Non-linear microbubble manipulation by ultrasonic wave

• Project/Area Number: 19360184
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Gunma University
• Principal Investigator: YAMAKOSHI Yoshiki Gunma University, 大学院・工学研究科, 教授 (10174640)
• Co-Investigator(Kenkyū-buntansha): 三輪 空司 群馬大学, 大学院・工学研究科, 助教 (30313414)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2007: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
• Keywords: 計測システム / 超音波 / ドラッグデリバリシステム / 微小気泡 / Secondary Bjerknes force / ソノポレーション / ドラッグデリバリ / 非線形超音波 / 気泡マニピュレーション / 音響放射圧 / 気泡 / 非線形振動 / マニピュレーション / Bjerknes力 / 自己付着

Research Abstract

超音波中での気泡の非線形振動を積極的に利用した気泡操作法(非線形気泡マニピュレーション法)を開発した。本手法ではポンピング波と呼ぶ気泡に非線形振動を生じさせる比較的音圧の高い超音波を用いて気泡を操作する点に特徴があるが、(1)ポンピング波の周波数に対して整数倍の周波数を持つコントロール波と呼ぶ超音波を用いた気泡の非線形トラッピング技術、(2)非線形気泡振動により気泡周囲に生じる非線形2次超音波を用いたターゲット壁面への非線形自己トラッピング法の2つを開発した。

