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Preparation of nanometer-scale rod array and biomedical application

Research Project

Project/Area Number 19360301
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Inorganic materials/Physical properties
Research InstitutionOkayama University

Principal Investigator

HAYAKAWA Satoshi  Okayama University, 大学院・自然科学研究科, 准教授 (20263618)

Co-Investigator(Kenkyū-buntansha) 尾坂 明義  岡山大学, 大学院・自然科学研究科, 教授 (20033409)
都留 寛治  岡山大学, 大学院・自然科学研究科, 助教 (50314654)
Co-Investigator(Renkei-kenkyūsha) OSAKA Akiyoshi  岡山大学, 大学院・自然科学研究科, 教授 (20033409)
TSURU Kanji  岡山大学, 大学院・自然科学研究科, 助教 (50314654)
Research Collaborator EIJI Fujii  岡山県工業技術センター, 技術員
SHIROSAKI Yuki  岡山大学, 大学院・自然科学研究科, 助教 (40533956)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2008: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2007: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords酸化チタン / ヒドロキシアパタイト / 生体活性 / ナノ結晶 / 自己組織化 / 金属チタン / 細胞接着性 / ロッド配列構造 / インプラント
Research Abstract

無機ナノ材料の創製には多くの化学的手法があるが, 医用インプラントの様な大型材料に高生体機能性表面層を創製するにはコスト面で厳しいだけでなく, 基材との固着力, 機械的強度の不足が大きな課題となっている。本研究では, 医用インプラント材料の組織結合性の改善のために, 医用金属チタンや医用ガラスセラミックス表面に, 自己組織化的な結晶の配向性とサイズを制御した, 基材に対する固着力の高い酸化チタン, または, 歯のエナメル質に類似した高結晶配向性の水酸アパタイトのナノ・サブマイクロ粒子配列構造を創製することにより, 高い生体活性と細胞接着性の発現に成功した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (38 results)

All 2009 2008 2007 Other

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (18 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Preparation of Nanometer-scale Rod Array of Hydroxyapatite Crystal2009

    • Author(s)
      S., Hayakawa, Y., Li, K., Tsuru, A., Osaka, E., Fujii, K., Kawabata
    • Journal Title

      Acta Biomaterialia

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] XPS study on potential suppression factors of suppressing in vitro apatite formation on anatase films prepared on various substrates2009

    • Author(s)
      T., Shozui, K., Tsuru, S., Hayakawa, Y., Shirosaki, A., Osaka
    • Journal Title

      Surface and Coatings Technology Vol.203[16]

      Pages: 2181-2185

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of in vitro apatite-forming ability of thermally oxidized titanium surfaces by ultraviolet irradiation2008

    • Author(s)
      T., Shozui, K., Tsuru, S., Hayakawa, A., Osaka
    • Journal Title

      Journal of the Ceramic Society of. Japan Vol.116[4]

      Pages: 530-535

    • NAID

      110006676869

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modification of Ti implant surface for cell proliferation and cell alignment2008

    • Author(s)
      Jia, Ming, Zhao, K., Tsuru, S., Hayakawa, A., Osaka
    • Journal Title

      Journal of Biomedical Materials Research Vol.84A[4]

      Pages: 988-993

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel fabrication of nano-rod array structures on titanium and in vitro cell responses2008

    • Author(s)
      Y., Liu, W., Chen, Y., Yang, J. L., Ong, K., Tsuru, S., Hayakawa, A., Osaka
    • Journal Title

      Journal of Materials Science : Materials in Medicine Vol.19[7]

      Pages: 1-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bilirubin adsorption property of sol-gel-derived titania particles for blood purification therapy2008

    • Author(s)
      T., Asano, K., Tsuru, S., Hayakawa, A., Osaka
    • Journal Title

      Acta Biomaterialia Vol.4[4]

      Pages: 1067-1072

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced in vitro apatite-formiang ability of sol-gel derived titania films by ultraviolet irradiation2008

    • Author(s)
      T., Shozui, K., Tsuru, S., Hayakawa, A., Osaka
    • Journal Title

      Key Engineering Materials(2008 Trans Tech Publications, Switzerland) Vols. 361-363

      Pages: 601-604

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of in vitro apatite-forming ability of thermally oxidized titanium surfaces by ultraviolet irradiation2008

    • Author(s)
      Shozui, et al.
    • Journal Title

      Journal of the Ceramics Society of Japan 116

      Pages: 530-535

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel fabrication of nano-rod array structures on titanium and in vitrocell responses2008

