| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
|---|
| Research Abstract |
Cell surface antigens have various forms depending on states of cells, whose structural characteristics can be recognized by paired immune receptors to control immune responses. Here, in order to clarify the molecular basis for these events, we performed the ligand binding and structural analyses of PILRs and KLRG1. PILRs bind to its ligand, CD99, with sugar- and peptide-dependent manner, furthermore, KLRG1 discriminate the monomer and the dimer configurations of the E-cadherin. These results provided important insights on the immune regulation by paired immune cell receptors.
|