Research Products

• [Journal Article] マルチチャンネル・マルチパラメータ胎児モニタ-胎児Behaviogram-の開発 (2009)
  • Author(s): 山越芳樹, 篠塚憲男, 三輪空司
  • Journal Title: Jpn. J. Med. Ultrasonics Vol.36, No.3(in Press)
  • NAID: 10026312064
  • Peer Reviewed
• [Journal Article] Localization of living-bodies using single-frequency multistatic Doppler radar system (2008)
  • Author(s): T. Miwa , S. Ogiwara and Y. Yamakoshi
  • Journal Title: IEICE Transactions on Communication Vol.E92-B(In Press)
  • NAID: 10026839684
  • Peer Reviewed
• [Journal Article] 超音波中での微小気泡のダイナミクスと医用応用 (2008)
  • Author(s): 山越芳樹
  • Journal Title: バイオレオロジー Vol.22, No.3 Pages: 59-70
  • NAID: 10026084818
  • Peer Reviewed
• [Journal Article] Microbubble Self-Trapping to Surface of Target (2008)
  • Author(s): Y. Yamakoshi and T. Miwa
  • Journal Title: Japanese Journal of Applied Physics Vol.47, No.5 Pages: 4127-4131
  • Peer Reviewed
• [Journal Article] 物体表面への微小気泡の自己付着 (2008)
  • Author(s): 山越芳樹
  • Journal Title: 超音波TECNO Vol.20, No.5 Pages: 106-110
  • Peer Reviewed
• [Journal Article] Microbubble Self-Trapping to Surface of Target (2008)
  • Author(s): Y. Yamakoshi, T. Miwa
  • Journal Title: Japanese Jotrnal of Applied Physics 47(5) Pages: 4127-4131
  • Peer Reviewed
• [Journal Article] 物体表面への微小気泡の自己付着 (2008)
  • Author(s): 山越芳樹
  • Journal Title: 超音波TECNO 20(5) Pages: 106-110
  • Peer Reviewed
• [Journal Article] 超音波由での微小気泡のダイナミクスと医用応用 (2008)
  • Author(s): 山越芳樹
  • Journal Title: 日本バイオレオ自ジー学会誌 22(3) Pages: 59-70
  • Peer Reviewed
• [Journal Article] 微小気泡の超音波マニピュレーションとドラッグデリバリシステム (2007)
  • Author(s): 山越芳樹
  • Journal Title: 日本音響学会誌 Vol.63, No.3 Pages: 157-162
  • NAID: 10018749656
  • Peer Reviewed
• [Journal Article] Microbubble Trapping by Nonlinear Bubble Oscillation Using Pumping Wave (2007)
  • Author(s): Y. Yamakoshi, N. Nakajima, and T. Miwa
  • Journal Title: Jpn. J. Appl. Phys 46 Pages: 4847-4850
  • Peer Reviewed
• [Journal Article] Blood Outflow from Capillary under Forced Pressure : Comparison between Electric Circuit Analog and optical Measurement (2007)
  • Author(s): Y. Yamakoshi, Y. Yamanaka
  • Journal Title: Japanese Journal of Applied Physics Vol.46 Pages: 7970-7976
  • NAID: 40015752615
  • Peer Reviewed
• [Journal Article] Microbubble Trapping by Nonlinear Bubble Oscillation Using Pumping Wave (2007)
  • Author(s): Y. Yamakoshi, N. Nakajima, and T. Miwa
  • Journal Title: Jpn.J.Appl.Phys 46 Pages: 4847-4850
  • Peer Reviewed
• [Journal Article] Blood Outflow from Capillary under Forced Pressure:Comparison betweell Electric Cireuit Analog and optical Measurement (2007)
  • Author(s): Y. Yamakoshi, Y. Yamanaka
  • Journal Title: Jp.J.Appl.Phys 46 Pages: 7970-7976
  • Peer Reviewed
• [Journal Article] Microbubble Adhesion to Target Wall by Ultrasonic Wave Frequency Sweep Method
  • Author(s): Y. Yamakoshi and T. Miwa
  • Journal Title: Japanese Journal of Applied Physics (in Press)
  • NAID: 210000067153
  • Peer Reviewed
• [Journal Article] Microbubble Adhesion to Target Wall by Ultrasonic Wave Frequency Sweep Method
  • Author(s): Y. Yamakoshi, H. Kawamoto
  • Journal Title: Japanese Journal of Applied Physics In press
  • NAID: 210000067153
  • Peer Reviewed
• [Presentation] Micro bubble adhesion to target wall by ultrasonic wave frequency sweep method (2008)
  • Author(s): Y. Yamakoshi and T. Miwa
  • Organizer: The 29th Symp. on Ultrasonic Electronics
  • Place of Presentation: 仙台
  • Year and Date: 2008-11-13
• [Presentation] Micro bubble adhesion to target wall by ultrasonic wave frequency sweep method (2008)
  • Author(s): Y. Yamakoshi, T. Miwa
  • Organizer: The 29th Symposium on Ultrasonic Electronics
  • Place of Presentation: 仙台
  • Year and Date: 2008-11-13
• [Presentation] Micro bubble adhesion to target wall by frequency sweep of ultrasonic pumping wave (2008)
  • Author(s): Y. Yamakoshi and T. Miwa
  • Organizer: IEEE 2008 US Symp
  • Place of Presentation: 北京
  • Year and Date: 2008-11-04
• [Presentation] Micro bubble adhesion to target wall by frequency sweep of ultrasonic pumping wave (2008)
  • Author(s): Y. Yamakoshi, T. Miwa
  • Organizer: IEEE 2008 Ultrasonic Symposium
  • Place of Presentation: 北京(中国)
  • Year and Date: 2008-11-04
• [Presentation] 加圧光センサによる皮膚毛細血管からの血液流失特性評価法 (2008)
  • Author(s): 山越芳樹
  • Organizer: 第31回日本バイオレオロジー学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-06
• [Presentation] Micro bubble self-adhesion to surface of object (2007)
  • Author(s): Y. Yamakoshi and T. Miwa
  • Organizer: The 28th Symp. on Ultrasonic Electronics
  • Place of Presentation: 筑波
  • Year and Date: 2007-11-15
• [Presentation] Micro bubble self-adhesion to surface of object (2007)
  • Author(s): Y. Yamakoshi, T. Miwa
  • Organizer: The 28th Symposium on Ultrasonic Electronics
  • Place of Presentation: Tsukuba
  • Year and Date: 2007-11-15
• [Presentation] Self-trapping of microbubbles to surface of target (2007)
  • Author(s): Y. Yamakoshi and T. Miwa
  • Organizer: IEEE 2007 US Symp
  • Place of Presentation: NewYork
  • Year and Date: 2007-10-29
• [Presentation] Self-trapping of microbubbles to surface of target (2007)
  • Author(s): Y. Yamakoshi
  • Organizer: IEEE 2007 Ultrasonic Symposium
  • Place of Presentation: New York,U.S.A.
  • Year and Date: 2007-10-29
• [Presentation] Localization of living-bodies using single-frequency MIMO radar system (2007)
  • Author(s): T. Miwa, Y. Kigure, Y. Yamakoshi
  • Organizer: 2007 Int. Symp. on Antennas and Propagation
  • Place of Presentation: Niigata
  • Year and Date: 2007-08-24
• [Presentation] 音響インピーダンスが異なる境界への微小気泡の自己トラッピング (2007)
  • Author(s): 山越 芳樹, 中島 成継
  • Organizer: 日本超音波医学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2007-05-18