    • Author(s)
      Liu, et al.
    • Journal Title

      Journal of Materials Science : Materials in Medicine 19

      Pages: 1-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bilirubin adsorption property of sol-gel-derived titania particles for blood purification therapy2008

    • Author(s)
      Asano, et al.
    • Journal Title

      Aota Biomaterialia 4

      Pages: 1067-1072

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced in vitro apatite-formiang ability of sol-gel derived titania films by ultraviolet irradiation2008

    • Author(s)
      Shozui, et. al.
    • Journal Title

      Key Engineering Materials 361-363

      Pages: 601-604

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Modification of Ti implant surface for cell proliferation and cell alignment2008

    • Author(s)
      Zhao, et. al.
    • Journal Title

      Journal of Biomedical Materials Research 84A

      Pages: 988-993

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Apatite-Forming Ability of Titania Films Depends on Their Substrates2007

    • Author(s)
      Shozui, et. al.
    • Journal Title

      Key Engineering Materials 330-332

      Pages: 663-636

    • Related Report
      2007 Annual Research Report
  • [Presentation] Osteoblastic cell adhesion on micro-patterned titania layers2009

    • Author(s)
      K., Kawanishi, A., Kaeriyama, Y., Shirosaki, S., Hayakawa, A., Osaka, E., Fujii, K., Kawabata
    • Organizer
      日本セラミックス協会基礎科学部会第47回セラミックス基礎科学討論会, 講演番号1D6国
    • Place of Presentation
      グランキューブ大阪(大阪国際会議場)
    • Year and Date
      2009-01-09
    • Related Report
      2008 Final Research Report
  • [Presentation] ケイ酸塩ガラスからのエナメル質類似アパタイトナノロツド配列構造の形成2009

    • Author(s)
      早川聡, 他4名
    • Organizer
      日本セラミックス協会基礎科学部会第47回セラミックス基礎科学討論会
    • Place of Presentation
      大阪
    • Year and Date
      2009-01-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 晶性酸化チタン層のアパタイト形成能に及ぼす紫外線照射の影響2, 講演番号3G082009

    • Author(s)
      金田治樹, 城崎由紀, 早川聡, 尾坂明義, 植月啓太
    • Organizer
      日本セラミックス協会2009年年会
    • Place of Presentation
      千葉
    • Related Report
      2008 Final Research Report
  • [Presentation] 酸化チタン層の物理的及び化学的パターニングとin vitroアパタイト形成2008

    • Author(s)
      歸山 亜弓, 他6名
    • Organizer
      基礎科学部会第46回セラミックス基礎科学討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-01-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Formation of Nano- and Micrometer-scale Hydroxyapatite Rod Array Structure on Ca-containing Glass, at 062 - Glasses and glass ceramics2008

    • Author(s)
      S. Hayakawa, H. Kazama, K. Tsuru, A. Osaka, E. Fujii, K. Kawabat
    • Organizer
      8^<th> World Biomaterials Congress
    • Related Report
      2008 Final Research Report
  • [Presentation] 結晶性酸化チタン層のアパタイト形成能に及ぼす紫外線照射の影響2008

    • Author(s)
      勝瑞哲也・都留寛治・早川 聡・尾坂明義・藤井英司・川端浩二
    • Organizer
      講演番号1K28, 日本セラミックス協会2008年年会
    • Place of Presentation
      長岡
    • Related Report
      2008 Final Research Report
  • [Presentation] 酸化チタン層の物理的及び化学的パターニングとin vitro アパタイト形成2008

    • Author(s)
      歸山亜弓・勝瑞哲也・都留寛治・早川聡・尾坂明義・藤井英司・川端浩二
    • Organizer
      講演番号2B02, 日本セラミックス協会基礎科学部会第46回セラミックス基礎科学討論会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] Enhanced in vitro apatite-formiang ability of sol-gel derived titania films by ultraviolet irradiation2008

    • Author(s)
      T. Shozui, K. Tsuru, S. Hayakawa, A. Osaka
    • Organizer
      Key Engineering Materials
    • Place of Presentation
      2008 Trans Tech Publications, Switzerland(Vols. 361-363pp. 601-604)
    • Related Report
      2008 Final Research Report
  • [Presentation] 酸化チタンナノ-ロッド配列構造の構築と血液適合性の評価2007

