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Molecular mechanism of irreversible changes in target organs induced by perinatal hormone exposure

Research Project

Project/Area Number 19370027
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphology/Structure
Research InstitutionNational Institutes of Natural Sciences Okazaki Research Facilities

Principal Investigator

IGUCHI Taisen  National Institutes of Natural Sciences Okazaki Research Facilities, 岡崎統合バイオサイエンスセンター, 教授 (90128588)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords組織形態 / 性ホルモン / 周生期曝露影響 / エピジェネテイクス / 不可逆的影響 / ホルモン / 曝露影響 / エピジェネティクス / 周生期 / 不可逆化
Research Abstract

Perinatal exposure of estrogens to mice during a critical period induces irreversible changes in various reproductive organs. Estrogen receptor α (ERα) has been demonstrated to be essential in induction of persistent changes in the mouse vagina. Microarray analyses demonstrate various up-regulated genes in the vagina of mice exposed perinatally to estrogens. Methylation status of growth factor related genes is not altered, however, one gene which suppress function of ERα is methylated and showing low expression. Methylation of this gene results in its low expression, thus, ERα is free from suppression, which may result in persistent activation of ERα. The persistently activated ERα induces expression of growth factor related genes which stimulate persistent cell proliferation in the mouse vagina.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (120 results)

All 2010 2009 2008 2007 Other

All Journal Article (71 results) (of which Peer Reviewed: 55 results) Presentation (35 results) Book (11 results) Remarks (3 results)

  • [Journal Article] Estrogen receptorαis indispensable for the induction of persistent vaginal change by neonatal 5α-dihydrotestosterone exposure.2010

    • Author(s)
      Miyagawa, S., Katsu, Y., Ohta, Y, Sudo, T., Lubahn, D.B., Iguchi, T.
    • Journal Title

      Biol. Reprod. 82

      Pages: 497-503

    • Related Report
      2009 Final Research Report
  • [Journal Article] Estrogen-dependent transactivation of amphioxus steroid hormone receptor via both estrogen-and androgen-response elements.2010

    • Author(s)
      Katsu, Y., Kubokawa, K., Urushitani, H., Iguchi, T.
    • Journal Title

      Endocrinology 151

      Pages: 639-648

    • Related Report
      2009 Final Research Report
  • [Journal Article] Influences of sex, incubation temperature, and environmental quality on gonadal estrogen and androgen receptor messenger RNA expression in juvenile American alligators(Alligator mississippiensis)2010

    • Author(s)
      Moore, B.C., Milnes, M.R., Kohno, S., Katsu, Y., Iguchi, T., Guillette, L.J.
    • Journal Title

      Biol.Reprod. 82

      Pages: 194-201

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen-dependent transactivation of amphioxus steroid hormone receptor via both estrogen- and androgen-response elements2010

    • Author(s)
      Katsu, Y., Kubokawa, K., Urushitani, H., Iguchi, T.
    • Journal Title

      Endocrinology 151

      Pages: 639-648

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptor α is indispensable for the induction of persistent vaginal change by neonatal 5α-dihydrotestosterone exposure2010

    • Author(s)
      Miyagawa, S., Katsu, Y., Ohta, Y, Sudo, T., Lubahn, D.B., Iguchi, T.
    • Journal Title

      Biol.Reprod. 82

      Pages: 497-503

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequence divergence and expression of a transformer gene in the branchiopod crustacean, Daphnia magna2010

    • Author(s)
      Kato, Y., Kobayashi, K., Oda, S., Tatarazako, N., Watanabe, H., Iguchi, T.
    • Journal Title

      Genomics 95

      Pages: 160-165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a polyclonal antibody against the retinoid X receptor of the rock shell Thais clavigera and its application to rock shell tissues for imposex research2010

    • Author(s)
      Horiguchi, T., Urushitani, H., Ohta, Y., Iguchi, T., Shiraishi, H.
    • Journal Title

      Ecotoxicology 19

      Pages: 571-576

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Introduction of foreign DNA into the water flea, Daphnia magna, by electroporation2010

    • Author(s)
      Kato, Y., Kobayashi, K., Watanabe, H., Iguchi, T.
    • Journal Title

      Ecotoxicology 19

      Pages: 589-592

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential contributions of heat shock proteins to temperature-dependentsex determination in the American alligator2010

    • Author(s)
      Kohno, S., Katsu, Y., Urushitani, H., Ohta, Y., Iguchi, T., Guillette, L.J.Jr.
    • Journal Title

      Sex.Devel. 4

      Pages: 73-87

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] From reptilian phylogenomics to reptilian genomes : analyses of c-Jun and DJ-1 protooncogenes2010

    • Author(s)
      Katsu, Y., Braun, E.L., Guillette, L.J.Jr, Iguchi, T.
    • Journal Title

      Cytogenet.Genome Res. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and characterization of ligand- and species-specificity of amphibian estrogen receptors2010

    • Author(s)
      Katsu, Y., Taniguchi, E., Urushitani, H., Miyagawa, S., Takase, M., Kubokawa, K., Tooi, O., Oka, T., Santo, N., Myburgh, J., Matsuno, A., Iguchi, T.
    • Journal Title

