| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Research Abstract |
Tumor necrosis factor-α TNF-α an inflammatory cytokine and causes several autoimmune diseases such as rheumatoid arthritis, chronic obstructive pulmonary disease etc. Neutralizing antibodies against TNF-α and its receptor have been developed as drugs for rheumatoid arthritis. However, it is noted that bad by-effects such as suppression of physiological function in life have been observed. Therefore, in this study, we challenged to make a highly functional molecule, "super catalytic antibody", which can overcome the drawback of the above drugs. As the result, we successfully produced the "super catalytic antibody" capable of enzymaticaly destroying the human TNF-α.
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