • Author(s): 渡部将平, 北島洋佑, 野林真, 澤江義則, 村上輝夫, 渡部正夫
  • Organizer: 日本機械学会第20回バイオエンジニアリング講演会
  • Place of Presentation: 芝浦工業大学豊洲キャンパス, 東京都江東区
  • Year and Date: 2008-01-08
• [Presentation] 培養軟骨における拡散と組織発達 (2007)
  • Author(s): 北島洋佑, 渡部将平, 野林真, 澤江義則, 村上輝夫, 渡部正夫
  • Organizer: 第18回バイオフロンティア講演会
  • Place of Presentation: 福岡市
  • Year and Date: 2007-10-07
• [Presentation] Transport Phenomena in Engineered Cartilage with Tissue Development in Agarose Gel (2007)
  • Author(s): Yosuke KITAJIMA, Shoichi SUGINO, Toshiyuki SANADA, Yoshinori SAWAE, Teruo MURAKAMI, Masao WATANABE
  • Organizer: 5th Joint ASME/JSME Fluids Engineering Conference
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-07-31
• [Presentation] Transport Phenomena in Engineered Cartilage with Tissue Development in Agarose Gel (2007)
  • Author(s): Yosuke KITAJIMA, Shoichi SUGINO, Toshiyuki SANADA, Yoshinori SAWAE, Teruo MURAKAMI, Masao WATANABE
  • Organizer: 5th Joint ASME/JSME Fluids Engineering Conference
  • Place of Presentation: Sheraton San Diego Hotel & Marina, San Diego, CA, USA
  • Year and Date: 2007-07-31