    • Author(s)
      正岡伸孝, 川西孝治, 関川彩子, 都留寛治, 早川聡, 尾坂明義
    • Organizer
      講演番号K70, 日本セラミックス協会中国四国支部主催第14回ヤングセラミスト・ミーティングin 中四国
    • Place of Presentation
      岡山理科大
    • Year and Date
      2007-12-08
    • Related Report
      2008 Final Research Report
  • [Presentation] 温水処理によるガラスからの酸化亜鉛マイクロファイバーの形成2007

    • Author(s)
      安東 民雄, 他3名
    • Organizer
      ガラス部会第48回ガラス及びフォトニクス材料討論会
    • Place of Presentation
      豊橋
    • Year and Date
      2007-11-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] ガラス表面でのアパタイトロッド配列構造の形成2007

    • Author(s)
      早川 聡, 他5名
    • Organizer
      日本セラミックス協会第20回秋季シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 酸化チタン層のin vitroアパタイト形成能に及ぼす隙間の効果2007

    • Author(s)
      岩本 奈美子, 他6名
    • Organizer
      日本セラミックス協会第20回秋季シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Formation of Micro-scale Rod Array of Hydroxyapatite on Glass Surface2007

    • Author(s)
      H. Kazama, K. Tsuru, S. Hayakawa, A. Osaka, E. Fujii, K. Kawabata
    • Organizer
      Y6, XXIst International Congress on Glass (ICG2007)
    • Place of Presentation
      Strasbourg, France
    • Year and Date
      2007-07-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Formation of Micro-scale Rod Array of Hydroxyapatite on Glass Surface2007

    • Author(s)
      風間 洋, 他5名
    • Organizer
      XXIst International Congress on Glass (ICG2007)
    • Place of Presentation
      Strasbourg, France
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Formation of Nano-scale Rod Array of Hydroxyapatite on Glass Surface2007

    • Author(s)
      早川 聡, 他6名
    • Organizer
      XXIst International Congress on Glass (ICG2007)
    • Place of Presentation
      Strasbourg, France
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 温水処理によるガラスからの酸化亜鉛マイクロファイバーの形成2007

    • Author(s)
      安東民雄, 都留寛治, 早川聡, 尾坂明義
    • Organizer
      講演番号2B03, 日本セラミックス協会ガラス部会第48回ガラス及びフォトニクス材料討論会
    • Place of Presentation
      豊橋
    • Related Report
      2008 Final Research Report
  • [Presentation] ガラス表面でのアパタイトロッド配列構造の形成2007

    • Author(s)
      早川聡・風間洋・都留寛治・尾坂明義・藤井英司・川端浩二
    • Organizer
      講演番号2G05, 日本セラミックス協会第20回秋季シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] Formation of Nano-scale Rod Array of Hydroxyapatite on Glass Surface2007

    • Author(s)
      S. Hayakawa, H. Kazama, Y. Nomura, K. Tsuru, A. Osaka, E. Fujii, K. Kawabata
    • Organizer
      Y9, XXIst International Congress on Glass (ICG2007)
    • Place of Presentation
      Strasbourg, France
    • Related Report
      2008 Final Research Report
  • [Book] 医用金属チタンの生体親和性の制御(未来材料 第9巻, 5月号)2009

    • Author(s)
      早川聡, 尾坂明義, 城崎由紀
    • Publisher
      (株)エヌ・ティー・エス
    • Related Report
      2008 Final Research Report
  • [Book] Part 3 : The microstructure of bioceramics and its analysis2008

    • Author(s)
      S. Hayakawa, K. Tsuru, A. Osaka
    • Publisher
      in Bioceramics and their clinical applications : edited by Tadashi Kokubo
    • Related Report
      2008 Final Research Report
  • [Remarks] 科学技術振興機構(JST)新技術説明会2009年1月20日発表

    • Related Report
      2008 Final Research Report
  • [Remarks] 日経産業新聞人工関節・歯根チタン2009年2月5日掲載

    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 生体親和性インプラントの製造方法2008

    • Inventor(s)
      早川聡, 尾坂明義, 都留寛治, 勝瑞哲也
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Filing Date
      2008-11-27
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 生体親和性インプラントの製造方法2007

    • Inventor(s)
      早川聡, 尾坂明義, 都留寛治, 勝瑞哲也
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Industrial Property Number
      2007-132708
    • Filing Date
      2007-05-18
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 生体親和性インプラントの製造方法2007

    • Inventor(s)
      早川 聡, 尾坂 明義, 都留 寛治, 勝瑞 哲也
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2007-05-18
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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