      Gen.Comp.Endocrinol. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of insulin-like growth factor-I for the regulation of prolactin synthesis by estrogen and postnatal proliferation of lactotrophs in the mouse anterior pituitary2010

    • Author(s)
      Saitoh, Y., Hikake, T., Hayashi, S., Iguchi, T., Sato, T.
    • Journal Title

      Cell Tiss.Res. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Technique for the collection of clean urine from the Nile crocodile(Crocodylus niloticus)2010

    • Author(s)
      Myburgh, J.G., Huchzermeyer, F.W., Groenewald, H.B., Soley, J.T., Bekker, L.C., Booyse, D.G., Iguchi, T., Guillette, L.J.Jr.
    • Journal Title

      J.South African Vet.Assoc. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential involvement of IGF-I and estrogen on prolactin cells in the mouse anterior pituitary2010

    • Author(s)
      Hikake, T., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T., Sato, T.
    • Journal Title

      Exp.Biol.Med. (In peress)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory aspects on the use of fish embryos in environmental toxicology2010

    • Author(s)
      Halder, M., Leonard, M.A., Iguchi, T.Oris, J.T., Ryder, K., Belanger, S.E., Braunbeck, T.A., Embry, M.R., Whale, G., Norberg-King, T., Lillicrap, A.
    • Journal Title

      Integ.Environ.Assess.Manage. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Species extrapolation for the 21^<st> century. Species extrapolation for the 21^<st> century2010

    • Author(s)
      Celander, M.C., Goldstone, J.V., Denslow, N.D., Iguchi, T., Kille, P., Meyerhoff, R.D., Smith, B.A., Hutchinson, T.H., Wheeler, J.R.
    • Journal Title

      Environ.Toxicol.Chem. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      Iguchi, T., Miyagawa, S., Sudo, T.
    • Journal Title

      Modern genetics of reproductive biology. In : Environmental Impacts on Reproductive Health and Fertility(Cambridge University Press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Dosage dependent hedgehog signals integrated with Wnt/β-catenin signaling regulate external genitalia formation as an appendicular program.2009

    • Author(s)
      Miyagawa, S., 他Iguchi, T. (15名中3番目)
    • Journal Title

      Development 136

      Pages: 3969-3978

    • NAID

      120002469485

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries.2009

    • Author(s)
      Kim, H., Nakajima, T., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T., Sato, T.
    • Journal Title

      Biol. Reprod. 81

      Pages: 1002-1009

    • Related Report
      2009 Final Research Report
  • [Journal Article] The role of IGF1 on the differentiation of prolactin secreting cells in the mouse anterior pituitary.2009

    • Author(s)
      Hikake, T., Hayashi, S., Iguchi, T., Sato, T.
    • Journal Title

      J. Endocrinol. 203

      Pages: 231-240

    • Related Report
      2009 Final Research Report
  • [Journal Article] Genetic integrations of the androgen and Wnt/β-catenin pathways for the masculinization of external genitalia.2009

    • Author(s)
      Miyagawa, S., 他Iguchi, T. (11名中5番目)
    • Journal Title

      Mol. Endocrinol. 23

      Pages: 871-880

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of diethylstilbestrol on ovarian follicle development in neonatal mice.2009

    • Author(s)
      Kim, H., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T., Sato, T.
    • Journal Title

      Reprod. Toxicol. 27

      Pages: 55-62

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of diethylstilbestrol on ovarian follicle development in neonatal mice2009

    • Author(s)
      Kim, H., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T., Sato, T.
    • Journal Title

      Reprod.Toxicol. 27

      Pages: 55-62

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol2009

    • Author(s)
      Lange, A., Paull, G.C., Coe, T.S., Katsu, Y., Urushitani, H., Iguchi, T., Tyler, C.R.
    • Journal Title

      Environ.Sci.Technol. 43

      Pages: 1219-1225

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Environmental health impacts of equine estrogens derived from hormone replacement therapy2009

    • Author(s)
      Tyler, C.R., Filby, A.L., Bickley, L.K., Cumming, R.I., Gibson, R., Labadie, P., Katsu, Y., Liney, K.E., Shears, J.A., Silva-Castros, V., Urushitani, H., Lange, A., Winter, M.J., Iguchi, T., Hill, E.M.
    • Journal Title

      Enviorn.Sci.Technol. 43

      Pages: 3897-3904

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances2009

    • Author(s)
      Grim, K.C., Wolfe, M., Braunbeck, T., Iguchi, T., Ohta, Y., Tooi, O., Touart, L., Douglas, C., Wolf, D.C., Tietge, J.
    • Journal Title

      Tox.Pathol. 37

      Pages: 415-424

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic integrations of the androgen and Wnt/β-catenin pathways for the masculinization of external genitalia2009

    • Author(s)
      Miyagawa, S., Satoh, Y., Haraguchi, R., Suzuki, K., Iguchi, T., Taketo, M.M., Nakagata, N., Matsumoto, T., Takeyama, K., Kato, S., Yamada, G.
    • Journal Title

      Mol.Endocrinol. 23

      Pages: 871-880

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of metamorphosis assay to a native Japanese amphibian species, Rana rugosa, for assessing effects of thyroid system affecting chemicals2009

