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Juggling-probe for local dosing to living cells

Research Project

Project/Area Number 19360188
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Measurement engineering
Research InstitutionKagawa University

Principal Investigator

ISHIMARU Ichirou  Kagawa University, 工学部, 教授 (70325322)

Co-Investigator(Kenkyū-buntansha) MASAKI Tsutomu  香川大学, 医学部, 教授 (30335848)
TANAKA Naotaka  香川大学, 農学部, 准教授 (60324109)
竹川 薫  香川大学, 農学部, 教授 (50197282)
Co-Investigator(Renkei-kenkyūsha) TAKEKAWA Kaoru  九州大学, 農学研究院, 教授 (50197282)
KURIYAMA Shigeki  香川大学, 医学部, 教授 (50244710)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords計測システム / 光圧力 / 細胞 / 投薬 / 多自由度 / 多自由度制御 / 粘性力 / 弾性力 / 触診 / 白色位相シフト干渉 / 断層像 / 分光
Research Abstract

We research the separation measurement technology of viscous force and elastic force for evaluate the effects of medicine to single living cells. This method palpates the cell surface with vibrated micro-sphere by light pressure. Because this method used light pressure which is low as elastic force and the surface effect is the dominant factor of dynamics of micro objects, rather than the volume effect, we think that viscous force which is very little force is obtained, and separation viscous force and elastic force. We constructed the model of separative cell-palpation method, and the measurement of the particle diameter to secure the high accuracy.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2010 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (12 results)

  • [Journal Article] 光操作マイクロプローブによる細胞の粘弾性力分離計測2010

    • Author(s)
      石丸伊知郎
    • Journal Title

      光アライアンス 10月号(掲載確定)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 単一細胞局所投薬マイクロプローブ技術2008

    • Author(s)
      石丸伊知郎
    • Journal Title

      光アライアンス, 日本工業出版 2巻

      Pages: 59-62

    • Related Report
      2009 Final Research Report
  • [Journal Article] 高感度高空間解像度2次元分光計測技術=単一細胞内蛍光標識3次元分光分布計測=2008

    • Author(s)
      石丸 伊知郎
    • Journal Title

      月刊「光アライアンス」 Vol.19, No.1

      Pages: 49-52

    • NAID

      40015775568

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 生きたままの細胞内3次元成分分布時系列計測(単一細胞分光トモグラフィ)2008

    • Author(s)
      石丸 伊知郎
    • Journal Title

      月刊「BIO INDUSTRY」 Vol.25, No.2

      Pages: 55-66

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Mid-infrared Spectroscopy Optical Coherence Tomography2007

    • Author(s)
      下所 和弘、石丸 伊知郎、山本 量也
    • Journal Title

      roc. of Frontiers in Optics 2007 OSA(Optical Siciety of America(CD-ROM)掲載番号FWK5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Separation Measurement of Viscous Force and Elastic Force for the Cell by the Optically Manipulated Floating Type Micro-Probe2010

    • Author(s)
      堤良介
    • Organizer
      ISMQC2010 (10th International Symposium on Measurement and Quality Control 2010)
    • Place of Presentation
      大阪大学(発表確定)
    • Year and Date
      2010-09-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光圧力操作マイクロプローブによる細胞の粘弾性力分離計測2010年度精密工学会春季学術講演会2010

    • Author(s)
      堤良介, 下所和弘, 西山成, 石丸伊知郎
    • Place of Presentation
      埼玉大学
    • Year and Date
      2010-03-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 光圧力操作マイクロプローブによる細胞の粘弾性力分離計測2010

    • Author(s)
      堤良介
    • Organizer
      精密工学会春季学術講演会
    • Place of Presentation
      埼玉大学
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光圧力駆動マイクロプローブによる粘弾性力計測技術2008

    • Author(s)
      浦木智央, 下所和弘, 合谷祥一, 末吉紀行, 石丸伊知郎
    • Organizer
      日本光学会年次学術講演会Optics & Photonics Japan 2008
    • Place of Presentation
      筑波大学
    • Year and Date
      2008-11-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Separative-mesurement of viscos and elastic force for living cells with floating-type micro probe2008

    • Author(s)
      Tomohiro Uraki, Kazuhiro Gesho, Shoichi Gohtani, Noriyuki Sueyoshi, Ichirou Ishimaru
    • Organizer
      The 25th Sensor symposium
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2008-10-21
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 光圧力駆動微粒子によるマイクロ流体粘性計測技術2008

    • Author(s)
      浦木智央, 下所和弘, 石丸伊知郎
    • Organizer
      2008年度精密工学会秋季大会学術講演会
    • Place of Presentation
      東北大学
    • Year and Date
      2008-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 光圧力駆動型多自由度マイクロプローブによる粘弾性力計測技術2008

    • Author(s)
      浦木智央, 下所和弘, 合谷祥一, 末吉紀行, 石丸伊知郎
    • Organizer
      知能メカトロニクスワークショップ
    • Place of Presentation
      高松サンポート
    • Year and Date
      2008-09-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Study on floating micro-probe with multi degrees of freedom and function for cell operation -Juggling probe-2008

    • Author(s)
      下所和弘
    • Organizer
      SPIE Optical Micromanipulation V
    • Place of Presentation
      アメリカ サンディエゴ
    • Year and Date
      2008-08-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Study on floating micro-probe with multi degrees of freedom and function for cell operation -Juggling probe-2008

    • Author(s)
      K. Gesho, T. Uraki, I. Ishimaru
    • Organizer
      SPIE Optical Micromanipulation V
    • Place of Presentation
      サンディエゴコンベンションセンター
    • Year and Date
      2008-08-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Light pressure driven floating-type micro-probe technology for operation of biological cell2008

    • Author(s)
      T. Uraki, K. Gesho, I. Ishimaru
    • Organizer
      7th France-Japan congress on Mecatronics
    • Place of Presentation
      サボアコンベンションセンター
    • Year and Date
      2008-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 浮遊型マイクロプローブによる生体細胞の粘弾性力計測技術2008

    • Author(s)
      浦木智央、下所和弘、石丸伊知郎
    • Organizer
      2008年度精密工学会春季大会
    • Place of Presentation
      明治大学
    • Year and Date
      2008-03-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 生きたままの単一細胞特性計測のためのマイクロプローブ非接触振動制御技術2007

    • Author(s)
      下所和弘, 山本量也, 近藤昌博, 原田伯城, 石丸伊知郎
    • Organizer
      Optics Photonics Japan 2007
    • Place of Presentation
      一橋会館
    • Year and Date
      2007-11-10
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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