Molecular basis for recognition of various cell surface ligands by paired immune receptors
Project/Area Number |
19370042
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Structural biochemistry
|
Research Institution | Kyushu University |
Principal Investigator |
MAENAKA Katsumi Kyushu University, 生体防御医学研究所, 准教授 (10322752)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | ペア型レセプター / 細胞表面受容体 / 蛋白質 / 蛋白質間相互作用 / 表面プラズモン共鳴 / NMR解析 / X線結晶構造解析 / 免疫制御 / ペア型受容体 / 細胞表面抗原 |
Research Abstract |
Cell surface antigens have various forms depending on states of cells, whose structural characteristics can be recognized by paired immune receptors to control immune responses. Here, in order to clarify the molecular basis for these events, we performed the ligand binding and structural analyses of PILRs and KLRG1. PILRs bind to its ligand, CD99, with sugar- and peptide-dependent manner, furthermore, KLRG1 discriminate the monomer and the dimer configurations of the E-cadherin. These results provided important insights on the immune regulation by paired immune cell receptors.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1).2009
Author(s)
Nakamura S, Kuroki K, Ohki I, Sasaki K, Kajikawa M, Maruyama T, Ito M, Kameda Y, Ikura M, Yamamoto K, Matsumoto K, Maenaka K*
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Journal Title
J Biol Chem. 284
Pages: 27327-35
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