    • Author(s)
      Oka, T., Miyahara, M., Yamamoto, J., Mitsui, N., Fujii, T., Tooi, O., Kashiwagi, K., Takase, M., Kashiwagi, A., Iguchi, T.
    • Journal Title

      Ecotoxicol.Environ.Safety 72

      Pages: 1400-1405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of IGF1 on the differentiation of prolactin secreting cells in the mouse anterior pituitary2009

    • Author(s)
      Hikake, T., Hayashi, S., Iguchi T., Sato, T.
    • Journal Title

      J.Endocrinol. 203

      Pages: 231-240

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries2009

    • Author(s)
      Kim, H., Nakajima, T., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T., Sato, T.
    • Journal Title

      Biol.Reprod. 81

      Pages: 1002-1009

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dosage dependent hedgehog signals integrated with Wnt/β-catenin signaling regulate external genitalia formation as an appendicular program2009

    • Author(s)
      Miyagawa, S., Moon, A., Haraguchi, R., Inoue, C., Harada, M., Nakahara, C., Suzuki, K., Matsumaru, D., Kaneko, T., Matsuo, I., Yang, L., Taketo, M.M., Iguchi, T., Evans, S.M., Yamada, G.
    • Journal Title

      Development 136

      Pages: 3969-3978

    • NAID

      120002469485

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of estrogen receptor β in the induction of polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol2009

    • Author(s)
      Kirigaya, A., Kim, H., Hayashi, S., Chambon, P., Watanabe, H., Iguchi, T., Sato, T.
    • Journal Title

      Zool.Sci. 26

      Pages: 704-712

    • NAID

      120004837273

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Why public health agencies cannot depend upon good laboratory practices as a criterion for selecting data : The case of bisphenol A.2009

    • Author(s)
      Myers, J.P., vom Saal, F.S., Akingbemi, B.T., Arizono, K., Belcher, S., Colborn, T., Chahoud, I., Crain, D.A., Farabollini, F., Guillette, L.J.Jr., Hassold, T., Ho, S.-M., Hunt, P.A., Iguchi, T., Jobling, S., Kanno, J., Laufer, H., Marcus, M., McLachlan, J.A., Nadal, A., Oehlmann, J., Olea, N., Palanza, P., Parmigiani, S., Rubin, B.S., Schoenfelder, G., Sonnenschein, C., Soto, A.M., Talsness, C.E., Taylor, J.A., Vandenberg, L.N., Vandenbergh, J.G., Vogel, S., Watson, C.S., Welshons, W.V., Zoeller, R.T.
    • Journal Title

      Environ.Health Perspect. 117

      Pages: 309-315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring : hurdles, achievements and future outlook2009

    • Author(s)
      Van Aggelen, G., Ankley, G.T, Baldwin, W.S., Bearden, D.W., Benson, W.H., Chipman, J.K., Collette, T.W., Craft, J.A., Denslow, N.D., Embry, M.R., Falciani, F., George, S.G., Helbing, C.C., Hoekstra, P.F., Iguchi, T., Kagami, Y., Katsiadaki, I., Kille, P., Liu, L., Lord, P.G., McIntyre, T., O'Neill, A., Osachoff, H., Perkins, E.J., Santos, E.M., Skirrow, R.C., Snape, J.R., Tyler, C.R., Versteeg, D., Viant, M.R., Volz, D.C., Williams, T.D., Yu, L.
    • Journal Title

      Environ.Health Perspect. 118

      Pages: 1-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of diethylstilbestrol on ovarian follicle development in neonatal mice2009

    • Author(s)
      H. Kim, S. Hayashi, P. Chambon, H. Watanabe, T. Iguchi, T. Sato
    • Journal Title

      Reprod. Toxicol. 27

      Pages: 55-62

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sexual re-programming and estrogenic sensitization in wild fish exposed to ethinylestradiol2009

    • Author(s)
      A. Lange, G. C. Paull, T. S. Coe, Y. Katsu, H. Urushitani, T. Iguchi, C. R. Tyler
    • Journal Title

      Environ. Sci. Technol. 43

      Pages: 1219-1225

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Environmental health impacts of equine estrogens derived from hormone replacement therapy2009

    • Author(s)
      C. R. Tyler, A. L. Filby, L. K. Bickley, R. I. Cumming, R. Gibson, P. Labadie, Y. Katsu, K. E. Liney, J. A. Shears, V. Silva-Castros, H. Urushitani, A. Lange, M. J. Winter, T. Iguchi, E. M. Hill
    • Journal Title

      Enviorn. Sci. Technol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances2009

    • Author(s)
      K. C. Grim, M. Wolfe, T. B raunbeck, T. Iguchi, Y. Ohta, O. Tooi, L. Touart, C. D ouglas, D. C. Wolf, J. Tietge
    • Journal Title

      Tox. Pathol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic integrations of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia2009

    • Author(s)
      S. Miyagawa, Y. Satoh, R. Haraguchi, K. Suzuki, T. Iguchi, M. M. Taketo, N. Nakagata, T. Matsumoto, K. Takeyama, S. Kato, G. Yamada
    • Journal Title

