Analysis of interaction between cell death-, cell growth-and differentiation-inducing signals

• Project/Area Number: 19370052
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Kyoto University
• Principal Investigator: YONEHARA Shin Kyoto University, 大学院・生命科学研究科, 教授 (00124503)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2007: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: アポトーシス / 細胞周期 / シグナル伝達 / 遺伝子 / 細胞・組織

Research Abstract

FLASH/casp8ap2の解析を行い、FLASH の発現抑制によって、細胞周期のS 期進行が停止しすること、FLASHはARS2(arsenite resisitant protein 2)という分子と会合し、ARS2の発現抑制によっても、細胞周期のS期進行が阻害されることを示した。さらに、FLASHの細胞周期進行活性は、ARS2 との会合によって媒介されていることを明らかにした。

Research Products

• [Journal Article] Novel cell death by downregulation of eEF1A1 expression in tetraploids (2009)
  • Author(s): Kobayashi Y, and Yonehara S
  • Journal Title: Cell Death Differ 16 Pages: 139-150
• [Journal Article] Novel cell death by downregulation of eEFlAl expression in tetraploids. (2009)
  • Author(s): Kobayashi Y, Yonehara S
  • Journal Title: Cell Death and Differentiation 16 Pages: 139-150
  • Peer Reviewed
• [Journal Article] Mechanism of NKTcell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza viruses (2008)
  • Author(s): Kanijukun. Nagatii Y. Jiang X. Ichinohe T, Tashiro T, Mori K, Taniguchi M. Hase K, Ohno H, Shimaoka T. Yonehara S, Odagiri T. Tashiro M, Sata T. Hasegaws H. Seino K
  • Journal Title: Mucosal Immunology 1 Pages: 208-218
  • Peer Reviewed
• [Journal Article] Critical Role for CXC Chemokine Ligand 16(SR-PSOX)in Th1 response mediated by NKT cells (2007)
  • Author(s): Shimaoka T, Seino K, Kume N, Minami M, Nishime C, Suematsu M, Kita T, Taniguchi M, Matsushima K, and Yonehara S.
  • Journal Title: J Immunol 179 Pages: 8191-8199
• [Journal Article] Conserved function of caspase-8 in apoptosis during bony fish evolution (2007)
  • Author(s): Sakata S, Yan Y, Satou Y, Momoi A, Ngo-Hazelett P, Nozaki M, Furutani-Seiki M, Postlethwait JH, Yonehara S, Sakamaki K.
  • Journal Title: Gene 396 Pages: 134-148
• [Journal Article] Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes (2007)
  • Author(s): Moriyama H, and Yonehara S.
  • Journal Title: Immunol Lett 109 Pages: 36-46
• [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation (2007)
  • Author(s): Kuninaka S, Iida SI, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S, Saya H.
  • Journal Title: Oncogene 26 Pages: 2395-2406
• [Journal Article] Critical Role for CXC Chemokine Ligand 16 (SR-PSOX) in Thl response mediated by NKT cells. (2007)
  • Author(s): Shimaoka T.
  • Journal Title: J Immunol 179 Pages: 8191-8199
  • Peer Reviewed
• [Journal Article] Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes. (2007)
  • Author(s): Moriyama H.
  • Journal Title: Immunol Lett 109 Pages: 36-46
  • Peer Reviewed
• [Journal Article] Conserved function of caspase-8 in apoptosis during bony fish evolution. (2007)
  • Author(s): Sakata S.
  • Journal Title: Gene 396 Pages: 134-148
  • Peer Reviewed
• [Journal Article] Intervention of MAdCAM-1 or fractalkine alleviates graft-versus-host reaction associated intestinal injury while preserving graft-versus-tumor effects. (2007)
  • Author(s): Ueha S.
  • Journal Title: J Leukoc Biol 81 Pages: 176-185
  • Peer Reviewed
• [Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation. (2007)
  • Author(s): Kuninaka S
  • Journal Title: Oncogene 26 Pages: 2395-2406
  • Peer Reviewed
• [Presentation] A novel type of caspase-independent cell death in tetraploids with chromosome aberrationA (2008)
  • Author(s): Shin Yonehara
  • Organizer: International Symposium 7 : Cell death and autophagy, The 38th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto
• [Presentation] Novel types of cell death identified in 1989 and 2008 (2008)
  • Author(s): Shin Yonehara
  • Organizer: Argenes Sponsored Symposium : Apoptotic Therapy in RA, MEDICAL-EXPO 2008 in APLAR's World : The 13th Congress of the Asia Pacific League of Associations for Rheumatology
  • Place of Presentation: Yokohama
• [Presentation] Novel caspaseindependent cell death by downregulation of Eef1a1/EF-1α expression in tetraploids with chromosomal aberrations (2008)
  • Author(s): Shin Yonehara
  • Organizer: The 15th East Asia Joint Conference on Biomedical Research
  • Place of Presentation: Seoul
• [Presentation] Fas下流シグナル分子の多様な生理機能 (2007)
  • Author(s): 米原 伸
  • Organizer: 生理研研究会「細胞死研究の新たな潮流と疾患研究への展開」
  • Place of Presentation: 岡崎市
  • Year and Date: 2007-08-15
• [Presentation] TGF-βによる細胞死誘導活性および細胞死誘導阻害活性の分子機構と制御機構 (2007)
  • Author(s): 米原 伸
  • Organizer: 第72回日本インターフェロン・サイトカイン学会学術集会シンポジウム「新しいサイトカインのシグナル伝達と生理機能」
  • Place of Presentation: 京都市
  • Year and Date: 2007-06-29
• [Remarks]
  • URL: http://www.lif.kyoto-u.ac.jp/labs/Fas/Home_j.htm
• [Patent(Industrial Property Rights)] 細胞増殖抑制剤及びそのスクリーニング法 (2009)
  • Inventor(s): 京都大学大学院生命科学研究科教授 米原伸 他3名
  • Industrial Property Rights Holder: 京都大学大学院生命科学研究科教授 米原伸 他3名
  • Industrial Property Number: 2009-052628
  • Filing Date: 2009-03-05
• [Patent(Industrial Property Rights)] 細胞増殖抑制剤及びそのスクリーニング法 (2009)
  • Inventor(s): 米原伸, 他
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: 2009-052628
  • Filing Date: 2009-03-10