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Analysis of interaction between cell death-, cell growth-and differentiation-inducing signals

Research Project

Project/Area Number 19370052
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionKyoto University

Principal Investigator

YONEHARA Shin  Kyoto University, 大学院・生命科学研究科, 教授 (00124503)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2007: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywordsアポトーシス / 細胞周期 / シグナル伝達 / 遺伝子 / 細胞・組織
Research Abstract

FLASH/casp8ap2の解析を行い、FLASH の発現抑制によって、細胞周期のS 期進行が停止しすること、FLASHはARS2(arsenite resisitant protein 2)という分子と会合し、ARS2の発現抑制によっても、細胞周期のS期進行が阻害されることを示した。さらに、FLASHの細胞周期進行活性は、ARS2 との会合によって媒介されていることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (5 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Novel cell death by downregulation of eEF1A1 expression in tetraploids2009

    • Author(s)
      Kobayashi Y, and Yonehara S
    • Journal Title

      Cell Death Differ 16

      Pages: 139-150

    • Related Report
      2008 Final Research Report
  • [Journal Article] Novel cell death by downregulation of eEFlAl expression in tetraploids.2009

    • Author(s)
      Kobayashi Y, Yonehara S
    • Journal Title

      Cell Death and Differentiation 16

      Pages: 139-150

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of NKTcell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza viruses2008

    • Author(s)
      Kanijukun. Nagatii Y. Jiang X. Ichinohe T, Tashiro T, Mori K, Taniguchi M. Hase K, Ohno H, Shimaoka T. Yonehara S, Odagiri T. Tashiro M, Sata T. Hasegaws H. Seino K
    • Journal Title

      Mucosal Immunology 1

      Pages: 208-218

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical Role for CXC Chemokine Ligand 16(SR-PSOX)in Th1 response mediated by NKT cells2007

    • Author(s)
      Shimaoka T, Seino K, Kume N, Minami M, Nishime C, Suematsu M, Kita T, Taniguchi M, Matsushima K, and Yonehara S.
    • Journal Title

      J Immunol 179

      Pages: 8191-8199

    • Related Report
      2008 Final Research Report
  • [Journal Article] Conserved function of caspase-8 in apoptosis during bony fish evolution2007

    • Author(s)
      Sakata S, Yan Y, Satou Y, Momoi A, Ngo-Hazelett P, Nozaki M, Furutani-Seiki M, Postlethwait JH, Yonehara S, Sakamaki K.
    • Journal Title

      Gene 396

      Pages: 134-148

    • Related Report
      2008 Final Research Report
  • [Journal Article] Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes2007

    • Author(s)
      Moriyama H, and Yonehara S.
    • Journal Title

      Immunol Lett 109

      Pages: 36-46

    • Related Report
      2008 Final Research Report
  • [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation2007

    • Author(s)
      Kuninaka S, Iida SI, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S, Saya H.
    • Journal Title

      Oncogene 26

      Pages: 2395-2406

    • Related Report
      2008 Final Research Report
  • [Journal Article] Critical Role for CXC Chemokine Ligand 16 (SR-PSOX) in Thl response mediated by NKT cells.2007

    • Author(s)
      Shimaoka T.
    • Journal Title

      J Immunol 179

      Pages: 8191-8199

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes.2007

    • Author(s)
      Moriyama H.
    • Journal Title

      Immunol Lett 109

      Pages: 36-46

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conserved function of caspase-8 in apoptosis during bony fish evolution.2007

    • Author(s)
      Sakata S.
    • Journal Title

      Gene 396

      Pages: 134-148

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intervention of MAdCAM-1 or fractalkine alleviates graft-versus-host reaction associated intestinal injury while preserving graft-versus-tumor effects.2007

    • Author(s)
      Ueha S.
    • Journal Title

      J Leukoc Biol 81

      Pages: 176-185

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.2007

    • Author(s)
      Kuninaka S
    • Journal Title

      Oncogene 26

      Pages: 2395-2406

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] A novel type of caspase-independent cell death in tetraploids with chromosome aberrationA2008

    • Author(s)
      Shin Yonehara
    • Organizer
      International Symposium 7 : Cell death and autophagy, The 38th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Final Research Report
  • [Presentation] Novel types of cell death identified in 1989 and 20082008

    • Author(s)
      Shin Yonehara
    • Organizer
      Argenes Sponsored Symposium : Apoptotic Therapy in RA, MEDICAL-EXPO 2008 in APLAR's World : The 13th Congress of the Asia Pacific League of Associations for Rheumatology
    • Place of Presentation
      Yokohama
    • Related Report
      2008 Final Research Report
  • [Presentation] Novel caspaseindependent cell death by downregulation of Eef1a1/EF-1α expression in tetraploids with chromosomal aberrations2008

    • Author(s)
      Shin Yonehara
    • Organizer
      The 15th East Asia Joint Conference on Biomedical Research
    • Place of Presentation
      Seoul
    • Related Report
      2008 Final Research Report
  • [Presentation] Fas下流シグナル分子の多様な生理機能2007

    • Author(s)
      米原 伸
    • Organizer
      生理研研究会「細胞死研究の新たな潮流と疾患研究への展開」
    • Place of Presentation
      岡崎市
    • Year and Date
      2007-08-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] TGF-βによる細胞死誘導活性および細胞死誘導阻害活性の分子機構と制御機構2007

    • Author(s)
      米原 伸
    • Organizer
      第72回日本インターフェロン・サイトカイン学会学術集会シンポジウム「新しいサイトカインのシグナル伝達と生理機能」
    • Place of Presentation
      京都市
    • Year and Date
      2007-06-29
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.lif.kyoto-u.ac.jp/labs/Fas/Home_j.htm

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞増殖抑制剤及びそのスクリーニング法2009

    • Inventor(s)
      京都大学大学院生命科学研究科教授 米原伸 他3名
    • Industrial Property Rights Holder
      京都大学大学院生命科学研究科教授 米原伸 他3名
    • Industrial Property Number
      2009-052628
    • Filing Date
      2009-03-05
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞増殖抑制剤及びそのスクリーニング法2009

    • Inventor(s)
      米原伸, 他
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Number
      2009-052628
    • Filing Date
      2009-03-10
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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