      Mol. Endocrinol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Why public health agencies cannot depend upon 'good laboratory practices' as a criterion for selecting data : The case of bisphenol A2009

    • Author(s)
      J. P. Myers, F. S. vom Saal, B. T. Akingbemi, K. Arizono, S. Belcher, T. Colborn, I. Chahoud, D. A. Crain, F. Farabollini, L. J. Guillette, Jr., T. Hassold, S. -M. Ho, P. A. Hunt, T. Iguchi, S. Jobling, J. Kanno, H. Laufer, M. Marcus, J. A. McLachlan, A. Nadal, J. Oehlmann, N. Olea, P. Palanza, S. Parmigiani, B. S. Rubin, G. S choenfelder, C. Sonnenschein, A. M. Soto, C. E. Talsness, J. A. Taylor, L. N. Vanden berg, J. G. Vandenbergh, S. Vogel, C. S. Watson, W. V. Welshons, R. T. Zoeller
    • Journal Title

      Environ. Health Perspect. 117

      Pages: 309-315

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel approaches for the study of vertebrate steroid hormone receptors2009

    • Author(s)
      S. Kohno, Y. Katsu, T. Iguchi, L. J. Guillette Jr.
    • Journal Title

      Integ. Comp. Biol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptor subtypes selectively mediate female mouse reproductive abnormalities induced by neonatal exposure to estrogenic chemicals.2008

    • Author(s)
      Nakamura, T., Katsu, Y., Watanabe, H., Iguchi, T.
    • Journal Title

      Toxicology 253

      Pages: 117-124

    • Related Report
      2009 Final Research Report
  • [Journal Article] Activation of steroid and xenobiotic receptor (SXR, NR112) and its orthologs in laboratory, toxicological, and genome model species.2008

    • Author(s)
      Milnes, M.R., Garcia, A., Grossman, E., Grun, F., Shiotsugu, J., Tabb, M.M., Kawashima, Y., Katsu, Y., Watanabe, H., Iguchi, T., Blumberg, B.
    • Journal Title

      Environ. Health Perspect. 116

      Pages: 880-885

    • Related Report
      2009 Final Research Report
  • [Journal Article] Molecular cloning and characterization of estrogen, androgen and progesterone nuclear receptors from a freshwater turtule (Pseudemys nelsoni)2008

    • Author(s)
      Y. Katsu, R. Ichikawa, T. Ikeuchi, S. Kohno, L. J. Guillette Jr., T. Iguchi
    • Journal Title

      Endocrinology 149

      Pages: 161-173

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning and sexually dimorphic expression of DM-domain genes in Daphnia magna2008

    • Author(s)
      Y. Kato, K. Kobayashi, S. Oda, J. K. Colbourne, N. Tatarazako, H. Watanabe, T. Iguchi
    • Journal Title

      Genomics 91

      Pages: 94-101

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vacuolar degeneration of skeletal muscle in transgenic mice overexpressing ORP1502008

    • Author(s)
      T. Kobayashi, Y. Takita, A. Suzuki, Y. Katsu, T. Iguchi, Y. Ohta
    • Journal Title

      J. Vet. Med. Sci. 70

      Pages: 115-118

    • NAID

      110006546649

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression analyses on the embryonic external genitalia : identification of regulatory genes possibly involved in masculinization processes2008

    • Author(s)
      H. Nishida, S. Miyagawa, D. Matsumaru, Y. Wada, Y. Satoh, Y. Ogino, T. Iguchi S Fukuda, T. Taga, G. Yamada
    • Journal Title

      Congen. Anorm. 48

      Pages: 63-67

    • NAID

      10027387190

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased post hatching mortality and loss of sexually dimorphic gene expression in alligators (Alligator mississippiensis) from a contaminated environment2008

    • Author(s)
      M. R. Milnes, T. A. Bryan, Y. Katsu, S. Kohno, B. C. Moore, T. Iguchi, L. J. Jr. Guillette
    • Journal Title

      Biol. Reprod 78

      Pages: 932-938

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linking molecular and population stress responses in Daphnia magna exposed to cadmium2008

    • Author(s)
      R. Connon, H. L. Hooper, R. M. Sibly, F. L. Lim, L. H. Heckmann, D. J. Moore, H. Watanabe, A. Soetaert, K. Cook, S. J. Maund, T. H. Hutchinson, J. Moggs, W. De Coen, T. Iguchi, A. Callaghan
    • Journal Title

      Environ. Sci. Technol. 42

      Pages: 2181-2188

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of atrazine on metamorphosis and sexual differentiation in Xenopus laevis2008

    • Author(s)
      T. Oka, O. Tooi, N. Mitsui, M. Miyahara, Y. Ohnishi, M. Takase, A. Kashiwagi, T. Shinkai, N. Santo, T. Iguchi
    • Journal Title

      Aquat. Toxicol. 87

      Pages: 215-226

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of steroid and xenobiotic receptor (SXR, NR112) and its orthologs in laboratory, toxicological, and genome model species2008

    • Author(s)
      M. R. Milnes, A. Garcia, E. Grossman, F. Grun, J. Shiotsugu, M. M. Tabb, Y. Kawashima, Y. Katsu, H. Watan abe, T. Iguchi, B. Blumberg
    • Journal Title

