Studies on biosensor device technology based on immobilization of intact liposome on Si-integrated sensor structure
| Project/Area Number |
19360162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Electron device/Electronic equipment
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
NODA Minoru Kyoto Institute of Technology, 工芸科学研究科, 教授 (20294168)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMANOUCHI Toshinori 大阪大学, 基礎工学研究科, 助教 (10335383)
OKUYAMA Masanori 大阪大学, ナノサイエンスデザイン教育研究センター, 特任教授 (60029569)
KUBOI Ryouichi 大阪大学, 事務局, 特任教授 (40029567)
MURAKAMI Shuichi 大阪府立産業技術総合研究所, 情報電子部, 研究員 (70359420)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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| Keywords | バイオセンサ / マイクロナノデバイス / 脂質 / バイオ関連機器 / バイオテクノロジー / リポソーム / 固定化 / 親水性 / 表面酸化 / SAM (self-assembled mono-layer) / 熱化学センサ / ボロメータ |
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| Research Abstract |
We have studied a series of biosensor device technologies based on immobilization of intact liposome on Si-integrated sensor structure. As a result, the immobilized liposome keeps its intact behavior more than 24hrs, meaning practically long time range for usual sensing. Based on the result, three type of liposome biosensor of microbolometer biothermochemical sensor, leakage current sensor and cantilever strain sensor are designed, fabricated and evaluated for detection of target proteins. Finally these sensors are confirmed to show their effective sensing performance.
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Report
(4 results)
Research Products
(53 results)
