Development of continuous separation process for optical isomers using chiral ionic liquid and supercritical carbon dioxide

• Project/Area Number: 19360348
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Properties in chemical engineering process/Transfer operation/Unit operation
• Research Institution: Tohoku University
• Principal Investigator: SMITH Richard Lee Jr Tohoku University, 大学院・環境科学研究科, 教授 (60261583)
• Co-Investigator(Kenkyū-buntansha): SATO Yoshiyuki 東北大学, 大学院・工学研究科, 准教授 (50243598)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2007: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
• Keywords: イオン液体 / 光学異性体 / 超臨界二酸化炭素 / 相平衡 / 状態式 / 超臨界クロマト / キラルイオン液体 / 分離プロセス / 超臨界流体 / 物性実験 / 化学工学 / 分離技術 / 環境調和

Research Abstract

イオン液体相と超臨界CO_2相の2相系を用いた抽出、分離システム開発を目的としている。その基礎的知見として、イオン液体-CO_2-芳香族化合物3成分系における無限希釈分配係数の測定を行い、溶質種、イオン液体種依存性の検討を行った。Sanchez-Lacombe状態式による相関では異種分子間においても温度、圧力変化も推算可能であることを示した。光学異性体の分離に関して、超臨界クロマト法により分離係数の評価を行った。光学分割を示すキラルイオン液体の構造の同定には官能基の相互作用に着目した構造探索が必要であることを明らかにした。