      Eviron. Health Perspect. 116

      Pages: 880-885

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression patterns in juvenile American alligators (Alligator mississippiensis) exposed to environmental contaminants2008

    • Author(s)
      S. Kohno, D. Bermudez, Y. Katsu, T. Iguchi, L. J. Guillette Jr.
    • Journal Title

      Aquat. Toxicol. 88

      Pages: 95-101

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered sexual development in roach (Rutilus rutilus) exposed to environmental concentrations of the pharmaceutical 17beta-ethinylestradiol and associated expression dynamics of aroma tases and estrogen receptors2008

    • Author(s)
      A. Lange, Y. Katsu, R. Ichikawa, G. C. Paull, L. L. Chidgey, T. S. Coe, T. Iguchi, C. R. Tyler
    • Journal Title

      Tox. Sci. 106

      Pages: 113-123

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptor subtypes selectively mediate female mouse reproductive abnormalities induced by neonatal exposure to estrogenic chemicals2008

    • Author(s)
      T. Nakamura, Y. Katsu, H. Watanabe, T. Iguchi
    • Journal Title

      Toxicology 253

      Pages: 117-124

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of non-toxic concentrations of DDT and DDE on the old world vulture estrogen receptor2008

    • Author(s)
      V. Naido, Y. Katsu, T. Iguchi
    • Journal Title

      Gen. Comp. Endocrinol 159

      Pages: 188-195

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptome profiling in crustaceans as a tool for ecotoxico genomics2008

    • Author(s)
      H. Watanabe, K. Kobayashi, Y. Kato, S. Oda, R. Abe, N. Tatarazako, T. Iguchi
    • Journal Title

      Cell Biol. Toxicol. 24

      Pages: 641-647

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning, characterization and evolutionary analysis of estrogen receptors from phylogenetically ancient fish2008

    • Author(s)
      Y. Katsu, S. Kohno, S. Hyodo, S. Ijiri, A. Hara, L. J. Guillette Jr., T. Iguchi
    • Journal Title

      Endocrinology 149

      Pages: 6300-6310

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental effects : estrogen induced vaginal changes and organotin induced adipogenesis2008

    • Author(s)
      T. Iguchi, H. Watanabe, Y. Ohta, B. Blumberg
    • Journal Title

      Int. J. Androl. 31

      Pages: 263-268

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Female reproductive disruption : The roles of endocrine disrupting compounds and developmental timing2008

    • Author(s)
      D. A. Crain, S. J. Janssen, T. M. Edwards, J. Heindel, S. -M. Ho, P. Hunt, T. Iguchi, A. Juul, J. A. McLachlan, J. Schwartz, N. Skakkebaek, A. M. Soto, S. Swan, C. Walker, T. Woodruff. T. Woodruff, L. C. Giudice, L. J. Guillette, Jr.
    • Journal Title

      Fertil. Steril. 90

      Pages: 911-940

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Commonality and difference in mechanisms of endocrine disruption in various animal species2008

    • Author(s)
      T. Iguchi, Y. Katsu
    • Journal Title

      BioScience 58

      Pages: 1061-1067

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 内分泌かく乱物質が及ぼす発生、成長への影響2008

    • Author(s)
      井口泰泉、中村武志
    • Journal Title

      ビオフィリア 4

      Pages: 13-17

    • Related Report
      2008 Annual Research Report
  • [Journal Article]2008

    • Author(s)
      T. Iguchi, H. Watanabe, Y. Katsu
    • Journal Title

      Toxicogenomics and ecotoxicogenomics : Studying chemical effects and basic biology in vertebrates and invertebrates." In : Toxicogenomics : A Powerful Tool for Toxicology Assessment(John Wiley & Sons)

      Pages: 143-158

    • Related Report
      2008 Annual Research Report
  • [Journal Article]2008

    • Author(s)
      H. Watanabe, K. Kobayashi, Y. Kato, S. Oda, R. Abe, N. Tatarazako, T. Iguchi
    • Journal Title

      Genomic response in Daphnia to chemical pollutants." In : Interdis ciplinary Studies on Environmental Chemistry-Biological Response to Chemical Pollutants. Eds. Y. Murakami, K. Nakayama, S. -I. Kitamura, H. Iwata and S. Tanabe(TERAPUB)

      Pages: 133-142

    • Related Report
      2008 Annual Research Report
  • [Journal Article]2008

    • Author(s)
      井口泰泉
    • Journal Title

      2. 13 乳腺・生殖器(女性)「からだと水の事典」佐々木成、石橋賢一(編集)(朝倉書店)

      Pages: 205-213

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Comparison of estrogen responsive genes in the mouse uterus, vagina and mammary gland.2007

    • Author(s)
      Suzuki, A., Urushitani, H., Watanabe, H., Sato, T., Iguchi, T., Kobayashi, T., Ohta, Y.
    • Journal Title

      J. Vet. Med. Sci. 69

      Pages: 725-731

    • NAID

      120004837330

    • Related Report
      2009 Final Research Report
  • [Journal Article] Gene expression change in the Mullerian duct of the mouse fetus exposed to diethylstilbestrol in utero.2007

    • Author(s)
      Suzuki, A., Urushitani, H., Sato, T., Watanabe, H., Ohta, Y., Iguchi, T.
    • Journal Title

      Exp. Biol. Med. 232

      Pages: 503-514

    • Related Report
      2009 Final Research Report
  • [Journal Article] Comparison of estrogen responsive genes in the mouse uterus, vagina and mammary gland2007

    • Author(s)
      Suzuki A
    • Journal Title

      Journal of Veterinary Medical Science 69

      Pages: 725-31

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cloning and characterization of the ecdysone receptor and ultraspiracle protein from the water flea Daphnia magna2007

    • Author(s)
      Kato Y
    • Journal Title

      Journal of Endocrinology 193

      Pages: 183-94

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression change in the Mullerian duct of the mouse fetus exposed to diethylstilbestrol in utero2007

    • Author(s)
      Suzuki A
    • Journal Title

      Experimental Biology and Medicine 232

      Pages: 503-14

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A betalipoproteinemia induced by ORP150 over-expression in mice2007

    • Author(s)
      Kobayashi, T.
    • Journal Title

      Comp.Med 57

      Pages: 247-54

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxicogenomics and ecotoxicogellomics for studying endocrine disruption and basic biology2007

    • Author(s)
      Iguchi, T.
    • Journal Title

      Gen.Comp.Endocr 153

      Pages: 25-29

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Current status of the endocrine disruptor research in Japan and OECD including my own laboratory2009

    • Author(s)
      Iguchi, T.
    • Organizer
      International Symposium of Environmental Emerging Compound Measurement Technology and Management
    • Place of Presentation
      National Pingtung University, Taiwan
    • Year and Date
      2009-05-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Genomic and epigenetic approaches for analysis of developmental effect of neonatal estrogen on mouse vagina.2009

    • Author(s)
      Iguchi, T., Koide-Yoshida, S., Watanabe, H., Igarashi, K. Kanno, J., Miyagawa, S.
    • Organizer
      Horiba Symposium, University of Tokyo
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Final Research Report
  • [Presentation] Genomic and epigenetic approaches for analysis of developmental effect of neonatal estrogen on mouse vagina2009

    • Author(s)
      Iguhi, T., Koide-Yohshida, S., Watanabe, H., Igarashi, K., Kannno, J., Miyagawa, S.
    • Organizer
      Horiba Symposium, University of Tokyo
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endocrine disrupting contaminants and the developing ovary : alteredactivin/inhibin and steroid leads to modified follliculogenesis2009

    • Author(s)
      Guillette, L.J.Jr., Moore, B.C., Iguchi, T.
    • Organizer
      5^<th> Copenhagen Workshop on Endocrine Disrupters
    • Place of Presentation
      Rigshospirtalet, Copenhagen, Denmark
    • Related Report
      2009 Annual Research Report
  • [Presentation] Modulation of sex determination by juvenile hormones and their analogs in Daphnia magna and endocrine disruption2009

    • Author(s)
      Iguchi, T., Kato, Y., Watanabe, H., Oda, S., Tatarazako, N.
    • Organizer
      International Conference on Comparative Endocrinology
    • Place of Presentation
      Hong Kong University, Hong Kong
    • Related Report
      2009 Annual Research Report
  • [Presentation] Endocrine disruption across multiple animal species-common mechanism2009

    • Author(s)
      Iguchi, T.
    • Organizer
      e.hormone
    • Place of Presentation
      Tulane University, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 内分泌かく乱物質の作用メカニズム2008

    • Author(s)
      井口泰泉
    • Organizer
      第9回比較3学会合同シンポジウム
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2008-08-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cloning and characterization of DM domain genes from the water flea, Daphnia magna.2008

    • Author(s)
      Y. Kato, K. Kobayashi, J. K. Colbourne, H. Watanabe, T. Iguchi
    • Organizer
      Cordon Research Conference on Environmental Endocrine Disruptors
    • Place of Presentation
      Waterville Valley Resort, NH, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development and application of molecular tools for establishing mechanistic information on chemical effect pathways2008

    • Author(s)
      A. Lange, Y. Katsu, T. Iguchi, C. R. Tyler
    • Organizer
      The 10th Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Place of Presentation
      Bovey Castle. Devon
    • Related Report
      2008 Annual Research Report
  • [Presentation] Comparative responsiveness and sensitivity of fish estrogen receptors to steroid estrogens and estrogen mimics mimicks2008

    • Author(s)
      Y. Katsu, A. Lange, C. R. Tyler, T. Iguchi
    • Organizer
      The 10th Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Place of Presentation
      Bovey Castle, Devon
    • Related Report
      2008 Annual Research Report
  • [Presentation] Estrogen receptor expression in American alligator oviduct2008

    • Author(s)
      Y. Ohta, Y. Katsu, T. Iguchi, S. Kohno, B. Moore, L. J. Jr. Guillette
    • Organizer
      The 10th Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Place of Presentation
      Bovey Castle, Devon
    • Related Report
      2008 Annual Research Report
  • [Presentation] Embryo toxicity in Japanese medaka and zebrafish exposed to endocrine disruptors, pesticides, and PPCPs2008