Research Products

• [Journal Article] Analysis of ionic liquid PVT behavior with a Modified Cell Model (2009)
  • Author(s): Hiroshi Machida, Ryosuke Taguchi, Yoshiyuki Sato, Richard L. Smith, Jr.
  • Journal Title: Fluid Phase Equilibria (印刷中)
  • Peer Reviewed
• [Journal Article] Measurement and correlation of supercritical CO_2 and ionic liquid systems for design of advanced unit operations (2009)
  • Author(s): Hiroshi Machida, Ryosuke Taguchi, Yoshiyuki Sato, Louw J. Florusse, Cor J. Peters, Richard L. Smith, Jr.
  • Journal Title: Frontiers of Chemical Engineering in China Pages: 1-8
  • Peer Reviewed
• [Journal Article] High-pressure densities of 1-alkyl-3-methylimidazolium hexafluorophosphates and 1-alkyl-3-methylimidazolium tetrafluoroborates at temperatures from(313 to 473)K and at pressures up to 200 Mpa (2009)
  • Author(s): Taguchi, R., Machida, H., Sato, Y., Smith Jr., R.L.
  • Journal Title: Journal of Chemical and Engineering Data 54 Pages: 22-27
  • Peer Reviewed
• [Journal Article] High-pressure densities of 1-alkyl-3-methylimidazolium hexaflu orophosphates and 1-alky1-3-methylimidazolium tetrafluoroborat es at temperatures from (313 to 473) K and at pressures up to 200 Mpa (2009)
  • Author(s): Taguchi, R., Machida, H., Sato, Y., Smith Jr., R. L.
  • Journal Title: Journal of Chemical and Engineering Data 54 Pages: 22-27
  • Peer Reviewed
• [Journal Article] Measurement and correlation of supercritical CO2_ and ionic liq uid systems for design of advanced unit operations (2009)
  • Author(s): Hiroshi Machida, Ryosuke Taguchi, Yoshiyuki Sato, Louw J. Florusse, Cor J. Peters, Richard L. Smith, Jr.
  • Journal Title: Frontiers of Chemical Engineering in China Pages: 1-8
  • Peer Reviewed
• [Journal Article] Analysis of ionic liquid PVT behavior with a Modified Cell Model (2009)
  • Author(s): Hiroshi Machida, Ryosuke Taguchi, Yoshiyuki Sato and Richard L. Smith, Jr.
  • Journal Title: Fluid Phase Equilibria (印刷中)
  • Peer Reviewed
• [Journal Article] Pressure-volume-temperature(PVT)measurements of ionic liquids ([bmim+][PF6 -], [bmim+][BF4 -], [bmim+][OcSO4 -]) and analysis with the Sanchez-Lacombe equation of state (2008)
  • Author(s): Machida, H., Sato, Y., Smith Jr., R.L.
  • Journal Title: Fluid Phase Equilibria 264 Pages: 147-155
  • Peer Reviewed
• [Journal Article] Measurement and correlation of infinite dilution partition coefficients of aromatic compounds in the ionic liquid 1-butyl-3-methyl-imidazolium hexafluorophosphate([bmim][PF6])-CO2 system at temperatures from 313 to 353 K and at pressures up to 16 Mpa (2008)
  • Author(s): Machida, H., Sato, Y., Smith Jr., R.L.
  • Journal Title: Journal of Supercritical Fluids 43 Pages: 430-437
  • Peer Reviewed
• [Journal Article] Measurement and correlation of infinite dilution partition coefficients of aromatic compounds in the ionic liquid 1-buty1-3-methyl-imidazolium hexafluorophosphate ([bmim][PF6])-CO2 system at temperatures from 313 to 353 K and at pressures up to 16 MPa (2008)
  • Author(s): Machida, H., Sato, Y., Smith Jr., R. L.
  • Journal Title: Journal of Supercritical Fluids 43 Pages: 430-437
  • Peer Reviewed
• [Journal Article] Pressure-volume-temperature (PVT) measurements of ionic liquids ([bmim+][PF6-],[bmim+][BF4-],[bmim+][0cSO4]) and analysis with the Sanchez-Lacombe equation of state (2008)
  • Author(s): Machida, H., Sato, Y., Smith Jr., R. L.
  • Journal Title: Fluid Phase Equilibria 264 Pages: 147-155
  • Peer Reviewed
• [Journal Article] Measurement and correlation of infinite dilution partition coefficients of aromatic compounds in the ionic liquid 1-butyl-3-methyl-imidazolium hexafluorophosphate([bmim][PF6])-CO2 system at temperatures from 313 to 353 K and at pressures up to 16 MPa (2008)
  • Author(s): Hiroshi Machida, Yoshiyuki Sato and Richard L. Smith Jr.
  • Journal Title: The Journal of Supercritical Fluids 43 Pages: 430-437
  • Peer Reviewed
• [Journal Article] Pressure-Volume-Temperature(PVT)measurements of ionic liquids([bmim+][PF6-],[bmim+][BF4-],[bmim+][OcSO4-])and analysis with the Sanchez-Lacombe equation of state (2008)
  • Author(s): Hiroshi Machida, Yoshiyuki Sato and Richard L. Smith Jr.
  • Journal Title: Fluid Phase Equilibria 264 Pages: 147-155
  • Peer Reviewed
• [Presentation] イオン液体-CO2-芳香族化合物系の相平衡測定と相関 (2009)
  • Author(s): 町田洋、渡邉賢、佐藤善之、田口亮介、Richard Smith
  • Organizer: SCEJ 74^<th>Annual Meeting
  • Place of Presentation: 横浜国立大学
• [Presentation] 機能性イオン液体中への高圧CO2溶解度の測定と推算式の構築 (2009)
  • Author(s): 田口亮介、町田洋、佐藤善之、Richard Smith
  • Organizer: SCEJ 74t^<th> Annual Meeting
  • Place of Presentation: 横浜国立大学
• [Presentation] イオン液体-CO2-芳香族化合物系の相平衡測定と相関 (2009)
  • Author(s): 町田洋
  • Organizer: SCEJ 74^<th> Annual Meeting
  • Place of Presentation: 横浜国立大学
• [Presentation] イオン液体-CO2を用いた光学異性体分離 (2008)
  • Author(s): 町田洋、遠藤航、佐藤善之、渡邉賢、Richard L.Smith Jr.
  • Organizer: 第8回GSCシンポジウム
  • Place of Presentation: 東京学術総合センター
  • Year and Date: 2008-03-06
• [Presentation] 機能性イオン液体中への高圧CO2溶解度の測定と推算式の構築 (2008)
  • Author(s): 田口亮介
  • Organizer: SCEJ 74^<th> Annual Meeting
  • Place of Presentation: 横浜国立大学
• [Presentation] イオン液体-CO2を用いた光学異性体分離 (2008)
  • Author(s): 町田 洋、遠藤 航、佐藤 善之、渡邉 賢、Richard L. Smith Jr.
  • Organizer: 第8回GSCシンポジウム
  • Place of Presentation: 学術総合センター・一橋記念講堂(東京)
• [Presentation] イオン液体のPVTに対するカチオン側鎖の影響 (2007)
  • Author(s): 田口亮介、町田洋、佐藤善之、Richard Smith
  • Organizer: 化学工学会第39回秋季大会
  • Place of Presentation: 北海道大学
• [Presentation] キラルイオン液体相-CO2相における光学異性体の分配係数測定 (2007)
  • Author(s): 町田洋、佐藤善之、Smith Richard
  • Organizer: 化学工学会第39回秋季大会
  • Place of Presentation: 北海道大学
• [Presentation] キラルイオン液体相-CO2相における光学異性体の分配係数測定 (2007)
  • Author(s): 町田洋、佐藤善之、Smith Richard
  • Organizer: 化学工学会 第39回秋季大会
  • Place of Presentation: 北海道大学、札幌
• [Presentation] イオン液体のPVTに対するカチオン側鎖の影響 (2007)
  • Author(s): 田口 亮介・町田 洋・佐藤 善之・Richard Smith
  • Organizer: 化学工学会 第39回秋季大会
  • Place of Presentation: 北海道大学、札幌