    • Author(s)
      N. Tatarazako, N. Hirai, T. Iguchi
    • Organizer
      The 10th Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Place of Presentation
      Bovey Castle, Devon
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sexual re-programming and oestrogenic sensitization in wild fish exposed to ethinylestradiol2008

    • Author(s)
      A. Lange. G. C. Paull, Y. Katsu, H. Urushitani, R. Ichikawa, T. S. Coe, T. Iguchi, C. R. Tyler
    • Organizer
      The 10th Annual Scientific Workshop on Research into Environmental Endocrine Disrupting Chemicals
    • Place of Presentation
      Bovey Castle, Devon
    • Related Report
      2008 Annual Research Report
  • [Presentation] New concepts in environmental endocrine signaling2008

    • Author(s)
      T. Iguchi
    • Organizer
      e. hormone
    • Place of Presentation
      Tulane University, New Orleans. LA. USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Activities in OECD and Japan2008

    • Author(s)
      T. Iguchi
    • Organizer
      NERC International Workshop on Fish Toxi cogenomics : Moving into Monitoring and Regulation
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sex determination mechanisms of fish food, Daphnia magna.2008

    • Author(s)
      T. Iguchi
    • Organizer
      Sex Determination and Gametegenesis in Fish : Current Status and Future Directions
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Achievements of UK Japan collaboration2008

    • Author(s)
      T. Iguchi, O. Tooi
    • Organizer
      DEFRA meeting : Endocrine Disruption in Aquatic Environments : Lessons for Taking the Science Forward in Support of Chemic al Management
    • Place of Presentation
      UK
    • Related Report
      2008 Annual Research Report
  • [Presentation] Current situation of endocrine disruptor issue in Japan2008

    • Author(s)
      T. Iguchi
    • Organizer
      Gordon Research Conference on Environmental Endocrine Disruptors
    • Place of Presentation
      Waterville, Valley Resort, NH, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] The novel field of ecotoxicogenomics in the study of endocrine disruption in non-mammalian models2008

    • Author(s)
      T. Iguchi
    • Organizer
      The Endocrine Society 90th Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ecotoxicogenomics, transactivation assays as tools for studying endocrine active chemicals in aquatic animals2008

    • Author(s)
      T. Iguchi
    • Organizer
      Korean Society of Toxicogenomics
    • Place of Presentation
      Incheon, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of ligand-independent activation of the estrogen receptor in mouse vagina2008

    • Author(s)
      N. Kikuchi, H. Watanabe, T. Iguchi
    • Organizer
      7^<th> OIB Symposium, Frontiers of Biological Imaging, Synergy of the Advanced Techniques
    • Place of Presentation
      Okazaki
    • Related Report
      2008 Annual Research Report
  • [Presentation] Epigenetic effect of estrogen exposure in prenatal mice2008

    • Author(s)
      S. Yoshida-Koide, H. Watanabe, T. Iguchi
    • Organizer
      7^<th> OIB Symposium, Frontiers of Biological Imaging, Synergy of the Advanced Techniques
    • Place of Presentation
      Okazaki
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular analysis of csd gene from the water flea, Daphnia magna.2008

    • Author(s)
      Y. Kato, K. Kobayashi, S. Oda, N. Tatarazako, H. Watanabe, T. Iguchi
    • Organizer
      7^<th> OIB Symposium, Frontiers of Biological Imaging, Synergy of the Advanced Techniques
    • Place of Presentation
      Okazaki
    • Related Report
      2008 Annual Research Report
  • [Presentation] Comparative responsiveness and sensitivity of fish estrogen receptor to steroid estrogens and other environmental estrogens2008

    • Author(s)
      Y. Katsu, A. Lange, C. R. Tyler, T. Iguchi
    • Organizer
      7^<th> OIB Symposium, Frontiers of Biological Imaging, Synergy of the Advanced Techniques
    • Place of Presentation
      Okazaki
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of ligand-independent activation of the estrogen receptor in mouse vagina2008

    • Author(s)
      N. Kikuchi, H. Watanabe, T. Iguchi
    • Organizer
      第11回環境ホルモン学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular analysis of the csd gene from the water flea, Daphnia magna.2008

    • Author(s)
      Y. Kato, K. Kobayashi, S. Oda, N. Tatarazako, H. Watanabe, T. Iguchi
    • Organizer
      第11回環境ホルモン学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Epigenetic effect of estrogen exposure in prenatal mice.2008

    • Author(s)
      S. Yoshida-Koide, H. Watanabe, T. Iguchi
    • Organizer
      第11回環境ホルモン学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] BPA投与により誘起した雌ラット卵管異常における網羅的遺伝子解析の試み2008

    • Author(s)
      太田康彦, 生川亮一郎, 竹内崇師, 鈴木敦子, 加藤英男, 渡邉肇, 井口泰泉
    • Organizer
      第11回環境ホルモン学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 外因性男性ホルモンにより誘導されるトゲウオ腎臓での特異的バイオマーカー(スピギン)と男性ホルモン受容体の遺伝子発現2008

    • Author(s)
      松尾昴, 坂井正, 征矢野清, 勝義直, 井口泰泉, 大久保伸幸, 松原孝博, I. Katsiadaki, A. P. Scott, 長江真樹
    • Organizer
      第11回環境ホルモン学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 古代魚のエストロゲン受容体の単離2008

    • Author(s)
      勝義直, 井口泰泉
    • Organizer
      日本動物学会第79回福岡大会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] What are the data on environmental contaminants disrupting reproductive function? Examples of mosquitofish,roach and medaka2007

    • Author(s)
      Iguchi, T.
    • Organizer
      International Federation of Fertility and Sterility
    • Place of Presentation
      Durban, South Africa
    • Related Report
      2007 Annual Research Report
  • [Presentation] Developmental effects of chemicals:TBT-induced adipogenesis and DES-induced Persistent vaginal changes in mice2007

    • Author(s)
      Iguchi, T.
    • Organizer
      4th Copenhagen Workshop on Endocrine Disrupters
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2007 Annual Research Report
  • [Presentation] エストロゲン受容体(ER)特異的リガンドによる無排卵と膣上皮細胞増殖の透起2007

    • Author(s)
      中村 武志
    • Organizer
      日本動物学会第78回大会
    • Place of Presentation
      弘前大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 周生期のエストロゲン様物質暴露による無排卵または膣上皮細胞不可逆的増殖はエストロゲンレセプターαによって制御されている2007

    • Author(s)
      中村 武志
    • Organizer
      第10回環境ホルモン学会研究発表会
    • Place of Presentation
      大宮ソニックシテイー
    • Related Report
      2007 Annual Research Report
  • [Presentation] 周生期のエストロゲン様物質暴露による無排卵または膣上皮細胞不可逆的増殖はエストロゲンレセプターαによって制御されている2007

    • Author(s)
      中村 武志
    • Organizer
      第30回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Book] Environmental Impacts on Reproductive Health and Fertility2010

    • Author(s)
      Iguchi, T., Miyagawa, S., Sudo, T.
    • Publisher
      Cambridge University Press
    • Related Report
      2009 Final Research Report
  • [Book] Novel approaches for the study of vertebrate steroid hormone receptors2009

    • Author(s)
      S. Kohno, Y. Katsu, T. Iguchi, L. J. Guillette Jr.
    • Publisher
      Integ. Comp. Biol. (in press)
    • Related Report
      2008 Annual Research Report
  • [Book] Genes to ecosystems : viviparous fishes and endocrine disruption2009

    • Author(s)
      T. M. Edwards, T. Iguchi, L. J. Guillette, Jr.
    • Publisher
      Viviparous Fishes II. Carmen, M. ed. (in press)
    • Related Report
      2008 Annual Research Report
  • [Book] Modern genetics of reproductive biology. In Environmental Impacts on Reproductive Health and Fertility2009

    • Author(s)
      T. Iguchi, T. Sudo
    • Publisher
      Cambridge University Press, Woodruff, T., Guillette, L. J. Jr. (Eds.)(in press)
    • Related Report
      2008 Annual Research Report
  • [Book] Tool for Toxicology Assessment(Studying chemical effects and basic biology in vertebrates and invertebrates)2008

    • Author(s)
      Iguchi, T., Watanabe, H., Katsu, Y.
    • Publisher
      John Wiley & Sons
    • Related Report
      2009 Final Research Report
  • [Book] Genomics in Regulatory Ecotoxicology: Applications and Challenges2007

    • Author(s)
      Tyler, C. R., Filby, A. L., Iguchi, T., Kramer, V., Larsson, J., van Aggelen, G., van Leeuwen, K., Viant, M., Tillet, D.
    • Publisher
      SETAC Press
    • Related Report
      2009 Final Research Report
  • [Book] Examples of mosquitofish, roach and medaka(van der Spuy, Z. and Kempers, R.D. eds., What are the data on environmental contaminants disrupting reproductive function?)2007

    • Author(s)
      Iguchi, T.
    • Publisher
      Advances in Fertility Studies and Reproductive Medicine
    • Related Report
      2009 Final Research Report
  • [Book] Genomic Approaches for Cross-Species Extrapolation in Toxicology.(Benson, W.H. and Di Giulio, R.T. (eds.), "Omic" Approaches in the context of environmental toxicology.)2007

    • Author(s)
      Cook, J., Iguchi, T., Linney, E., Miracle, A., Shaw, J., Viant, M., Zacharewski, T.
    • Publisher
      Taylor and Francis, CRC Press
    • Related Report
      2009 Final Research Report
  • [Book] "Omic"Approaches in the context of environmental toxicology,2007

    • Author(s)
      Cook, J.
    • Publisher
      CRC Press
    • Related Report
      2007 Annual Research Report
  • [Book] 内分泌かく乱物質.ホルモンハンドブック2007

    • Author(s)
      井口 泰泉
    • Publisher
      南江堂(eBOOK)
    • Related Report
      2007 Annual Research Report
  • [Book] 内分泌と生命現象2007

    • Author(s)
      井口 泰泉
    • Publisher
      培風館
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.nibb.ac.jp/bioenv1/index-j.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.nibb.ac.jp/bioenv1/index-j.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.nibb.ac.jp/bioenvl/index-j.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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